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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: BHF-UCL
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • cellular response to gonadotropin stimulus Source: BHF-UCL
  • cellular response to luteinizing hormone stimulus Source: UniProtKB
  • cognition Source: MGI
  • development of secondary male sexual characteristics Source: MGI
  • female gonad development Source: MGI
  • follicle-stimulating hormone signaling pathway Source: GO_Central
  • hormone-mediated signaling pathway Source: GO_Central
  • luteinizing hormone signaling pathway Source: UniProtKB
  • male gonad development Source: MGI
  • ovarian follicle development Source: MGI
  • ovulation cycle process Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of adenylate cyclase activity Source: MGI
  • positive regulation of cAMP-mediated signaling Source: BHF-UCL
  • positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
  • primary ovarian follicle growth Source: GO_Central
  • regulation of osteoclast differentiation Source: GO_Central
  • regulation of steroid hormone biosynthetic process Source: MGI
  • seminiferous tubule development Source: MGI
  • spermatogenesis Source: MGI
  • uterus development Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:Lhcgr
Synonyms:Lhr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96783. Lhcgr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 362ExtracellularSequence analysisAdd BLAST336
Transmembranei363 – 390Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 422Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini423 – 443ExtracellularSequence analysisAdd BLAST21
Transmembranei444 – 466Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini467 – 486CytoplasmicSequence analysisAdd BLAST20
Transmembranei487 – 509Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini510 – 529ExtracellularSequence analysisAdd BLAST20
Transmembranei530 – 551Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini552 – 574CytoplasmicSequence analysisAdd BLAST23
Transmembranei575 – 598Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini599 – 609ExtracellularSequence analysisAdd BLAST11
Transmembranei610 – 631Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini632 – 700CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001278127 – 700Lutropin-choriogonadotropic hormone receptorAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335SulfotyrosineBy similarity1
Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
Lipidationi647S-palmitoyl cysteineBy similarity1
Lipidationi648S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

Proteomic databases

MaxQBiP30730.
PaxDbiP30730.
PRIDEiP30730.

PTM databases

PhosphoSitePlusiP30730.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024107.
CleanExiMM_LHCGR.
GenevisibleiP30730. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024916.

Structurei

3D structure databases

ProteinModelPortaliP30730.
SMRiP30730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 75LRR 1Add BLAST24
Repeati126 – 150LRR 2Add BLAST25
Repeati176 – 200LRR 3Add BLAST25
Repeati225 – 248LRR 4Add BLAST24

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP30730.
KOiK04248.
OMAiIKIYFAV.
OrthoDBiEOG091G02BV.
PhylomeDBiP30730.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
IPR034298. TSHR/LHCGR/FSHR.
PANTHERiPTHR24372. PTHR24372. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRVPALRQ LLVLAMLVLK QSQLHSPELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSEILIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVSKISS
160 170 180 190 200
SEFNFILEIC DNLYITTIPG NAFQGMNNES ITLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG TFQGATGPSI LDVSSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIATSSYSL KTLPSREKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVREANNETL YSAIFEENEL SGWDYDYDFC SPKTLQCTPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCSAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWIFSTL
510 520 530 540 550
MATLPLVGVS SYMKVSICLP MDVESTLSQV YILSILLLNA VAFVVICACY
560 570 580 590 600
VRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKV LLVLFYPVNS CANPFLYAVF TKAFQRDFFL LLSRFGCCKH
660 670 680 690 700
RAELYRRKEF SACTFNSKNG FPRSSKPSQA ALKLSIVHCQ QPTPPRVLIQ
Length:700
Mass (Da):78,215
Last modified:April 1, 1993 - v1
Checksum:i8A6840A011E1E014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81310 mRNA. Translation: AAA39432.1.
M87571 Genomic DNA. Translation: AAA39433.1.
S49753 Genomic DNA. Translation: AAB24402.1.
CCDSiCCDS29025.1.
PIRiA42395.
I77464.
RefSeqiNP_038610.1. NM_013582.2.
UniGeneiMm.1644.

Genome annotation databases

EnsembliENSMUST00000024916; ENSMUSP00000024916; ENSMUSG00000024107.
GeneIDi16867.
KEGGimmu:16867.
UCSCiuc008dvw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLSHR_MOUSE
AccessioniPrimary (citable) accession number: P30730
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 25, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families