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P30730

- LSHR_MOUSE

UniProt

P30730 - LSHR_MOUSE

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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  1. choriogonadotropin hormone binding Source: BHF-UCL
  2. choriogonadotropin hormone receptor activity Source: BHF-UCL
  3. luteinizing hormone receptor activity Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: BHF-UCL
  2. cellular response to gonadotropin stimulus Source: BHF-UCL
  3. cognition Source: Ensembl
  4. development of secondary male sexual characteristics Source: MGI
  5. female gonad development Source: MGI
  6. luteinizing hormone signaling pathway Source: GOC
  7. male gonad development Source: MGI
  8. ovarian follicle development Source: MGI
  9. ovulation cycle process Source: MGI
  10. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  11. positive regulation of cAMP-mediated signaling Source: BHF-UCL
  12. positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
  13. regulation of steroid hormone biosynthetic process Source: MGI
  14. seminiferous tubule development Source: MGI
  15. spermatogenesis Source: MGI
  16. uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_243909. Hormone ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
Synonyms:Lhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:96783. Lhcgr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 362336ExtracellularSequence AnalysisAdd
BLAST
Transmembranei363 – 39028Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini391 – 3999CytoplasmicSequence Analysis
Transmembranei400 – 42223Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini423 – 44321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei444 – 46623Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini467 – 48620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei487 – 50923Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini510 – 52920ExtracellularSequence AnalysisAdd
BLAST
Transmembranei530 – 55122Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini552 – 57423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei575 – 59824Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini599 – 60911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei610 – 63122Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini632 – 70069CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 700674Lutropin-choriogonadotropic hormone receptorPRO_0000012781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647 – 6471S-palmitoyl cysteineBy similarity
Lipidationi648 – 6481S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30730.
PRIDEiP30730.

PTM databases

PhosphoSiteiP30730.

Expressioni

Gene expression databases

BgeeiP30730.
CleanExiMM_LHCGR.
GenevestigatoriP30730.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024916.

Structurei

3D structure databases

ProteinModelPortaliP30730.
SMRiP30730. Positions 51-360, 363-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 7524LRR 1Add
BLAST
Repeati126 – 15025LRR 2Add
BLAST
Repeati176 – 20025LRR 3Add
BLAST
Repeati225 – 24824LRR 4Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285844.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP30730.
KOiK04248.
OMAiIYFAVQN.
OrthoDBiEOG73BVCG.
PhylomeDBiP30730.
TreeFamiTF316814.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30730-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSEILIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVSKISS
160 170 180 190 200
SEFNFILEIC DNLYITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWIFSTL
510 520 530 540 550
MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA VAFVVICACY
560 570 580 590 600
VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH
660 670 680 690 700
RAELYRRKEF SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ
Length:700
Mass (Da):78,215
Last modified:April 1, 1993 - v1
Checksum:i8A6840A011E1E014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81310 mRNA. Translation: AAA39432.1.
M87571 Genomic DNA. Translation: AAA39433.1.
S49753 Genomic DNA. Translation: AAB24402.1.
CCDSiCCDS29025.1.
PIRiA42395.
I77464.
RefSeqiNP_038610.1. NM_013582.2.
UniGeneiMm.1644.

Genome annotation databases

EnsembliENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
GeneIDi16867.
KEGGimmu:16867.
UCSCiuc008dvw.1. mouse.

Cross-referencesi

Web resourcesi

GRIS

Glycoprotein-hormone Receptors Information System

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81310 mRNA. Translation: AAA39432.1 .
M87571 Genomic DNA. Translation: AAA39433.1 .
S49753 Genomic DNA. Translation: AAB24402.1 .
CCDSi CCDS29025.1.
PIRi A42395.
I77464.
RefSeqi NP_038610.1. NM_013582.2.
UniGenei Mm.1644.

3D structure databases

ProteinModelPortali P30730.
SMRi P30730. Positions 51-360, 363-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000024916.

Chemistry

GuidetoPHARMACOLOGYi 254.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30730.

Proteomic databases

MaxQBi P30730.
PRIDEi P30730.

Protocols and materials databases

DNASUi 16867.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024916 ; ENSMUSP00000024916 ; ENSMUSG00000024107 .
GeneIDi 16867.
KEGGi mmu:16867.
UCSCi uc008dvw.1. mouse.

Organism-specific databases

CTDi 3973.
MGIi MGI:96783. Lhcgr.

Phylogenomic databases

eggNOGi NOG285844.
GeneTreei ENSGT00760000119088.
HOGENOMi HOG000045902.
HOVERGENi HBG003521.
InParanoidi P30730.
KOi K04248.
OMAi IYFAVQN.
OrthoDBi EOG73BVCG.
PhylomeDBi P30730.
TreeFami TF316814.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_243909. Hormone ligand-binding receptors.

Miscellaneous databases

NextBioi 290826.
PROi P30730.
SOURCEi Search...

Gene expression databases

Bgeei P30730.
CleanExi MM_LHCGR.
Genevestigatori P30730.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view ]
PANTHERi PTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view ]
PRINTSi PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells."
    Gudermann T., Birnbaumer M., Birnbaumer L.
    J. Biol. Chem. 267:4479-4488(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
    Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
    Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.

Entry informationi

Entry nameiLSHR_MOUSE
AccessioniPrimary (citable) accession number: P30730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3