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Protein

M-phase inducer phosphatase cdc-25.3

Gene

cdc-25.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: WormBase
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cell cycle Source: WormBase
  • mitotic nuclear division Source: UniProtKB-KW
  • protein dephosphorylation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_282536. p53-Independent DNA Damage Response.
REACT_283635. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_289687. Cyclin B2 mediated events.
REACT_290674. Cyclin A:Cdk2-associated events at S phase entry.
REACT_305488. Cyclin E associated events during G1/S transition.
REACT_308901. Cyclin A/B1 associated events during G2/M transition.
REACT_316728. Polo-like kinase mediated events.
REACT_317000. Activation of ATR in response to replication stress.
REACT_328546. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_345542. E2F-enabled inhibition of pre-replication complex formation.
REACT_357469. RHO GTPases activate PKNs.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.3 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.3
Gene namesi
Name:cdc-25.3
ORF Names:ZK637.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK637.11; CE00429; WBGene00000388; cdc-25.3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316M-phase inducer phosphatase cdc-25.3PRO_0000198657Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi41461. 2 interactions.
IntActiP30634. 2 interactions.
MINTiMINT-228682.
STRINGi6239.ZK637.11.2.

Structurei

3D structure databases

ProteinModelPortaliP30634.
SMRiP30634. Positions 126-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 242107RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5105.
GeneTreeiENSGT00390000018747.
HOGENOMiHOG000018501.
InParanoidiP30634.
OMAiYEEIYVL.
PhylomeDBiP30634.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS
60 70 80 90 100
PPTRKRSIDG GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ
110 120 130 140 150
VDYHLETVTP SCSTVYQKIT SETLIEIMQK LSQIEFMQKY ILIDCRYDYE
160 170 180 190 200
YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK INRIPIFYCE YSQKRGPTMA
210 220 230 240 250
NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL EKEQRVQLCE
260 270 280 290 300
PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI
310
STLRQTCDPI HEHDAH
Length:316
Mass (Da):36,469
Last modified:April 1, 1993 - v1
Checksum:i6C6EA2921623DB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11115 Genomic DNA. Translation: CAA77456.1.
PIRiS15799.
RefSeqiNP_498972.1. NM_066571.4.
UniGeneiCel.10680.

Genome annotation databases

EnsemblMetazoaiZK637.11; ZK637.11; WBGene00000388.
GeneIDi176260.
KEGGicel:CELE_ZK637.11.
UCSCiZK637.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11115 Genomic DNA. Translation: CAA77456.1.
PIRiS15799.
RefSeqiNP_498972.1. NM_066571.4.
UniGeneiCel.10680.

3D structure databases

ProteinModelPortaliP30634.
SMRiP30634. Positions 126-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41461. 2 interactions.
IntActiP30634. 2 interactions.
MINTiMINT-228682.
STRINGi6239.ZK637.11.2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK637.11; ZK637.11; WBGene00000388.
GeneIDi176260.
KEGGicel:CELE_ZK637.11.
UCSCiZK637.11. c. elegans.

Organism-specific databases

CTDi176260.
WormBaseiZK637.11; CE00429; WBGene00000388; cdc-25.3.

Phylogenomic databases

eggNOGiCOG5105.
GeneTreeiENSGT00390000018747.
HOGENOMiHOG000018501.
InParanoidiP30634.
OMAiYEEIYVL.
PhylomeDBiP30634.

Enzyme and pathway databases

ReactomeiREACT_282536. p53-Independent DNA Damage Response.
REACT_283635. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_289687. Cyclin B2 mediated events.
REACT_290674. Cyclin A:Cdk2-associated events at S phase entry.
REACT_305488. Cyclin E associated events during G1/S transition.
REACT_308901. Cyclin A/B1 associated events during G2/M transition.
REACT_316728. Polo-like kinase mediated events.
REACT_317000. Activation of ATR in response to replication stress.
REACT_328546. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
REACT_345542. E2F-enabled inhibition of pre-replication complex formation.
REACT_357469. RHO GTPases activate PKNs.

Miscellaneous databases

NextBioi891818.
PROiP30634.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR00716. MPIPHPHTASE.
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The four cdc25 genes from the nematode Caenorhabditis elegans."
    Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
    Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMPIP3_CAEEL
AccessioniPrimary (citable) accession number: P30634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.