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Protein

Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2

Gene

R08D7.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59ZincPROSITE-ProRule annotation1
Metal bindingi64ZincPROSITE-ProRule annotation1
Metal bindingi97ZincPROSITE-ProRule annotation1
Metal bindingi101ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 121RTR1-typePROSITE-ProRule annotationAdd BLAST86

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2 (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2
Gene namesi
ORF Names:R08D7.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR08D7.2; CE00290; WBGene00011143.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000654301 – 455Putative RNA polymerase II subunit B1 CTD phosphatase R08D7.2Add BLAST455

Proteomic databases

EPDiP30641.
PaxDbiP30641.
PeptideAtlasiP30641.

Expressioni

Gene expression databases

BgeeiWBGene00011143.

Interactioni

Protein-protein interaction databases

STRINGi6239.R08D7.2.1.

Structurei

3D structure databases

ProteinModelPortaliP30641.
SMRiP30641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RPAP2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 121RTR1-typePROSITE-ProRule annotationAdd BLAST86

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4780. Eukaryota.
ENOG410ZZZC. LUCA.
HOGENOMiHOG000018107.
InParanoidiP30641.
KOiK20827.
OMAiPNLDKYN.
OrthoDBiEOG091G0TLM.

Family and domain databases

InterProiView protein in InterPro
IPR007308. DUF408.
PfamiView protein in Pfam
PF04181. RPAP2_Rtr1. 1 hit.
PROSITEiView protein in PROSITE
PS51479. ZF_RTR1. 1 hit.

Sequencei

Sequence statusi: Complete.

P30641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METEIPVNEK ETSFRRRVYT TIETLIDIEN TDQLQEHLPH LHCLGWDEVV
60 70 80 90 100
EERYVNKQCG FPSCQKAPPK ITRNQMFEID RKEGKIFEFR KQRAKFCSEM
110 120 130 140 150
CYQKSSFVRK QLDEHPLWIT GLTEARTQKV YEVPDESFVS PIAEKSEPVD
160 170 180 190 200
SQFKKEPSIW LVTDSIIAKV QDMKLSEEAE EPKSLDPEDQ DIEPFKLTDD
210 220 230 240 250
DKDFIKSIKE FRNSNFGPPS TSKLLKTAPK PVLSAKDRKK EDEVLAKLRA
260 270 280 290 300
KYGNKNALQK KPPILIEAQE IHSKLKTMEK AKEAWLVDLI KSWFTPETRK
310 320 330 340 350
LVREGARPTG GAAEQILMDF LSGKKVDAEK LVNLPNLDKY NVKEKRLNIF
360 370 380 390 400
LHSIRNHWMD LEARLHLTPT RRDILSRVAS TFQLDSENIT GWTKREINSI
410 420 430 440 450
VIALFIVICL VDVELGDDYF KKDNASPELT AISNELCGLD SFQITGLHAA

IKSQC
Length:455
Mass (Da):52,438
Last modified:April 1, 1993 - v1
Checksum:i1FDFADAA58980F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12017 Genomic DNA. Translation: CAA78048.1.
PIRiS41037. S24458.
RefSeqiNP_498983.1. NM_066582.4.
UniGeneiCel.10207.

Genome annotation databases

EnsemblMetazoaiR08D7.2.1; R08D7.2.1; WBGene00011143.
R08D7.2.2; R08D7.2.2; WBGene00011143.
GeneIDi176267.
KEGGicel:CELE_R08D7.2.
UCSCiR08D7.2.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRPAP2_CAEEL
AccessioniPrimary (citable) accession number: P30641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 5, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families