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P30730

- LSHR_MOUSE

UniProt

P30730 - LSHR_MOUSE

Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

    GO - Molecular functioni

    1. choriogonadotropin hormone binding Source: BHF-UCL
    2. choriogonadotropin hormone receptor activity Source: BHF-UCL
    3. luteinizing hormone receptor activity Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: BHF-UCL
    2. cellular response to gonadotropin stimulus Source: BHF-UCL
    3. development of secondary male sexual characteristics Source: MGI
    4. female gonad development Source: MGI
    5. luteinizing hormone signaling pathway Source: GOC
    6. male gonad development Source: MGI
    7. ovarian follicle development Source: MGI
    8. ovulation cycle process Source: MGI
    9. phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    10. positive regulation of cAMP-mediated signaling Source: BHF-UCL
    11. positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
    12. regulation of steroid hormone biosynthetic process Source: MGI
    13. seminiferous tubule development Source: MGI
    14. spermatogenesis Source: MGI
    15. uterus development Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lutropin-choriogonadotropic hormone receptor
    Short name:
    LH/CG-R
    Alternative name(s):
    Luteinizing hormone receptor
    Short name:
    LSH-R
    Gene namesi
    Name:Lhcgr
    Synonyms:Lhr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:96783. Lhcgr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 700674Lutropin-choriogonadotropic hormone receptorPRO_0000012781Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
    Lipidationi647 – 6471S-palmitoyl cysteineBy similarity
    Lipidationi648 – 6481S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP30730.
    PRIDEiP30730.

    PTM databases

    PhosphoSiteiP30730.

    Expressioni

    Gene expression databases

    BgeeiP30730.
    CleanExiMM_LHCGR.
    GenevestigatoriP30730.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000024916.

    Structurei

    3D structure databases

    ProteinModelPortaliP30730.
    SMRiP30730. Positions 51-360, 363-635.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 362336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini391 – 3999CytoplasmicSequence Analysis
    Topological domaini423 – 44321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini467 – 48620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini510 – 52920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini552 – 57423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini599 – 60911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini632 – 70069CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei363 – 39028Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei400 – 42223Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46623Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei487 – 50923Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei530 – 55122Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei575 – 59824Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei610 – 63122Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati52 – 7524LRR 1Add
    BLAST
    Repeati126 – 15025LRR 2Add
    BLAST
    Repeati176 – 20025LRR 3Add
    BLAST
    Repeati225 – 24824LRR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
    Contains 4 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285844.
    GeneTreeiENSGT00730000110262.
    HOGENOMiHOG000045902.
    HOVERGENiHBG003521.
    InParanoidiP30730.
    KOiK04248.
    OMAiIYFAVQN.
    OrthoDBiEOG73BVCG.
    PhylomeDBiP30730.
    TreeFamiTF316814.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    IPR002273. LSH_rcpt.
    [Graphical view]
    PANTHERiPTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF1. PTHR24372:SF1. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    PF13306. LRR_5. 2 hits.
    [Graphical view]
    PRINTSiPR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    PR01144. LSHRECEPTOR.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P30730-1 [UniParc]FASTAAdd to Basket

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    MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG    50
    PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN 100
    LLNLSEILIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVSKISS 150
    SEFNFILEIC DNLYITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG 200
    TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA LPSHGLESIQ 250
    TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI 300
    FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE 350
    PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF 400
    LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT 450
    VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWIFSTL 500
    MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA VAFVVICACY 550
    VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV 600
    PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH 650
    RAELYRRKEF SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ 700
    Length:700
    Mass (Da):78,215
    Last modified:April 1, 1993 - v1
    Checksum:i8A6840A011E1E014
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81310 mRNA. Translation: AAA39432.1.
    M87571 Genomic DNA. Translation: AAA39433.1.
    S49753 Genomic DNA. Translation: AAB24402.1.
    CCDSiCCDS29025.1.
    PIRiA42395.
    I77464.
    RefSeqiNP_038610.1. NM_013582.2.
    UniGeneiMm.1644.

    Genome annotation databases

    EnsembliENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
    GeneIDi16867.
    KEGGimmu:16867.
    UCSCiuc008dvw.1. mouse.

    Cross-referencesi

    Web resourcesi

    GRIS

    Glycoprotein-hormone Receptors Information System

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81310 mRNA. Translation: AAA39432.1 .
    M87571 Genomic DNA. Translation: AAA39433.1 .
    S49753 Genomic DNA. Translation: AAB24402.1 .
    CCDSi CCDS29025.1.
    PIRi A42395.
    I77464.
    RefSeqi NP_038610.1. NM_013582.2.
    UniGenei Mm.1644.

    3D structure databases

    ProteinModelPortali P30730.
    SMRi P30730. Positions 51-360, 363-635.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000024916.

    Chemistry

    GuidetoPHARMACOLOGYi 254.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30730.

    Proteomic databases

    MaxQBi P30730.
    PRIDEi P30730.

    Protocols and materials databases

    DNASUi 16867.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024916 ; ENSMUSP00000024916 ; ENSMUSG00000024107 .
    GeneIDi 16867.
    KEGGi mmu:16867.
    UCSCi uc008dvw.1. mouse.

    Organism-specific databases

    CTDi 3973.
    MGIi MGI:96783. Lhcgr.

    Phylogenomic databases

    eggNOGi NOG285844.
    GeneTreei ENSGT00730000110262.
    HOGENOMi HOG000045902.
    HOVERGENi HBG003521.
    InParanoidi P30730.
    KOi K04248.
    OMAi IYFAVQN.
    OrthoDBi EOG73BVCG.
    PhylomeDBi P30730.
    TreeFami TF316814.

    Miscellaneous databases

    NextBioi 290826.
    PROi P30730.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30730.
    CleanExi MM_LHCGR.
    Genevestigatori P30730.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR000372. LRR-contain_N.
    IPR026906. LRR_5.
    IPR002273. LSH_rcpt.
    [Graphical view ]
    PANTHERi PTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF1. PTHR24372:SF1. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    PF13306. LRR_5. 2 hits.
    [Graphical view ]
    PRINTSi PR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    PR01144. LSHRECEPTOR.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells."
      Gudermann T., Birnbaumer M., Birnbaumer L.
      J. Biol. Chem. 267:4479-4488(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
      Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
      Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.

    Entry informationi

    Entry nameiLSHR_MOUSE
    AccessioniPrimary (citable) accession number: P30730
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3