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P30634 (MPIP3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase inducer phosphatase cdc-25.3

EC=3.1.3.48
Alternative name(s):
Cell division cycle-related protein 25.3
Gene names
Name:cdc-25.3
ORF Names:ZK637.11
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the MPI phosphatase family.

Contains 1 rhodanese domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316M-phase inducer phosphatase cdc-25.3
PRO_0000198657

Regions

Domain136 – 242107Rhodanese

Sequences

Sequence LengthMass (Da)Tools
P30634 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 6C6EA2921623DB59

FASTA31636,469
        10         20         30         40         50         60 
MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS PPTRKRSIDG 

        70         80         90        100        110        120 
GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ VDYHLETVTP SCSTVYQKIT 

       130        140        150        160        170        180 
SETLIEIMQK LSQIEFMQKY ILIDCRYDYE YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK 

       190        200        210        220        230        240 
INRIPIFYCE YSQKRGPTMA NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL 

       250        260        270        280        290        300 
EKEQRVQLCE PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI 

       310 
STLRQTCDPI HEHDAH 

« Hide

References

« Hide 'large scale' references
[1]"The C. elegans genome sequencing project: a beginning."
Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R., Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A., Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R., Waterston R.
Nature 356:37-41(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"The four cdc25 genes from the nematode Caenorhabditis elegans."
Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.
Gene 214:59-66(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11115 Genomic DNA. Translation: CAA77456.1.
PIRS15799.
RefSeqNP_498972.1. NM_066571.4.
UniGeneCel.10680.

3D structure databases

ProteinModelPortalP30634.
SMRP30634. Positions 126-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41461. 2 interactions.
IntActP30634. 2 interactions.
MINTMINT-228682.
STRING6239.ZK637.11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK637.11; ZK637.11; WBGene00000388.
GeneID176260.
KEGGcel:CELE_ZK637.11.
UCSCZK637.11. c. elegans.

Organism-specific databases

CTD176260.
WormBaseZK637.11; CE00429; WBGene00000388; cdc-25.3.

Phylogenomic databases

eggNOGCOG5105.
GeneTreeENSGT00390000018747.
HOGENOMHOG000018501.
InParanoidP30634.
OMAYEEIYVL.
PhylomeDBP30634.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000751. MPI_Phosphatase.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamPF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR00716. MPIPHPHTASE.
SMARTSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891818.

Entry information

Entry nameMPIP3_CAEEL
AccessionPrimary (citable) accession number: P30634
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase