##gff-version 3 P30636 UniProtKB Chain 1 243 . . . ID=PRO_0000072646;Note=Thiamin pyrophosphokinase 1 P30636 UniProtKB Mutagenesis 67 67 . . . Note=In qm162%3B maternal-effect mutation. Partial loss-of-function. Prolongs embryonic and postembryonic development%2C increases lifespan%2C reduces brood size%2C reduces the rate of pharyngeal pumping and increases the defecation cycle rate. Animals appear slimmer and more transparent. In response to a thiamine-depleted diet%2C the pharyngeal pumping rate further reduces and animals subsquently die. In the absence of food%2C animals die within a few days as arrested L1 larvae and fail to resume development when placed in the presence of food. No effect on oxygen consumption rate. Reduces lifespan in aha-1%2C ceh-18%2C hif-1%2C jun-1%2C nhr-105 or taf-4 RNAi mutant background. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15514058;Dbxref=PMID:15514058 P30636 UniProtKB Sequence conflict 146 160 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305