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Protein

Major outer membrane protein P.IB

Gene

porB

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a slightly cation selective porin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-2101-MONOMER.
ReactomeiR-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).

Names & Taxonomyi

Protein namesi
Recommended name:
Major outer membrane protein P.IB
Short name:
PIB
Short name:
Protein IB
Alternative name(s):
Class 3 protein
Porin
Gene namesi
Name:porB
Ordered Locus Names:NMB2039
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 331312Major outer membrane protein P.IBPRO_0000025281Add
BLAST

Proteomic databases

PaxDbiP30690.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi122586.NMB2039.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 3919Combined sources
Beta strandi41 – 5515Combined sources
Beta strandi59 – 6911Combined sources
Beta strandi72 – 8110Combined sources
Beta strandi94 – 1029Combined sources
Beta strandi105 – 1139Combined sources
Helixi116 – 1183Combined sources
Turni130 – 1345Combined sources
Turni136 – 1405Combined sources
Beta strandi143 – 1508Combined sources
Beta strandi157 – 1648Combined sources
Helixi166 – 1694Combined sources
Beta strandi176 – 18510Combined sources
Beta strandi188 – 20013Combined sources
Beta strandi203 – 2053Combined sources
Beta strandi208 – 22215Combined sources
Beta strandi225 – 24016Combined sources
Beta strandi245 – 25612Combined sources
Beta strandi262 – 27110Combined sources
Beta strandi277 – 2793Combined sources
Beta strandi285 – 31026Combined sources
Beta strandi314 – 3163Combined sources
Beta strandi318 – 33114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WI4X-ray3.32A20-331[»]
3WI5X-ray2.40A20-331[»]
ProteinModelPortaliP30690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108Z9W. Bacteria.
ENOG4111NJJ. LUCA.
HOGENOMiHOG000114654.
KOiK18133.
OMAiARTPANF.
OrthoDBiEOG6358DM.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVFHQ NGQVTEVTTA
60 70 80 90 100
TGIVDLGSKI GFKGQEDLGN GLKAIWQVEQ KASIAGTDSG WGNRQSFIGL
110 120 130 140 150
KGGFGKLRVG RLNSVLKDTG DINPWDSKSD YLGVNKIAEP EARLISVRYD
160 170 180 190 200
SPEFAGLSGS VQYALNDNAG RHNSESYHAG FNYKNGGFFV QYGGAYKRHH
210 220 230 240 250
QVQEGLNIEK YQIHRLVSGY DNDALYASVA VQQQDAKLTD ASNSHNSQTE
260 270 280 290 300
VAATLAYRFG NVTPRVSYAH GFKGLVDDAD IGNEYDQVVV GAEYDFSKRT
310 320 330
SALVSAGWLQ EGKGENKFVA TAGGVGLRHK F
Length:331
Mass (Da):35,682
Last modified:April 1, 1993 - v1
Checksum:iD6945BC81B04B6AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65532 Genomic DNA. Translation: CAA46502.1.
AE002098 Genomic DNA. Translation: AAF42360.1.
PIRiS21407.
RefSeqiNP_275030.1. NC_003112.2.
WP_002244345.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF42360; AAF42360; NMB2039.
GeneIDi904054.
KEGGinme:NMB2039.
PATRICi20360214. VBINeiMen85645_2608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65532 Genomic DNA. Translation: CAA46502.1.
AE002098 Genomic DNA. Translation: AAF42360.1.
PIRiS21407.
RefSeqiNP_275030.1. NC_003112.2.
WP_002244345.1. NC_003112.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WI4X-ray3.32A20-331[»]
3WI5X-ray2.40A20-331[»]
ProteinModelPortaliP30690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB2039.

Proteomic databases

PaxDbiP30690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF42360; AAF42360; NMB2039.
GeneIDi904054.
KEGGinme:NMB2039.
PATRICi20360214. VBINeiMen85645_2608.

Phylogenomic databases

eggNOGiENOG4108Z9W. Bacteria.
ENOG4111NJJ. LUCA.
HOGENOMiHOG000114654.
KOiK18133.
OMAiARTPANF.
OrthoDBiEOG6358DM.

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-2101-MONOMER.
ReactomeiR-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and relationships between meningococcal class 3 serotype proteins and other porins from pathogenic and non-pathogenic Neisseria species."
    Ward M.J., Lambden P.R., Heckels J.E.
    FEMS Microbiol. Lett. 73:283-289(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MC58.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.
  3. "Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry."
    Vipond C., Wheeler J.X., Jones C., Feavers I.M., Suker J.
    Hum. Vaccin. 1:80-84(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254."
    Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.
    Proteomics 6:3400-3413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: NZ98/254 / Serogroup B.

Entry informationi

Entry nameiOMPB1_NEIMB
AccessioniPrimary (citable) accession number: P30690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.