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P30708 (GPX4_NICSY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 27, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phospholipid hydroperoxide glutathione peroxidase

Short name=PHGPx
EC=1.11.1.12
Alternative name(s):
6P229
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
Taxonomic identifier4096 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.

Catalytic activity

2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.

Subcellular location

Cytoplasm Potential.

Tissue specificity

Germinating seed, apex, flower, as well as in stressed tissues.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: InterPro

phospholipid-hydroperoxide glutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Probable phospholipid hydroperoxide glutathione peroxidase
PRO_0000066633

Sites

Active site431 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30708 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 401919069E1E97C7

FASTA16918,767
        10         20         30         40         50         60 
MASQSSKPQS IYDFTVKDAK GNDVDLSIYK GKVLIIVNVA SQCGLTNSNY TDLTEIYKKY 

        70         80         90        100        110        120 
KDQGLEILAF PCNQFGGQEP GSIEEIQNMV CTRFKAEYPI FDKVDVNGDN AAPLYKFLKS 

       130        140        150        160 
SKGGFFGDSI KWNFSKFLVD KEGNVVDRYS PTTTPASMEK DIKKLLGVA 

« Hide

References

[1]"Isolation and characterization of a plant cDNA showing homology to animal glutathione peroxidases."
Criqui M.-C., Jamet E., Parmentier Y., Marbach J., Durr A., Fleck J.
Plant Mol. Biol. 18:623-627(1992) [PubMed: 1536938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Protoplast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60219 mRNA. Translation: CAA42780.1.
PIRS20501.

3D structure databases

ProteinModelPortalP30708.
SMRP30708. Positions 5-168.
ModBaseSearch...

Protein family/group databases

PeroxiBase2868. NsGPx06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX4_NICSY
AccessionPrimary (citable) accession number: P30708
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 27, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families