Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P30728

- DRD3_MOUSE

UniProt

P30728 - DRD3_MOUSE

Protein

D(3) dopamine receptor

Gene

Drd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101AgonistBy similarity

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGI
    3. drug binding Source: Ensembl
    4. protein binding Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
    2. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    3. arachidonic acid secretion Source: Ensembl
    4. behavioral response to cocaine Source: BHF-UCL
    5. cellular calcium ion homeostasis Source: Ensembl
    6. circadian regulation of gene expression Source: MGI
    7. gastric emptying Source: Ensembl
    8. G-protein coupled receptor internalization Source: Ensembl
    9. locomotory behavior Source: MGI
    10. musculoskeletal movement, spinal reflex action Source: MGI
    11. negative regulation of adenylate cyclase activity Source: Ensembl
    12. negative regulation of blood pressure Source: MGI
    13. negative regulation of dopamine receptor signaling pathway Source: MGI
    14. negative regulation of oligodendrocyte differentiation Source: MGI
    15. negative regulation of protein kinase B signaling Source: MGI
    16. negative regulation of protein secretion Source: Ensembl
    17. negative regulation of sodium:proton antiporter activity Source: Ensembl
    18. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    19. positive regulation of cell proliferation Source: Ensembl
    20. positive regulation of dopamine receptor signaling pathway Source: MGI
    21. positive regulation of mitosis Source: Ensembl
    22. positive regulation of renal sodium excretion Source: Ensembl
    23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. prepulse inhibition Source: Ensembl
    25. regulation of blood volume by renin-angiotensin Source: MGI
    26. regulation of circadian sleep/wake cycle, sleep Source: Ensembl
    27. regulation of dopamine secretion Source: MGI
    28. regulation of lipid metabolic process Source: MGI
    29. regulation of locomotion involved in locomotory behavior Source: Ensembl
    30. regulation of multicellular organism growth Source: MGI
    31. response to amphetamine Source: MGI
    32. response to cocaine Source: MGI
    33. response to drug Source: Ensembl
    34. response to ethanol Source: MGI
    35. response to histamine Source: Ensembl
    36. response to morphine Source: MGI
    37. synaptic transmission, dopaminergic Source: Ensembl
    38. visual learning Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(3) dopamine receptor
    Alternative name(s):
    Dopamine D3 receptor
    Gene namesi
    Name:Drd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:94925. Drd3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell projection Source: Ensembl
    3. endocytic vesicle Source: Ensembl
    4. integral component of plasma membrane Source: InterPro
    5. membrane Source: MGI
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446D(3) dopamine receptorPRO_0000069398Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 181PROSITE-ProRule annotation
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi401 ↔ 404PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by GRK4.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP30728.
    PRIDEiP30728.

    PTM databases

    PhosphoSiteiP30728.

    Expressioni

    Gene expression databases

    BgeeiP30728.
    CleanExiMM_DRD3.
    GenevestigatoriP30728.

    Interactioni

    Subunit structurei

    Interacts with CLIC6, GRK4 and PALM.By similarity

    Protein-protein interaction databases

    BioGridi199307. 1 interaction.
    STRINGi10090.ENSMUSP00000023390.

    Structurei

    3D structure databases

    ProteinModelPortaliP30728.
    SMRiP30728. Positions 32-224, 351-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularBy similarityAdd
    BLAST
    Topological domaini56 – 6510CytoplasmicBy similarity
    Topological domaini89 – 10416ExtracellularBy similarityAdd
    BLAST
    Topological domaini127 – 14923CytoplasmicBy similarityAdd
    BLAST
    Topological domaini171 – 18717ExtracellularBy similarityAdd
    BLAST
    Topological domaini213 – 375163CytoplasmicBy similarityAdd
    BLAST
    Topological domaini398 – 41215ExtracellularBy similarityAdd
    BLAST
    Topological domaini435 – 44612CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5523Helical; Name=1By similarityAdd
    BLAST
    Transmembranei66 – 8823Helical; Name=2By similarityAdd
    BLAST
    Transmembranei105 – 12622Helical; Name=3By similarityAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4By similarityAdd
    BLAST
    Transmembranei188 – 21225Helical; Name=5By similarityAdd
    BLAST
    Transmembranei376 – 39722Helical; Name=6By similarityAdd
    BLAST
    Transmembranei413 – 43422Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni189 – 1968Agonist bindingBy similarity
    Regioni388 – 3969Agonist bindingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309657.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP30728.
    KOiK04146.
    OMAiLHPIRQF.
    OrthoDBiEOG769ZMG.
    PhylomeDBiP30728.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001620. Dopamine_D3_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24249:SF38. PTHR24249:SF38. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00568. DOPAMINED3R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform D3Long (identifier: P30728-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPLSQISSH INSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV    50
    CAAVLRERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 100
    ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 150
    ALMITAVWVL AFAVSCPLLF GFNTTGDPSI CSISNPDFVI YSSVVSFYVP 200
    FGVTVLVYAR IYMVLRQRRR KRILTRQNSQ CISIRPGFPQ QSSCLRLHPI 250
    RQFSIRARFL SDATGQMEHI EDKPYPQKCQ DPLLSHLQPL SPGQTHGELK 300
    RYYSICQDTA LRHPNFEGGG GMSQVERTRN SLSPTMAPKL SLEVRKLSNG 350
    RLSTSLKLGP LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH 400
    CQACHVSPEL YRATTWLGYV NSALNPVIYT TFNIEFRKAF LKILSC 446
    Length:446
    Mass (Da):49,669
    Last modified:April 1, 1993 - v1
    Checksum:iB391C2D493B58242
    GO
    Isoform D3Short (identifier: P30728-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-288: Missing.

    Show »
    Length:425
    Mass (Da):47,168
    Checksum:iE4C0EDFB345BAE87
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei268 – 28821Missing in isoform D3Short. 1 PublicationVSP_001873Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67274 mRNA. Translation: CAA47691.1.
    S78580
    , S78574, S78638, S78577, S78578, S78579, S78639 Genomic DNA. Translation: AAB35066.2.
    CCDSiCCDS28179.1. [P30728-1]
    PIRiI48322.
    RefSeqiNP_031903.1. NM_007877.1. [P30728-1]
    UniGeneiMm.439735.

    Genome annotation databases

    EnsembliENSMUST00000023390; ENSMUSP00000023390; ENSMUSG00000022705. [P30728-1]
    GeneIDi13490.
    KEGGimmu:13490.
    UCSCiuc007zgi.1. mouse. [P30728-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67274 mRNA. Translation: CAA47691.1 .
    S78580
    , S78574 , S78638 , S78577 , S78578 , S78579 , S78639 Genomic DNA. Translation: AAB35066.2 .
    CCDSi CCDS28179.1. [P30728-1 ]
    PIRi I48322.
    RefSeqi NP_031903.1. NM_007877.1. [P30728-1 ]
    UniGenei Mm.439735.

    3D structure databases

    ProteinModelPortali P30728.
    SMRi P30728. Positions 32-224, 351-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199307. 1 interaction.
    STRINGi 10090.ENSMUSP00000023390.

    Chemistry

    BindingDBi P30728.
    ChEMBLi CHEMBL2111359.
    GuidetoPHARMACOLOGYi 216.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30728.

    Proteomic databases

    PaxDbi P30728.
    PRIDEi P30728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023390 ; ENSMUSP00000023390 ; ENSMUSG00000022705 . [P30728-1 ]
    GeneIDi 13490.
    KEGGi mmu:13490.
    UCSCi uc007zgi.1. mouse. [P30728-1 ]

    Organism-specific databases

    CTDi 1814.
    MGIi MGI:94925. Drd3.

    Phylogenomic databases

    eggNOGi NOG309657.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P30728.
    KOi K04146.
    OMAi LHPIRQF.
    OrthoDBi EOG769ZMG.
    PhylomeDBi P30728.
    TreeFami TF334382.

    Miscellaneous databases

    NextBioi 284005.
    PROi P30728.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30728.
    CleanExi MM_DRD3.
    Genevestigatori P30728.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001620. Dopamine_D3_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24249:SF38. PTHR24249:SF38. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00568. DOPAMINED3R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel short isoform of the D3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop."
      Fishburn C.S., Belleli D., David C., Carmon S., Fuchs S.
      J. Biol. Chem. 268:5872-5878(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D3LONG AND D3SHORT).
      Strain: BALB/c.
    2. "Molecular cloning and characterization of the mouse dopamine D3 receptor gene: an additional intron and an mRNA variant."
      Fu D., Skryabin B.V., Brosius J., Robakis N.K.
      DNA Cell Biol. 14:485-492(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiDRD3_MOUSE
    AccessioniPrimary (citable) accession number: P30728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3