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Protein

Trypsin inhibitor A

Gene
N/A
Organism
Momordica charantia (Bitter gourd) (Balsam pear)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits trypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5 – 6Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI07.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor A
OrganismiMomordica charantia (Bitter gourd) (Balsam pear)
Taxonomic identifieri3673 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeMomordiceaeMomordica

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000443891 – 28Trypsin inhibitor AAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 20
Disulfide bondi10 ↔ 22
Disulfide bondi16 ↔ 27

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-1512997.

Structurei

Secondary structure

128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 15Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MCTX-ray1.60I1-28[»]
ProteinModelPortaliP30709.
SMRiP30709.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30709.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

CDDicd00150. PlantTI. 1 hit.
InterProiView protein in InterPro
IPR000737. Prot_inh_squash.
IPR011052. Proteinase_amylase_inhib_sf.
PfamiView protein in Pfam
PF00299. Squash. 1 hit.
PRINTSiPR00293. SQUASHINHBTR.
SUPFAMiSSF57027. SSF57027. 1 hit.
PROSITEiView protein in PROSITE
PS00286. SQUASH_INHIBITOR. 1 hit.

Sequencei

Sequence statusi: Complete.

P30709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
RSCPRIWMEC TRDSDCMAKC ICVAGHCG
Length:28
Mass (Da):3,133
Last modified:April 1, 1993 - v1
Checksum:i67E8E6A2D404FEDF
GO

Sequence databases

PIRiS20393.

Similar proteinsi

Entry informationi

Entry nameiITRA_MOMCH
AccessioniPrimary (citable) accession number: P30709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families