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Protein

60 kDa chaperonin

Gene

groL

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4471-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:PA4385
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4385

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000634862 – 54760 kDa chaperoninAdd BLAST546

Proteomic databases

PaxDbiP30718
PRIDEiP30718

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi208964.PA4385

Structurei

3D structure databases

ProteinModelPortaliP30718
SMRiP30718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
HOGENOMiHOG000076290
InParanoidiP30718
KOiK04077
OMAiTDTDKME
PhylomeDBiP30718

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKEVKFGD SARKKMLVGV NVLADAVKAT LGPKGRNVVL DKSFGAPTIT
60 70 80 90 100
KDGVSVAKEI ELKDKFENMG AQLVKDVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKATVAIVAQ LKELAKPCAD TKAIAQVGTI
160 170 180 190 200
SANSDESIGQ IIAEAMEKVG KEGVITVEEG SGLENELSVV EGMQFDRGYL
210 220 230 240 250
SPYFVNKPDT MAAELDSPLL LLVDKKISNI REMLPVLEAV AKAGRPLLIV
260 270 280 290 300
AEDVEGEALA TLVVNNMRGI VKVAAVKAPG FGDRRKAMLQ DIAILTGGTV
310 320 330 340 350
ISEEVGLSLE GATLEHLGNA KRVVINKENT TIIDGAGVQA DIEARVLQIR
360 370 380 390 400
KQIEETTSDY DREKLQERLA KLAGGVAVIK VGAATEVEMK EKKARVEDAL
410 420 430 440 450
HATRAAVEEG VVPGGGVALV RALQAIEGLK GDNEEQNVGI ALLRRAVESP
460 470 480 490 500
LRQIVANAGD EPSVVVDKVK QGSGNYGFNA ATGVYGDMIE MGILDPAKVT
510 520 530 540
RSALQAAASI GGLMITTEAM VAEIVEDKPA MGGMPDMGGM GGMGGMM
Length:547
Mass (Da):57,086
Last modified:December 8, 2000 - v3
Checksum:iFB82EB49D0F4748D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 82KAN → RPT in AAA25830 (PubMed:1715325).Curated3
Sequence conflicti80 – 82KAN → RPT in AAB34346 (PubMed:7538307).Curated3
Sequence conflicti123A → P in AAA25830 (PubMed:1715325).Curated1
Sequence conflicti138 – 139CA → WR in AAA25830 (PubMed:1715325).Curated2
Sequence conflicti319 – 320NA → KP in AAA25830 (PubMed:1715325).Curated2
Sequence conflicti370A → G in AAA53369 (PubMed:8857035).Curated1
Sequence conflicti395R → P in AAA25830 (PubMed:1715325).Curated1
Sequence conflicti395R → P in AAB34346 (PubMed:7538307).Curated1
Sequence conflicti451L → V in AAA25830 (PubMed:1715325).Curated1
Sequence conflicti451L → V in AAB34346 (PubMed:7538307).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63957 Genomic DNA Translation: AAA25830.1
S77424 Genomic DNA Translation: AAB34346.1
U17072 Genomic DNA Translation: AAA53369.1
AE004091 Genomic DNA Translation: AAG07773.1
PIRiB43606
B83098
RefSeqiNP_253075.1, NC_002516.2
WP_003094059.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07773; AAG07773; PA4385
GeneIDi881348
KEGGipae:PA4385
PATRICifig|208964.12.peg.4593

Similar proteinsi

Entry informationi

Entry nameiCH60_PSEAE
AccessioniPrimary (citable) accession number: P30718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 8, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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