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P30685

- 1B35_HUMAN

UniProt

P30685 - 1B35_HUMAN

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Protein

HLA class I histocompatibility antigen, B-35 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-35 alpha chain
Alternative name(s):
MHC class I antigen B*35
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-35 alpha chainPRO_0000018840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiP30685.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.
GenevestigatoriP30685.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

Protein-protein interaction databases

IntActiP30685. 1 interaction.
MINTiMINT-1516663.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610
Beta strandi41 – 433
Beta strandi45 – 528
Beta strandi55 – 617
Beta strandi64 – 663
Beta strandi69 – 713
Helixi74 – 763
Helixi81 – 10828
Beta strandi113 – 1153
Beta strandi118 – 12710
Beta strandi133 – 14210
Beta strandi145 – 1506
Beta strandi157 – 1615
Helixi162 – 17312
Helixi176 – 18510
Helixi187 – 19812
Helixi200 – 2034
Beta strandi210 – 2178
Beta strandi219 – 23517
Beta strandi238 – 2436
Helixi249 – 2513
Beta strandi252 – 2543
Beta strandi261 – 2633
Beta strandi265 – 27410
Helixi278 – 2803
Beta strandi281 – 2866
Beta strandi290 – 2923
Beta strandi294 – 2963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A1NX-ray2.00A25-300[»]
1A9BX-ray3.20A/D25-301[»]
1A9EX-ray2.50A25-301[»]
1CG9X-ray2.70A25-301[»]
1XH3X-ray1.48A25-300[»]
1ZHKX-ray1.60A25-300[»]
1ZHLX-ray1.50A25-300[»]
1ZSDX-ray1.70A25-300[»]
2AK4X-ray2.50A/F/K/Q25-300[»]
2AXFX-ray1.80A25-300[»]
2AXGX-ray2.00A25-300[»]
2CIKX-ray1.75A25-300[»]
2FYYX-ray1.50A25-300[»]
2FZ3X-ray1.90A25-300[»]
2H6PX-ray1.90A25-300[»]
2NW3X-ray1.70A25-300[»]
2NX5X-ray2.70A/F/K/Q25-300[»]
3BW9X-ray1.75A25-300[»]
3BWAX-ray1.30A25-300[»]
3KWWX-ray2.18A25-300[»]
3KXFX-ray3.10A/C/I/K25-300[»]
3LKNX-ray2.00A25-300[»]
3LKOX-ray1.80A25-300[»]
3LKPX-ray1.80A25-300[»]
3LKQX-ray1.80A25-300[»]
3LKRX-ray2.00A25-300[»]
3LKSX-ray1.90A25-300[»]
3MV7X-ray2.00A25-300[»]
3MV8X-ray2.10A25-300[»]
3MV9X-ray2.70A25-300[»]
3VFSX-ray1.85A25-300[»]
3VFTX-ray1.95A25-300[»]
3VFUX-ray1.65A25-300[»]
3VFVX-ray1.55A25-300[»]
3VFWX-ray2.30A25-300[»]
4LNRX-ray2.00A25-300[»]
4PR5X-ray1.80A25-300[»]
4PRNX-ray1.65A25-300[»]
ProteinModelPortaliP30685.
SMRiP30685. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30685.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30685-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,455
Last modified:April 1, 1993 - v1
Checksum:i52906854FC43E7A6
GO

Polymorphismi

The following alleles of B-35 are known: B*35:01, B*35:02, B*35:03, B*35:04, B*35:05 (B35-G), B*35:06 (B35-K), B*35:07, B*35:08, B*35:25, B*35:28, B*35:29 (B*KG), B*35:30, B*35:32 (B*TMUL) and B*35:36. The sequence shown is that of B*35:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401G → V in allele B*35:07.
VAR_016393
Natural varianti48 – 481A → S in allele B*35:25.
VAR_016394
Natural varianti69 – 691T → E in allele B*35:25; requires 2 nucleotide substitutions.
VAR_016395
Natural varianti87 – 871N → E in allele B*35:28; requires 2 nucleotide substitutions.
VAR_016396
Natural varianti91 – 911F → S in allele B*35:28.
VAR_016397
Natural varianti98 – 981Y → D in allele B*35:29.
VAR_016398
Natural varianti107 – 1071G → D in allele B*35:36.
VAR_016399
Natural varianti118 – 1192II → TL in allele B*35:05 and allele B*35:32.
VAR_016400
Natural varianti121 – 1211R → S in allele B*35:05 and allele B*35:30.
VAR_016401
Natural varianti127 – 1271L → V in allele B*35:32.
VAR_016402
Natural varianti133 – 1331L → F in allele B*35:02.
VAR_016403
Natural varianti138 – 1381D → N in allele B*35:02, allele B*35:04 and allele B*35:06.
VAR_016404
Natural varianti140 – 1401S → F in allele B*35:06 and allele B*35:36.
VAR_016405
Natural varianti140 – 1401S → Y in allele B*35:02, allele B*35:03 and allele B*35:04. 1 Publication
VAR_016406
Natural varianti180 – 1801L → R in allele B*35:08.
VAR_016407

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28115
, M28109, M28110, M28111, M28112, M28113, M28114 Genomic DNA. Translation: AAA59617.1.
M63454 Genomic DNA. Translation: AAA59682.1.
M81798 mRNA. Translation: AAA59684.1.
D50299 mRNA. Translation: BAA08828.1.
M84385 mRNA. Translation: AAA59635.1.
M84381 mRNA. Translation: AAA59631.1.
L04695 mRNA. Translation: AAA59694.1.
L04696 mRNA. Translation: AAA52674.1.
Z22651 mRNA. Translation: CAA80366.1.
M86403 mRNA. No translation available.
AH007565 Genomic DNA. Translation: AAD23460.1.
AH007706 Genomic DNA. Translation: AAD30277.1.
AH006372 Genomic DNA. Translation: AAC32570.1.
AH007604 Genomic DNA. Translation: AAD27538.1.
AH008126 Genomic DNA. Translation: AAD51745.1.
AH007584 Genomic DNA. Translation: AAD26151.1.
AH009759 Genomic DNA. Translation: AAG01819.1.
PIRiA45880.
I54298.
I56133.
I61904.
I61907.
I81233.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Polymorphism databases

DMDMi231390.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28115
, M28109 , M28110 , M28111 , M28112 , M28113 , M28114 Genomic DNA. Translation: AAA59617.1 .
M63454 Genomic DNA. Translation: AAA59682.1 .
M81798 mRNA. Translation: AAA59684.1 .
D50299 mRNA. Translation: BAA08828.1 .
M84385 mRNA. Translation: AAA59635.1 .
M84381 mRNA. Translation: AAA59631.1 .
L04695 mRNA. Translation: AAA59694.1 .
L04696 mRNA. Translation: AAA52674.1 .
Z22651 mRNA. Translation: CAA80366.1 .
M86403 mRNA. No translation available.
AH007565 Genomic DNA. Translation: AAD23460.1 .
AH007706 Genomic DNA. Translation: AAD30277.1 .
AH006372 Genomic DNA. Translation: AAC32570.1 .
AH007604 Genomic DNA. Translation: AAD27538.1 .
AH008126 Genomic DNA. Translation: AAD51745.1 .
AH007584 Genomic DNA. Translation: AAD26151.1 .
AH009759 Genomic DNA. Translation: AAG01819.1 .
PIRi A45880.
I54298.
I56133.
I61904.
I61907.
I81233.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A1N X-ray 2.00 A 25-300 [» ]
1A9B X-ray 3.20 A/D 25-301 [» ]
1A9E X-ray 2.50 A 25-301 [» ]
1CG9 X-ray 2.70 A 25-301 [» ]
1XH3 X-ray 1.48 A 25-300 [» ]
1ZHK X-ray 1.60 A 25-300 [» ]
1ZHL X-ray 1.50 A 25-300 [» ]
1ZSD X-ray 1.70 A 25-300 [» ]
2AK4 X-ray 2.50 A/F/K/Q 25-300 [» ]
2AXF X-ray 1.80 A 25-300 [» ]
2AXG X-ray 2.00 A 25-300 [» ]
2CIK X-ray 1.75 A 25-300 [» ]
2FYY X-ray 1.50 A 25-300 [» ]
2FZ3 X-ray 1.90 A 25-300 [» ]
2H6P X-ray 1.90 A 25-300 [» ]
2NW3 X-ray 1.70 A 25-300 [» ]
2NX5 X-ray 2.70 A/F/K/Q 25-300 [» ]
3BW9 X-ray 1.75 A 25-300 [» ]
3BWA X-ray 1.30 A 25-300 [» ]
3KWW X-ray 2.18 A 25-300 [» ]
3KXF X-ray 3.10 A/C/I/K 25-300 [» ]
3LKN X-ray 2.00 A 25-300 [» ]
3LKO X-ray 1.80 A 25-300 [» ]
3LKP X-ray 1.80 A 25-300 [» ]
3LKQ X-ray 1.80 A 25-300 [» ]
3LKR X-ray 2.00 A 25-300 [» ]
3LKS X-ray 1.90 A 25-300 [» ]
3MV7 X-ray 2.00 A 25-300 [» ]
3MV8 X-ray 2.10 A 25-300 [» ]
3MV9 X-ray 2.70 A 25-300 [» ]
3VFS X-ray 1.85 A 25-300 [» ]
3VFT X-ray 1.95 A 25-300 [» ]
3VFU X-ray 1.65 A 25-300 [» ]
3VFV X-ray 1.55 A 25-300 [» ]
3VFW X-ray 2.30 A 25-300 [» ]
4LNR X-ray 2.00 A 25-300 [» ]
4PR5 X-ray 1.80 A 25-300 [» ]
4PRN X-ray 1.65 A 25-300 [» ]
ProteinModelPortali P30685.
SMRi P30685. Positions 25-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P30685. 1 interaction.
MINTi MINT-1516663.

Polymorphism databases

DMDMi 231390.

Proteomic databases

PRIDEi P30685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359635 ; ENSP00000352656 ; ENSG00000206450 .

Organism-specific databases

GeneCardsi GC06M031321.
GC06Mn31311.
H-InvDB HIX0167180.
HGNCi HGNC:4932. HLA-B.
MIMi 142830. gene.
neXtProti NX_P30685.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
EvolutionaryTracei P30685.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-B.
Genevestigatori P30685.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of HLA-B35 suggests that it is derived from HLA-Bw58 by two genetic mechanisms."
    Ooba T., Hayashi H., Karaki S., Tanabe M., Kano K., Takiguchi M.
    Immunogenetics 30:76-80(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:01).
  2. "Complete nucleotide sequence of a genomic clone encoding HLA-B35 isolated from a Caucasian individual of Hispanic origin. Identification of a new variant of HLA-B35."
    Chertkoff L.P., Herrera M., Fainboim L., Satz M.L.
    Hum. Immunol. 31:153-158(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*35:02).
  3. "The HLA-A,B 'negative' mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon."
    Zemmour J., Little A.-M., Schendel D.J., Parham P.
    J. Immunol. 148:1941-1948(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:03).
  4. "Polymorphism of human minor histocompatibility antigens: T cell recognition of human minor histocompatibility peptides presented by HLA-B35 subtype molecules."
    Beck Y., Satz L., Takamiya Y., Nakayama S., Ling L., Ishikawa Y., Nagao T., Uchida H., Tokunaga K., Mueller C., Juji T., Takiguchi M.
    J. Exp. Med. 181:2037-2048(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*35:03).
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE (ALLELES B*35:05 AND B*35:06).
  6. "Isolation and characterization of two new functional subtypes of HLA-B35."
    Theiler G., Pando M., Delfino J.M., Takiguchi M., Satz M.L.
    Tissue Antigens 41:143-147(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*35:07 AND B*35:08).
  7. "Microheterogeneity in HLA-B35 alleles influences peptide-dependent allorecognition by cytotoxic T cells but not binding of a peptide-restricted monoclonal antibody."
    Steinle A., Reinhardt C., Noessner E., Uchanska-Ziegler B., Ziegler A., Schendel D.J.
    Hum. Immunol. 38:261-269(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*35:08).
  8. "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci."
    Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., Troup G.M., Hughes A.L., Letvin N.L.
    Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 9-362 (ALLELE B*35:04).
  9. "Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508."
    Kennedy C.T., Dodd R., Le T., Wallace R., Ng G., Greville W.D., Kennedy A., Taverniti A., Moses J.H., Clow N., Watson N., Dunckley H.
    Tissue Antigens 55:266-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES B*35:29 AND B*35:32).
  10. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES B*35:25; B*35:28; B*35:29; B*35:30 AND B*35:36).
  11. "An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501."
    Smith K.J., Reid S.W., Stuart D.I., McMichael A.J., Jones E.Y., Bell J.I.
    Immunity 4:203-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 25-300.
  12. "Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C-terminus."
    Menssen R., Orth P., Ziegler A., Saenger W.
    J. Mol. Biol. 285:645-653(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B35_HUMAN
AccessioniPrimary (citable) accession number: P30685
Secondary accession number(s): O62919
, P30468, P30469, P30470, P30471, P30472, P30473, P30474, Q9GJM7, Q9TPV2, Q9TQH3, Q9TQH9, Q9TQN4, Q9TQN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3