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Protein

D(4) dopamine receptor

Gene

Drd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity).By similarity

GO - Molecular functioni

  • dopamine binding Source: RGD
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: RGD
  • drug binding Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: InterPro
  • associative learning Source: RGD
  • behavioral fear response Source: RGD
  • circadian rhythm Source: RGD
  • dopamine receptor signaling pathway Source: RGD
  • locomotory behavior Source: RGD
  • modulation of synaptic transmission Source: RGD
  • olfactory learning Source: RGD
  • photoperiodism Source: RGD
  • positive regulation of excitatory postsynaptic potential Source: RGD
  • positive regulation of penile erection Source: RGD
  • regulation of calcium-mediated signaling Source: RGD
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of neurotransmitter secretion Source: RGD
  • response to steroid hormone Source: RGD
  • retina development in camera-type eye Source: RGD
  • short-term memory Source: RGD
  • synaptic transmission, dopaminergic Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
D(4) dopamine receptor
Alternative name(s):
D(2C) dopamine receptor
Dopamine D4 receptor
Gene namesi
Name:Drd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2522. Drd4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 6710CytoplasmicSequence analysis
Transmembranei68 – 9023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10616ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14618CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 17024Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 18616ExtracellularSequence analysisAdd
BLAST
Transmembranei187 – 20822Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini209 – 314106CytoplasmicSequence analysisAdd
BLAST
Transmembranei315 – 33723Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini338 – 3469ExtracellularSequence analysis
Transmembranei347 – 36923Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini370 – 38718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • axon terminus Source: RGD
  • cell cortex Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • dendritic spine Source: RGD
  • integral component of plasma membrane Source: InterPro
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • terminal bouton Source: RGD
  • vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2093868.
GuidetoPHARMACOLOGYi217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387D(4) dopamine receptorPRO_0000069403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30729.

PTM databases

PhosphoSiteiP30729.

Expressioni

Tissue specificityi

Central nervous system: hypothalamus, thalamus, olfactory bulb, and frontal cortex.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD2 (By similarity). The interaction with DRD2 may modulate agonist-induced downstream signaling (By similarity). Interacts with GPRASP1 (By similarity). May interact with ADORA2A (By similarity). Interacts with CLIC6.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-59866N.
STRINGi10116.ENSRNOP00000024137.

Chemistry

BindingDBiP30729.

Structurei

3D structure databases

ProteinModelPortaliP30729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30729.
PhylomeDBiP30729.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSSATGDG GLLAGRGPES LGTGTGLGGA GAAALVGGVL LIGMVLAGNS
60 70 80 90 100
LVCVSVASER ILQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL
110 120 130 140 150
SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL
160 170 180 190 200
IAATWLLSAA VAAPVVCGLN DVPGRDPTVC CLEDRDYVVY SSICSFFLPC
210 220 230 240 250
PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPLFS
260 270 280 290 300
DCPPPSPSLR TSPTVSSRPE SDLSQSPCSP GCLLPDAALA QPPAPSSRRK
310 320 330 340 350
RGAKITGRER KAMRVLPVVV GAFLMCWTPF FVVHITRALC PACFVSPRLV
360 370 380
SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC
Length:387
Mass (Da):41,294
Last modified:May 30, 2000 - v2
Checksum:i1E0A5D74524F5050
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 942Missing in AAA96716 (PubMed:1554689).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84009 mRNA. Translation: AAA96716.1.
U03551 Genomic DNA. Translation: AAA18588.1.
AC118351 Genomic DNA. No translation available.
UniGeneiRn.10159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84009 mRNA. Translation: AAA96716.1.
U03551 Genomic DNA. Translation: AAA18588.1.
AC118351 Genomic DNA. No translation available.
UniGeneiRn.10159.

3D structure databases

ProteinModelPortaliP30729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59866N.
STRINGi10116.ENSRNOP00000024137.

Chemistry

BindingDBiP30729.
ChEMBLiCHEMBL2093868.
GuidetoPHARMACOLOGYi217.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30729.

Proteomic databases

PaxDbiP30729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2522. Drd4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30729.
PhylomeDBiP30729.

Miscellaneous databases

NextBioi606629.
PROiP30729.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system."
    O'Malley K.L., Harmon S., Tang L., Todd R.D.
    New Biol. 4:137-146(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes."
    Asghari V., Schoots O., van Kats S., Ohara K., Jovanovic V., Guan H.-C., Bunzow J.R., Petronis A., Van Tol H.H.M.
    Mol. Pharmacol. 46:364-373(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  4. "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors."
    Griffon N., Jeanneteau F., Prieur F., Diaz J., Sokoloff P.
    Brain Res. Mol. Brain Res. 117:47-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLIC6.

Entry informationi

Entry nameiDRD4_RAT
AccessioniPrimary (citable) accession number: P30729
Secondary accession number(s): Q62610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.