P30648 (DCTD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable deoxycytidylate deaminase
EC=3.5.4.12

Alternative name(s):
dCMP deaminase

Gene names

ORF Names:

ZK643.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Supplies the nucleotide substrate for thymidylate synthetase By similarity.
Catalytic activity	dCMP + H2O = dUMP + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dCMP deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Probable deoxycytidylate deaminase		PRO_0000171695
Sites
	Active site	119	1	Proton donor By similarity
	Metal binding	117	1	Zinc; catalytic By similarity
	Metal binding	143	1	Zinc; catalytic By similarity
	Metal binding	146	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30648 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 33B6A723AD3F9FE7	FASTA	197	22,528
	10 20 30 40 50 60 MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK HQRFLRIAKV 70 80 90 100 110 120 TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF RWDKEDPEDN KHLYVVHAEM 130 140 150 160 170 180 NAIINKRCTT LHDCTVYVTL FPCNKCAQML IQSRVKKVYF LENRDELAFR ASKKMLDHAR 190 LPYEQIVMPQ EAYVIEL

References

[1]	"The C. elegans genome sequencing project: a beginning." Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R., Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A., Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R., Waterston R. Nature 356:37-41(1992) [PubMed: 1538779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z11126 Genomic DNA. Translation: CAA77473.1.
PIR	S23240.
RefSeq	NP_498980.1. NM_066579.3.
UniGene	Cel.9533.
3D structure databases
ProteinModelPortal	P30648.
SMR	P30648. Positions 47-197.
ModBase	Search...
Protein-protein interaction databases
STRING	P30648.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK643.2; ZK643.2; ZK643.2.
GeneID	191373.
KEGG	cel:ZK643.2.
NMPDR	fig|6239.3.peg.11011.
UCSC	ZK643.2. c. elegans.
Organism-specific databases
CTD	191373.
WormBase	ZK643.2; CE00441; WBGene00014034.
Phylogenomic databases
eggNOG	meNOG09360.
GeneTree	EMGT00050000011470.
HOGENOM	HBG741046.
InParanoid	P30648.
OMA	WDKEDPE.
PhylomeDB	P30648.
Gene expression databases
ArrayExpress	P30648.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR015517. Cyt_deaminase. IPR016193. Cytidine_deaminase-like. IPR016473. dCMP_deaminase. [Graphical view]
KO	K01493.
PANTHER	PTHR11086. Cyt_deaminase. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
PIRSF	PIRSF006019. dCMP_deaminase. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	948932.

Entry information

Entry name

DCTD_CAEEL

Accession

Primary (citable) accession number: P30648

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project