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P30635

- GSHR_CAEEL

UniProt

P30635 - GSHR_CAEEL

Protein

Probable glutathione reductase 2

Gene

trxr-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Maintains high levels of reduced glutathione in the cytosol.

    Catalytic activityi

    2 glutathione + NADP+ = glutathione disulfide + NADPH.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei476 – 4761Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi58 – 6710FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. glutathione-disulfide reductase activity Source: UniProtKB-EC
    3. NADP binding Source: InterPro
    4. thioredoxin-disulfide reductase activity Source: WormBase

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. oxidation-reduction process Source: WormBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione reductase 2 (EC:1.8.1.7)
    Short name:
    GR
    Short name:
    GRase
    Gene namesi
    Name:trxr-2
    ORF Names:ZK637.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiZK637.10; CE15373; WBGene00014028; trxr-2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Probable glutathione reductase 2PRO_0000067958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 72Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP30635.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZK637.10.

    Structurei

    3D structure databases

    ProteinModelPortaliP30635.
    SMRiP30635. Positions 18-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1249.
    GeneTreeiENSGT00390000007578.
    HOGENOMiHOG000276712.
    InParanoidiP30635.
    KOiK00383.
    OMAiGLSCSKR.
    PhylomeDBiP30635.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR006338. Thioredoxin/glutathione_Rdtase.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.
    TIGRFAMsiTIGR01438. TGR. 1 hit.
    PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLSTFKRHL PIRRLFSSNK FDLIVIGAGS GGLSCSKRAA DLGANVALID    50
    AVEPTPHGHS WGIGGTCANV GCIPKKLMHQ AAIVGKELKH ADKYGWNGID 100
    QEKIKHDWNV LSKNVNDRVK ANNWIYRVQL NQKKINYFNA YAEFVDKDKI 150
    VITGTDKNKT KNFLSAPNVV ISTGLRPKYP NIPGAELGIT SDDLFTLASV 200
    PGKTLIVGGG YVALECAGFL SAFNQNVEVL VRSIPLKGFD RDCVHFVMEH 250
    LKTTGVKVKE HVEVERVEAV GSKKKVTFTG NGGVEEYDTV IWAAGRVPNL 300
    KSLNLDNAGV RTDKRSGKIL ADEFDRASCN GVYAVGDIVQ DRQELTPLAI 350
    QSGKLLADRL FSNSKQIVRF DGVATTVFTP LELSTVGLTE EEAIQKHGED 400
    SIEVFHSHFT PFEYVVPQNK DSGFCYVKAV CTRDESQKIL GLHFVGPNAA 450
    EVIQGYAVAF RVGISMSDLQ NTIAIHPCSS EEFVKLHITK RSGQDPRTQG 500
    CCG 503
    Length:503
    Mass (Da):55,046
    Last modified:November 1, 1997 - v2
    Checksum:iCE2385C9ACBD9AD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11115 Genomic DNA. Translation: CAA77459.1.
    PIRiD88542.
    S15798.
    RefSeqiNP_498971.1. NM_066570.4.
    UniGeneiCel.9538.

    Genome annotation databases

    EnsemblMetazoaiZK637.10.1; ZK637.10.1; WBGene00014028.
    ZK637.10.2; ZK637.10.2; WBGene00014028.
    GeneIDi176259.
    KEGGicel:CELE_ZK637.10.
    UCSCiZK637.10. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11115 Genomic DNA. Translation: CAA77459.1 .
    PIRi D88542.
    S15798.
    RefSeqi NP_498971.1. NM_066570.4.
    UniGenei Cel.9538.

    3D structure databases

    ProteinModelPortali P30635.
    SMRi P30635. Positions 18-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK637.10.

    Proteomic databases

    PaxDbi P30635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK637.10.1 ; ZK637.10.1 ; WBGene00014028 .
    ZK637.10.2 ; ZK637.10.2 ; WBGene00014028 .
    GeneIDi 176259.
    KEGGi cel:CELE_ZK637.10.
    UCSCi ZK637.10. c. elegans.

    Organism-specific databases

    CTDi 40475.
    WormBasei ZK637.10 ; CE15373 ; WBGene00014028 ; trxr-2.

    Phylogenomic databases

    eggNOGi COG1249.
    GeneTreei ENSGT00390000007578.
    HOGENOMi HOG000276712.
    InParanoidi P30635.
    KOi K00383.
    OMAi GLSCSKR.
    PhylomeDBi P30635.

    Miscellaneous databases

    NextBioi 891814.
    PROi P30635.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    IPR006338. Thioredoxin/glutathione_Rdtase.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    TIGRFAMsi TIGR01438. TGR. 1 hit.
    PROSITEi PS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGSHR_CAEEL
    AccessioniPrimary (citable) accession number: P30635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Miscellaneous

    The active site is a redox-active disulfide bond.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3