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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  • choriogonadotropin hormone binding Source: BHF-UCL
  • choriogonadotropin hormone receptor activity Source: BHF-UCL
  • G-protein coupled peptide receptor activity Source: GO_Central
  • luteinizing hormone receptor activity Source: MGI

GO - Biological processi

  • activation of adenylate cyclase activity Source: BHF-UCL
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • cellular response to gonadotropin stimulus Source: BHF-UCL
  • cognition Source: MGI
  • development of secondary male sexual characteristics Source: MGI
  • female gonad development Source: MGI
  • hormone-mediated signaling pathway Source: GO_Central
  • male gonad development Source: MGI
  • ovarian follicle development Source: MGI
  • ovulation cycle process Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of cAMP-mediated signaling Source: BHF-UCL
  • positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
  • regulation of steroid hormone biosynthetic process Source: MGI
  • seminiferous tubule development Source: MGI
  • spermatogenesis Source: MGI
  • uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
Synonyms:Lhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96783. Lhcgr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 362ExtracellularSequence analysisAdd BLAST336
Transmembranei363 – 390Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 422Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini423 – 443ExtracellularSequence analysisAdd BLAST21
Transmembranei444 – 466Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini467 – 486CytoplasmicSequence analysisAdd BLAST20
Transmembranei487 – 509Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini510 – 529ExtracellularSequence analysisAdd BLAST20
Transmembranei530 – 551Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini552 – 574CytoplasmicSequence analysisAdd BLAST23
Transmembranei575 – 598Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini599 – 609ExtracellularSequence analysisAdd BLAST11
Transmembranei610 – 631Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini632 – 700CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001278127 – 700Lutropin-choriogonadotropic hormone receptorAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647S-palmitoyl cysteineBy similarity1
Lipidationi648S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30730.
PaxDbiP30730.
PRIDEiP30730.

PTM databases

PhosphoSitePlusiP30730.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024107.
CleanExiMM_LHCGR.
GenevisibleiP30730. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024916.

Structurei

3D structure databases

ProteinModelPortaliP30730.
SMRiP30730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 75LRR 1Add BLAST24
Repeati126 – 150LRR 2Add BLAST25
Repeati176 – 200LRR 3Add BLAST25
Repeati225 – 248LRR 4Add BLAST24

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP30730.
KOiK04248.
OMAiHAILIML.
OrthoDBiEOG091G02BV.
PhylomeDBiP30730.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSEILIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVSKISS
160 170 180 190 200
SEFNFILEIC DNLYITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWIFSTL
510 520 530 540 550
MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA VAFVVICACY
560 570 580 590 600
VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH
660 670 680 690 700
RAELYRRKEF SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ
Length:700
Mass (Da):78,215
Last modified:April 1, 1993 - v1
Checksum:i8A6840A011E1E014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81310 mRNA. Translation: AAA39432.1.
M87571 Genomic DNA. Translation: AAA39433.1.
S49753 Genomic DNA. Translation: AAB24402.1.
CCDSiCCDS29025.1.
PIRiA42395.
I77464.
RefSeqiNP_038610.1. NM_013582.2.
UniGeneiMm.1644.

Genome annotation databases

EnsembliENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
GeneIDi16867.
KEGGimmu:16867.
UCSCiuc008dvw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81310 mRNA. Translation: AAA39432.1.
M87571 Genomic DNA. Translation: AAA39433.1.
S49753 Genomic DNA. Translation: AAB24402.1.
CCDSiCCDS29025.1.
PIRiA42395.
I77464.
RefSeqiNP_038610.1. NM_013582.2.
UniGeneiMm.1644.

3D structure databases

ProteinModelPortaliP30730.
SMRiP30730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024916.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30730.

Proteomic databases

MaxQBiP30730.
PaxDbiP30730.
PRIDEiP30730.

Protocols and materials databases

DNASUi16867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
GeneIDi16867.
KEGGimmu:16867.
UCSCiuc008dvw.1. mouse.

Organism-specific databases

CTDi3973.
MGIiMGI:96783. Lhcgr.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP30730.
KOiK04248.
OMAiHAILIML.
OrthoDBiEOG091G02BV.
PhylomeDBiP30730.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP30730.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024107.
CleanExiMM_LHCGR.
GenevisibleiP30730. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHR_MOUSE
AccessioniPrimary (citable) accession number: P30730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.