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Protein

Probable deoxycytidylate deaminase

Gene

ZK643.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Zinc; catalyticBy similarity
Active sitei119 – 1191Proton donorBy similarity
Metal bindingi143 – 1431Zinc; catalyticBy similarity
Metal bindingi146 – 1461Zinc; catalyticBy similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_237601. Pyrimidine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:ZK643.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiZK643.2; CE00441; WBGene00014034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Probable deoxycytidylate deaminasePRO_0000171695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK643.2.

Structurei

3D structure databases

ProteinModelPortaliP30648.
SMRiP30648. Positions 52-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
InParanoidiP30648.
KOiK01493.
OMAiWDKEDPE.
OrthoDBiEOG7JDQZR.
PhylomeDBiP30648.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK
60 70 80 90 100
HQRFLRIAKV TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF
110 120 130 140 150
RWDKEDPEDN KHLYVVHAEM NAIINKRCTT LHDCTVYVTL FPCNKCAQML
160 170 180 190
IQSRVKKVYF LENRDELAFR ASKKMLDHAR LPYEQIVMPQ EAYVIEL
Length:197
Mass (Da):22,528
Last modified:April 1, 1993 - v1
Checksum:i33B6A723AD3F9FE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRiS23240.
RefSeqiNP_498980.1. NM_066579.4.
UniGeneiCel.9533.

Genome annotation databases

EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
GeneIDi191373.
KEGGicel:CELE_ZK643.2.
UCSCiZK643.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRiS23240.
RefSeqiNP_498980.1. NM_066579.4.
UniGeneiCel.9533.

3D structure databases

ProteinModelPortaliP30648.
SMRiP30648. Positions 52-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK643.2.

Chemistry

ChEMBLiCHEMBL2448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
GeneIDi191373.
KEGGicel:CELE_ZK643.2.
UCSCiZK643.2. c. elegans.

Organism-specific databases

CTDi191373.
WormBaseiZK643.2; CE00441; WBGene00014034.

Phylogenomic databases

eggNOGiCOG2131.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
InParanoidiP30648.
KOiK01493.
OMAiWDKEDPE.
OrthoDBiEOG7JDQZR.
PhylomeDBiP30648.

Enzyme and pathway databases

ReactomeiREACT_237601. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi948932.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDCTD_CAEEL
AccessioniPrimary (citable) accession number: P30648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.