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Protein

Probable G-protein coupled receptor 83

Gene

Gpr83

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Could be a neuropeptide Y receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 83
Alternative name(s):
Glucocorticoid-induced receptor
Gene namesi
Name:Gpr83
Synonyms:Gir, Gpr72
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:95712. Gpr83.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 71ExtracellularSequence analysisAdd BLAST54
Transmembranei72 – 92Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini93 – 107CytoplasmicSequence analysisAdd BLAST15
Transmembranei108 – 129Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini130 – 145ExtracellularSequence analysisAdd BLAST16
Transmembranei146 – 167Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini168 – 186CytoplasmicSequence analysisAdd BLAST19
Transmembranei187 – 208Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini209 – 238ExtracellularSequence analysisAdd BLAST30
Transmembranei239 – 260Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini261 – 293CytoplasmicSequence analysisAdd BLAST33
Transmembranei294 – 315Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini316 – 327ExtracellularSequence analysisAdd BLAST12
Transmembranei328 – 348Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini349 – 423CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • non-motile cilium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001280418 – 423Probable G-protein coupled receptor 83Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 224PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30731.
PRIDEiP30731.

PTM databases

PhosphoSitePlusiP30731.

Expressioni

Tissue specificityi

Brain, thymus and spleen.

Inductioni

By glucocorticoids and cAMP; in T-cells.

Gene expression databases

BgeeiENSMUSG00000031932.
CleanExiMM_GPR83.
ExpressionAtlasiP30731. baseline and differential.
GenevisibleiP30731. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034408.

Structurei

3D structure databases

ProteinModelPortaliP30731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000112793.
HOVERGENiHBG051819.
InParanoidiP30731.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P30731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVPPVLLLF LLSSVRATEQ PQVVTEHPSM EAALTGPNAS SHFWANYTFS
60 70 80 90 100
DWQNFVGRRR YGAESQNPTV KALLIVAYSF TIVFSLFGNV LVCHVIFKNQ
110 120 130 140 150
RMHSATSLFI VNLAVADIMI TLLNTPFTLV RFVNSTWVFG KGMCHVSRFA
160 170 180 190 200
QYCSLHVSAL TLTAIAVDRH QVIMHPLKPR ISITKGVIYI AVIWVMATFF
210 220 230 240 250
SLPHAICQKL FTFKYSEDIV RSLCLPDFPE PADLFWKYLD LATFILLYLL
260 270 280 290 300
PLFIISVAYA RVAKKLWLCN TIGDVTTEQY LALRRKKKTT VKMLVLVVVL
310 320 330 340 350
FALCWFPLNC YVLLLSSKAI HTNNALYFAF HWFAMSSTCY NPFIYCWLNE
360 370 380 390 400
NFRVELKALL SMCQRPPKPQ EDRLPSPVPS FRVAWTEKSH GRRAPLPNHH
410 420
LPSSQIQSGK TDLSSVEPVV AMS
Length:423
Mass (Da):48,137
Last modified:November 1, 1995 - v2
Checksum:i3ACE43452BF15391
GO
Isoform 2 (identifier: P30731-2) [UniParc]FASTAAdd to basket
Also known as: RP39

The sequence of this isoform differs from the canonical sequence as follows:
     130-171: Missing.

Show »
Length:381
Mass (Da):43,417
Checksum:i2EEDB8584184A0A3
GO
Isoform 3 (identifier: P30731-3) [UniParc]FASTAAdd to basket
Also known as: RP82

The sequence of this isoform differs from the canonical sequence as follows:
     171-171: Q → QGLTAIAVDRHQGLELQKMVRPRGDGGELRSPSVTFVPSSLCPALFTCKRPWDFQESQSLHDTLFPPLE

Show »
Length:491
Mass (Da):55,683
Checksum:iBAEE1C4B96B088DD
GO
Isoform 4 (identifier: P30731-4) [UniParc]FASTAAdd to basket
Also known as: RP105

The sequence of this isoform differs from the canonical sequence as follows:
     171-171: Q → QRPWDFQESQSLHDTLFPPLE

Show »
Length:443
Mass (Da):50,561
Checksum:i5A4DFB3543C29152
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001988130 – 171Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_001989171Q → QGLTAIAVDRHQGLELQKMV RPRGDGGELRSPSVTFVPSS LCPALFTCKRPWDFQESQSL HDTLFPPLE in isoform 3. 1 Publication1
Alternative sequenceiVSP_001990171Q → QRPWDFQESQSLHDTLFPPL E in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80481 mRNA. Translation: AAA17882.1.
CCDSiCCDS22829.1. [P30731-1]
CCDS80959.1. [P30731-2]
PIRiA40470.
B40470.
C40470.
D40470.
RefSeqiNP_034417.1. NM_010287.3. [P30731-1]
XP_006510080.1. XM_006510017.2. [P30731-4]
UniGeneiMm.4672.

Genome annotation databases

EnsembliENSMUST00000034408; ENSMUSP00000034408; ENSMUSG00000031932. [P30731-1]
ENSMUST00000115624; ENSMUSP00000111287; ENSMUSG00000031932. [P30731-2]
GeneIDi14608.
KEGGimmu:14608.
UCSCiuc009off.1. mouse. [P30731-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80481 mRNA. Translation: AAA17882.1.
CCDSiCCDS22829.1. [P30731-1]
CCDS80959.1. [P30731-2]
PIRiA40470.
B40470.
C40470.
D40470.
RefSeqiNP_034417.1. NM_010287.3. [P30731-1]
XP_006510080.1. XM_006510017.2. [P30731-4]
UniGeneiMm.4672.

3D structure databases

ProteinModelPortaliP30731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034408.

Chemistry databases

GuidetoPHARMACOLOGYi119.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30731.

Proteomic databases

PaxDbiP30731.
PRIDEiP30731.

Protocols and materials databases

DNASUi14608.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034408; ENSMUSP00000034408; ENSMUSG00000031932. [P30731-1]
ENSMUST00000115624; ENSMUSP00000111287; ENSMUSG00000031932. [P30731-2]
GeneIDi14608.
KEGGimmu:14608.
UCSCiuc009off.1. mouse. [P30731-1]

Organism-specific databases

CTDi10888.
MGIiMGI:95712. Gpr83.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000112793.
HOVERGENiHBG051819.
InParanoidiP30731.
KOiK04210.
OMAiNENFRIE.
OrthoDBiEOG091G0YEQ.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP30731.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031932.
CleanExiMM_GPR83.
ExpressionAtlasiP30731. baseline and differential.
GenevisibleiP30731. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR83_MOUSE
AccessioniPrimary (citable) accession number: P30731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.