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Protein

Epididymal secretory glutathione peroxidase

Gene

Gpx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3735 RnoGPx05

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory glutathione peroxidase (EC:1.11.1.9)
Alternative name(s):
Epididymis-specific glutathione peroxidase-like protein
Short name:
EGLP
Glutathione peroxidase 5
Short name:
GPx-5
Short name:
GSHPx-5
Gene namesi
Name:Gpx5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69227 Gpx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001308022 – 221Epididymal secretory glutathione peroxidaseAdd BLAST200

Proteomic databases

PRIDEiP30710

Expressioni

Tissue specificityi

Epididymis.

Structurei

3D structure databases

ProteinModelPortaliP30710
SMRiP30710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004333
InParanoidiP30710
KOiK00432
PhylomeDBiP30710

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIQLRVFYL VPLLLASYVQ TTPRLEKMKM DCYKDVKGTI YNYEALSLNG
60 70 80 90 100
KERIPFKQYA GKHVLFVNVA TYCGLTIQYP ELNALQDDLK QFGLVILGFP
110 120 130 140 150
CNQFGKQEPG DNTEILPGLK YVRPGKGFLP NFQLFAKGDV NGEKEQEIFT
160 170 180 190 200
FLKRSCPHPS ETVVTSKHTF WEPIKVHDIR WNFEKFLVGP NGVPVMRWFH
210 220
QAPVSTVKSD ILAYLNQFKT I
Length:221
Mass (Da):25,385
Last modified:April 1, 1993 - v1
Checksum:i0D9D3FAAC9F12D16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62404 mRNA Translation: CAA44274.1
PIRiS24328
RefSeqiNP_001099208.1, NM_001105738.1
UniGeneiRn.218434

Genome annotation databases

GeneIDi113919
KEGGirno:113919

Similar proteinsi

Entry informationi

Entry nameiGPX5_RAT
AccessioniPrimary (citable) accession number: P30710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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