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P30645 (PDE2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3',5'-cyclic phosphodiesterase pde-2

EC=3.1.4.17
Gene names
Name:pde-2
ORF Names:R08D7.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 1 GAF domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandcGMP
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P30645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: P30645-3)

The sequence of this isoform differs from the canonical sequence as follows:
     48-50: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 831831Probable 3',5'-cyclic phosphodiesterase pde-2
PRO_0000198845

Regions

Domain177 – 312136GAF

Sites

Active site4221Proton donor By similarity
Metal binding4261Divalent metal cation 1 By similarity
Metal binding4621Divalent metal cation 1 By similarity
Metal binding4631Divalent metal cation 1 By similarity
Metal binding4631Divalent metal cation 2 By similarity
Metal binding5761Divalent metal cation 1 By similarity

Natural variations

Alternative sequence48 – 503Missing in isoform b.
VSP_014355

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: 0BCD803345E113B1

FASTA83194,364
        10         20         30         40         50         60 
MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF TGANAAKSSN 

        70         80         90        100        110        120 
EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT KDDWGASLRY DIEEPTSSGL 

       130        140        150        160        170        180 
LELLPDVPIV RKLSRPLVKM DDQDDACSVA SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA 

       190        200        210        220        230        240 
LISCIIAEAK KNTEAEDYAV FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR 

       250        260        270        280        290        300 
TMNIRDVSRC PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY 

       310        320        330        340        350        360 
IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR LVNDPLRDWR 

       370        380        390        400        410        420 
YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL NKRKLSYLVL RVSAGYRPVP 

       430        440        450        460        470        480 
YHNWSHAFAV THFCWLTLRT DAIRRALSDM ERLSLLIACL CHDIDHRGTT NSFQMQSLQK 

       490        500        510        520        530        540 
TPLSVLYSTE GSVLERHHFA QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA 

       550        560        570        580        590        600 
HLRKQERIKT MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA 

       610        620        630        640        650        660 
QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR TTSEAIDANH 

       670        680        690        700        710        720 
LCWVALDEEV RNNPSATNTL EYLRDENLER RIYDRVRKQD PRAAEIASKR FEPVYANGSV 

       730        740        750        760        770        780 
PQTQDILDHR FDGYDKKYQI GCSGGQNQSN GKQQQIRSLQ KIRSKTSEDD ALLKPMDNGG 

       790        800        810        820        830 
SVAASSTRRG SRTPRRLWRR ARQLISSMSS SCASCSPLPS RRQVSEDSES C 

« Hide

Isoform b [UniParc].

Checksum: 6C8B0F649C7E09D5
Show »

FASTA82894,017

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z12017 Genomic DNA. Translation: CAA78052.3.
Z12017 Genomic DNA. Translation: CAE47469.2.
PIRD88544.
S24462. S41041.
RefSeqNP_001022705.2. NM_001027534.3.
NP_001022706.2. NM_001027535.4.
UniGeneCel.6004.

3D structure databases

ProteinModelPortalP30645.
SMRP30645. Positions 135-683.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP30645.
PRIDEP30645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR08D7.6a; R08D7.6a; R08D7.6. [P30645-1]
GeneID176270.
KEGGcel:CELE_R08D7.6.
UCSCR08D7.6b. c. elegans. [P30645-1]

Organism-specific databases

CTD176270.
WormBaseR08D7.6a; CE44867; WBGene00011146; pde-2.
R08D7.6b; CE44922; WBGene00011146; pde-2.

Phylogenomic databases

eggNOGNOG270709.
HOGENOMHOG000018108.
InParanoidP30645.
OMARYDIEEP.
OrthoDBEOG767393.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003018. GAF.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 1 hit.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 1 hit.
SM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891854.
PROP30645.

Entry information

Entry namePDE2_CAEEL
AccessionPrimary (citable) accession number: P30645
Secondary accession number(s): Q65ZC7, Q7JMU8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 100 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase