Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D(4) dopamine receptor

Gene

Drd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity).By similarity

GO - Molecular functioni

  • dopamine binding Source: RGD
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: RGD
  • dopamine neurotransmitter receptor activity, coupled via Gs Source: GO_Central
  • drug binding Source: RGD

GO - Biological processi

  • adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: InterPro
  • associative learning Source: RGD
  • behavioral fear response Source: RGD
  • circadian rhythm Source: RGD
  • dopamine receptor signaling pathway Source: RGD
  • locomotory behavior Source: RGD
  • modulation of synaptic transmission Source: RGD
  • olfactory learning Source: RGD
  • photoperiodism Source: RGD
  • positive regulation of excitatory postsynaptic potential Source: RGD
  • positive regulation of penile erection Source: RGD
  • regulation of calcium-mediated signaling Source: RGD
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of neurotransmitter secretion Source: RGD
  • response to steroid hormone Source: RGD
  • retina development in camera-type eye Source: RGD
  • short-term memory Source: RGD
  • synaptic transmission, dopaminergic Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
D(4) dopamine receptor
Alternative name(s):
D(2C) dopamine receptor
Dopamine D4 receptor
Gene namesi
Name:Drd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2522. Drd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 57Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini58 – 67CytoplasmicSequence analysis10
Transmembranei68 – 90Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini91 – 106ExtracellularSequence analysisAdd BLAST16
Transmembranei107 – 128Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini129 – 146CytoplasmicSequence analysisAdd BLAST18
Transmembranei147 – 170Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini171 – 186ExtracellularSequence analysisAdd BLAST16
Transmembranei187 – 208Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini209 – 314CytoplasmicSequence analysisAdd BLAST106
Transmembranei315 – 337Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini338 – 346ExtracellularSequence analysis9
Transmembranei347 – 369Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini370 – 387CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • axon Source: RGD
  • axon terminus Source: RGD
  • cell cortex Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • dendritic spine Source: RGD
  • integral component of plasma membrane Source: InterPro
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • terminal bouton Source: RGD
  • vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3361.
GuidetoPHARMACOLOGYi217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694031 – 387D(4) dopamine receptorAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30729.

PTM databases

PhosphoSitePlusiP30729.

Expressioni

Tissue specificityi

Central nervous system: hypothalamus, thalamus, olfactory bulb, and frontal cortex.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD2 (By similarity). The interaction with DRD2 may modulate agonist-induced downstream signaling (By similarity). Interacts with GPRASP1 (By similarity). May interact with ADORA2A (By similarity). Interacts with CLIC6.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-59866N.
STRINGi10116.ENSRNOP00000024137.

Chemistry databases

BindingDBiP30729.

Structurei

3D structure databases

ProteinModelPortaliP30729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30729.
PhylomeDBiP30729.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSSATGDG GLLAGRGPES LGTGTGLGGA GAAALVGGVL LIGMVLAGNS
60 70 80 90 100
LVCVSVASER ILQTPTNYFI VSLAAADLLL AVLVLPLFVY SEVQGGVWLL
110 120 130 140 150
SPRLCDTLMA MDVMLCTASI FNLCAISVDR FVAVTVPLRY NQQGQCQLLL
160 170 180 190 200
IAATWLLSAA VAAPVVCGLN DVPGRDPTVC CLEDRDYVVY SSICSFFLPC
210 220 230 240 250
PLMLLLYWAT FRGLRRWEAA RHTKLHSRAP RRPSGPGPPV SDPTQGPLFS
260 270 280 290 300
DCPPPSPSLR TSPTVSSRPE SDLSQSPCSP GCLLPDAALA QPPAPSSRRK
310 320 330 340 350
RGAKITGRER KAMRVLPVVV GAFLMCWTPF FVVHITRALC PACFVSPRLV
360 370 380
SAVTWLGYVN SALNPIIYTI FNAEFRSVFR KTLRLRC
Length:387
Mass (Da):41,294
Last modified:May 30, 2000 - v2
Checksum:i1E0A5D74524F5050
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 94Missing in AAA96716 (PubMed:1554689).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84009 mRNA. Translation: AAA96716.1.
U03551 Genomic DNA. Translation: AAA18588.1.
AC118351 Genomic DNA. No translation available.
UniGeneiRn.10159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84009 mRNA. Translation: AAA96716.1.
U03551 Genomic DNA. Translation: AAA18588.1.
AC118351 Genomic DNA. No translation available.
UniGeneiRn.10159.

3D structure databases

ProteinModelPortaliP30729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59866N.
STRINGi10116.ENSRNOP00000024137.

Chemistry databases

BindingDBiP30729.
ChEMBLiCHEMBL3361.
GuidetoPHARMACOLOGYi217.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30729.

Proteomic databases

PaxDbiP30729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2522. Drd4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP30729.
PhylomeDBiP30729.

Miscellaneous databases

PROiP30729.

Family and domain databases

InterProiIPR002185. Dopamine_D4_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00569. DOPAMINED4R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD4_RAT
AccessioniPrimary (citable) accession number: P30729
Secondary accession number(s): Q62610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.