ID   COX4_DICDI              Reviewed;         148 AA.
AC   P30815; Q54U12;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   24-JAN-2024, entry version 98.
DE   RecName: Full=Cytochrome c oxidase subunit 4, mitochondrial;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
DE   Flags: Precursor;
GN   Name=cxdA; Synonyms=cox4; ORFNames=DDB_G0281393;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RX   PubMed=1653019;
RA   Rizzuto R., Sandona D., Capaldi R.A., Bisson R.;
RT   "Nucleotide sequence of a cDNA coding for the mitochondrial precursor
RT   protein of cytochrome c oxidase subunit IV from the slime mold
RT   Dictyostelium discoideum.";
RL   Biochim. Biophys. Acta 1090:125-128(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: This protein is one of the nuclear-coded polypeptide chains
CC       of cytochrome c oxidase, the terminal oxidase in mitochondrial electron
CC       transport.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Slime mold cytochrome c oxidase consists of at least seven
CC       different polypeptides species, subunits I, II, III, IV, V, VI, and
CC       VIIe/s in order of MW.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
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DR   EMBL; X55670; CAA39205.2; -; mRNA.
DR   EMBL; AAFI02000041; EAL66678.1; -; Genomic_DNA.
DR   PIR; S17660; S17660.
DR   RefSeq; XP_640649.1; XM_635557.1.
DR   AlphaFoldDB; P30815; -.
DR   SMR; P30815; -.
DR   STRING; 44689.P30815; -.
DR   PaxDb; 44689-DDB0214995; -.
DR   EnsemblProtists; EAL66678; EAL66678; DDB_G0281393.
DR   GeneID; 8623033; -.
DR   KEGG; ddi:DDB_G0281393; -.
DR   dictyBase; DDB_G0281393; cxdA.
DR   eggNOG; ENOG502RHIJ; Eukaryota.
DR   HOGENOM; CLU_1762187_0_0_1; -.
DR   InParanoid; P30815; -.
DR   OMA; PILHICV; -.
DR   PRO; PR:P30815; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Translocase.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT   CHAIN           25..148
FT                   /note="Cytochrome c oxidase subunit 4, mitochondrial"
FT                   /id="PRO_0000006078"
FT   CONFLICT        56
FT                   /note="P -> G (in Ref. 1; CAA39205)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        136
FT                   /note="I -> V (in Ref. 1; CAA39205)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  16944 MW;  985853837B43857F CRC64;
     MFALRSIRSA TKAFQTTSIV SQRGFLQTTL KNVLFPTERQ LRRQYLADNH IKVGSPEFDK
     FYEDLQPSEL SKQSGLSDAL LDDPILHICV IKYNKNIVQR YNLTPEQEKD IMENYNVSAG
     DPSLEQILPI PVPAHIFEEL PIVKVLNN
//