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Protein

Galanin

Gene

GAL

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_250082. Peptide ligand-binding receptors.
REACT_253620. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin
Gene namesi
Name:GAL
Synonyms:GALN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2929GalaninPRO_0000043873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291Threonine amide

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP30802.

Expressioni

Gene expression databases

ExpressionAtlasiP30802. baseline.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Phylogenomic databases

eggNOGiNOG44932.
HOVERGENiHBG005798.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
GWTLNSAGYL LGPHAVDNHR SFNDKHGFT
Length:29
Mass (Da):3,212
Last modified:July 1, 1993 - v1
Checksum:iEB66919B2D271629
GO

Sequence databases

PIRiS17147.
UniGeneiGga.12649.

Cross-referencesi

Sequence databases

PIRiS17147.
UniGeneiGga.12649.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP30802.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG44932.
HOVERGENiHBG005798.

Enzyme and pathway databases

ReactomeiREACT_250082. Peptide ligand-binding receptors.
REACT_253620. G alpha (i) signalling events.

Miscellaneous databases

PROiP30802.

Gene expression databases

ExpressionAtlasiP30802. baseline.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chemical detection of natural peptides by specific structures. Isolation of chicken galanin by monitoring for its N-terminal dipeptide, and determination of the amino acid sequence."
    Norberg A., Sillard R., Carlquist M., Joernvall H., Mutt V.
    FEBS Lett. 288:151-153(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Intestine.

Entry informationi

Entry nameiGALA_CHICK
AccessioniPrimary (citable) accession number: P30802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.