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Protein

Major outer membrane protein P.IB

Gene

porB

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a slightly cation selective porin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).

Names & Taxonomyi

Protein namesi
Recommended name:
Major outer membrane protein P.IB
Short name:
PIB
Short name:
Protein IB
Alternative name(s):
Class 3 protein
Porin
Gene namesi
Name:porB
Ordered Locus Names:NMB2039
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002528120 – 331Major outer membrane protein P.IBAdd BLAST312

Proteomic databases

PaxDbiP30690.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi122586.NMB2039.

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 39Combined sources19
Beta strandi41 – 55Combined sources15
Beta strandi59 – 69Combined sources11
Beta strandi72 – 81Combined sources10
Beta strandi94 – 102Combined sources9
Beta strandi105 – 113Combined sources9
Helixi116 – 118Combined sources3
Turni130 – 134Combined sources5
Turni136 – 140Combined sources5
Beta strandi143 – 150Combined sources8
Beta strandi157 – 164Combined sources8
Helixi166 – 169Combined sources4
Beta strandi176 – 185Combined sources10
Beta strandi188 – 200Combined sources13
Beta strandi203 – 205Combined sources3
Beta strandi208 – 222Combined sources15
Beta strandi225 – 240Combined sources16
Beta strandi245 – 256Combined sources12
Beta strandi262 – 271Combined sources10
Beta strandi277 – 279Combined sources3
Beta strandi285 – 310Combined sources26
Beta strandi314 – 316Combined sources3
Beta strandi318 – 331Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WI4X-ray3.32A20-331[»]
3WI5X-ray2.40A20-331[»]
ProteinModelPortaliP30690.
SMRiP30690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108Z9W. Bacteria.
ENOG4111NJJ. LUCA.
HOGENOMiHOG000114654.
KOiK18133.
OMAiARTPANF.
OrthoDBiPOG091H0GKV.

Family and domain databases

CDDicd00342. gram_neg_porins. 1 hit.
Gene3Di2.40.160.10. 1 hit.
InterProiIPR033900. Gram_neg_porin_domain.
IPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSLIALTL AALPVAAMAD VTLYGTIKAG VETSRSVFHQ NGQVTEVTTA
60 70 80 90 100
TGIVDLGSKI GFKGQEDLGN GLKAIWQVEQ KASIAGTDSG WGNRQSFIGL
110 120 130 140 150
KGGFGKLRVG RLNSVLKDTG DINPWDSKSD YLGVNKIAEP EARLISVRYD
160 170 180 190 200
SPEFAGLSGS VQYALNDNAG RHNSESYHAG FNYKNGGFFV QYGGAYKRHH
210 220 230 240 250
QVQEGLNIEK YQIHRLVSGY DNDALYASVA VQQQDAKLTD ASNSHNSQTE
260 270 280 290 300
VAATLAYRFG NVTPRVSYAH GFKGLVDDAD IGNEYDQVVV GAEYDFSKRT
310 320 330
SALVSAGWLQ EGKGENKFVA TAGGVGLRHK F
Length:331
Mass (Da):35,682
Last modified:April 1, 1993 - v1
Checksum:iD6945BC81B04B6AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65532 Genomic DNA. Translation: CAA46502.1.
AE002098 Genomic DNA. Translation: AAF42360.1.
PIRiS21407.
RefSeqiNP_275030.1. NC_003112.2.
WP_002244345.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF42360; AAF42360; NMB2039.
GeneIDi904054.
KEGGinme:NMB2039.
PATRICi20360214. VBINeiMen85645_2608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65532 Genomic DNA. Translation: CAA46502.1.
AE002098 Genomic DNA. Translation: AAF42360.1.
PIRiS21407.
RefSeqiNP_275030.1. NC_003112.2.
WP_002244345.1. NC_003112.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WI4X-ray3.32A20-331[»]
3WI5X-ray2.40A20-331[»]
ProteinModelPortaliP30690.
SMRiP30690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB2039.

Proteomic databases

PaxDbiP30690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF42360; AAF42360; NMB2039.
GeneIDi904054.
KEGGinme:NMB2039.
PATRICi20360214. VBINeiMen85645_2608.

Phylogenomic databases

eggNOGiENOG4108Z9W. Bacteria.
ENOG4111NJJ. LUCA.
HOGENOMiHOG000114654.
KOiK18133.
OMAiARTPANF.
OrthoDBiPOG091H0GKV.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).

Family and domain databases

CDDicd00342. gram_neg_porins. 1 hit.
Gene3Di2.40.160.10. 1 hit.
InterProiIPR033900. Gram_neg_porin_domain.
IPR023614. Porin_dom.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPB1_NEIMB
AccessioniPrimary (citable) accession number: P30690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.