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Protein

Probable deoxycytidylate deaminase

Gene

ZK643.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi117Zinc; catalyticBy similarity1
Active sitei119Proton donorBy similarity1
Metal bindingi143Zinc; catalyticBy similarity1
Metal bindingi146Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-500753. Pyrimidine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:ZK643.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK643.2; CE00441; WBGene00014034.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716951 – 197Probable deoxycytidylate deaminaseAdd BLAST197

Proteomic databases

PaxDbiP30648.

Expressioni

Gene expression databases

BgeeiWBGene00014034.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK643.2.

Structurei

3D structure databases

ProteinModelPortaliP30648.
SMRiP30648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 183CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
InParanoidiP30648.
KOiK01493.
OMAiWDKEDPE.
OrthoDBiEOG091G0JEC.
PhylomeDBiP30648.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK
60 70 80 90 100
HQRFLRIAKV TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF
110 120 130 140 150
RWDKEDPEDN KHLYVVHAEM NAIINKRCTT LHDCTVYVTL FPCNKCAQML
160 170 180 190
IQSRVKKVYF LENRDELAFR ASKKMLDHAR LPYEQIVMPQ EAYVIEL
Length:197
Mass (Da):22,528
Last modified:April 1, 1993 - v1
Checksum:i33B6A723AD3F9FE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRiS23240.
RefSeqiNP_498980.1. NM_066579.4.
UniGeneiCel.9533.

Genome annotation databases

EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
GeneIDi191373.
KEGGicel:CELE_ZK643.2.
UCSCiZK643.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRiS23240.
RefSeqiNP_498980.1. NM_066579.4.
UniGeneiCel.9533.

3D structure databases

ProteinModelPortaliP30648.
SMRiP30648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK643.2.

Chemistry databases

ChEMBLiCHEMBL2448.

Proteomic databases

PaxDbiP30648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK643.2; ZK643.2; WBGene00014034.
GeneIDi191373.
KEGGicel:CELE_ZK643.2.
UCSCiZK643.2. c. elegans.

Organism-specific databases

CTDi191373.
WormBaseiZK643.2; CE00441; WBGene00014034.

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
InParanoidiP30648.
KOiK01493.
OMAiWDKEDPE.
OrthoDBiEOG091G0JEC.
PhylomeDBiP30648.

Enzyme and pathway databases

ReactomeiR-CEL-500753. Pyrimidine biosynthesis.

Miscellaneous databases

PROiP30648.

Gene expression databases

BgeeiWBGene00014034.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTD_CAEEL
AccessioniPrimary (citable) accession number: P30648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.