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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACE272562:GJIH-1331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:CA_C1282
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 615614Chaperone protein DnaKPRO_0000078448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP30721.

Expressioni

Inductioni

By heat shock.

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C1282.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ROHmodel-B-[»]
ProteinModelPortaliP30721.
SMRiP30721. Positions 1-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiFYSAKRF.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVIGIDLG TTNSCVAVME GGDPAVIANS EGARTTPSVV SFQKNGERLV
60 70 80 90 100
GQVAKRQSIT NPDKTIISIK RKMGTAEKVA IDDKNYTPQE ISAMILQKLK
110 120 130 140 150
ADAEAYLGET VTQAVITVPA YFNDSQRQAT KDAGKIAGLE VLRIINEPTA
160 170 180 190 200
ASLAYGLDKM DTNQKILVYD LGGGTFDVSV LELGDGVFEV KSTNGNTHLG
210 220 230 240 250
GDDFDEKIMD YIAEEFKKDN GIDLRNDKMA LQRLKEAAEK AKIELSSSTQ
260 270 280 290 300
TNINLPFITA DATGPKHIDM NLTRAKFNEL TEGLVQDTIE PMKKALSDAG
310 320 330 340 350
LSINDIDKIV LVGGSTRIPA VQEAVKNYTG KDPSKGVNPD ECVAIGAAIQ
360 370 380 390 400
AGVLTGDVKD VLLLDVSPLT LGIETLGGVA TPLIERNTTI PTRKSQVFST
410 420 430 440 450
AADNQPSVEI NIVQGERKMA ADNKSLGRFT LDGIAPAPRG VPQIEVTFDI
460 470 480 490 500
DANGIVNVSA KDKGTGKESH ITITASTNLS DEEIDKAVKD AEKFAEEDKK
510 520 530 540 550
KKENIEVKNN ADQIVFQTDK ALKDLGDKVS AEDKSNIEAK KEALSKVKDG
560 570 580 590 600
DDIEAIKKAT EDLTQALYAI TTKMYEQSGA QGAPGADPNA GASQKTNGGA
610
DDNVVDADFK VDNDK
Length:615
Mass (Da):65,649
Last modified:January 23, 2007 - v3
Checksum:i3D014929157F7567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74569 Genomic DNA. Translation: AAA23246.1.
AE001437 Genomic DNA. Translation: AAK79253.1.
PIRiB41873.
B97058.
RefSeqiNP_347913.1. NC_003030.1.
WP_010964594.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK79253; AAK79253; CA_C1282.
GeneIDi1117465.
KEGGicac:CA_C1282.
PATRICi32036939. VBICloAce74127_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74569 Genomic DNA. Translation: AAA23246.1.
AE001437 Genomic DNA. Translation: AAK79253.1.
PIRiB41873.
B97058.
RefSeqiNP_347913.1. NC_003030.1.
WP_010964594.1. NC_003030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ROHmodel-B-[»]
ProteinModelPortaliP30721.
SMRiP30721. Positions 1-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C1282.

Proteomic databases

PRIDEiP30721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK79253; AAK79253; CA_C1282.
GeneIDi1117465.
KEGGicac:CA_C1282.
PATRICi32036939. VBICloAce74127_1483.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228135.
KOiK04043.
OMAiFYSAKRF.

Enzyme and pathway databases

BioCyciCACE272562:GJIH-1331-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_CLOAB
AccessioniPrimary (citable) accession number: P30721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.