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P30648

- DCTD_CAEEL

UniProt

P30648 - DCTD_CAEEL

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Protein

Probable deoxycytidylate deaminase

Gene

ZK643.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zinc.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Zinc; catalyticBy similarity
Active sitei119 – 1191Proton donorBy similarity
Metal bindingi143 – 1431Zinc; catalyticBy similarity
Metal bindingi146 – 1461Zinc; catalyticBy similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
  2. pyrimidine nucleotide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:ZK643.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiZK643.2; CE00441; WBGene00014034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Probable deoxycytidylate deaminasePRO_0000171695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK643.2.

Structurei

3D structure databases

ProteinModelPortaliP30648.
SMRiP30648. Positions 52-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
InParanoidiP30648.
KOiK01493.
OMAiLHDCTVY.
OrthoDBiEOG7JDQZR.
PhylomeDBiP30648.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30648-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK
60 70 80 90 100
HQRFLRIAKV TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF
110 120 130 140 150
RWDKEDPEDN KHLYVVHAEM NAIINKRCTT LHDCTVYVTL FPCNKCAQML
160 170 180 190
IQSRVKKVYF LENRDELAFR ASKKMLDHAR LPYEQIVMPQ EAYVIEL
Length:197
Mass (Da):22,528
Last modified:April 1, 1993 - v1
Checksum:i33B6A723AD3F9FE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRiS23240.
RefSeqiNP_498980.1. NM_066579.4.
UniGeneiCel.9533.

Genome annotation databases

EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
GeneIDi191373.
KEGGicel:CELE_ZK643.2.
UCSCiZK643.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1 .
PIRi S23240.
RefSeqi NP_498980.1. NM_066579.4.
UniGenei Cel.9533.

3D structure databases

ProteinModelPortali P30648.
SMRi P30648. Positions 52-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZK643.2.

Chemistry

ChEMBLi CHEMBL2448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK643.2 ; ZK643.2 ; WBGene00014034 .
GeneIDi 191373.
KEGGi cel:CELE_ZK643.2.
UCSCi ZK643.2. c. elegans.

Organism-specific databases

CTDi 191373.
WormBasei ZK643.2 ; CE00441 ; WBGene00014034 .

Phylogenomic databases

eggNOGi COG2131.
GeneTreei ENSGT00390000000501.
HOGENOMi HOG000015715.
InParanoidi P30648.
KOi K01493.
OMAi LHDCTVY.
OrthoDBi EOG7JDQZR.
PhylomeDBi P30648.

Miscellaneous databases

NextBioi 948932.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDCTD_CAEEL
AccessioniPrimary (citable) accession number: P30648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3