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P30822

- XPO1_YEAST

UniProt

P30822 - XPO1_YEAST

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Protein

Exportin-1

Gene

CRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).

GO - Molecular functioni

  1. protein transporter activity Source: SGD

GO - Biological processi

  1. mRNA export from nucleus Source: SGD
  2. protein export from nucleus Source: SGD
  3. protein localization to kinetochore Source: SGD
  4. ribosomal large subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance protein 1
Karyopherin-124
Gene namesi
Name:CRM1
Synonyms:KAP124, XPO1
Ordered Locus Names:YGR218W
ORF Names:G8514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR218w.
SGDiS000003450. CRM1.

Subcellular locationi

Nucleus 1 Publication. Cytoplasmperinuclear region 1 Publication
Note: Localized in the nucleus and at its periphery.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinetochore Source: SGD
  3. nucleus Source: SGD
  4. spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10841084Exportin-1PRO_0000204710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1080 – 10801Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30822.
PaxDbiP30822.
PeptideAtlasiP30822.
PRIDEiP30822.

Expressioni

Gene expression databases

GenevestigatoriP30822.

Interactioni

Subunit structurei

Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PKIAP6192517EBI-20589,EBI-2682139From a different organism.

Protein-protein interaction databases

BioGridi33472. 135 interactions.
DIPiDIP-2244N.
IntActiP30822. 47 interactions.
MINTiMINT-474317.
STRINGi4932.YGR218W.

Structurei

Secondary structure

1084
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 55Combined sources
Helixi13 – 2513Combined sources
Helixi28 – 4316Combined sources
Helixi47 – 504Combined sources
Helixi51 – 577Combined sources
Helixi61 – 7818Combined sources
Helixi79 – 813Combined sources
Helixi84 – 10320Combined sources
Helixi105 – 1106Combined sources
Helixi112 – 12918Combined sources
Turni130 – 1334Combined sources
Helixi137 – 1448Combined sources
Turni145 – 1473Combined sources
Helixi149 – 16719Combined sources
Turni171 – 1733Combined sources
Helixi176 – 20328Combined sources
Beta strandi205 – 2073Combined sources
Helixi208 – 22013Combined sources
Turni221 – 2233Combined sources
Helixi227 – 2304Combined sources
Beta strandi231 – 2333Combined sources
Helixi234 – 2396Combined sources
Helixi241 – 2444Combined sources
Helixi246 – 26015Combined sources
Helixi269 – 28921Combined sources
Helixi297 – 3037Combined sources
Helixi308 – 32619Combined sources
Helixi327 – 3304Combined sources
Helixi334 – 3363Combined sources
Helixi337 – 35014Combined sources
Helixi356 – 37318Combined sources
Turni414 – 4163Combined sources
Helixi417 – 4204Combined sources
Helixi421 – 43313Combined sources
Beta strandi443 – 4453Combined sources
Beta strandi451 – 4533Combined sources
Helixi459 – 4613Combined sources
Helixi462 – 47817Combined sources
Helixi480 – 49516Combined sources
Beta strandi497 – 4993Combined sources
Helixi502 – 51413Combined sources
Turni515 – 5173Combined sources
Helixi521 – 54121Combined sources
Helixi545 – 56016Combined sources
Helixi563 – 5686Combined sources
Helixi570 – 58314Combined sources
Helixi589 – 60618Combined sources
Helixi608 – 6114Combined sources
Helixi621 – 6277Combined sources
Helixi629 – 6335Combined sources
Beta strandi634 – 6363Combined sources
Helixi638 – 65215Combined sources
Helixi658 – 66811Combined sources
Helixi670 – 68516Combined sources
Helixi689 – 6913Combined sources
Helixi693 – 71321Combined sources
Helixi714 – 7174Combined sources
Helixi718 – 74629Combined sources
Helixi748 – 7525Combined sources
Helixi754 – 77623Combined sources
Helixi780 – 7867Combined sources
Helixi788 – 80114Combined sources
Helixi804 – 8063Combined sources
Helixi809 – 82214Combined sources
Helixi823 – 8253Combined sources
Helixi827 – 84519Combined sources
Beta strandi849 – 8524Combined sources
Helixi853 – 86917Combined sources
Helixi872 – 8754Combined sources
Helixi879 – 89315Combined sources
Helixi898 – 91821Combined sources
Helixi922 – 94423Combined sources
Beta strandi945 – 9473Combined sources
Helixi949 – 9513Combined sources
Helixi952 – 96716Combined sources
Turni978 – 9803Combined sources
Helixi987 – 100216Combined sources
Helixi1008 – 102013Combined sources
Turni1021 – 10233Combined sources
Helixi1025 – 103814Combined sources
Beta strandi1041 – 10433Combined sources
Helixi1046 – 10505Combined sources
Turni1055 – 10573Combined sources
Helixi1079 – 10813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
ProteinModelPortaliP30822.
SMRiP30822. Positions 515-641.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30822.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10067Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5101.
GeneTreeiENSGT00390000000572.
HOGENOMiHOG000209012.
InParanoidiP30822.
KOiK14290.
OMAiSEDTEKR.
OrthoDBiEOG7MWH56.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30822-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
60 70 80 90 100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
110 120 130 140 150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
160 170 180 190 200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
210 220 230 240 250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
260 270 280 290 300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
360 370 380 390 400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
410 420 430 440 450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
460 470 480 490 500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
510 520 530 540 550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
560 570 580 590 600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
660 670 680 690 700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
710 720 730 740 750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
760 770 780 790 800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
810 820 830 840 850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
860 870 880 890 900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
960 970 980 990 1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
1010 1020 1030 1040 1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
1060 1070 1080
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Length:1,084
Mass (Da):124,104
Last modified:July 1, 1993 - v1
Checksum:iA81833C7F60F5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA. Translation: BAA02371.1.
X87941 Genomic DNA. Translation: CAA61166.1.
Z73003 Genomic DNA. Translation: CAA97246.1.
BK006941 Genomic DNA. Translation: DAA08312.1.
PIRiS57681.
RefSeqiNP_011734.3. NM_001181347.3.

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W.
GeneIDi853133.
KEGGisce:YGR218W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA. Translation: BAA02371.1 .
X87941 Genomic DNA. Translation: CAA61166.1 .
Z73003 Genomic DNA. Translation: CAA97246.1 .
BK006941 Genomic DNA. Translation: DAA08312.1 .
PIRi S57681.
RefSeqi NP_011734.3. NM_001181347.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3M1I X-ray 2.00 C 1-1084 [» ]
3VYC X-ray 2.10 A 1-1084 [» ]
4GMX X-ray 2.10 C 1-1058 [» ]
4GPT X-ray 2.22 C 1-1058 [» ]
4HAT X-ray 1.78 C 1-1058 [» ]
4HAU X-ray 2.00 C 1-1058 [» ]
4HAV X-ray 2.00 C 1-1058 [» ]
4HAW X-ray 1.90 C 1-1058 [» ]
4HAX X-ray 2.28 C 1-1058 [» ]
4HAY X-ray 2.30 C 1-1058 [» ]
4HAZ X-ray 1.90 C 1-1058 [» ]
4HB0 X-ray 2.20 C 1-1058 [» ]
4HB2 X-ray 1.80 C 1-1058 [» ]
4HB3 X-ray 2.80 C 1-1058 [» ]
4HB4 X-ray 2.05 C 1-1058 [» ]
ProteinModelPortali P30822.
SMRi P30822. Positions 515-641.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33472. 135 interactions.
DIPi DIP-2244N.
IntActi P30822. 47 interactions.
MINTi MINT-474317.
STRINGi 4932.YGR218W.

Proteomic databases

MaxQBi P30822.
PaxDbi P30822.
PeptideAtlasi P30822.
PRIDEi P30822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR218W ; YGR218W ; YGR218W .
GeneIDi 853133.
KEGGi sce:YGR218W.

Organism-specific databases

CYGDi YGR218w.
SGDi S000003450. CRM1.

Phylogenomic databases

eggNOGi COG5101.
GeneTreei ENSGT00390000000572.
HOGENOMi HOG000209012.
InParanoidi P30822.
KOi K14290.
OMAi SEDTEKR.
OrthoDBi EOG7MWH56.

Enzyme and pathway databases

BioCyci YEAST:G3O-30900-MONOMER.

Miscellaneous databases

EvolutionaryTracei P30822.
NextBioi 973192.
PROi P30822.

Gene expression databases

Genevestigatori P30822.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view ]
SMARTi SM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1."
    Toda T., Shimanuki M., Saka Y., Yamano H., Adachi Y., Shirakawa M., Kyogoku Y., Yanagida M.
    Mol. Cell. Biol. 12:5474-5484(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1 region from the right arm of Saccharomyces cerevisiae chromosome VII."
    van der Aart Q.J.M., Kleine K., Steensma H.Y.
    Yeast 12:385-390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Exportin 1 (Crm1p) is an essential nuclear export factor."
    Stade K., Ford C.S., Guthrie C., Weis K.
    Cell 90:1041-1050(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export."
    Brune C., Munchel S.E., Fischer N., Podtelejnikov A.V., Weis K.
    RNA 11:517-531(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PAB1.
  9. "The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing."
    Murphy M.W., Olson B.L., Siliciano P.G.
    Genetics 166:53-65(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRP40.
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXPO1_YEAST
AccessioniPrimary (citable) accession number: P30822
Secondary accession number(s): D6VV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3