Reviewed,
UniProtKB/Swiss-Prot P30804 (ADCY6_CANFA)
Last modified
June 16, 2009.
Version 69.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Adenylate cyclase type 6 EC=4.6.1.1 Alternative name(s): Adenylate cyclase type VI ATP pyrophosphate-lyase 6 Adenylyl cyclase 6 Ca(2+)-inhibitable adenylyl cyclase | ||
| Gene names |
| ||
| Organism | Canis familiaris (Dog) | ||
| Taxonomic identifier | 9615 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 1165 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Membrane-bound, calcium-inhibitable adenylyl cyclase. |
| Catalytic activity | ATP = 3',5'-cyclic AMP + diphosphate. |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. |
| Enzyme regulation | Inhibition by calcium in the submicromolar concentration range. |
| Subcellular location | |
| Sequence similarities | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | cAMP biosynthesis |
| Cellular component | Membrane |
| Domain | Repeat Transmembrane |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Lyase |
| PTM | Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascadeInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1165 | 1165 | Adenylate cyclase type 6 | PRO_0000195698 | |||||
Regions | |||||||||
| Topological domain | 1 – 149 | 149 | Cytoplasmic Potential | ||||||
| Transmembrane | 150 – 166 | 17 | Potential | ||||||
| Transmembrane | 179 – 195 | 17 | Potential | ||||||
| Transmembrane | 212 – 228 | 17 | Potential | ||||||
| Transmembrane | 237 – 253 | 17 | Potential | ||||||
| Transmembrane | 257 – 273 | 17 | Potential | ||||||
| Transmembrane | 287 – 303 | 17 | Potential | ||||||
| Topological domain | 304 – 670 | 367 | Cytoplasmic Potential | ||||||
| Transmembrane | 671 – 688 | 18 | Potential | ||||||
| Transmembrane | 699 – 715 | 17 | Potential | ||||||
| Transmembrane | 740 – 756 | 17 | Potential | ||||||
| Topological domain | 757 – 816 | 60 | Extracellular Potential | ||||||
| Transmembrane | 817 – 833 | 17 | Potential | ||||||
| Transmembrane | 836 – 852 | 17 | Potential | ||||||
| Transmembrane | 894 – 910 | 17 | Potential | ||||||
| Topological domain | 911 – 1165 | 255 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Metal binding | 382 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 382 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 383 | 1 | Magnesium 2; via carbonyl oxygen By similarity | ||||||
| Metal binding | 426 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 426 | 1 | Magnesium 2 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 53 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 573 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 790 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 875 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family." Katsushika S., Chen L., Kawabe J., Nilakantan R., Halnon N.J., Homcy C.J., Ishikawa Y. Proc. Natl. Acad. Sci. U.S.A. 89:8774-8778(1992) [PubMed: 1528892] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
Cross-references
Sequence databases | |
|---|---|
| M94968 mRNA. No translation available. | |
| PIR | A46180. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AZS based on UniProtKB P30803. |
| SMR | P30804. Positions 362-550. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSCAFG00000008907. Canis familiaris. [Contig view] |
Phylogenomic databases | |
| HOVERGEN | P30804. |
Enzyme and pathway databases | |
| BRENDA | 4.6.1.1. 463. |
Family and domain databases | |
| InterPro | IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Aden_cycl-like. [Graphical view] |
| Gene3D | G3DSA:3.30.70.1230. A/G_cyclase. 2 hits. |
| Pfam | PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view] |
| SMART | SM00044. CYCc. 2 hits. [Graphical view] |
| PROSITE | PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADCY6_CANFA | ||||||||
| Accession | Primary (citable) accession number: P30804 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
