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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

GNG7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041 Activation of G protein gated Potassium channels
R-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-202040 G-protein activation
R-BTA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-BTA-392170 ADP signalling through P2Y purinoceptor 12
R-BTA-392451 G beta:gamma signalling through PI3Kgamma
R-BTA-392851 Prostacyclin signalling through prostacyclin receptor
R-BTA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-BTA-4086398 Ca2+ pathway
R-BTA-416476 G alpha (q) signalling events
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-418217 G beta:gamma signalling through PLC beta
R-BTA-418555 G alpha (s) signalling events
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418594 G alpha (i) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-420092 Glucagon-type ligand receptors
R-BTA-428930 Thromboxane signalling through TP receptor
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-500657 Presynaptic function of Kainate receptors
R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-BTA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Alternative name(s):
G gamma-II
Gene namesi
Name:GNG7
Synonyms:GNGT7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:29468 GNG7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000126332 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7Add BLAST64
PropeptideiPRO_000001263466 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ser); alternate1
Modified residuei2N-acetylserine; alternateBy similarity1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Ser-2 is probably acetylated.

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP30671
PRIDEiP30671

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

BgeeiENSBTAG00000007644

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

DIPiDIP-203N
STRINGi9913.ENSBTAP00000010058

Structurei

3D structure databases

ProteinModelPortaliP30671
SMRiP30671
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP30671
KOiK04543
OMAiSELMNYC
OrthoDBiEOG091G17J0
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30671-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MSATNNIAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,552
Last modified:April 1, 1993 - v1
Checksum:i7041326CBD906312
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 29Missing AA sequence (PubMed:8439334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99393 mRNA No translation available.
BC151397 mRNA Translation: AAI51398.1
PIRiA45128
RefSeqiNP_001106785.1, NM_001113314.1
UniGeneiBt.45640

Genome annotation databases

EnsembliENSBTAT00000010058; ENSBTAP00000010058; ENSBTAG00000007644
GeneIDi618399
KEGGibta:618399

Entry informationi

Entry nameiGBG7_BOVIN
AccessioniPrimary (citable) accession number: P30671
Secondary accession number(s): A7MB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health