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P30710 (GPX5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Epididymal secretory glutathione peroxidase
EC=1.11.1.9
Alternative name(s):
Epididymis-specific glutathione peroxidase-like protein
Short name=EGLP
Glutathione peroxidase 5
Short name=GPx-5
Short name=GSHPx-5
Gene names
Name:Gpx5
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Secreted.

Tissue specificity

Epididymis.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 221200Epididymal secretory glutathione peroxidase
PRO_0000013080

Sites

Active site731 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30710 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 0D9D3FAAC9F12D16

FASTA22125,385
        10         20         30         40         50         60 
MAIQLRVFYL VPLLLASYVQ TTPRLEKMKM DCYKDVKGTI YNYEALSLNG KERIPFKQYA 

        70         80         90        100        110        120 
GKHVLFVNVA TYCGLTIQYP ELNALQDDLK QFGLVILGFP CNQFGKQEPG DNTEILPGLK 

       130        140        150        160        170        180 
YVRPGKGFLP NFQLFAKGDV NGEKEQEIFT FLKRSCPHPS ETVVTSKHTF WEPIKVHDIR 

       190        200        210        220 
WNFEKFLVGP NGVPVMRWFH QAPVSTVKSD ILAYLNQFKT I

« Hide

References

[1]"Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon."
Perry A.C.F., Jones R., Niang L.S.P., Jackson R.M., Hall L.
Biochem. J. 285:863-870(1992) [PubMed: 1386734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Epididymis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X62404 mRNA. Translation: CAA44274.1.
IPIIPI00869678.
PIRS24328.
RefSeqNP_001099208.1. NM_001105738.1.
UniGeneRn.218434.

3D structure databases

ProteinModelPortalP30710.
SMRP30710. Positions 31-218.
ModBaseSearch...

Protein family/group databases

PeroxiBase3735. RnoGPx05.

Proteomic databases

PRIDEP30710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID113919.
KEGGrno:113919.

Organism-specific databases

CTD2880.
RGD69227. Gpx5.

Phylogenomic databases

eggNOGmaNOG15650.
HOVERGENHBG004333.

Gene expression databases

GenevestigatorP30710.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK00432.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618026.

Entry information

Entry nameGPX5_RAT
AccessionPrimary (citable) accession number: P30710
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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