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P30815

- COX4_DICDI

UniProt

P30815 - COX4_DICDI

Protein

Cytochrome c oxidase subunit 4, mitochondrial

Gene

cxdA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 4, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide IV
    Gene namesi
    Name:cxdA
    Synonyms:cox4
    ORF Names:DDB_G0281393
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0281393. cxdA.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionAdd
    BLAST
    Chaini25 – 148124Cytochrome c oxidase subunit 4, mitochondrialPRO_0000006078Add
    BLAST

    Proteomic databases

    PRIDEiP30815.

    Interactioni

    Subunit structurei

    Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    OMAiILHICVI.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30815-1 [UniParc]FASTAAdd to Basket

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    MFALRSIRSA TKAFQTTSIV SQRGFLQTTL KNVLFPTERQ LRRQYLADNH    50
    IKVGSPEFDK FYEDLQPSEL SKQSGLSDAL LDDPILHICV IKYNKNIVQR 100
    YNLTPEQEKD IMENYNVSAG DPSLEQILPI PVPAHIFEEL PIVKVLNN 148
    Length:148
    Mass (Da):16,944
    Last modified:December 4, 2007 - v2
    Checksum:i985853837B43857F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561P → G in CAA39205. (PubMed:1653019)Curated
    Sequence conflicti136 – 1361I → V in CAA39205. (PubMed:1653019)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55670 mRNA. Translation: CAA39205.2.
    AAFI02000041 Genomic DNA. Translation: EAL66678.1.
    PIRiS17660.
    RefSeqiXP_640649.1. XM_635557.1.

    Genome annotation databases

    EnsemblProtistsiDDB0214995; DDB0214995; DDB_G0281393.
    GeneIDi8623033.
    KEGGiddi:DDB_G0281393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55670 mRNA. Translation: CAA39205.2 .
    AAFI02000041 Genomic DNA. Translation: EAL66678.1 .
    PIRi S17660.
    RefSeqi XP_640649.1. XM_635557.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P30815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0214995 ; DDB0214995 ; DDB_G0281393 .
    GeneIDi 8623033.
    KEGGi ddi:DDB_G0281393.

    Organism-specific databases

    dictyBasei DDB_G0281393. cxdA.

    Phylogenomic databases

    OMAi ILHICVI.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA coding for the mitochondrial precursor protein of cytochrome c oxidase subunit IV from the slime mold Dictyostelium discoideum."
      Rizzuto R., Sandona D., Capaldi R.A., Bisson R.
      Biochim. Biophys. Acta 1090:125-128(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AX3.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCOX4_DICDI
    AccessioniPrimary (citable) accession number: P30815
    Secondary accession number(s): Q54U12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

    External Data

    Dasty 3