Reviewed, UniProtKB/Swiss-Prot P30710 (GPX5_RAT)

Names and origin

Protein names

Recommended name:
    Epididymal secretory glutathione peroxidase
    EC=1.11.1.9
Alternative name(s):
    Epididymis-specific glutathione peroxidase-like protein
      Short name=EGLP

Gene names

Name:

Gpx5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Catalytic activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subcellular location	Secreted.
Tissue specificity	Epididymis.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 221	200	Epididymal secretory glutathione peroxidase		PRO_0000013080
Sites
	Active site	73	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30710-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 0D9D3FAAC9F12D16	FASTA	221	25,385
	10 20 30 40 50 60 MAIQLRVFYL VPLLLASYVQ TTPRLEKMKM DCYKDVKGTI YNYEALSLNG KERIPFKQYA 70 80 90 100 110 120 GKHVLFVNVA TYCGLTIQYP ELNALQDDLK QFGLVILGFP CNQFGKQEPG DNTEILPGLK 130 140 150 160 170 180 YVRPGKGFLP NFQLFAKGDV NGEKEQEIFT FLKRSCPHPS ETVVTSKHTF WEPIKVHDIR 190 200 210 220 WNFEKFLVGP NGVPVMRWFH QAPVSTVKSD ILAYLNQFKT I

References

[1]

"Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon." Perry A.C.F., Jones R., Niang L.S.P., Jackson R.M., Hall L. Biochem. J. 285:863-870(1992) [PubMed: 1386734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Epididymis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62404 mRNA. Translation: CAA44274.1.
PIR	S24328.
RefSeq	NP_001099208.1.
UniGene	Rn.218434
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	3735. RnoGPx05.
Genome annotation databases
GeneID	113919.
KEGG	rno:113919.
Organism-specific databases
RGD	69227. Gpx5.
Phylogenomic databases
HOVERGEN	P30710.
Family and domain databases
InterPro	IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	618026.

Entry information

Entry name

GPX5_RAT

Accession

Primary (citable) accession number: P30710

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)