Reviewed, UniProtKB/Swiss-Prot P30679 (GNA15_HUMAN)

Names and origin

Protein names

Recommended name:
    Guanine nucleotide-binding protein subunit alpha-15
      Short name=G-protein subunit alpha-15
      Short name=G alpha-15
Alternative name(s):
    Guanine nucleotide-binding protein subunit alpha-16
      Short name=G-protein subunit alpha-16
      Short name=G alpha-16

Gene names

Name:	GNA15
Synonyms:	GNA16

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Tissue specificity	Specifically expressed in hematopoietic cells.
Sequence similarities	Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Transducer
PTM	ADP-ribosylation
Gene Ontology (GO)
Biological process	activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway Traceable author statement. Source: ProtInc elevation of cytosolic calcium ion concentration Inferred from genetic interaction. Source: UniProtKB protein amino acid ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Cellular component	heterotrimeric G-protein complex Non-traceable author statement. Source: UniProtKB
Molecular function	GTP binding Non-traceable author statement. Source: UniProtKB GTPase activity Traceable author statement. Source: ProtInc signal transducer activity Inferred from genetic interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Guanine nucleotide-binding protein subunit alpha-15		PRO_0000203755
Regions
	Nucleotide binding	49 – 56	8	GTP By similarity
	Nucleotide binding	208 – 212	5	GTP By similarity
	Nucleotide binding	277 – 280	4	GTP By similarity
Amino acid modifications
	Modified residue	186	1	ADP-ribosylarginine; by cholera toxin By similarity
Natural variations
	Natural variant	147	1	C → Y: dbSNP rs310680. Ref.3		VAR_028000

Sequences

	Sequence		Length	Mass (Da)
	P30679-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 8127AC16FC212507	FASTA	374	43,508
	10 20 30 40 50 60 MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP GESGKSTFIK 70 80 90 100 110 120 QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL QIPFSRPESK HHASLVMSQD 130 140 150 160 170 180 PYKVTTFEKR YAAAMQWLWR DAGIRACYER RREFHLLDSA VYYLSHLERI TEEGYVPTAQ 190 200 210 220 230 240 DVLRSRMPTT GINEYCFSVQ KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ 250 260 270 280 290 300 CLEENNQENR MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG 310 320 330 340 350 360 PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ NIRKVFKDVR 370 DSVLARYLDE INLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells." Amatruda T.T. III, Steele D.A., Slepak V.Z., Simon M.I. Proc. Natl. Acad. Sci. U.S.A. 88:5587-5591(1991) [PubMed: 1905813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TYR-147.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M63904 mRNA. Translation: AAA35860.1. AF493904 mRNA. Translation: AAM12618.1. AC005264 Genomic DNA. Translation: AAC25612.1. AC005262 Genomic DNA. Translation: AAC25616.1. BC013585 mRNA. Translation: AAH13585.1.
IPI	IPI00027243.
PIR	A41096.
RefSeq	NP_002059.2.
UniGene	Hs.73797
3D structure databases
HSSP	HSSP built from PDB template 1CUL based on UniProtKB P04896.
ModBase	Search...
Proteomic databases
PRIDE	P30679.
Genome annotation databases
Ensembl	ENSG00000060558. Homo sapiens. [Contig view]
GeneID	2769.
KEGG	hsa:2769.
Organism-specific databases
GeneCards	GC19P003087.
H-InvDB	HIX0014634. HIX0027530.
HGNC	HGNC:4383. GNA15.
MIM	139314. gene.
PharmGKB	PA28768.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P30679.
HOVERGEN	P30679.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6cyclingpathway. Arf6 signaling events. endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. er_nongenomic_pathway. Plasma membrane estrogen receptor signaling. s1p_s1p2_pathway. S1P2 pathway. s1p_s1p3_pathway. S1P3 pathway. s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway. txa2pathway. Thromboxane A2 receptor signaling.
Gene expression databases
ArrayExpress	P30679.
Bgee	P30679.
CleanEx	HS_GNA15.
GermOnline	ENSG00000060558. Homo sapiens.
Family and domain databases
InterPro	IPR001019. Gprotein_alph_bd. IPR000654. Gprotein_alpha_Q. [Graphical view]
PANTHER	PTHR10218. Gprotein_alph_bd. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00442. GPROTEINAQ.
ProDom	PD000281. Gprotein_alpha. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	10892.
SOURCE	Search...

Entry information

Entry name

GNA15_HUMAN

Accession

Primary (citable) accession number: P30679
Secondary accession number(s): O75247

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)