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Protein

Exportin-1

Gene

CRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central
  • protein transporter activity Source: SGD

GO - Biological processi

  • mRNA export from nucleus Source: SGD
  • protein export from nucleus Source: SGD
  • protein localization to kinetochore Source: SGD
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: SGD
  • ribosomal small subunit export from nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER.
ReactomeiR-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance protein 1
Karyopherin-124
Gene namesi
Name:CRM1
Synonyms:KAP124, XPO1
Ordered Locus Names:YGR218W
ORF Names:G8514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR218W.
SGDiS000003450. CRM1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • kinetochore Source: SGD
  • nucleus Source: SGD
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047101 – 1084Exportin-1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30822.
PRIDEiP30822.

PTM databases

iPTMnetiP30822.

Interactioni

Subunit structurei

Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PKIAP6192517EBI-20589,EBI-2682139From a different organism.
YMR124WP395233EBI-20589,EBI-27256

Protein-protein interaction databases

BioGridi33472. 823 interactors.
DIPiDIP-2244N.
IntActiP30822. 744 interactors.
MINTiMINT-474317.

Structurei

Secondary structure

11084
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 5Combined sources5
Beta strandi7 – 9Combined sources3
Helixi13 – 25Combined sources13
Helixi28 – 43Combined sources16
Helixi47 – 50Combined sources4
Helixi51 – 57Combined sources7
Helixi61 – 78Combined sources18
Helixi79 – 81Combined sources3
Helixi84 – 103Combined sources20
Helixi105 – 110Combined sources6
Helixi112 – 129Combined sources18
Turni130 – 133Combined sources4
Helixi137 – 144Combined sources8
Turni145 – 147Combined sources3
Helixi149 – 167Combined sources19
Turni171 – 173Combined sources3
Helixi176 – 203Combined sources28
Beta strandi205 – 207Combined sources3
Helixi208 – 220Combined sources13
Turni221 – 223Combined sources3
Helixi227 – 230Combined sources4
Beta strandi231 – 233Combined sources3
Helixi234 – 239Combined sources6
Helixi241 – 244Combined sources4
Helixi246 – 260Combined sources15
Helixi269 – 289Combined sources21
Helixi297 – 303Combined sources7
Helixi308 – 326Combined sources19
Helixi327 – 330Combined sources4
Helixi334 – 336Combined sources3
Helixi337 – 350Combined sources14
Helixi356 – 373Combined sources18
Turni414 – 416Combined sources3
Helixi417 – 420Combined sources4
Helixi421 – 433Combined sources13
Beta strandi443 – 445Combined sources3
Beta strandi451 – 453Combined sources3
Helixi459 – 461Combined sources3
Helixi462 – 478Combined sources17
Helixi480 – 495Combined sources16
Beta strandi497 – 499Combined sources3
Helixi502 – 514Combined sources13
Turni515 – 517Combined sources3
Helixi521 – 541Combined sources21
Helixi545 – 560Combined sources16
Helixi563 – 568Combined sources6
Helixi570 – 583Combined sources14
Helixi589 – 606Combined sources18
Helixi608 – 611Combined sources4
Beta strandi617 – 619Combined sources3
Helixi621 – 627Combined sources7
Helixi629 – 633Combined sources5
Beta strandi634 – 636Combined sources3
Helixi638 – 652Combined sources15
Helixi658 – 668Combined sources11
Helixi670 – 685Combined sources16
Helixi689 – 691Combined sources3
Helixi693 – 713Combined sources21
Helixi714 – 717Combined sources4
Helixi718 – 746Combined sources29
Helixi748 – 752Combined sources5
Helixi754 – 776Combined sources23
Helixi780 – 786Combined sources7
Helixi788 – 801Combined sources14
Helixi804 – 806Combined sources3
Helixi809 – 822Combined sources14
Helixi823 – 825Combined sources3
Helixi827 – 845Combined sources19
Beta strandi849 – 852Combined sources4
Helixi853 – 869Combined sources17
Helixi872 – 875Combined sources4
Helixi879 – 893Combined sources15
Helixi898 – 918Combined sources21
Helixi922 – 944Combined sources23
Beta strandi945 – 947Combined sources3
Helixi949 – 951Combined sources3
Helixi952 – 967Combined sources16
Turni978 – 980Combined sources3
Helixi987 – 1002Combined sources16
Helixi1008 – 1020Combined sources13
Turni1021 – 1023Combined sources3
Helixi1025 – 1038Combined sources14
Beta strandi1041 – 1043Combined sources3
Helixi1046 – 1050Combined sources5
Helixi1051 – 1054Combined sources4
Turni1055 – 1057Combined sources3
Helixi1079 – 1081Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
3WYFX-ray2.22C/F1-1084[»]
3WYGX-ray2.15C1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
5DH9X-ray2.55C1-1058[»]
5DHAX-ray2.95C1-1058[»]
5DHFX-ray2.29C1-1058[»]
5DI9X-ray2.28C1-1058[»]
5DIFX-ray2.09C1-1058[»]
5JLJX-ray2.50C1-1058[»]
ProteinModelPortaliP30822.
SMRiP30822.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30822.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000000572.
HOGENOMiHOG000209012.
InParanoidiP30822.
KOiK14290.
OMAiVGHMIPE.
OrthoDBiEOG092C0C5J.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
60 70 80 90 100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
110 120 130 140 150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
160 170 180 190 200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
210 220 230 240 250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
260 270 280 290 300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
360 370 380 390 400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
410 420 430 440 450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
460 470 480 490 500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
510 520 530 540 550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
560 570 580 590 600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
660 670 680 690 700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
710 720 730 740 750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
760 770 780 790 800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
810 820 830 840 850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
860 870 880 890 900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
960 970 980 990 1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
1010 1020 1030 1040 1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
1060 1070 1080
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Length:1,084
Mass (Da):124,104
Last modified:July 1, 1993 - v1
Checksum:iA81833C7F60F5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA. Translation: BAA02371.1.
X87941 Genomic DNA. Translation: CAA61166.1.
Z73003 Genomic DNA. Translation: CAA97246.1.
BK006941 Genomic DNA. Translation: DAA08312.1.
PIRiS57681.
RefSeqiNP_011734.3. NM_001181347.3.

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W.
GeneIDi853133.
KEGGisce:YGR218W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA. Translation: BAA02371.1.
X87941 Genomic DNA. Translation: CAA61166.1.
Z73003 Genomic DNA. Translation: CAA97246.1.
BK006941 Genomic DNA. Translation: DAA08312.1.
PIRiS57681.
RefSeqiNP_011734.3. NM_001181347.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
3WYFX-ray2.22C/F1-1084[»]
3WYGX-ray2.15C1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
5DH9X-ray2.55C1-1058[»]
5DHAX-ray2.95C1-1058[»]
5DHFX-ray2.29C1-1058[»]
5DI9X-ray2.28C1-1058[»]
5DIFX-ray2.09C1-1058[»]
5JLJX-ray2.50C1-1058[»]
ProteinModelPortaliP30822.
SMRiP30822.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33472. 823 interactors.
DIPiDIP-2244N.
IntActiP30822. 744 interactors.
MINTiMINT-474317.

PTM databases

iPTMnetiP30822.

Proteomic databases

MaxQBiP30822.
PRIDEiP30822.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W.
GeneIDi853133.
KEGGisce:YGR218W.

Organism-specific databases

EuPathDBiFungiDB:YGR218W.
SGDiS000003450. CRM1.

Phylogenomic databases

GeneTreeiENSGT00390000000572.
HOGENOMiHOG000209012.
InParanoidiP30822.
KOiK14290.
OMAiVGHMIPE.
OrthoDBiEOG092C0C5J.

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER.
ReactomeiR-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.

Miscellaneous databases

EvolutionaryTraceiP30822.
PROiP30822.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_YEAST
AccessioniPrimary (citable) accession number: P30822
Secondary accession number(s): D6VV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.