SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P30645

- PDE2_CAEEL

UniProt

P30645 - PDE2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable 3',5'-cyclic phosphodiesterase pde-2
Gene
pde-2, R08D7.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221Proton donor By similarity
Metal bindingi426 – 4261Divalent metal cation 1 By similarity
Metal bindingi462 – 4621Divalent metal cation 1 By similarity
Metal bindingi463 – 4631Divalent metal cation 1 By similarity
Metal bindingi463 – 4631Divalent metal cation 2 By similarity
Metal bindingi576 – 5761Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-2 (EC:3.1.4.17)
Gene namesi
Name:pde-2
ORF Names:R08D7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiR08D7.6a; CE44867; WBGene00011146; pde-2.
R08D7.6b; CE44922; WBGene00011146; pde-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Probable 3',5'-cyclic phosphodiesterase pde-2
PRO_0000198845Add
BLAST

Proteomic databases

PaxDbiP30645.
PRIDEiP30645.

Structurei

3D structure databases

ProteinModelPortaliP30645.
SMRiP30645. Positions 135-683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 312136GAF
Add
BLAST

Sequence similaritiesi

Contains 1 GAF domain.

Phylogenomic databases

eggNOGiNOG270709.
GeneTreeiENSGT00750000117253.
HOGENOMiHOG000018108.
InParanoidiP30645.
KOiK18283.
OMAiRYDIEEP.
OrthoDBiEOG767393.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 1 hit.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 1 hit.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P30645-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF    50
TGANAAKSSN EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT 100
KDDWGASLRY DIEEPTSSGL LELLPDVPIV RKLSRPLVKM DDQDDACSVA 150
SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA LISCIIAEAK KNTEAEDYAV 200
FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR TMNIRDVSRC 250
PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY 300
IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR 350
LVNDPLRDWR YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL 400
NKRKLSYLVL RVSAGYRPVP YHNWSHAFAV THFCWLTLRT DAIRRALSDM 450
ERLSLLIACL CHDIDHRGTT NSFQMQSLQK TPLSVLYSTE GSVLERHHFA 500
QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA HLRKQERIKT 550
MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA 600
QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR 650
TTSEAIDANH LCWVALDEEV RNNPSATNTL EYLRDENLER RIYDRVRKQD 700
PRAAEIASKR FEPVYANGSV PQTQDILDHR FDGYDKKYQI GCSGGQNQSN 750
GKQQQIRSLQ KIRSKTSEDD ALLKPMDNGG SVAASSTRRG SRTPRRLWRR 800
ARQLISSMSS SCASCSPLPS RRQVSEDSES C 831

Note: No experimental confirmation available.

Length:831
Mass (Da):94,364
Last modified:July 27, 2011 - v4
Checksum:i0BCD803345E113B1
GO
Isoform b (identifier: P30645-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-50: Missing.

Note: No experimental confirmation available.

Show »
Length:828
Mass (Da):94,017
Checksum:i6C8B0F649C7E09D5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 503Missing in isoform b.
VSP_014355

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12017 Genomic DNA. Translation: CAA78052.3.
Z12017 Genomic DNA. Translation: CAE47469.2.
PIRiD88544.
S41041. S24462.
RefSeqiNP_001022705.2. NM_001027534.3. [P30645-1]
NP_001022706.2. NM_001027535.4. [P30645-3]
UniGeneiCel.6004.

Genome annotation databases

EnsemblMetazoaiR08D7.6a; R08D7.6a; WBGene00011146. [P30645-1]
GeneIDi176270.
KEGGicel:CELE_R08D7.6.
UCSCiR08D7.6b. c. elegans. [P30645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12017 Genomic DNA. Translation: CAA78052.3 .
Z12017 Genomic DNA. Translation: CAE47469.2 .
PIRi D88544.
S41041. S24462.
RefSeqi NP_001022705.2. NM_001027534.3. [P30645-1 ]
NP_001022706.2. NM_001027535.4. [P30645-3 ]
UniGenei Cel.6004.

3D structure databases

ProteinModelPortali P30645.
SMRi P30645. Positions 135-683.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P30645.
PRIDEi P30645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R08D7.6a ; R08D7.6a ; WBGene00011146 . [P30645-1 ]
GeneIDi 176270.
KEGGi cel:CELE_R08D7.6.
UCSCi R08D7.6b. c. elegans. [P30645-1 ]

Organism-specific databases

CTDi 176270.
WormBasei R08D7.6a ; CE44867 ; WBGene00011146 ; pde-2.
R08D7.6b ; CE44922 ; WBGene00011146 ; pde-2.

Phylogenomic databases

eggNOGi NOG270709.
GeneTreei ENSGT00750000117253.
HOGENOMi HOG000018108.
InParanoidi P30645.
KOi K18283.
OMAi RYDIEEP.
OrthoDBi EOG767393.

Miscellaneous databases

NextBioi 891854.
PROi P30645.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 1 hit.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 1 hit.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 1 hit.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 1 hit.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE2_CAEEL
AccessioniPrimary (citable) accession number: P30645
Secondary accession number(s): Q65ZC7, Q7JMU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi