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P30648

- DCTD_CAEEL

UniProt

P30648 - DCTD_CAEEL

Protein

Probable deoxycytidylate deaminase

Gene

ZK643.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.By similarity

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi117 – 1171Zinc; catalyticBy similarity
    Active sitei119 – 1191Proton donorBy similarity
    Metal bindingi143 – 1431Zinc; catalyticBy similarity
    Metal bindingi146 – 1461Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nucleotide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    ORF Names:ZK643.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiZK643.2; CE00441; WBGene00014034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Probable deoxycytidylate deaminasePRO_0000171695Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZK643.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP30648.
    SMRiP30648. Positions 52-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2131.
    GeneTreeiENSGT00390000000501.
    HOGENOMiHOG000015715.
    InParanoidiP30648.
    KOiK01493.
    OMAiLHDCTVY.
    OrthoDBiEOG7JDQZR.
    PhylomeDBiP30648.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30648-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK    50
    HQRFLRIAKV TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF 100
    RWDKEDPEDN KHLYVVHAEM NAIINKRCTT LHDCTVYVTL FPCNKCAQML 150
    IQSRVKKVYF LENRDELAFR ASKKMLDHAR LPYEQIVMPQ EAYVIEL 197
    Length:197
    Mass (Da):22,528
    Last modified:April 1, 1993 - v1
    Checksum:i33B6A723AD3F9FE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11126 Genomic DNA. Translation: CAA77473.1.
    PIRiS23240.
    RefSeqiNP_498980.1. NM_066579.4.
    UniGeneiCel.9533.

    Genome annotation databases

    EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
    GeneIDi191373.
    KEGGicel:CELE_ZK643.2.
    UCSCiZK643.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11126 Genomic DNA. Translation: CAA77473.1 .
    PIRi S23240.
    RefSeqi NP_498980.1. NM_066579.4.
    UniGenei Cel.9533.

    3D structure databases

    ProteinModelPortali P30648.
    SMRi P30648. Positions 52-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK643.2.

    Chemistry

    ChEMBLi CHEMBL2448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK643.2 ; ZK643.2 ; WBGene00014034 .
    GeneIDi 191373.
    KEGGi cel:CELE_ZK643.2.
    UCSCi ZK643.2. c. elegans.

    Organism-specific databases

    CTDi 191373.
    WormBasei ZK643.2 ; CE00441 ; WBGene00014034 .

    Phylogenomic databases

    eggNOGi COG2131.
    GeneTreei ENSGT00390000000501.
    HOGENOMi HOG000015715.
    InParanoidi P30648.
    KOi K01493.
    OMAi LHDCTVY.
    OrthoDBi EOG7JDQZR.
    PhylomeDBi P30648.

    Miscellaneous databases

    NextBioi 948932.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiDCTD_CAEEL
    AccessioniPrimary (citable) accession number: P30648
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3