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P30730 (LSHR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lutropin-choriogonadotropic hormone receptor

Short name=LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name=LSH-R
Gene names
Name:Lhcgr
Synonyms:Lhr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

Contains 4 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of adenylate cyclase activity

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

cellular response to gonadotropin stimulus

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

development of secondary male sexual characteristics

Inferred from mutant phenotype PubMed 11145748. Source: MGI

female gonad development

Inferred from mutant phenotype PubMed 11145748PubMed 15951841. Source: MGI

luteinizing hormone signaling pathway

Traceable author statement Ref.1. Source: GOC

male gonad development

Inferred from mutant phenotype PubMed 11145748. Source: MGI

ovarian follicle development

Inferred from mutant phenotype PubMed 11145748. Source: MGI

ovulation cycle process

Inferred from mutant phenotype PubMed 11145748. Source: MGI

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

positive regulation of cAMP-mediated signaling

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

positive regulation of inositol trisphosphate biosynthetic process

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

regulation of steroid hormone biosynthetic process

Inferred from mutant phenotype PubMed 11145748. Source: MGI

seminiferous tubule development

Inferred from mutant phenotype PubMed 11145748. Source: MGI

spermatogenesis

Inferred from mutant phenotype PubMed 11145748. Source: MGI

uterus development

Inferred from mutant phenotype PubMed 11145748. Source: MGI

   Cellular_componentintegral component of plasma membrane

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

   Molecular_functionchoriogonadotropin hormone binding

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

choriogonadotropin hormone receptor activity

Inferred from direct assay PubMed 10493819. Source: BHF-UCL

luteinizing hormone receptor activity

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 700674Lutropin-choriogonadotropic hormone receptor
PRO_0000012781

Regions

Topological domain27 – 362336Extracellular Potential
Transmembrane363 – 39028Helical; Name=1; Potential
Topological domain391 – 3999Cytoplasmic Potential
Transmembrane400 – 42223Helical; Name=2; Potential
Topological domain423 – 44321Extracellular Potential
Transmembrane444 – 46623Helical; Name=3; Potential
Topological domain467 – 48620Cytoplasmic Potential
Transmembrane487 – 50923Helical; Name=4; Potential
Topological domain510 – 52920Extracellular Potential
Transmembrane530 – 55122Helical; Name=5; Potential
Topological domain552 – 57423Cytoplasmic Potential
Transmembrane575 – 59824Helical; Name=6; Potential
Topological domain599 – 60911Extracellular Potential
Transmembrane610 – 63122Helical; Name=7; Potential
Topological domain632 – 70069Cytoplasmic Potential
Repeat52 – 7524LRR 1
Repeat126 – 15025LRR 2
Repeat176 – 20025LRR 3
Repeat225 – 24824LRR 4

Amino acid modifications

Lipidation6471S-palmitoyl cysteine By similarity
Lipidation6481S-palmitoyl cysteine By similarity
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Disulfide bond443 ↔ 518 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30730 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 8A6840A011E1E014

FASTA70078,215
        10         20         30         40         50         60 
MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG PRAGLARLSL 

        70         80         90        100        110        120 
TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN LLNLSEILIQ NTKNLLYIEP 

       130        140        150        160        170        180 
GAFTNLPRLK YLSICNTGIR TLPDVSKISS SEFNFILEIC DNLYITTIPG NAFQGMNNES 

       190        200        210        220        230        240 
ITLKLYGNGF EEVQSHAFNG TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA 

       250        260        270        280        290        300 
LPSHGLESIQ TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI 

       310        320        330        340        350        360 
FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE PDAFNPCEDI 

       370        380        390        400        410        420 
MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF LMCNLSFADF CMGLYLLLIA 

       430        440        450        460        470        480 
SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT VFASELSVYT LTVITLERWH TITYAVQLDQ 

       490        500        510        520        530        540 
KLRLRHAIPI MLGGWIFSTL MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA 

       550        560        570        580        590        600 
VAFVVICACY VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV 

       610        620        630        640        650        660 
PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH RAELYRRKEF 

       670        680        690        700 
SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ 

« Hide

References

[1]"Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells."
Gudermann T., Birnbaumer M., Birnbaumer L.
J. Biol. Chem. 267:4479-4488(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.
+Additional computationally mapped references.

Web resources

GRIS

Glycoprotein-hormone Receptors Information System

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81310 mRNA. Translation: AAA39432.1.
M87571 Genomic DNA. Translation: AAA39433.1.
S49753 Genomic DNA. Translation: AAB24402.1.
PIRA42395.
I77464.
RefSeqNP_038610.1. NM_013582.2.
UniGeneMm.1644.

3D structure databases

ProteinModelPortalP30730.
SMRP30730. Positions 51-360, 364-643.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000024916.

Chemistry

GuidetoPHARMACOLOGY254.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30730.

Proteomic databases

PRIDEP30730.

Protocols and materials databases

DNASU16867.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
GeneID16867.
KEGGmmu:16867.
UCSCuc008dvw.1. mouse.

Organism-specific databases

CTD3973.
MGIMGI:96783. Lhcgr.

Phylogenomic databases

eggNOGNOG285844.
GeneTreeENSGT00730000110262.
HOGENOMHOG000045902.
HOVERGENHBG003521.
InParanoidP30730.
KOK04248.
OMAIYFAVQN.
OrthoDBEOG73BVCG.
PhylomeDBP30730.
TreeFamTF316814.

Gene expression databases

BgeeP30730.
CleanExMM_LHCGR.
GenevestigatorP30730.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR000372. LRR-contain_N.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290826.
PROP30730.
SOURCESearch...

Entry information

Entry nameLSHR_MOUSE
AccessionPrimary (citable) accession number: P30730
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries