ID DRD3_MOUSE Reviewed; 446 AA. AC P30728; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 1. DT 27-MAR-2024, entry version 190. DE RecName: Full=D(3) dopamine receptor; DE AltName: Full=Dopamine D3 receptor; GN Name=Drd3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D3LONG AND D3SHORT). RC STRAIN=BALB/cJ; RX PubMed=8449953; DOI=10.1016/s0021-9258(18)53401-3; RA Fishburn C.S., Belleli D., David C., Carmon S., Fuchs S.; RT "A novel short isoform of the D3 dopamine receptor generated by alternative RT splicing in the third cytoplasmic loop."; RL J. Biol. Chem. 268:5872-5878(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=7598803; DOI=10.1089/dna.1995.14.485; RA Fu D., Skryabin B.V., Brosius J., Robakis N.K.; RT "Molecular cloning and characterization of the mouse dopamine D3 receptor RT gene: an additional intron and an mRNA variant."; RL DNA Cell Biol. 14:485-492(1995). CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins CC which inhibit adenylyl cyclase. Promotes cell proliferation (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with CLIC6 (By similarity). Interacts with GRK4. CC Interacts with PALM. Interacts with FLNA (via filamin repeat 21); CC increases PKA-mediated phosphorylation of FLNA (By similarity). CC {ECO:0000250|UniProtKB:P19020, ECO:0000250|UniProtKB:P35462}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=D3Long; CC IsoId=P30728-1; Sequence=Displayed; CC Name=D3Short; CC IsoId=P30728-2; Sequence=VSP_001873; CC -!- PTM: Phosphorylated by GRK4. {ECO:0000250|UniProtKB:P35462}. CC -!- PTM: Palmitoylated. {ECO:0000250|UniProtKB:P35462}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X67274; CAA47691.1; -; mRNA. DR EMBL; S78580; AAB35066.2; -; Genomic_DNA. DR EMBL; S78574; AAB35066.2; JOINED; Genomic_DNA. DR EMBL; S78638; AAB35066.2; JOINED; Genomic_DNA. DR EMBL; S78577; AAB35066.2; JOINED; Genomic_DNA. DR EMBL; S78578; AAB35066.2; JOINED; Genomic_DNA. DR EMBL; S78579; AAB35066.2; JOINED; Genomic_DNA. DR EMBL; S78639; AAB35066.2; JOINED; Genomic_DNA. DR CCDS; CCDS28179.1; -. [P30728-1] DR PIR; I48322; I48322. DR RefSeq; NP_031903.1; NM_007877.2. [P30728-1] DR AlphaFoldDB; P30728; -. DR SMR; P30728; -. DR BioGRID; 199307; 2. DR CORUM; P30728; -. DR STRING; 10090.ENSMUSP00000023390; -. DR BindingDB; P30728; -. DR ChEMBL; CHEMBL3441; -. DR DrugCentral; P30728; -. DR GlyCosmos; P30728; 4 sites, No reported glycans. DR GlyGen; P30728; 4 sites. DR PhosphoSitePlus; P30728; -. DR PaxDb; 10090-ENSMUSP00000023390; -. DR Antibodypedia; 16482; 336 antibodies from 38 providers. DR DNASU; 13490; -. DR Ensembl; ENSMUST00000023390.5; ENSMUSP00000023390.5; ENSMUSG00000022705.6. [P30728-1] DR GeneID; 13490; -. DR KEGG; mmu:13490; -. DR UCSC; uc007zgi.1; mouse. [P30728-1] DR AGR; MGI:94925; -. DR CTD; 1814; -. DR MGI; MGI:94925; Drd3. DR VEuPathDB; HostDB:ENSMUSG00000022705; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT00940000159661; -. DR HOGENOM; CLU_009579_11_1_1; -. DR InParanoid; P30728; -. DR OMA; QINSTCG; -. DR OrthoDB; 2999405at2759; -. DR PhylomeDB; P30728; -. DR TreeFam; TF334382; -. DR Reactome; R-MMU-390651; Dopamine receptors. DR Reactome; R-MMU-418594; G alpha (i) signalling events. DR BioGRID-ORCS; 13490; 4 hits in 78 CRISPR screens. DR PRO; PR:P30728; -. DR Proteomes; UP000000589; Chromosome 16. DR RNAct; P30728; Protein. DR Bgee; ENSMUSG00000022705; Expressed in blastoderm cell in morula and 53 other cell types or tissues. DR ExpressionAtlas; P30728; baseline and differential. DR GO; GO:0045177; C:apical part of cell; ISO:MGI. DR GO; GO:0042995; C:cell projection; ISO:MGI. DR GO; GO:0098691; C:dopaminergic synapse; IDA:SynGO. DR GO; GO:0030139; C:endocytic vesicle; ISO:MGI. DR GO; GO:0098982; C:GABA-ergic synapse; ISO:MGI. DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0098839; C:postsynaptic density membrane; ISO:MGI. DR GO; GO:0031748; F:D1 dopamine receptor binding; ISO:MGI. DR GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:MGI. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR GO; GO:0019904; F:protein domain specific binding; ISO:MGI. DR GO; GO:0046717; P:acid secretion; ISO:MGI. DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:MGI. DR GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; ISO:MGI. DR GO; GO:0050482; P:arachidonic acid secretion; ISO:MGI. DR GO; GO:0006914; P:autophagy; ISO:MGI. DR GO; GO:0048148; P:behavioral response to cocaine; IMP:BHF-UCL. DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:MGI. DR GO; GO:0007212; P:dopamine receptor signaling pathway; IMP:MGI. DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:MGI. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; ISO:MGI. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IMP:MGI. DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI. DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI. DR GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IGI:MGI. DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IDA:MGI. DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IMP:MGI. DR GO; GO:0050709; P:negative regulation of protein secretion; ISO:MGI. DR GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0048709; P:oligodendrocyte differentiation; IDA:MGI. DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IMP:MGI. DR GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI. DR GO; GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:MGI. DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0060134; P:prepulse inhibition; ISO:MGI. DR GO; GO:0002016; P:regulation of blood volume by renin-angiotensin; IMP:MGI. DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISO:MGI. DR GO; GO:0014059; P:regulation of dopamine secretion; IMP:MGI. DR GO; GO:0019216; P:regulation of lipid metabolic process; IMP:MGI. DR GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; ISO:MGI. DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0051580; P:regulation of neurotransmitter uptake; IDA:SynGO. DR GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; ISO:MGI. DR GO; GO:0043266; P:regulation of potassium ion transport; IBA:GO_Central. DR GO; GO:0001975; P:response to amphetamine; IGI:MGI. DR GO; GO:0042220; P:response to cocaine; IMP:MGI. DR GO; GO:0045471; P:response to ethanol; IMP:MGI. DR GO; GO:0034776; P:response to histamine; ISO:MGI. DR GO; GO:0043278; P:response to morphine; IMP:MGI. DR GO; GO:0009410; P:response to xenobiotic stimulus; ISO:MGI. DR GO; GO:0008542; P:visual learning; IMP:MGI. DR CDD; cd15310; 7tmA_D3_dopamine_R; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2. DR InterPro; IPR001620; Dopamine_D3_rcpt. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24248:SF154; D(3) DOPAMINE RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00568; DOPAMINED3R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; P30728; MM. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..446 FT /note="D(3) dopamine receptor" FT /id="PRO_0000069398" FT TOPO_DOM 1..32 FT /note="Extracellular" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 33..55 FT /note="Helical; Name=1" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 56..65 FT /note="Cytoplasmic" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 66..88 FT /note="Helical; Name=2" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 89..104 FT /note="Extracellular" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 105..126 FT /note="Helical; Name=3" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 127..149 FT /note="Cytoplasmic" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 150..170 FT /note="Helical; Name=4" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 171..187 FT /note="Extracellular" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 188..209 FT /note="Helical; Name=5" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 210..375 FT /note="Cytoplasmic" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 376..397 FT /note="Helical; Name=6" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 398..412 FT /note="Extracellular" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TRANSMEM 413..432 FT /note="Helical; Name=7" FT /evidence="ECO:0000250|UniProtKB:P35462" FT TOPO_DOM 433..446 FT /note="Cytoplasmic" FT /evidence="ECO:0000250|UniProtKB:P35462" FT CARBOHYD 12 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 19 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 97 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 173 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 103..181 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT DISULFID 401..404 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VAR_SEQ 268..288 FT /note="Missing (in isoform D3Short)" FT /evidence="ECO:0000303|PubMed:8449953" FT /id="VSP_001873" SQ SEQUENCE 446 AA; 49669 MW; B391C2D493B58242 CRC64; MAPLSQISSH INSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV CAAVLRERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPSI CSISNPDFVI YSSVVSFYVP FGVTVLVYAR IYMVLRQRRR KRILTRQNSQ CISIRPGFPQ QSSCLRLHPI RQFSIRARFL SDATGQMEHI EDKPYPQKCQ DPLLSHLQPL SPGQTHGELK RYYSICQDTA LRHPNFEGGG GMSQVERTRN SLSPTMAPKL SLEVRKLSNG RLSTSLKLGP LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH CQACHVSPEL YRATTWLGYV NSALNPVIYT TFNIEFRKAF LKILSC //