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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:ML1891
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1891.

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11781178DNA-directed RNA polymerase subunit betaPRO_0000047920Add
BLAST

Proteomic databases

PRIDEiP30760.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1891.

Structurei

3D structure databases

ProteinModelPortaliP30760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGCILPDF GQSKTDVSPS QSRPQSSPNN SVPGAPNRIS FAKLREPLEV
60 70 80 90 100
PGLLDVQTDS FEWLIGSPCW RAAAASRGDL KPVGGLEEVL YELSPIEDFS
110 120 130 140 150
GSMSLSFSDP RFDEVKAPVE ECKDKDMTYA APLFVTAEFI NNNTGEIKSQ
160 170 180 190 200
TVFMGDFPMM TEKGTFIING TERVVVSQLV RSPGVYFDET IDKSTEKTLH
210 220 230 240 250
SVKVIPSRGA WLEFDVDKRD TVGVRIDRKR RQPVTVLLKA LGWTSEQITE
260 270 280 290 300
RFGFSEIMRS TLEKDNTVGT DEALLDIYRK LRPGEPPTKE SAQTLLENLF
310 320 330 340 350
FKEKRYDLAR VGRYKVNKKL GLHAGELITS STLTEEDVVA TIEYLVRLHE
360 370 380 390 400
GQSTMTVPGG VEVPVETDDI DHFGNRRLRT VGELIQNQIR VGMSRMERVV
410 420 430 440 450
RERMTTQDVE AITPQTLINI RPVVAAIKEF FGTSQLSQFM DQNNPLSGLT
460 470 480 490 500
HKRRLSALGP GGLSRERAGL EVRDVHPSHY GRMCPIETPE GPNIGLIGSL
510 520 530 540 550
SVYARVNPFG FIETPYRKVV DGVVSDEIEY LTADEEDRHV VAQANSPIDE
560 570 580 590 600
AGRFLEPRVL VRRKAGEVEY VASSEVDYMD VSPRQMVSVA TAMIPFLEHD
610 620 630 640 650
DANRALMGAN MQRQAVPLVR SEAPLVGTGM ELRAAIDAGH VVVAEKSGVI
660 670 680 690 700
EEVSADYITV MADDGTRRTY RMRKFARSNH GTCANQSPIV DAGDRVEAGQ
710 720 730 740 750
VIADGPCTEN GEMALGKNLL VAIMPWEGHN YEDAIILSNR LVEEDVLTSI
760 770 780 790 800
HIEEHEIDAR DTKLGAEEIT RDIPNVSDEV LADLDERGIV RIGAEVRDGD
810 820 830 840 850
ILVGKVTPKG ETELTPEERL LRAIFGEKAR EVRDTSLKVP HGESGKVIGI
860 870 880 890 900
RVFSHEDDDE LPAGVNELVR VYVAQKRKIS DGDKLAGRHG NKGVIGKILP
910 920 930 940 950
AEDMPFLPDG TPVDIILNTH GVPRRMNVGQ ILETHLGWVA KSGWKIDVAG
960 970 980 990 1000
GIPDWAVNLP EELLHAAPNQ IVSTPVFDGA KEEELQGLLS STLPNRDGDV
1010 1020 1030 1040 1050
MVGGDGKAVL FDGRSGEPFP YPVTVGYMYI MKLHHLVDDK IHARSTGPYS
1060 1070 1080 1090 1100
MITQQPLGGK AQFGGQRFGE MECWAMQAYG AAYTLQELLT IKSDDTVGRV
1110 1120 1130 1140 1150
KVYEAIVKGE NIPEPGIPES FKVLLKELQS LCLNVEVLSS DGAAIELREG
1160 1170
EDEDLERAAA NLGINLSRNE SASIEDLA
Length:1,178
Mass (Da):129,728
Last modified:April 27, 2001 - v2
Checksum:iC8720D1A44C556FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti554 – 5607FLEPRVL → SSSRACW in CAA78668 (PubMed:8446028).Curated
Sequence conflicti623 – 6231A → R in CAA78668 (PubMed:8446028).Curated
Sequence conflicti724 – 7318MPWEGHNY → NAVGGSTTN in CAA78668 (PubMed:8446028).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14314 Genomic DNA. Translation: CAA78668.1.
AL583923 Genomic DNA. Translation: CAC30845.1.
PIRiE87145.
S31145.
RefSeqiNP_302273.1. NC_002677.1.
WP_010908594.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30845; CAC30845; CAC30845.
GeneIDi910599.
KEGGimle:ML1891.
PATRICi18057308. VBIMycLep78757_3581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14314 Genomic DNA. Translation: CAA78668.1.
AL583923 Genomic DNA. Translation: CAC30845.1.
PIRiE87145.
S31145.
RefSeqiNP_302273.1. NC_002677.1.
WP_010908594.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP30760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1891.

Proteomic databases

PRIDEiP30760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30845; CAC30845; CAC30845.
GeneIDi910599.
KEGGimle:ML1891.
PATRICi18057308. VBIMycLep78757_3581.

Organism-specific databases

LepromaiML1891.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions."
    Honore N.T., Bergh S., Chanteau S., Doucet-Populaire F., Eiglmeier K., Garnier T., Georges C., Launois P., Limpaiboon T., Newton S., Niang K., del Portillo P., Ramesh G.R., Reddi P., Ridel P.R., Sittisombut N., Wu-Hunter S., Cole S.T.
    Mol. Microbiol. 7:207-214(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiRPOB_MYCLE
AccessioniPrimary (citable) accession number: P30760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 27, 2001
Last modified: July 6, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.