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P30641

- RPAP2_CAEEL

UniProt

P30641 - RPAP2_CAEEL

Protein

Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2

Gene

R08D7.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 12186RTR1-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2 (EC:3.1.3.16)
    Alternative name(s):
    RNA polymerase II-associated protein 2
    Gene namesi
    ORF Names:R08D7.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiR08D7.2; CE00290; WBGene00011143.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2PRO_0000065430Add
    BLAST

    Proteomic databases

    PaxDbiP30641.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.R08D7.2.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP30641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RPAP2 family.Curated
    Contains 1 RTR1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 12186RTR1-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241465.
    HOGENOMiHOG000018107.
    InParanoidiP30641.
    OMAiLPNLDKY.
    OrthoDBiEOG7XWPQD.

    Family and domain databases

    InterProiIPR007308. DUF408.
    [Graphical view]
    PfamiPF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view]
    PROSITEiPS51479. ZF_RTR1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30641-1 [UniParc]FASTAAdd to Basket

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    METEIPVNEK ETSFRRRVYT TIETLIDIEN TDQLQEHLPH LHCLGWDEVV    50
    EERYVNKQCG FPSCQKAPPK ITRNQMFEID RKEGKIFEFR KQRAKFCSEM 100
    CYQKSSFVRK QLDEHPLWIT GLTEARTQKV YEVPDESFVS PIAEKSEPVD 150
    SQFKKEPSIW LVTDSIIAKV QDMKLSEEAE EPKSLDPEDQ DIEPFKLTDD 200
    DKDFIKSIKE FRNSNFGPPS TSKLLKTAPK PVLSAKDRKK EDEVLAKLRA 250
    KYGNKNALQK KPPILIEAQE IHSKLKTMEK AKEAWLVDLI KSWFTPETRK 300
    LVREGARPTG GAAEQILMDF LSGKKVDAEK LVNLPNLDKY NVKEKRLNIF 350
    LHSIRNHWMD LEARLHLTPT RRDILSRVAS TFQLDSENIT GWTKREINSI 400
    VIALFIVICL VDVELGDDYF KKDNASPELT AISNELCGLD SFQITGLHAA 450
    IKSQC 455
    Length:455
    Mass (Da):52,438
    Last modified:April 1, 1993 - v1
    Checksum:i1FDFADAA58980F3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12017 Genomic DNA. Translation: CAA78048.1.
    PIRiS41037. S24458.
    RefSeqiNP_498983.1. NM_066582.4.
    UniGeneiCel.10207.

    Genome annotation databases

    EnsemblMetazoaiR08D7.2.1; R08D7.2.1; WBGene00011143.
    R08D7.2.2; R08D7.2.2; WBGene00011143.
    GeneIDi176267.
    KEGGicel:CELE_R08D7.2.
    UCSCiR08D7.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12017 Genomic DNA. Translation: CAA78048.1 .
    PIRi S41037. S24458.
    RefSeqi NP_498983.1. NM_066582.4.
    UniGenei Cel.10207.

    3D structure databases

    ProteinModelPortali P30641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.R08D7.2.2.

    Proteomic databases

    PaxDbi P30641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R08D7.2.1 ; R08D7.2.1 ; WBGene00011143 .
    R08D7.2.2 ; R08D7.2.2 ; WBGene00011143 .
    GeneIDi 176267.
    KEGGi cel:CELE_R08D7.2.
    UCSCi R08D7.2.1. c. elegans.

    Organism-specific databases

    CTDi 176267.
    WormBasei R08D7.2 ; CE00290 ; WBGene00011143 .

    Phylogenomic databases

    eggNOGi NOG241465.
    HOGENOMi HOG000018107.
    InParanoidi P30641.
    OMAi LPNLDKY.
    OrthoDBi EOG7XWPQD.

    Miscellaneous databases

    NextBioi 891842.
    PROi P30641.

    Family and domain databases

    InterProi IPR007308. DUF408.
    [Graphical view ]
    Pfami PF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view ]
    PROSITEi PS51479. ZF_RTR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiRPAP2_CAEEL
    AccessioniPrimary (citable) accession number: P30641
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3