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P30645

- PDE2_CAEEL

UniProt

P30645 - PDE2_CAEEL

Protein

Probable 3',5'-cyclic phosphodiesterase pde-2

Gene

pde-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei422 – 4221Proton donorBy similarity
    Metal bindingi426 – 4261Divalent metal cation 1By similarity
    Metal bindingi462 – 4621Divalent metal cation 1By similarity
    Metal bindingi463 – 4631Divalent metal cation 1By similarity
    Metal bindingi463 – 4631Divalent metal cation 2By similarity
    Metal bindingi576 – 5761Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3',5'-cyclic phosphodiesterase pde-2 (EC:3.1.4.17)
    Gene namesi
    Name:pde-2
    ORF Names:R08D7.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiR08D7.6a; CE44867; WBGene00011146; pde-2.
    R08D7.6b; CE44922; WBGene00011146; pde-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Probable 3',5'-cyclic phosphodiesterase pde-2PRO_0000198845Add
    BLAST

    Proteomic databases

    PaxDbiP30645.
    PRIDEiP30645.

    Structurei

    3D structure databases

    ProteinModelPortaliP30645.
    SMRiP30645. Positions 135-683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini177 – 312136GAFAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GAF domain.Curated

    Phylogenomic databases

    eggNOGiNOG270709.
    GeneTreeiENSGT00750000117253.
    HOGENOMiHOG000018108.
    InParanoidiP30645.
    KOiK18283.
    OMAiRYDIEEP.
    OrthoDBiEOG767393.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 1 hit.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 1 hit.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 1 hit.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 1 hit.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P30645-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF    50
    TGANAAKSSN EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT 100
    KDDWGASLRY DIEEPTSSGL LELLPDVPIV RKLSRPLVKM DDQDDACSVA 150
    SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA LISCIIAEAK KNTEAEDYAV 200
    FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR TMNIRDVSRC 250
    PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY 300
    IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR 350
    LVNDPLRDWR YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL 400
    NKRKLSYLVL RVSAGYRPVP YHNWSHAFAV THFCWLTLRT DAIRRALSDM 450
    ERLSLLIACL CHDIDHRGTT NSFQMQSLQK TPLSVLYSTE GSVLERHHFA 500
    QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA HLRKQERIKT 550
    MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA 600
    QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR 650
    TTSEAIDANH LCWVALDEEV RNNPSATNTL EYLRDENLER RIYDRVRKQD 700
    PRAAEIASKR FEPVYANGSV PQTQDILDHR FDGYDKKYQI GCSGGQNQSN 750
    GKQQQIRSLQ KIRSKTSEDD ALLKPMDNGG SVAASSTRRG SRTPRRLWRR 800
    ARQLISSMSS SCASCSPLPS RRQVSEDSES C 831

    Note: No experimental confirmation available.

    Length:831
    Mass (Da):94,364
    Last modified:July 27, 2011 - v4
    Checksum:i0BCD803345E113B1
    GO
    Isoform b (identifier: P30645-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-50: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:828
    Mass (Da):94,017
    Checksum:i6C8B0F649C7E09D5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei48 – 503Missing in isoform b. CuratedVSP_014355

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12017 Genomic DNA. Translation: CAA78052.3.
    Z12017 Genomic DNA. Translation: CAE47469.2.
    PIRiD88544.
    S41041. S24462.
    RefSeqiNP_001022705.2. NM_001027534.3. [P30645-1]
    NP_001022706.2. NM_001027535.4. [P30645-3]
    UniGeneiCel.6004.

    Genome annotation databases

    EnsemblMetazoaiR08D7.6a; R08D7.6a; WBGene00011146. [P30645-1]
    GeneIDi176270.
    KEGGicel:CELE_R08D7.6.
    UCSCiR08D7.6b. c. elegans. [P30645-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12017 Genomic DNA. Translation: CAA78052.3 .
    Z12017 Genomic DNA. Translation: CAE47469.2 .
    PIRi D88544.
    S41041. S24462.
    RefSeqi NP_001022705.2. NM_001027534.3. [P30645-1 ]
    NP_001022706.2. NM_001027535.4. [P30645-3 ]
    UniGenei Cel.6004.

    3D structure databases

    ProteinModelPortali P30645.
    SMRi P30645. Positions 135-683.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P30645.
    PRIDEi P30645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R08D7.6a ; R08D7.6a ; WBGene00011146 . [P30645-1 ]
    GeneIDi 176270.
    KEGGi cel:CELE_R08D7.6.
    UCSCi R08D7.6b. c. elegans. [P30645-1 ]

    Organism-specific databases

    CTDi 176270.
    WormBasei R08D7.6a ; CE44867 ; WBGene00011146 ; pde-2.
    R08D7.6b ; CE44922 ; WBGene00011146 ; pde-2.

    Phylogenomic databases

    eggNOGi NOG270709.
    GeneTreei ENSGT00750000117253.
    HOGENOMi HOG000018108.
    InParanoidi P30645.
    KOi K18283.
    OMAi RYDIEEP.
    OrthoDBi EOG767393.

    Miscellaneous databases

    NextBioi 891854.
    PROi P30645.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 1 hit.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 1 hit.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 1 hit.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 1 hit.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDE2_CAEEL
    AccessioniPrimary (citable) accession number: P30645
    Secondary accession number(s): Q65ZC7, Q7JMU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3