P30804 (ADCY6_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase type 6
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase 6
Adenylate cyclase type VI
Adenylyl cyclase 6
Ca(2+)-inhibitable adenylyl cyclase

Gene names

Name:

ADCY6

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	1165 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation By similarity.
Subunit structure	Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 By similarity. Interacts with RAF1 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein. Cell projection › cilium By similarity.
Post-translational modification	Phosphorylated by RAF1 By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell projection Cilium Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cilium Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1165	1165	Adenylate cyclase type 6		PRO_0000195698
Regions
	Topological domain	1 – 149	149	Cytoplasmic Potential
	Transmembrane	150 – 166	17	Helical; Potential
	Transmembrane	179 – 195	17	Helical; Potential
	Transmembrane	212 – 228	17	Helical; Potential
	Transmembrane	237 – 253	17	Helical; Potential
	Transmembrane	257 – 273	17	Helical; Potential
	Transmembrane	287 – 303	17	Helical; Potential
	Topological domain	304 – 670	367	Cytoplasmic Potential
	Transmembrane	671 – 688	18	Helical; Potential
	Transmembrane	699 – 715	17	Helical; Potential
	Transmembrane	740 – 756	17	Helical; Potential
	Topological domain	757 – 816	60	Extracellular Potential
	Transmembrane	817 – 833	17	Helical; Potential
	Transmembrane	836 – 852	17	Helical; Potential
	Transmembrane	894 – 910	17	Helical; Potential
	Topological domain	911 – 1165	255	Cytoplasmic Potential
Sites
	Metal binding	382	1	Magnesium 1 By similarity
	Metal binding	382	1	Magnesium 2 By similarity
	Metal binding	383	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	426	1	Magnesium 1 By similarity
	Metal binding	426	1	Magnesium 2 By similarity
Amino acid modifications
	Modified residue	53	1	Phosphoserine By similarity
	Modified residue	573	1	Phosphoserine By similarity
	Glycosylation	790	1	N-linked (GlcNAc...) Potential
	Glycosylation	875	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P30804 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: BA9D2D329120615E	FASTA	1,165	130,324
	10 20 30 40 50 60 MSWFSGLLVP KVDERKTAWG ERNGQKRPRR GTRTSGFCTP RYMSCLRDAQ PPSPTPAAPP 70 80 90 100 110 120 RCPWQDEAFI RRGGPGKGTE LGLRAVALGF EDTEAMSAVG AAGGGPDVTP GSRRSCWRRL 130 140 150 160 170 180 AQVFQSKQFR SAKLERLYQR YFFQMNQSSL TLLMAVLVLL TAVLLAFHAA PARPQPAYVA 190 200 210 220 230 240 LLACAATLFV ALMVVCNRHS FRQDSMWVVS YVVLGILAAV QVGGALAANP RSPSVGLWCP 250 260 270 280 290 300 VFFVYITYTL LPIRMRAAVF SGLGLSTLHL ILAWQLNRGD AFLWKQLGAN MLLFLCTNVI 310 320 330 340 350 360 GICTHYPAEV SQRQAFQETR GYIQARLHLP DENRQQERLL LSVLPQHVAM EMKEDINTKK 370 380 390 400 410 420 EDMMFHKIYI QKHDNVSILF ADIEGFTSLA SQCTAQELVM TLNELFARFD KLAAENHCLR 430 440 450 460 470 480 IKILGDCYYC VSGLPEARAD HAHCCVEMGV DMIEAISLVR EVTGVNVNMR VGIHSGRVHC 490 500 510 520 530 540 GVLGLRKWQF DVWSNDVTLA NHMEAARAGR IHITRATLQY LNGDYEVEPG RGGERNAYLK 550 560 570 580 590 600 EQHIETFLIL GASQKRKEEK AMLAKLQRTR ANSMEGLMPR WVPDRAFSRT KDSKAFRQMG 610 620 630 640 650 660 IDDSSKDNRG AQDALNPEDE VDEFLGRAID ARSIDQLRKD HVRRFLLTFQ REDLEKKYSR 670 680 690 700 710 720 KVDPRFGAYV ACALLVFCFI CFIQLLVFPH STVMLGIYAS IFVLLLITVL TCAVYSCGSL 730 740 750 760 770 780 FPKALRRLSR SIVRSRAHST VVGIFSVLLV FTSAIANMFT CNHTPIRTCA ARMLNVTPAD 790 800 810 820 830 840 ITACHLQQLN YSLGLDAPLC EGTAPTCSFP EYFVGNMLLS LLASSVFLHI SSIGKLAMIF 850 860 870 880 890 900 VLGLIYLVLL LLGPPSTIFD NYDLLLGVHG LASSNDTFDG LDCPAAGRVA LKYMTPVILL 910 920 930 940 950 960 VFALALYLHA QQVESTARLD FLWKLQATGE KEEMEELQAY NRRLLHNILP KDVAAHFLAR 970 980 990 1000 1010 1020 ERRNDELYYQ SCECVAVMFA SIANFSEFYV ELEANNEGVE CLRLLNEIIA DFDEIISEER 1030 1040 1050 1060 1070 1080 FRQLEKIKTI GSTYMAASGL NASTYDQAGR SHITALADYA MRLMEQMKHI NEHSFNNFQM 1090 1100 1110 1120 1130 1140 KIGLNMGPVV AGVIGARKPQ YDIWGNTVNV SSRMDSTGVP DRIQVTTDLY QVLAAKRYQL 1150 1160 ECRGVVKVKG KGEMTTYFLN GGPPS

References

[1]	"Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family." Katsushika S., Chen L., Kawabe J., Nilakantan R., Halnon N.J., Homcy C.J., Ishikawa Y. Proc. Natl. Acad. Sci. U.S.A. 89:8774-8778(1992) [PubMed: 1528892] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94968 mRNA. No translation available.
PIR	A46180.
3D structure databases
ProteinModelPortal	P30804.
SMR	P30804. Positions 362-550, 967-1142.
ModBase	Search...
Protein-protein interaction databases
STRING	P30804.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	maNOG12560.
GeneTree	ENSGT00590000082802.
HOVERGEN	HBG050458.
InParanoid	P30804.
OrthoDB	EOG4255S0.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADCY6_CANFA

Accession

Primary (citable) accession number: P30804

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program