P30815 (COX4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4, mitochondrial
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide IV

Gene names

Name:	cxdA
Synonyms:	cox4
ORF Names:	DDB_G0281393

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.
Subcellular location	Mitochondrion inner membrane.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 24	24	Mitochondrion
	Chain	25 – 148	124	Cytochrome c oxidase subunit 4, mitochondrial		PRO_0000006078
Experimental info
	Sequence conflict	56	1	P → G in CAA39205. Ref.1
	Sequence conflict	136	1	I → V in CAA39205. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P30815 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 985853837B43857F	FASTA	148	16,944
	10 20 30 40 50 60 MFALRSIRSA TKAFQTTSIV SQRGFLQTTL KNVLFPTERQ LRRQYLADNH IKVGSPEFDK 70 80 90 100 110 120 FYEDLQPSEL SKQSGLSDAL LDDPILHICV IKYNKNIVQR YNLTPEQEKD IMENYNVSAG 130 140 DPSLEQILPI PVPAHIFEEL PIVKVLNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a cDNA coding for the mitochondrial precursor protein of cytochrome c oxidase subunit IV from the slime mold Dictyostelium discoideum." Rizzuto R., Sandona D., Capaldi R.A., Bisson R. Biochim. Biophys. Acta 1090:125-128(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX3.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55670 mRNA. Translation: CAA39205.2. AAFI02000041 Genomic DNA. Translation: EAL66678.1.
PIR	S17660.
RefSeq	XP_640649.1. XM_635557.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P30815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0214995; DDB0214995; DDB_G0281393.
GeneID	8623033.
KEGG	ddi:DDB_G0281393.
Organism-specific databases
dictyBase	DDB_G0281393. cxdA.
Phylogenomic databases
OMA	ILHICVI.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

COX4_DICDI

Accession

Primary (citable) accession number: P30815
Secondary accession number(s): Q54U12

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)