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P30676 (GNAI_PATPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(i) subunit alpha
Alternative name(s):
Adenylate cyclase-inhibiting G alpha protein
OrganismPatiria pectinifera (Starfish) (Asterina pectinifera)
Taxonomic identifier7594 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaValvataceaValvatidaAsterinidaePatiria

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This G protein is involved in 1-methyladenine-induced oocyte maturation.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Sequence similarities

Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 354353Guanine nucleotide-binding protein G(i) subunit alpha
PRO_0000203685

Regions

Nucleotide binding40 – 478GTP By similarity
Nucleotide binding175 – 1817GTP By similarity
Nucleotide binding200 – 2045GTP By similarity
Nucleotide binding269 – 2724GTP By similarity

Sites

Metal binding471Magnesium By similarity
Metal binding1811Magnesium By similarity
Binding site3261GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation21N-myristoyl glycine Potential
Lipidation31S-palmitoyl cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
P30676 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E242F5BB911B05E1

FASTA35440,043
        10         20         30         40         50         60 
MGCATSAEDK AAAERSKAID RNLRIDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEEG 

        70         80         90        100        110        120 
YSEEDCKQYK PVVYSNTIQS MIAIIRAMGS LKVDFGDGDR TDDARQLFAL AGQAEEGELS 

       130        140        150        160        170        180 
PELAAVMKRL WADGGVQGCF SRSREYQLND SASYYLNALD RLAAPGYIPT QQDVLRTRVK 

       190        200        210        220        230        240 
TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSAY DLVLAEDEEM 

       250        260        270        280        290        300 
NRMHESMKLF DSICNNKWFT ETSIILFLNK KDLFEEKITK SPLTICFPEY TGSNTYEEAA 

       310        320        330        340        350 
AYIQMQFEDL NKRKDQKEIY THFTCATDTN NIQFVFDAVT DVIIKNNLKD CGLF 

« Hide

References

[1]"The primary structure of the alpha subunit of a starfish guanosine-nucleotide-binding regulatory protein involved in 1-methyladenine-induced oocyte maturation."
Chiba K., Tadenuma H., Matsumoto M., Takahashi K., Katada T., Hoshi M.
Eur. J. Biochem. 207:833-838(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66378 mRNA. Translation: CAA47019.1.
PIRS24362.

3D structure databases

ProteinModelPortalP30676.
SMRP30676. Positions 6-353.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP30676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10218. PTHR10218. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Entry information

Entry nameGNAI_PATPE
AccessionPrimary (citable) accession number: P30676
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families