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Protein

Exportin-1

Gene

CRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mRNA export from nucleus Source: SGD
  • protein export from nucleus Source: SGD
  • protein localization to kinetochore Source: SGD
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: SGD
  • ribosomal small subunit export from nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER
ReactomeiR-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance protein 1
Karyopherin-124
Gene namesi
Name:CRM1
Synonyms:KAP124, XPO1
Ordered Locus Names:YGR218W
ORF Names:G8514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR218W
SGDiS000003450 CRM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047101 – 1084Exportin-1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30822
PaxDbiP30822
PRIDEiP30822

PTM databases

iPTMnetiP30822

Interactioni

Subunit structurei

Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33472, 979 interactors
DIPiDIP-2244N
IntActiP30822, 747 interactors
MINTiP30822
STRINGi4932.YGR218W

Structurei

Secondary structure

11084
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 5Combined sources5
Beta strandi7 – 9Combined sources3
Helixi13 – 25Combined sources13
Helixi28 – 43Combined sources16
Helixi47 – 50Combined sources4
Helixi54 – 57Combined sources4
Helixi61 – 77Combined sources17
Helixi79 – 81Combined sources3
Helixi84 – 103Combined sources20
Helixi105 – 110Combined sources6
Helixi112 – 129Combined sources18
Turni130 – 133Combined sources4
Helixi137 – 145Combined sources9
Helixi149 – 167Combined sources19
Turni171 – 173Combined sources3
Helixi176 – 203Combined sources28
Helixi207 – 220Combined sources14
Turni221 – 223Combined sources3
Helixi227 – 230Combined sources4
Beta strandi231 – 233Combined sources3
Helixi234 – 239Combined sources6
Helixi241 – 244Combined sources4
Helixi246 – 248Combined sources3
Helixi253 – 257Combined sources5
Helixi268 – 280Combined sources13
Helixi283 – 296Combined sources14
Helixi300 – 303Combined sources4
Helixi308 – 317Combined sources10
Helixi319 – 326Combined sources8
Helixi327 – 329Combined sources3
Helixi332 – 342Combined sources11
Helixi348 – 354Combined sources7
Helixi356 – 361Combined sources6
Helixi367 – 373Combined sources7
Helixi375 – 381Combined sources7
Turni382 – 385Combined sources4
Helixi388 – 395Combined sources8
Turni396 – 398Combined sources3
Helixi400 – 412Combined sources13
Helixi415 – 420Combined sources6
Turni421 – 423Combined sources3
Helixi426 – 448Combined sources23
Helixi450 – 454Combined sources5
Beta strandi456 – 458Combined sources3
Helixi459 – 471Combined sources13
Turni472 – 474Combined sources3
Helixi478 – 481Combined sources4
Beta strandi482 – 484Combined sources3
Helixi485 – 488Combined sources4
Helixi490 – 493Combined sources4
Helixi495 – 509Combined sources15
Turni515 – 517Combined sources3
Helixi522 – 539Combined sources18
Helixi547 – 553Combined sources7
Helixi562 – 581Combined sources20
Helixi589 – 591Combined sources3
Helixi592 – 604Combined sources13
Helixi608 – 611Combined sources4
Helixi618 – 621Combined sources4
Helixi623 – 636Combined sources14
Turni638 – 640Combined sources3
Helixi641 – 644Combined sources4
Helixi645 – 648Combined sources4
Helixi653 – 661Combined sources9
Beta strandi670 – 672Combined sources3
Helixi676 – 681Combined sources6
Helixi684 – 687Combined sources4
Helixi689 – 713Combined sources25
Helixi714 – 717Combined sources4
Helixi718 – 725Combined sources8
Beta strandi727 – 729Combined sources3
Helixi732 – 744Combined sources13
Helixi748 – 750Combined sources3
Helixi753 – 776Combined sources24
Helixi780 – 786Combined sources7
Helixi788 – 801Combined sources14
Helixi804 – 806Combined sources3
Helixi809 – 822Combined sources14
Helixi823 – 825Combined sources3
Helixi828 – 845Combined sources18
Beta strandi849 – 851Combined sources3
Helixi859 – 870Combined sources12
Helixi872 – 875Combined sources4
Helixi879 – 893Combined sources15
Turni894 – 896Combined sources3
Helixi899 – 909Combined sources11
Helixi911 – 918Combined sources8
Helixi922 – 944Combined sources23
Beta strandi945 – 947Combined sources3
Helixi949 – 951Combined sources3
Helixi952 – 967Combined sources16
Turni978 – 980Combined sources3
Helixi987 – 1002Combined sources16
Helixi1008 – 1020Combined sources13
Turni1021 – 1023Combined sources3
Helixi1025 – 1038Combined sources14
Beta strandi1041 – 1043Combined sources3
Helixi1046 – 1050Combined sources5
Helixi1051 – 1054Combined sources4
Turni1055 – 1057Combined sources3
Helixi1079 – 1081Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
3WYFX-ray2.22C/F1-1084[»]
3WYGX-ray2.15C1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
5DH9X-ray2.55C1-1058[»]
5DHAX-ray2.95C1-1058[»]
5DHFX-ray2.29C1-1058[»]
5DI9X-ray2.28C1-1058[»]
5DIFX-ray2.09C1-1058[»]
5JLJX-ray2.50C1-1058[»]
5UWHX-ray2.26C1-1058[»]
5UWIX-ray2.14C1-1058[»]
5UWJX-ray2.22C1-1058[»]
5UWOX-ray2.35C1-1058[»]
5UWPX-ray2.05C1-1058[»]
5UWQX-ray2.28C1-1058[»]
5UWRX-ray2.24C1-1058[»]
5UWSX-ray2.40C1-1058[»]
5UWTX-ray2.34C1-1058[»]
5UWUX-ray2.24C1-1058[»]
5UWWX-ray2.15C1-1058[»]
5XOJX-ray2.20C1-1084[»]
ProteinModelPortaliP30822
SMRiP30822
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30822

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
InParanoidiP30822
KOiK14290
OMAiCENNMII
OrthoDBiEOG092C0C5J

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 CRM1_C_dom
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P30822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
60 70 80 90 100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
110 120 130 140 150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
160 170 180 190 200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
210 220 230 240 250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
260 270 280 290 300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
360 370 380 390 400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
410 420 430 440 450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
460 470 480 490 500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
510 520 530 540 550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
560 570 580 590 600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
660 670 680 690 700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
710 720 730 740 750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
760 770 780 790 800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
810 820 830 840 850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
860 870 880 890 900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
960 970 980 990 1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
1010 1020 1030 1040 1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
1060 1070 1080
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Length:1,084
Mass (Da):124,104
Last modified:July 1, 1993 - v1
Checksum:iA81833C7F60F5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA Translation: BAA02371.1
X87941 Genomic DNA Translation: CAA61166.1
Z73003 Genomic DNA Translation: CAA97246.1
BK006941 Genomic DNA Translation: DAA08312.1
PIRiS57681
RefSeqiNP_011734.3, NM_001181347.3

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W
GeneIDi853133
KEGGisce:YGR218W

Similar proteinsi

Entry informationi

Entry nameiXPO1_YEAST
AccessioniPrimary (citable) accession number: P30822
Secondary accession number(s): D6VV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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