ID PSB5_YEAST Reviewed; 287 AA. AC P30656; D6W4A1; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 3. DT 27-MAR-2024, entry version 225. DE RecName: Full=Proteasome subunit beta type-5; DE EC=3.4.25.1; DE AltName: Full=Macropain subunit PRE2; DE AltName: Full=Multicatalytic endopeptidase complex subunit PRE2; DE AltName: Full=Proteasome component PRE2; DE AltName: Full=Proteinase YSCE subunit PRE2; DE Flags: Precursor; GN Name=PRE2; Synonyms=DOA3, PRG1; OrderedLocusNames=YPR103W; GN ORFNames=P8283.10; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1452031; DOI=10.1016/0378-1119(92)90051-p; RA Friedman H., Goebel M., Snyder M.; RT "A homolog of the proteasome-related RING10 gene is essential for yeast RT cell growth."; RL Gene 122:203-206(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=5288C; RX PubMed=8383129; DOI=10.1016/s0021-9258(18)53509-2; RA Heinemeyer W., Gruhler A., Moehrle V., Mahe Y., Wolf D.H.; RT "PRE2, highly homologous to the human major histocompatibility complex- RT linked RING10 gene, codes for a yeast proteasome subunit necessary for RT chymotryptic activity and degradation of ubiquitinated proteins."; RL J. Biol. Chem. 268:5115-5120(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 76-90, AND RP MUTAGENESIS OF ASP-126. RX PubMed=7781614; DOI=10.1002/j.1460-2075.1995.tb07260.x; RA Chen P., Hochstrasser M.; RT "Biogenesis, structure and function of the yeast 20S proteasome."; RL EMBO J. 14:2620-2630(1995). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169875; RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., RA Vo D.H., Hani J.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."; RL Nature 387:103-105(1997). RN [5] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 176-287. RC STRAIN=ATCC 28383 / FL100 / VTT C-80102; RX PubMed=8164651; DOI=10.1128/mcb.14.5.2905-2913.1994; RA Hermann-Ledenmat S., Werner M., Sentenac A., Thuriaux P.; RT "Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding RT for a fork head protein involved in rRNA processing."; RL Mol. Cell. Biol. 14:2905-2913(1994). RN [7] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [8] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME, PROTEOLYTIC PROCESSING, AND ACTIVE SITE. RX PubMed=9087403; DOI=10.1038/386463a0; RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D., RA Huber R.; RT "Structure of 20S proteasome from yeast at 2.4-A resolution."; RL Nature 386:463-471(1997). RN [9] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME AND A 11S REGULATORY COMPLEX. RX PubMed=11081519; DOI=10.1038/35040607; RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., RA Hill C.P.; RT "Structural basis for the activation of 20S proteasomes by 11S RT regulators."; RL Nature 408:115-120(2000). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11062564; DOI=10.1038/80992; RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R., RA Glickman M.H., Finley D.; RT "A gated channel into the proteasome core particle."; RL Nat. Struct. Biol. 7:1062-1067(2000). RN [11] RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME AND A TMC-95-BASED INHIBITOR. RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005; RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.; RT "TMC-95-based inhibitor design provides evidence for the catalytic RT versatility of the proteasome."; RL Chem. Biol. 13:607-614(2006). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME AND SALINOSPORAMIDE. RX PubMed=16608349; DOI=10.1021/ja058320b; RA Groll M., Huber R., Potts B.C.M.; RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in RT complex with the 20S proteasome reveal important consequences of beta- RT lactone ring opening and a mechanism for irreversible binding."; RL J. Am. Chem. Soc. 128:5136-5141(2006). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 76-287 OF COMPLEX WITH THE 20S RP PROTEASOME AND BORTEZOMIB. RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019; RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.; RT "Crystal structure of the boronic acid-based proteasome inhibitor RT bortezomib in complex with the yeast 20S proteasome."; RL Structure 14:451-456(2006). RN [14] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 76-287 IN COMPLEX WITH THE RP PROTEASOME. RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002; RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.; RT "Structure of a Blm10 complex reveals common mechanisms for proteasome RT binding and gate opening."; RL Mol. Cell 37:728-735(2010). RN [15] RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME. RX PubMed=22927375; DOI=10.1073/pnas.1213333109; RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E., RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.; RT "Near-atomic resolution structural model of the yeast 26S proteasome."; RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012). CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the CC cytoplasm and in the nucleus. It is essential for the regulated CC turnover of proteins and for the removal of misfolded proteins. The CC proteasome is a multicatalytic proteinase complex that is characterized CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu CC adjacent to the leaving group at neutral or slightly basic pH. It has CC an ATP-dependent proteolytic activity. This unit is responsible of the CC chymotrypsin-like activity of the proteasome and is one of the CC principal target of the proteasome inhibitor bortezomib. CC -!- FUNCTION: This subunit is necessary for chymotryptic activity and CC degradation of ubiquitinated proteins. CC -!- CATALYTIC ACTIVITY: CC Reaction=Cleavage of peptide bonds with very broad specificity.; CC EC=3.4.25.1; CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two CC 19S regulatory subunits. The 20S proteasome core is composed of 28 CC subunits that are arranged in four stacked rings, resulting in a CC barrel-shaped structure. The two end rings are each formed by seven CC alpha subunits, and the two central rings are each formed by seven beta CC subunits. The catalytic chamber with the active sites is on the inside CC of the barrel. {ECO:0000269|PubMed:20227375}. CC -!- INTERACTION: CC P30656; P43583: BLM10; NbExp=3; IntAct=EBI-14001, EBI-22761; CC P30656; P22141: PRE1; NbExp=4; IntAct=EBI-14001, EBI-13988; CC P30656; P21242: PRE10; NbExp=3; IntAct=EBI-14001, EBI-13963; CC P30656; P30657: PRE4; NbExp=2; IntAct=EBI-14001, EBI-13997; CC P30656; P40302: PRE5; NbExp=2; IntAct=EBI-14001, EBI-13955; CC P30656; P40303: PRE6; NbExp=3; IntAct=EBI-14001, EBI-13980; CC P30656; P23724: PRE7; NbExp=2; IntAct=EBI-14001, EBI-13984; CC P30656; P23638: PRE9; NbExp=2; IntAct=EBI-14001, EBI-13967; CC P30656; P21243: SCL1; NbExp=8; IntAct=EBI-14001, EBI-13975; CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- MISCELLANEOUS: The side chain of Thr-76 acts as a nucleophile, and the CC N-terminal amino group acts as a proton acceptor. CC -!- MISCELLANEOUS: Present with 8530 molecules/cell in log phase SD medium. CC {ECO:0000269|PubMed:14562106}. CC -!- SIMILARITY: Belongs to the peptidase T1B family. {ECO:0000255|PROSITE- CC ProRule:PRU00809}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA82203.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M96667; AAA34906.1; -; Genomic_DNA. DR EMBL; X68662; CAA48628.1; -; Genomic_DNA. DR EMBL; U32445; AAB68073.1; -; Genomic_DNA. DR EMBL; Z28348; CAA82203.1; ALT_INIT; Genomic_DNA. DR EMBL; BK006949; DAA11517.1; -; Genomic_DNA. DR PIR; A45411; A45411. DR RefSeq; NP_015428.1; NM_001184200.1. DR PDB; 1FNT; X-ray; 3.20 A; L/Z=76-287. DR PDB; 1G0U; X-ray; 2.40 A; K/Y=76-287. DR PDB; 1G65; X-ray; 2.25 A; K/Y=76-287. DR PDB; 1JD2; X-ray; 3.00 A; K/R=76-287. DR PDB; 1RYP; X-ray; 1.90 A; L/Z=76-287. DR PDB; 1Z7Q; X-ray; 3.22 A; L/Z=76-287. DR PDB; 2F16; X-ray; 2.80 A; K/Y=76-287. DR PDB; 2FAK; X-ray; 2.80 A; K/Y=76-287. DR PDB; 2GPL; X-ray; 2.81 A; K/Y=76-287. DR PDB; 2ZCY; X-ray; 2.90 A; K/Y=76-287. DR PDB; 3BDM; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3D29; X-ray; 2.60 A; K/Y=76-287. DR PDB; 3DY3; X-ray; 2.81 A; K/Y=76-287. DR PDB; 3DY4; X-ray; 2.80 A; K/Y=76-287. DR PDB; 3E47; X-ray; 3.00 A; K/Y=76-287. DR PDB; 3GPJ; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3GPT; X-ray; 2.41 A; K/Y=76-287. DR PDB; 3GPW; X-ray; 2.50 A; K/Y=76-287. DR PDB; 3HYE; X-ray; 2.50 A; K/Y=76-287. DR PDB; 3JCO; EM; 4.80 A; 7/l=1-287. DR PDB; 3JCP; EM; 4.60 A; 7/l=1-287. DR PDB; 3MG0; X-ray; 2.68 A; K/Y=76-287. DR PDB; 3MG4; X-ray; 3.11 A; K/Y=76-287. DR PDB; 3MG6; X-ray; 2.60 A; K/Y=76-287. DR PDB; 3MG7; X-ray; 2.78 A; K/Y=76-287. DR PDB; 3MG8; X-ray; 2.59 A; K/Y=76-287. DR PDB; 3NZJ; X-ray; 2.40 A; K/Y=1-287. DR PDB; 3NZW; X-ray; 2.50 A; K/Y=1-287. DR PDB; 3NZX; X-ray; 2.70 A; K/Y=1-287. DR PDB; 3OEU; X-ray; 2.60 A; K/Y=76-287. DR PDB; 3OEV; X-ray; 2.85 A; K/Y=76-287. DR PDB; 3OKJ; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3SDI; X-ray; 2.65 A; K/Y=76-287. DR PDB; 3SDK; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3SHJ; X-ray; 2.80 A; K/Y=76-287. DR PDB; 3TDD; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3UN4; X-ray; 3.40 A; K/Y=76-287. DR PDB; 3UN8; X-ray; 2.70 A; K/Y=76-287. DR PDB; 3WXR; X-ray; 3.15 A; L/Z=1-287. DR PDB; 4CR2; EM; 7.70 A; 5=1-287. DR PDB; 4CR3; EM; 9.30 A; 5=1-287. DR PDB; 4CR4; EM; 8.80 A; 5=1-287. DR PDB; 4EU2; X-ray; 2.51 A; L/Z=76-287. DR PDB; 4FZC; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4FZG; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4G4S; X-ray; 2.49 A; L=76-287. DR PDB; 4GK7; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4HNP; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4HRC; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4HRD; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4INR; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4INT; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4INU; X-ray; 3.10 A; K/Y=76-287. DR PDB; 4J70; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4JSQ; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4JSU; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4JT0; X-ray; 3.10 A; K/Y=76-287. DR PDB; 4LQI; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4LTC; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4NNN; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4NNW; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4NO1; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4NO6; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4NO8; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4NO9; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4Q1S; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QBY; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QLQ; X-ray; 2.40 A; K/Y=76-287. DR PDB; 4QLS; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QLT; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QLU; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QLV; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QUX; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QUY; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QV0; X-ray; 3.10 A; K/Y=76-287. DR PDB; 4QV1; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4QV3; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QV4; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4QV5; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4QV6; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QV7; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QV8; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QV9; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QVL; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QVM; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QVN; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QVP; X-ray; 2.30 A; K/Y=76-287. DR PDB; 4QVQ; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QVV; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QVW; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QVY; X-ray; 2.51 A; K/Y=76-287. DR PDB; 4QW0; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QW1; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QW3; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QW4; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QW5; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QW6; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QW7; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4QWF; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QWG; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QWI; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QWJ; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QWK; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QWL; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QWR; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QWS; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QWU; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QWX; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QXJ; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QZ0; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QZ1; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QZ2; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4QZ3; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QZ4; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QZ5; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QZ6; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4QZ7; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4QZW; X-ray; 3.00 A; K/Y=76-287. DR PDB; 4QZX; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4QZZ; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4R00; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4R02; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4R17; X-ray; 2.10 A; K/Y=76-287. DR PDB; 4R18; X-ray; 2.40 A; K/Y=76-287. DR PDB; 4RUR; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4V7O; X-ray; 3.00 A; A2/AP/BL/BZ=76-287. DR PDB; 4X6Z; X-ray; 2.70 A; L/Z=1-287. DR PDB; 4Y69; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4Y6A; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y6V; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y6Z; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y70; X-ray; 2.40 A; K/Y=76-287. DR PDB; 4Y74; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y75; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y77; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4Y78; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y7W; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4Y7X; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y7Y; X-ray; 2.40 A; K/Y=76-287. DR PDB; 4Y80; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4Y81; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y82; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y84; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8G; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y8H; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4Y8I; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y8J; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8K; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y8L; X-ray; 2.40 A; K/Y=76-287. DR PDB; 4Y8M; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y8N; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y8O; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8P; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y8Q; X-ray; 2.60 A; K/Y=76-287. DR PDB; 4Y8R; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8S; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8T; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Y8U; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4Y9Y; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4Y9Z; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4YA0; X-ray; 2.80 A; K/Y=76-287. DR PDB; 4YA1; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4YA2; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4YA3; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4YA4; X-ray; 2.90 A; K/Y=76-287. DR PDB; 4YA5; X-ray; 2.50 A; K/Y=76-287. DR PDB; 4YA7; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4YA9; X-ray; 2.70 A; K/Y=76-287. DR PDB; 4Z1L; X-ray; 3.00 A; K/Y=76-287. DR PDB; 5A5B; EM; 9.50 A; 5=1-287. DR PDB; 5AHJ; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5BOU; X-ray; 2.60 A; K/Y=76-287. DR PDB; 5BXL; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5BXN; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5CGF; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5CGG; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5CGH; X-ray; 2.50 A; K/Y=76-287. DR PDB; 5CGI; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5CZ4; X-ray; 2.30 A; K/Y=76-287. DR PDB; 5CZ5; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5CZ6; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5CZ7; X-ray; 2.50 A; K/Y=71-287. DR PDB; 5CZ8; X-ray; 2.80 A; K/Y=67-287. DR PDB; 5CZ9; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5CZA; X-ray; 2.50 A; K/Y=76-287. DR PDB; 5D0S; X-ray; 2.50 A; K/Y=76-287. DR PDB; 5D0T; X-ray; 2.60 A; K/Y=76-287. DR PDB; 5D0V; X-ray; 2.90 A; K/Y=70-287. DR PDB; 5D0W; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5D0X; X-ray; 2.60 A; K/Y=76-287. DR PDB; 5D0Z; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5DKI; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5DKJ; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5FG7; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5FG9; X-ray; 2.60 A; K/Y=76-287. DR PDB; 5FGA; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5FGD; X-ray; 2.80 A; K/Y=72-287. DR PDB; 5FGE; X-ray; 2.60 A; K/Y=70-287. DR PDB; 5FGF; X-ray; 2.60 A; K/Y=74-287. DR PDB; 5FGG; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5FGH; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5FGI; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5FHS; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5JHR; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5JHS; X-ray; 3.00 A; K/Y=76-287. DR PDB; 5L52; X-ray; 2.70 A; K/Y=76-287. DR PDB; 5L54; X-ray; 2.80 A; K/Y=76-287. DR PDB; 5L55; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5L5A; X-ray; 2.40 A; K/Y=215-287. DR PDB; 5L5B; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L5D; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L5E; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5F; X-ray; 2.50 A; K/Y=215-287. DR PDB; 5L5H; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L5I; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5J; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5O; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L5P; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L5Q; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L5R; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5S; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L5T; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5U; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L5V; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L5W; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L5X; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L5Y; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L5Z; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L60; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L61; X-ray; 2.80 A; K/Y=211-287. DR PDB; 5L62; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L63; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L64; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L65; X-ray; 2.90 A; K/Y=215-287. DR PDB; 5L66; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L67; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L68; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L69; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5L6A; X-ray; 2.80 A; K/Y=215-287. DR PDB; 5L6B; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5L6C; X-ray; 2.60 A; K/Y=215-287. DR PDB; 5LAI; X-ray; 2.50 A; K/Y=76-287. DR PDB; 5LAJ; X-ray; 2.90 A; K/Y=76-287. DR PDB; 5LTT; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5M2B; X-ray; 2.70 A; K/Y=215-287. DR PDB; 5MP9; EM; 4.10 A; 5/l=1-287. DR PDB; 5MPA; EM; 4.50 A; 5/l=1-287. DR PDB; 5MPB; EM; 7.80 A; 5/l=1-287. DR PDB; 5MPC; EM; 7.70 A; 5/l=1-287. DR PDB; 5NIF; X-ray; 3.00 A; L/Z=1-287. DR PDB; 5WVI; EM; 6.30 A; 5/f=1-287. DR PDB; 5WVK; EM; 4.20 A; 5/f=1-287. DR PDB; 6EF3; EM; 4.17 A; 5=1-287. DR PDB; 6FVT; EM; 4.10 A; 5/l=76-287. DR PDB; 6FVU; EM; 4.50 A; 5/l=76-287. DR PDB; 6FVV; EM; 5.40 A; 5/l=76-287. DR PDB; 6FVW; EM; 4.50 A; 5/l=76-287. DR PDB; 6FVX; EM; 4.90 A; 5/l=76-287. DR PDB; 6FVY; EM; 6.10 A; 5/l=76-287. DR PDB; 6G7F; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6G8M; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6G8N; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6GOP; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6H39; X-ray; 2.50 A; K/Y=76-287. DR PDB; 6HTB; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HTC; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HTD; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HTP; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HTR; X-ray; 2.60 A; K/Y=76-287. DR PDB; 6HUB; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HUC; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HUQ; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HUU; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HUV; X-ray; 3.10 A; K/Y=76-287. DR PDB; 6HV3; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HV4; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HV5; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HV7; X-ray; 3.40 A; K/Y=76-287. DR PDB; 6HVA; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HVR; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HVS; X-ray; 3.10 A; K/Y=76-287. DR PDB; 6HVT; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HVU; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HVV; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HVW; X-ray; 3.00 A; K/Y=76-287. DR PDB; 6HVX; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HVY; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HW0; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HW3; X-ray; 2.60 A; K/Y=76-287. DR PDB; 6HW4; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HW5; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6HW6; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HW7; X-ray; 2.70 A; K/Y=76-287. DR PDB; 6HW8; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HW9; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HWA; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HWB; X-ray; 2.60 A; K/Y=76-287. DR PDB; 6HWC; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HWD; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6HWE; X-ray; 2.30 A; K/Y=76-287. DR PDB; 6HWF; X-ray; 2.50 A; K/Y=76-287. DR PDB; 6J2C; EM; 7.00 A; 5/f=1-287. DR PDB; 6J2N; EM; 7.50 A; 5/f=1-287. DR PDB; 6J2Q; EM; 3.80 A; 5/f=1-287. DR PDB; 6J2X; EM; 3.80 A; 5/f=1-287. DR PDB; 6J30; EM; 4.50 A; 5/f=1-287. DR PDB; 6ZOU; X-ray; 2.90 A; K/Y=76-287. DR PDB; 6ZP6; X-ray; 2.80 A; K/Y=76-287. DR PDB; 6ZP8; X-ray; 3.00 A; K/Y=76-287. DR PDB; 7LS5; EM; 2.74 A; L/Z=1-287. DR PDB; 7LS6; EM; 3.17 A; L=1-287. DR PDB; 7O2L; X-ray; 3.00 A; K/Y=76-287. DR PDB; 7QO3; EM; 6.10 A; 5/l=1-287. DR PDB; 7QO5; EM; 6.00 A; 5/l=1-287. DR PDB; 7TEJ; EM; 2.74 A; L/Z=1-287. DR PDB; 7TEO; EM; 2.97 A; L/Z=1-287. DR PDB; 8OLR; X-ray; 2.80 A; K/Y=76-287. DR PDB; 8T08; EM; 3.00 A; L/c=1-287. DR PDB; 8T0M; EM; 2.40 A; L/Z=1-287. DR PDBsum; 1FNT; -. DR PDBsum; 1G0U; -. DR PDBsum; 1G65; -. DR PDBsum; 1JD2; -. DR PDBsum; 1RYP; -. DR PDBsum; 1Z7Q; -. DR PDBsum; 2F16; -. DR PDBsum; 2FAK; -. DR PDBsum; 2GPL; -. DR PDBsum; 2ZCY; -. DR PDBsum; 3BDM; -. DR PDBsum; 3D29; -. DR PDBsum; 3DY3; -. DR PDBsum; 3DY4; -. DR PDBsum; 3E47; -. DR PDBsum; 3GPJ; -. DR PDBsum; 3GPT; -. DR PDBsum; 3GPW; -. DR PDBsum; 3HYE; -. DR PDBsum; 3JCO; -. DR PDBsum; 3JCP; -. DR PDBsum; 3MG0; -. DR PDBsum; 3MG4; -. DR PDBsum; 3MG6; -. DR PDBsum; 3MG7; -. DR PDBsum; 3MG8; -. DR PDBsum; 3NZJ; -. DR PDBsum; 3NZW; -. DR PDBsum; 3NZX; -. DR PDBsum; 3OEU; -. DR PDBsum; 3OEV; -. DR PDBsum; 3OKJ; -. DR PDBsum; 3SDI; -. DR PDBsum; 3SDK; -. DR PDBsum; 3SHJ; -. DR PDBsum; 3TDD; -. DR PDBsum; 3UN4; -. DR PDBsum; 3UN8; -. DR PDBsum; 3WXR; -. DR PDBsum; 4CR2; -. DR PDBsum; 4CR3; -. DR PDBsum; 4CR4; -. DR PDBsum; 4EU2; -. DR PDBsum; 4FZC; -. DR PDBsum; 4FZG; -. DR PDBsum; 4G4S; -. DR PDBsum; 4GK7; -. DR PDBsum; 4HNP; -. DR PDBsum; 4HRC; -. DR PDBsum; 4HRD; -. DR PDBsum; 4INR; -. DR PDBsum; 4INT; -. DR PDBsum; 4INU; -. DR PDBsum; 4J70; -. DR PDBsum; 4JSQ; -. DR PDBsum; 4JSU; -. DR PDBsum; 4JT0; -. DR PDBsum; 4LQI; -. DR PDBsum; 4LTC; -. DR PDBsum; 4NNN; -. DR PDBsum; 4NNW; -. DR PDBsum; 4NO1; -. DR PDBsum; 4NO6; -. DR PDBsum; 4NO8; -. DR PDBsum; 4NO9; -. DR PDBsum; 4Q1S; -. DR PDBsum; 4QBY; -. DR PDBsum; 4QLQ; -. DR PDBsum; 4QLS; -. DR PDBsum; 4QLT; -. DR PDBsum; 4QLU; -. DR PDBsum; 4QLV; -. DR PDBsum; 4QUX; -. DR PDBsum; 4QUY; -. DR PDBsum; 4QV0; -. DR PDBsum; 4QV1; -. DR PDBsum; 4QV3; -. DR PDBsum; 4QV4; -. DR PDBsum; 4QV5; -. DR PDBsum; 4QV6; -. DR PDBsum; 4QV7; -. DR PDBsum; 4QV8; -. DR PDBsum; 4QV9; -. DR PDBsum; 4QVL; -. DR PDBsum; 4QVM; -. DR PDBsum; 4QVN; -. DR PDBsum; 4QVP; -. DR PDBsum; 4QVQ; -. DR PDBsum; 4QVV; -. DR PDBsum; 4QVW; -. DR PDBsum; 4QVY; -. DR PDBsum; 4QW0; -. DR PDBsum; 4QW1; -. DR PDBsum; 4QW3; -. DR PDBsum; 4QW4; -. DR PDBsum; 4QW5; -. DR PDBsum; 4QW6; -. DR PDBsum; 4QW7; -. DR PDBsum; 4QWF; -. DR PDBsum; 4QWG; -. DR PDBsum; 4QWI; -. DR PDBsum; 4QWJ; -. DR PDBsum; 4QWK; -. DR PDBsum; 4QWL; -. DR PDBsum; 4QWR; -. DR PDBsum; 4QWS; -. DR PDBsum; 4QWU; -. DR PDBsum; 4QWX; -. DR PDBsum; 4QXJ; -. DR PDBsum; 4QZ0; -. DR PDBsum; 4QZ1; -. DR PDBsum; 4QZ2; -. DR PDBsum; 4QZ3; -. DR PDBsum; 4QZ4; -. DR PDBsum; 4QZ5; -. DR PDBsum; 4QZ6; -. DR PDBsum; 4QZ7; -. DR PDBsum; 4QZW; -. DR PDBsum; 4QZX; -. DR PDBsum; 4QZZ; -. DR PDBsum; 4R00; -. DR PDBsum; 4R02; -. DR PDBsum; 4R17; -. DR PDBsum; 4R18; -. DR PDBsum; 4RUR; -. DR PDBsum; 4V7O; -. DR PDBsum; 4X6Z; -. DR PDBsum; 4Y69; -. DR PDBsum; 4Y6A; -. DR PDBsum; 4Y6V; -. DR PDBsum; 4Y6Z; -. DR PDBsum; 4Y70; -. DR PDBsum; 4Y74; -. DR PDBsum; 4Y75; -. DR PDBsum; 4Y77; -. DR PDBsum; 4Y78; -. DR PDBsum; 4Y7W; -. DR PDBsum; 4Y7X; -. DR PDBsum; 4Y7Y; -. DR PDBsum; 4Y80; -. DR PDBsum; 4Y81; -. DR PDBsum; 4Y82; -. DR PDBsum; 4Y84; -. DR PDBsum; 4Y8G; -. DR PDBsum; 4Y8H; -. DR PDBsum; 4Y8I; -. DR PDBsum; 4Y8J; -. DR PDBsum; 4Y8K; -. DR PDBsum; 4Y8L; -. DR PDBsum; 4Y8M; -. DR PDBsum; 4Y8N; -. DR PDBsum; 4Y8O; -. DR PDBsum; 4Y8P; -. DR PDBsum; 4Y8Q; -. DR PDBsum; 4Y8R; -. DR PDBsum; 4Y8S; -. DR PDBsum; 4Y8T; -. DR PDBsum; 4Y8U; -. DR PDBsum; 4Y9Y; -. DR PDBsum; 4Y9Z; -. DR PDBsum; 4YA0; -. DR PDBsum; 4YA1; -. DR PDBsum; 4YA2; -. DR PDBsum; 4YA3; -. DR PDBsum; 4YA4; -. DR PDBsum; 4YA5; -. DR PDBsum; 4YA7; -. DR PDBsum; 4YA9; -. DR PDBsum; 4Z1L; -. DR PDBsum; 5A5B; -. DR PDBsum; 5AHJ; -. DR PDBsum; 5BOU; -. DR PDBsum; 5BXL; -. DR PDBsum; 5BXN; -. DR PDBsum; 5CGF; -. DR PDBsum; 5CGG; -. DR PDBsum; 5CGH; -. DR PDBsum; 5CGI; -. DR PDBsum; 5CZ4; -. DR PDBsum; 5CZ5; -. DR PDBsum; 5CZ6; -. DR PDBsum; 5CZ7; -. DR PDBsum; 5CZ8; -. DR PDBsum; 5CZ9; -. DR PDBsum; 5CZA; -. DR PDBsum; 5D0S; -. DR PDBsum; 5D0T; -. DR PDBsum; 5D0V; -. DR PDBsum; 5D0W; -. DR PDBsum; 5D0X; -. DR PDBsum; 5D0Z; -. DR PDBsum; 5DKI; -. DR PDBsum; 5DKJ; -. DR PDBsum; 5FG7; -. DR PDBsum; 5FG9; -. DR PDBsum; 5FGA; -. DR PDBsum; 5FGD; -. DR PDBsum; 5FGE; -. DR PDBsum; 5FGF; -. DR PDBsum; 5FGG; -. DR PDBsum; 5FGH; -. DR PDBsum; 5FGI; -. DR PDBsum; 5FHS; -. DR PDBsum; 5JHR; -. DR PDBsum; 5JHS; -. DR PDBsum; 5L52; -. DR PDBsum; 5L54; -. DR PDBsum; 5L55; -. DR PDBsum; 5L5A; -. DR PDBsum; 5L5B; -. DR PDBsum; 5L5D; -. DR PDBsum; 5L5E; -. DR PDBsum; 5L5F; -. DR PDBsum; 5L5H; -. DR PDBsum; 5L5I; -. DR PDBsum; 5L5J; -. DR PDBsum; 5L5O; -. DR PDBsum; 5L5P; -. DR PDBsum; 5L5Q; -. DR PDBsum; 5L5R; -. DR PDBsum; 5L5S; -. DR PDBsum; 5L5T; -. DR PDBsum; 5L5U; -. DR PDBsum; 5L5V; -. DR PDBsum; 5L5W; -. DR PDBsum; 5L5X; -. DR PDBsum; 5L5Y; -. DR PDBsum; 5L5Z; -. DR PDBsum; 5L60; -. DR PDBsum; 5L61; -. DR PDBsum; 5L62; -. DR PDBsum; 5L63; -. DR PDBsum; 5L64; -. DR PDBsum; 5L65; -. DR PDBsum; 5L66; -. DR PDBsum; 5L67; -. DR PDBsum; 5L68; -. DR PDBsum; 5L69; -. DR PDBsum; 5L6A; -. DR PDBsum; 5L6B; -. DR PDBsum; 5L6C; -. DR PDBsum; 5LAI; -. DR PDBsum; 5LAJ; -. DR PDBsum; 5LTT; -. DR PDBsum; 5M2B; -. DR PDBsum; 5MP9; -. DR PDBsum; 5MPA; -. DR PDBsum; 5MPB; -. DR PDBsum; 5MPC; -. DR PDBsum; 5NIF; -. DR PDBsum; 5WVI; -. DR PDBsum; 5WVK; -. DR PDBsum; 6EF3; -. DR PDBsum; 6FVT; -. DR PDBsum; 6FVU; -. DR PDBsum; 6FVV; -. DR PDBsum; 6FVW; -. DR PDBsum; 6FVX; -. DR PDBsum; 6FVY; -. DR PDBsum; 6G7F; -. DR PDBsum; 6G8M; -. DR PDBsum; 6G8N; -. DR PDBsum; 6GOP; -. DR PDBsum; 6H39; -. DR PDBsum; 6HTB; -. DR PDBsum; 6HTC; -. DR PDBsum; 6HTD; -. DR PDBsum; 6HTP; -. DR PDBsum; 6HTR; -. DR PDBsum; 6HUB; -. DR PDBsum; 6HUC; -. DR PDBsum; 6HUQ; -. DR PDBsum; 6HUU; -. DR PDBsum; 6HUV; -. DR PDBsum; 6HV3; -. DR PDBsum; 6HV4; -. DR PDBsum; 6HV5; -. DR PDBsum; 6HV7; -. DR PDBsum; 6HVA; -. DR PDBsum; 6HVR; -. DR PDBsum; 6HVS; -. DR PDBsum; 6HVT; -. DR PDBsum; 6HVU; -. DR PDBsum; 6HVV; -. DR PDBsum; 6HVW; -. DR PDBsum; 6HVX; -. DR PDBsum; 6HVY; -. DR PDBsum; 6HW0; -. DR PDBsum; 6HW3; -. DR PDBsum; 6HW4; -. DR PDBsum; 6HW5; -. DR PDBsum; 6HW6; -. DR PDBsum; 6HW7; -. DR PDBsum; 6HW8; -. DR PDBsum; 6HW9; -. DR PDBsum; 6HWA; -. DR PDBsum; 6HWB; -. DR PDBsum; 6HWC; -. DR PDBsum; 6HWD; -. DR PDBsum; 6HWE; -. DR PDBsum; 6HWF; -. DR PDBsum; 6J2C; -. DR PDBsum; 6J2N; -. DR PDBsum; 6J2Q; -. DR PDBsum; 6J2X; -. DR PDBsum; 6J30; -. DR PDBsum; 6ZOU; -. DR PDBsum; 6ZP6; -. DR PDBsum; 6ZP8; -. DR PDBsum; 7LS5; -. DR PDBsum; 7LS6; -. DR PDBsum; 7O2L; -. DR PDBsum; 7QO3; -. DR PDBsum; 7QO5; -. DR PDBsum; 7TEJ; -. DR PDBsum; 7TEO; -. DR PDBsum; 8OLR; -. DR PDBsum; 8T08; -. DR PDBsum; 8T0M; -. DR AlphaFoldDB; P30656; -. DR EMDB; EMD-14082; -. DR EMDB; EMD-14084; -. DR EMDB; EMD-23502; -. DR EMDB; EMD-23503; -. DR EMDB; EMD-25847; -. DR EMDB; EMD-25848; -. DR EMDB; EMD-3534; -. DR EMDB; EMD-3535; -. DR EMDB; EMD-3536; -. DR EMDB; EMD-3537; -. DR EMDB; EMD-40938; -. DR EMDB; EMD-40944; -. DR EMDB; EMD-4321; -. DR EMDB; EMD-4322; -. DR EMDB; EMD-4323; -. DR EMDB; EMD-4324; -. DR EMDB; EMD-6693; -. DR EMDB; EMD-6694; -. DR EMDB; EMD-9045; -. DR EMDB; EMD-9769; -. DR EMDB; EMD-9770; -. DR EMDB; EMD-9771; -. DR EMDB; EMD-9772; -. DR EMDB; EMD-9773; -. DR SMR; P30656; -. DR BioGRID; 36269; 731. DR ComplexPortal; CPX-2262; 26S Proteasome complex. DR DIP; DIP-2806N; -. DR IntAct; P30656; 21. DR MINT; P30656; -. DR STRING; 4932.YPR103W; -. DR BindingDB; P30656; -. DR ChEMBL; CHEMBL4659; -. DR MEROPS; T01.012; -. DR iPTMnet; P30656; -. DR MaxQB; P30656; -. DR PaxDb; 4932-YPR103W; -. DR PeptideAtlas; P30656; -. DR EnsemblFungi; YPR103W_mRNA; YPR103W; YPR103W. DR GeneID; 856218; -. DR KEGG; sce:YPR103W; -. DR AGR; SGD:S000006307; -. DR SGD; S000006307; PRE2. DR VEuPathDB; FungiDB:YPR103W; -. DR eggNOG; KOG0175; Eukaryota. DR GeneTree; ENSGT00940000166784; -. DR HOGENOM; CLU_035750_7_1_1; -. DR InParanoid; P30656; -. DR OMA; NLGMAMQ; -. DR OrthoDB; 4492251at2759; -. DR BioCyc; YEAST:G3O-34243-MONOMER; -. DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes). DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-SCE-5689880; Ub-specific processing proteases. DR BioGRID-ORCS; 856218; 9 hits in 10 CRISPR screens. DR EvolutionaryTrace; P30656; -. DR PRO; PR:P30656; -. DR Proteomes; UP000002311; Chromosome XVI. DR RNAct; P30656; Protein. DR GO; GO:0005829; C:cytosol; HDA:SGD. DR GO; GO:0005634; C:nucleus; HDA:SGD. DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal. DR GO; GO:0019774; C:proteasome core complex, beta-subunit complex; IDA:SGD. DR GO; GO:0004175; F:endopeptidase activity; IMP:SGD. DR GO; GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central. DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD. DR GO; GO:0080129; P:proteasome core complex assembly; IMP:SGD. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD. DR CDD; cd03761; proteasome_beta_type_5; 1. DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR000243; Pept_T1A_subB. DR InterPro; IPR016050; Proteasome_bsu_CS. DR InterPro; IPR001353; Proteasome_sua/b. DR InterPro; IPR023333; Proteasome_suB-type. DR PANTHER; PTHR32194:SF0; ATP-DEPENDENT PROTEASE SUBUNIT HSLV; 1. DR PANTHER; PTHR32194; METALLOPROTEASE TLDD; 1. DR Pfam; PF00227; Proteasome; 1. DR PRINTS; PR00141; PROTEASOME. DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1. DR PROSITE; PS00854; PROTEASOME_BETA_1; 1. DR PROSITE; PS51476; PROTEASOME_BETA_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; KW Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. FT PROPEP 1..75 FT /note="Removed in mature form" FT /evidence="ECO:0000269|PubMed:7781614" FT /id="PRO_0000026611" FT CHAIN 76..287 FT /note="Proteasome subunit beta type-5" FT /id="PRO_0000026612" FT ACT_SITE 76 FT /note="Nucleophile" FT /evidence="ECO:0000269|PubMed:9087403" FT BINDING 124 FT /ligand="bortezomib" FT /ligand_id="ChEBI:CHEBI:52717" FT MUTAGEN 126 FT /note="D->N: In DOA3-1; decrease in activity." FT /evidence="ECO:0000269|PubMed:7781614" FT CONFLICT 282..287 FT /note="FNNVIG -> STTLLAK (in Ref. 1; AAA34906)" FT /evidence="ECO:0000305" FT HELIX 2..9 FT /evidence="ECO:0007829|PDB:7LS6" FT STRAND 78..83 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 86..91 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 95..97 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 100..104 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 109..113 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 116..119 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 121..123 FT /evidence="ECO:0007829|PDB:3GPJ" FT HELIX 124..145 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 151..164 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 165..167 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 172..180 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 181..183 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 184..191 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 192..194 FT /evidence="ECO:0007829|PDB:1G0U" FT STRAND 196..198 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 200..205 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 208..218 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 225..242 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 243..246 FT /evidence="ECO:0007829|PDB:4EU2" FT STRAND 248..256 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 259..267 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 268..279 FT /evidence="ECO:0007829|PDB:1RYP" SQ SEQUENCE 287 AA; 31637 MW; D0EBAC611F7A4F37 CRC64; MQAIADSFSV PNRLVKELQY DNEQNLESDF VTGASQFQRL APSLTVPPIA SPQQFLRAHT DDSRNPDCKI KIAHGTTTLA FRFQGGIIVA VDSRATAGNW VASQTVKKVI EINPFLLGTM AGGAADCQFW ETWLGSQCRL HELREKERIS VAAASKILSN LVYQYKGAGL SMGTMICGYT RKEGPTIYYV DSDGTRLKGD IFCVGSGQTF AYGVLDSNYK WDLSVEDALY LGKRSILAAA HRDAYSGGSV NLYHVTEDGW IYHGNHDVGE LFWKVKEEEG SFNNVIG //