Fibril-forming collagen alpha chain - Riftia pachyptila (Tube worm)

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Reviewed, UniProtKB/Swiss-Prot P30754 (CAFF_RIFPA)

Last modified November 24, 2009. Version 50. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names	Recommended name: Fibril-forming collagen alpha chain
Organism	Riftia pachyptila (Tube worm)
Taxonomic identifier	6426 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Pogonophora › Vestimentifera › Riftiida › Riftiidae › Riftia

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Protein attributes

Sequence length	1027 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Fibril-forming collagen.
Subunit structure	Homotetramer.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.

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Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat
PTM	Glycoprotein Hydroxylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – ›1027

›1027

Fibril-forming collagen alpha chain

PRO_0000059394

Regions

Region

1 – 12

Nonhelical region (N-terminal)

Region

13 – 1023

1011

Triple-helical region

Region

1024 – 1027

Nonhelical region (C-terminal)

Sites

Site

610

Imperfection in the GAA repeat

Amino acid modifications

Modified residue

4-hydroxyproline; partial Ref.1

Modified residue

4-hydroxyproline; partial

Modified residue

4-hydroxyproline Ref.1

Modified residue

4-hydroxyproline Ref.1

Modified residue

3-hydroxyproline; partial

Modified residue

4-hydroxyproline Ref.1

Modified residue

4-hydroxyproline; partial Ref.1

Modified residue

4-hydroxyproline Ref.1

Modified residue

4-hydroxyproline Ref.1

Modified residue

5-hydroxylysine Probable

Modified residue

108

5-hydroxylysine Probable

Modified residue

123

4-hydroxyproline; partial Ref.1

Modified residue

128

4-hydroxyproline; partial Ref.1

Modified residue

150

4-hydroxyproline Ref.1

Modified residue

161

3-hydroxyproline; partial

Modified residue

162

4-hydroxyproline Ref.1

Modified residue

164

4-hydroxyproline; partial

Modified residue

165

3-hydroxyproline

Modified residue

174

4-hydroxyproline Ref.1

Modified residue

177

4-hydroxyproline Ref.1

Modified residue

180

4-hydroxyproline Ref.1

Modified residue

183

5-hydroxylysine Ref.1

Modified residue

192

5-hydroxylysine Probable

Modified residue

207

4-hydroxyproline Ref.1

Modified residue

216

4-hydroxyproline Ref.1

Modified residue

219

4-hydroxyproline Ref.1

Modified residue

228

4-hydroxyproline Ref.1

Modified residue

237

4-hydroxyproline Ref.1

Modified residue

243

4-hydroxyproline; partial Ref.1

Modified residue

249

4-hydroxyproline Ref.1

Modified residue

255

4-hydroxyproline Ref.1

Modified residue

261

5-hydroxylysine Probable

Modified residue

273

4-hydroxyproline; partial Ref.1

Modified residue

276

4-hydroxyproline; partial Ref.1

Modified residue

279

5-hydroxylysine Probable

Modified residue

285

4-hydroxyproline; partial Ref.1

Modified residue

291

4-hydroxyproline; partial Ref.1

Modified residue

303

4-hydroxyproline; partial Ref.1

Modified residue

306

4-hydroxyproline Ref.1

Modified residue

312

4-hydroxyproline Ref.1

Modified residue

321

4-hydroxyproline Ref.1

Modified residue

327

4-hydroxyproline Ref.1

Modified residue

339

4-hydroxyproline Ref.1

Modified residue

342

5-hydroxylysine Ref.1

Modified residue

348

4-hydroxyproline; partial Ref.1

Modified residue

351

5-hydroxylysine; partial Ref.1

Modified residue

366

4-hydroxyproline Ref.1

Modified residue

372

4-hydroxyproline Ref.1

Modified residue

375

4-hydroxyproline Ref.1

Modified residue

381

4-hydroxyproline; partial Ref.1

Modified residue

387

4-hydroxyproline Ref.1

Modified residue

416

3-hydroxyproline; partial

Modified residue

417

4-hydroxyproline Ref.1

Modified residue

423

4-hydroxyproline Ref.1

Modified residue

429

4-hydroxyproline Ref.1

Modified residue

432

4-hydroxyproline Ref.1

Modified residue

453

4-hydroxyproline Ref.1

Modified residue

465

4-hydroxyproline Ref.1

Modified residue

483

4-hydroxyproline Ref.1

Modified residue

500

4-hydroxyproline; partial

Modified residue

503

4-hydroxyproline; partial

Modified residue

506

4-hydroxyproline; partial

Modified residue

513

4-hydroxyproline Ref.1

Modified residue

525

4-hydroxyproline Ref.1

Modified residue

533

4-hydroxyproline; partial

Modified residue

536

4-hydroxyproline; partial

Modified residue

540

4-hydroxyproline Ref.1

Modified residue

546

5-hydroxylysine Ref.1

Modified residue

551

3-hydroxyproline; partial

Modified residue

552

4-hydroxyproline Ref.1

Modified residue

561

4-hydroxyproline Ref.1

Modified residue

567

5-hydroxylysine

Modified residue

573

5-hydroxylysine Probable

Modified residue

603

4-hydroxyproline Ref.1

Modified residue

612

5-hydroxylysine Probable

Modified residue

621

4-hydroxyproline; partial Ref.1

Modified residue

627

4-hydroxyproline Ref.1

Modified residue

645

4-hydroxyproline; partial Ref.1

Modified residue

647

3-hydroxyproline; partial

Modified residue

648

4-hydroxyproline Ref.1

Modified residue

657

5-hydroxylysine Probable

Modified residue

663

4-hydroxyproline Ref.1

Modified residue

708

4-hydroxyproline Ref.1

Modified residue

711

4-hydroxyproline Ref.1

Modified residue

714

4-hydroxyproline Ref.1

Modified residue

717

4-hydroxyproline Ref.1

Modified residue

723

4-hydroxyproline Ref.1

Modified residue

738

5-hydroxylysine Probable

Modified residue

744

4-hydroxyproline Ref.1

Modified residue

759

4-hydroxyproline Ref.1

Modified residue

765

5-hydroxylysine Probable

Modified residue

773

3-hydroxyproline; partial

Modified residue

774

4-hydroxyproline Ref.1

Modified residue

783

4-hydroxyproline Ref.1

Modified residue

792

4-hydroxyproline Ref.1

Modified residue

810

5-hydroxylysine Probable

Modified residue

815

3-hydroxyproline; partial

Modified residue

816

4-hydroxyproline Ref.1

Modified residue

843

4-hydroxyproline Ref.1

Modified residue

849

4-hydroxyproline Ref.1

Modified residue

855

4-hydroxyproline Ref.1

Modified residue

861

4-hydroxyproline Ref.1

Modified residue

867

4-hydroxyproline Ref.1

Modified residue

888

4-hydroxyproline Ref.1

Modified residue

894

4-hydroxyproline Ref.1

Modified residue

903

4-hydroxyproline

Modified residue

915

4-hydroxyproline

Modified residue

927

5-hydroxylysine Probable

Modified residue

933

5-hydroxylysine; partial

Modified residue

936

5-hydroxylysine Probable

Modified residue

939

5-hydroxylysine

Modified residue

945

4-hydroxyproline

Modified residue

954

4-hydroxyproline; partial

Modified residue

963

4-hydroxyproline

Modified residue

966

4-hydroxyproline

Modified residue

984

4-hydroxyproline

Modified residue

990

4-hydroxyproline

Modified residue

1010

3-hydroxyproline; partial

Modified residue

1011

4-hydroxyproline

Modified residue

1013

3-hydroxyproline; partial

Modified residue

1014

4-hydroxyproline

Modified residue

1016

3-hydroxyproline; partial

Modified residue

1017

4-hydroxyproline

Modified residue

1019

3-hydroxyproline; partial

Modified residue

1020

4-hydroxyproline

Glycosylation

O-linked (Gal...) Probable

Glycosylation

108

O-linked (Gal...) Probable

Glycosylation

192

O-linked (Gal...) Probable

Glycosylation

261

O-linked (Gal...) Probable

Glycosylation

279

O-linked (Gal...) Probable

Glycosylation

573

O-linked (Gal...) Probable

Glycosylation

612

O-linked (Gal...) Probable

Glycosylation

657

O-linked (Gal...) Probable

Glycosylation

738

O-linked (Gal...) Probable

Glycosylation

765

O-linked (Gal...) Probable

Glycosylation

810

O-linked (Gal...) Probable

Glycosylation

927

O-linked (Gal...) Probable

Glycosylation

936

O-linked (Gal...) Probable

Natural variations

Natural variant

903

P → A

Experimental info

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Sequence uncertainty

Non-terminal residue

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Sequences

Sequence

Length

Mass (Da)

Tools

P30754-1 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 0555C50E880FDAF6
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FASTA

1,027

94,587

        10         20         30         40         50         60 
YRAGPRYIQA QVGPIGPRGP PGPPGSPGQQ GYQGLRGEPG DSGPMGPIGK RGPPGPAGIA 

        70         80         90        100        110        120 
GKSGDDGRDG EPGPRGGIGP MGPRGAGGMP GMPGPKGHRG FRGLSGSKGE QGKSGNQGPD 

       130        140        150        160        170        180 
GGPGPAGPSG PIGPRGQTGE RGRDGKSGLP GLRGVDGLAG PPGPPGPIGS TGSPGFPGTP 

       190        200        210        220        230        240 
GSKGDRGQSG IKGAQGLQGP VGLSGQPGVA GENGHPGMPG MDGANGEPGA SGESGLPGPS 

       250        260        270        280        290        300 
GFPGPRGMPG TAGSPGQAGA KGDGGPTGEQ GRPGAPGVKG SSGPPGDVGA PGHAGEAGKR 

       310        320        330        340        350        360 
GSPGSPGPAG SPGPQGDRGL PGSRGLPGMT GASGAMGIPG EKGPSGEPGA KGPTGDTGRQ 

       370        380        390        400        410        420 
GNQGTPGIAG LPGNPGSDGR PGKDGRPGIR GKDGKQGEQG PQGPQGLAGL QGRAGPPGAR 

       430        440        450        460        470        480 
GEPGKNGAPG EPGAHGEQGD AGKDGETGAA GPPGAAGPTG ARGPPGPRGQ QGFQGLAGAQ 

       490        500        510        520        530        540 
GTPGEAGKTG ERGAVGATGP SGPAGPGGER GAPGDRGNVG PRGMPGERGA TGPAGPTGSP 

       550        560        570        580        590        600 
GVAGAKGQGG PPGPAGLVGL PGERGPKGVG GSKGSRGDIG PRGKAGERGK DGERGERGEN 

       610        620        630        640        650        660 
GLPGPSGLAA SKGERGDMGS PGERGSPGPA GERGPAGSQG IQGQPGPPGD AGPAGTKGDI 

       670        680        690        700        710        720 
GFPGERGTRG ATGKQGARGP RGLAGKRGLR GAGGSRGETG AQGEIGLPGS PGQPGLPGPS 

       730        740        750        760        770        780 
GQPGPSGPAG TAGKQGVKGA RGSPGLVGKQ GDRGSDGEPG RDGTKGERGE DGPPGVSGPT 

       790        800        810        820        830        840 
GAPGQQGERG MPGMVGLRGE TGPMGGQGMK GDGGPPGPSG DRGERGNAGP QGPTGPSGQA 

       850        860        870        880        890        900 
GAPGQEGAPG KDGLPGLAGR PGERGEPGVA GRAGSQGLAG LMGQRGLPGA AGPPGDRGER 

       910        920        930        940        950        960 
GEPGGQGVQG PVGAPGSQGP AGIMGMKGEA GGKGAKGDKG WTGLPGLQGL QGTPGHSGES 

       970        980        990       1000       1010       1020 
GPPGAPGPRG ARGEAGGRGS QGPPGKDGQP GPSGRVGPRG PSGDDGRSGP PGPPGPPGPP 


GNSDYGA

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References

[1]	"Amino-acid sequence and cell-adhesion activity of a fibril-forming collagen from the tube worm Riftia pachyptila living at deep sea hydrothermal vents." Mann K., Gaill F., Timpl R. Eur. J. Biochem. 210:839-847(1992) [PubMed: 1483468] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Molecular characterization of cuticle and interstitial collagens from worms collected at deep sea hydrothermal vents." Gaill F., Wiedemann H., Mann K., Kuhn K., Timpl R., Engel J. J. Mol. Biol. 221:209-223(1991) [PubMed: 1920405] [Abstract] Cited for: PROTEIN SEQUENCE OF 8-45; 525-618 AND 810-882. Tissue: Cuticle.

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Cross-references

Sequence databases
PIR	S28774.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008160. Collagen. [Graphical view]
Pfam	PF01391. Collagen. 15 hits. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CAFF_RIFPA

Accession

Primary (citable) accession number: P30754

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	August 16, 2004
Last modified:	November 24, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Family and domain databases

Entry information