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P30634

- MPIP3_CAEEL

UniProt

P30634 - MPIP3_CAEEL

Protein

M-phase inducer phosphatase cdc-25.3

Gene

cdc-25.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: WormBase
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic cell cycle Source: WormBase
    2. mitotic nuclear division Source: UniProtKB-KW
    3. protein dephosphorylation Source: WormBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase inducer phosphatase cdc-25.3 (EC:3.1.3.48)
    Alternative name(s):
    Cell division cycle-related protein 25.3
    Gene namesi
    Name:cdc-25.3
    ORF Names:ZK637.11
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiZK637.11; CE00429; WBGene00000388; cdc-25.3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316M-phase inducer phosphatase cdc-25.3PRO_0000198657Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi41461. 2 interactions.
    IntActiP30634. 2 interactions.
    MINTiMINT-228682.
    STRINGi6239.ZK637.11.

    Structurei

    3D structure databases

    ProteinModelPortaliP30634.
    SMRiP30634. Positions 126-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 242107RhodanesePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MPI phosphatase family.Curated
    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5105.
    GeneTreeiENSGT00390000018747.
    HOGENOMiHOG000018501.
    InParanoidiP30634.
    OMAiYEEIYVL.
    PhylomeDBiP30634.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    InterProiIPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view]
    PfamiPF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR00716. MPIPHPHTASE.
    SMARTiSM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30634-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS    50
    PPTRKRSIDG GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ 100
    VDYHLETVTP SCSTVYQKIT SETLIEIMQK LSQIEFMQKY ILIDCRYDYE 150
    YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK INRIPIFYCE YSQKRGPTMA 200
    NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL EKEQRVQLCE 250
    PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI 300
    STLRQTCDPI HEHDAH 316
    Length:316
    Mass (Da):36,469
    Last modified:April 1, 1993 - v1
    Checksum:i6C6EA2921623DB59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11115 Genomic DNA. Translation: CAA77456.1.
    PIRiS15799.
    RefSeqiNP_498972.1. NM_066571.4.
    UniGeneiCel.10680.

    Genome annotation databases

    EnsemblMetazoaiZK637.11; ZK637.11; WBGene00000388.
    GeneIDi176260.
    KEGGicel:CELE_ZK637.11.
    UCSCiZK637.11. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11115 Genomic DNA. Translation: CAA77456.1 .
    PIRi S15799.
    RefSeqi NP_498972.1. NM_066571.4.
    UniGenei Cel.10680.

    3D structure databases

    ProteinModelPortali P30634.
    SMRi P30634. Positions 126-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41461. 2 interactions.
    IntActi P30634. 2 interactions.
    MINTi MINT-228682.
    STRINGi 6239.ZK637.11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK637.11 ; ZK637.11 ; WBGene00000388 .
    GeneIDi 176260.
    KEGGi cel:CELE_ZK637.11.
    UCSCi ZK637.11. c. elegans.

    Organism-specific databases

    CTDi 176260.
    WormBasei ZK637.11 ; CE00429 ; WBGene00000388 ; cdc-25.3.

    Phylogenomic databases

    eggNOGi COG5105.
    GeneTreei ENSGT00390000018747.
    HOGENOMi HOG000018501.
    InParanoidi P30634.
    OMAi YEEIYVL.
    PhylomeDBi P30634.

    Miscellaneous databases

    NextBioi 891818.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    InterProi IPR000751. MPI_Phosphatase.
    IPR001763. Rhodanese-like_dom.
    [Graphical view ]
    Pfami PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR00716. MPIPHPHTASE.
    SMARTi SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "The four cdc25 genes from the nematode Caenorhabditis elegans."
      Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
      Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMPIP3_CAEEL
    AccessioniPrimary (citable) accession number: P30634
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3