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P30634

- MPIP3_CAEEL

UniProt

P30634 - MPIP3_CAEEL

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Protein

M-phase inducer phosphatase cdc-25.3

Gene

cdc-25.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: WormBase
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic cell cycle Source: WormBase
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein dephosphorylation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_218111. Polo-like kinase mediated events.
REACT_218728. Cyclin A/B1 associated events during G2/M transition.
REACT_230732. G0 and Early G1.
REACT_234286. E2F-enabled inhibition of pre-replication complex formation.
REACT_238173. Activation of ATR in response to replication stress.
REACT_244835. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_250477. Cyclin B2 mediated events.
REACT_250616. Cyclin A:Cdk2-associated events at S phase entry.
REACT_263599. p53-Independent DNA Damage Response.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.3 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.3
Gene namesi
Name:cdc-25.3
ORF Names:ZK637.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiZK637.11; CE00429; WBGene00000388; cdc-25.3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316M-phase inducer phosphatase cdc-25.3PRO_0000198657Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi41461. 2 interactions.
IntActiP30634. 2 interactions.
MINTiMINT-228682.
STRINGi6239.ZK637.11.

Structurei

3D structure databases

ProteinModelPortaliP30634.
SMRiP30634. Positions 126-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 242107RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5105.
GeneTreeiENSGT00390000018747.
HOGENOMiHOG000018501.
InParanoidiP30634.
OMAiYEEIYVL.
PhylomeDBiP30634.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30634-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS
60 70 80 90 100
PPTRKRSIDG GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ
110 120 130 140 150
VDYHLETVTP SCSTVYQKIT SETLIEIMQK LSQIEFMQKY ILIDCRYDYE
160 170 180 190 200
YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK INRIPIFYCE YSQKRGPTMA
210 220 230 240 250
NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL EKEQRVQLCE
260 270 280 290 300
PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI
310
STLRQTCDPI HEHDAH
Length:316
Mass (Da):36,469
Last modified:April 1, 1993 - v1
Checksum:i6C6EA2921623DB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11115 Genomic DNA. Translation: CAA77456.1.
PIRiS15799.
RefSeqiNP_498972.1. NM_066571.4.
UniGeneiCel.10680.

Genome annotation databases

EnsemblMetazoaiZK637.11; ZK637.11; WBGene00000388.
GeneIDi176260.
KEGGicel:CELE_ZK637.11.
UCSCiZK637.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11115 Genomic DNA. Translation: CAA77456.1 .
PIRi S15799.
RefSeqi NP_498972.1. NM_066571.4.
UniGenei Cel.10680.

3D structure databases

ProteinModelPortali P30634.
SMRi P30634. Positions 126-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41461. 2 interactions.
IntActi P30634. 2 interactions.
MINTi MINT-228682.
STRINGi 6239.ZK637.11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK637.11 ; ZK637.11 ; WBGene00000388 .
GeneIDi 176260.
KEGGi cel:CELE_ZK637.11.
UCSCi ZK637.11. c. elegans.

Organism-specific databases

CTDi 176260.
WormBasei ZK637.11 ; CE00429 ; WBGene00000388 ; cdc-25.3.

Phylogenomic databases

eggNOGi COG5105.
GeneTreei ENSGT00390000018747.
HOGENOMi HOG000018501.
InParanoidi P30634.
OMAi YEEIYVL.
PhylomeDBi P30634.

Enzyme and pathway databases

Reactomei REACT_218111. Polo-like kinase mediated events.
REACT_218728. Cyclin A/B1 associated events during G2/M transition.
REACT_230732. G0 and Early G1.
REACT_234286. E2F-enabled inhibition of pre-replication complex formation.
REACT_238173. Activation of ATR in response to replication stress.
REACT_244835. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_250477. Cyclin B2 mediated events.
REACT_250616. Cyclin A:Cdk2-associated events at S phase entry.
REACT_263599. p53-Independent DNA Damage Response.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

NextBioi 891818.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
InterProi IPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view ]
Pfami PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR00716. MPIPHPHTASE.
SMARTi SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The four cdc25 genes from the nematode Caenorhabditis elegans."
    Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
    Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMPIP3_CAEEL
AccessioniPrimary (citable) accession number: P30634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 26, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3