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Protein

Probable 3',5'-cyclic phosphodiesterase pde-2

Gene

pde-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.1 Publication

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei422Proton donorBy similarity1
Metal bindingi426Divalent metal cation 1By similarity1
Metal bindingi462Divalent metal cation 1By similarity1
Metal bindingi463Divalent metal cation 1By similarity1
Metal bindingi463Divalent metal cation 2By similarity1
Metal bindingi576Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • cGMP catabolic process Source: WormBase
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • negative regulation of cGMP-mediated signaling Source: UniProtKB
  • negative regulation of cyclic nucleotide-gated ion channel activity Source: WormBase
  • phototransduction Source: UniProtKB
  • positive regulation of cGMP-mediated signaling Source: WormBase
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of multicellular organism growth Source: UniProtKB
  • positive regulation of oviposition Source: UniProtKB
  • regulation of multicellular organism growth Source: UniProtKB
  • regulation of oviposition Source: UniProtKB
  • response to alkaline pH Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB
  • response to oxygen levels Source: WormBase

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-418457 cGMP effects
R-CEL-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-2 (EC:3.1.4.17)
Gene namesi
Name:pde-2Imported
ORF Names:R08D7.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR08D7.6a ; CE44867 ; WBGene00011146 ; pde-2
R08D7.6b ; CE44922 ; WBGene00011146 ; pde-2

Pathology & Biotechi

Disruption phenotypei

Reduced body size and an egg-laying constitutive phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988451 – 831Probable 3',5'-cyclic phosphodiesterase pde-2Add BLAST831

Proteomic databases

PaxDbiP30645
PeptideAtlasiP30645

PTM databases

iPTMnetiP30645

Expressioni

Gene expression databases

BgeeiWBGene00011146

Interactioni

Protein-protein interaction databases

STRINGi6239.R08D7.6a

Structurei

3D structure databases

ProteinModelPortaliP30645
SMRiP30645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 312GAFAdd BLAST136
Domaini341 – 670PDEasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000018108
InParanoidiP30645
KOiK18283
OMAiRYDIEEP
OrthoDBiEOG091G0L2F

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: P30645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLELRRNSSP SSAHPSPQTN CQNSQRGDGL HHHHHEAASG STCCGGMTVF
60 70 80 90 100
TGANAAKSSN EPAGSASPTV WRKTSHPPLH FNNNETRNRN LQMQLKNRGT
110 120 130 140 150
KDDWGASLRY DIEEPTSSGL LELLPDVPIV RKLSRPLVKM DDQDDACSVA
160 170 180 190 200
SNESDRTVLS PLVPMSIFDQ FLCLTNNLSA LISCIIAEAK KNTEAEDYAV
210 220 230 240 250
FLHDEDNKQM VLFNNETMLM TGKKFDMGYG IVGKVASTMR TMNIRDVSRC
260 270 280 290 300
PFFNEEIDEQ FSIKARNLIA FPLIDSSCSL IGVIVLYNKE NGFSRHDEKY
310 320 330 340 350
IKRFSYFVAN SIAHAILAKQ IEEVRTRIHM VEEFKIQGED AVIEEVDIMR
360 370 380 390 400
LVNDPLRDWR YFSQNFADFS FPPRSVGENH FHRASMMFFE DLGFSMLYKL
410 420 430 440 450
NKRKLSYLVL RVSAGYRPVP YHNWSHAFAV THFCWLTLRT DAIRRALSDM
460 470 480 490 500
ERLSLLIACL CHDIDHRGTT NSFQMQSLQK TPLSVLYSTE GSVLERHHFA
510 520 530 540 550
QTIKLLQQEE CSILENLPAA DFRTIVNTIR EVILATDISA HLRKQERIKT
560 570 580 590 600
MISEGYNPMS FDHRYLLMCL VMTASDLSDQ AKNFHNAKRI AENIYLEFFA
610 620 630 640 650
QGDLELQLGV KPLEMMDRTN AYVPTVQIDF LFKIGVPVFQ LLASVVPEGR
660 670 680 690 700
TTSEAIDANH LCWVALDEEV RNNPSATNTL EYLRDENLER RIYDRVRKQD
710 720 730 740 750
PRAAEIASKR FEPVYANGSV PQTQDILDHR FDGYDKKYQI GCSGGQNQSN
760 770 780 790 800
GKQQQIRSLQ KIRSKTSEDD ALLKPMDNGG SVAASSTRRG SRTPRRLWRR
810 820 830
ARQLISSMSS SCASCSPLPS RRQVSEDSES C
Note: No experimental confirmation available.
Length:831
Mass (Da):94,364
Last modified:July 27, 2011 - v4
Checksum:i0BCD803345E113B1
GO
Isoform bImported (identifier: P30645-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-50: Missing.

Note: No experimental confirmation available.
Show »
Length:828
Mass (Da):94,017
Checksum:i6C8B0F649C7E09D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01435548 – 50Missing in isoform b. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12017 Genomic DNA Translation: CAA78052.3
Z12017 Genomic DNA Translation: CAE47469.2
PIRiD88544
S41041 S24462
RefSeqiNP_001022705.2, NM_001027534.3 [P30645-1]
NP_001022706.2, NM_001027535.4 [P30645-3]
UniGeneiCel.6004

Genome annotation databases

EnsemblMetazoaiR08D7.6a; R08D7.6a; WBGene00011146 [P30645-1]
GeneIDi176270
KEGGicel:CELE_R08D7.6
UCSCiR08D7.6b c. elegans [P30645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDE2_CAEEL
AccessioniPrimary (citable) accession number: P30645
Secondary accession number(s): Q65ZC7, Q7JMU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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