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P30648 (DCTD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable deoxycytidylate deaminase

EC=3.5.4.12
Alternative name(s):
dCMP deaminase
Gene names
ORF Names:ZK643.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Supplies the nucleotide substrate for thymidylate synthetase By similarity.

Catalytic activity

dCMP + H2O = dUMP + NH3.

Cofactor

Zinc By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondCMP deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197Probable deoxycytidylate deaminase
PRO_0000171695

Sites

Active site1191Proton donor By similarity
Metal binding1171Zinc; catalytic By similarity
Metal binding1431Zinc; catalytic By similarity
Metal binding1461Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P30648 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 33B6A723AD3F9FE7

FASTA19722,528
        10         20         30         40         50         60 
MVPPITSDEF CETSGCFGDS ANLHTTLERL KININSDAKK LVDTNGDLKK HQRFLRIAKV 

        70         80         90        100        110        120 
TSLRSKDPNT QVGCVIVDKD NCIVSVGYNG FPIGVDDDVF RWDKEDPEDN KHLYVVHAEM 

       130        140        150        160        170        180 
NAIINKRCTT LHDCTVYVTL FPCNKCAQML IQSRVKKVYF LENRDELAFR ASKKMLDHAR 

       190 
LPYEQIVMPQ EAYVIEL 

« Hide

References

[1]"The C. elegans genome sequencing project: a beginning."
Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R., Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A., Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R., Waterston R.
Nature 356:37-41(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11126 Genomic DNA. Translation: CAA77473.1.
PIRS23240.
RefSeqNP_498980.1. NM_066579.4.
UniGeneCel.9533.

3D structure databases

ProteinModelPortalP30648.
SMRP30648. Positions 52-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.ZK643.2.

Chemistry

ChEMBLCHEMBL2448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK643.2; ZK643.2; WBGene00014034.
GeneID191373.
KEGGcel:CELE_ZK643.2.
UCSCZK643.2. c. elegans.

Organism-specific databases

CTD191373.
WormBaseZK643.2; CE00441; WBGene00014034.

Phylogenomic databases

eggNOGCOG2131.
GeneTreeENSGT00390000000501.
HOGENOMHOG000015715.
InParanoidP30648.
KOK01493.
OMALHDCTVY.
OrthoDBEOG7JDQZR.
PhylomeDBP30648.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR015517. Cyt_deaminase.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
[Graphical view]
PANTHERPTHR11086. PTHR11086. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMSSF53927. SSF53927. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio948932.

Entry information

Entry nameDCTD_CAEEL
AccessionPrimary (citable) accession number: P30648
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase