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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

GNG7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Alternative name(s):
G gamma-II
Gene namesi
Name:GNG7
Synonyms:GNGT7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity1 Publication
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012633Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012634

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ser); alternate
Modified residuei2 – 21N-acetylserine; alternateBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Ser-2 is probably acetylated.

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP30671.
PRIDEiP30671.

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

BgeeiENSBTAG00000007644.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

DIPiDIP-203N.
STRINGi9913.ENSBTAP00000010058.

Structurei

3D structure databases

ProteinModelPortaliP30671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP30671.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATNNIAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,552
Last modified:April 1, 1993 - v1
Checksum:i7041326CBD906312
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 293Missing AA sequence (PubMed:8439334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99393 mRNA. No translation available.
BC151397 mRNA. Translation: AAI51398.1.
PIRiA45128.
RefSeqiNP_001106785.1. NM_001113314.1.
UniGeneiBt.45640.

Genome annotation databases

EnsembliENSBTAT00000010058; ENSBTAP00000010058; ENSBTAG00000007644.
GeneIDi618399.
KEGGibta:618399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99393 mRNA. No translation available.
BC151397 mRNA. Translation: AAI51398.1.
PIRiA45128.
RefSeqiNP_001106785.1. NM_001113314.1.
UniGeneiBt.45640.

3D structure databases

ProteinModelPortaliP30671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-203N.
STRINGi9913.ENSBTAP00000010058.

Proteomic databases

PaxDbiP30671.
PRIDEiP30671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010058; ENSBTAP00000010058; ENSBTAG00000007644.
GeneIDi618399.
KEGGibta:618399.

Organism-specific databases

CTDi2788.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP30671.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Gene expression databases

BgeeiENSBTAG00000007644.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG7_BOVIN
AccessioniPrimary (citable) accession number: P30671
Secondary accession number(s): A7MB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.