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Protein

M-phase inducer phosphatase cdc-25.3

Gene

cdc-25.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: WormBase
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cell cycle Source: WormBase
  • positive regulation of cell cycle G2/M phase transition Source: InterPro
  • protein dephosphorylation Source: WormBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-156711 Polo-like kinase mediated events
R-CEL-176187 Activation of ATR in response to replication stress
R-CEL-5625740 RHO GTPases activate PKNs
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase inducer phosphatase cdc-25.3 (EC:3.1.3.48)
Alternative name(s):
Cell division cycle-related protein 25.3
Gene namesi
ORF Names:ZK637.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK637.11 ; CE00429 ; WBGene00000388 ; cdc-25.3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001986571 – 316M-phase inducer phosphatase cdc-25.3Add BLAST316

Proteomic databases

EPDiP30634
PaxDbiP30634

Expressioni

Gene expression databases

BgeeiWBGene00000388

Interactioni

Protein-protein interaction databases

BioGridi41461, 2 interactors
IntActiP30634, 2 interactors
MINTiP30634
STRINGi6239.ZK637.11.2

Structurei

3D structure databases

ProteinModelPortaliP30634
SMRiP30634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 242RhodanesePROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3772 Eukaryota
COG5105 LUCA
GeneTreeiENSGT00390000018747
HOGENOMiHOG000018501
InParanoidiP30634
OMAiYEEIYVL
OrthoDBiEOG091G0866
PhylomeDBiP30634

Family and domain databases

CDDicd01530 Cdc25, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR000751 MPI_Phosphatase
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PRINTSiPR00716 MPIPHPHTASE
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P30634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS
60 70 80 90 100
PPTRKRSIDG GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ
110 120 130 140 150
VDYHLETVTP SCSTVYQKIT SETLIEIMQK LSQIEFMQKY ILIDCRYDYE
160 170 180 190 200
YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK INRIPIFYCE YSQKRGPTMA
210 220 230 240 250
NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL EKEQRVQLCE
260 270 280 290 300
PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI
310
STLRQTCDPI HEHDAH
Length:316
Mass (Da):36,469
Last modified:April 1, 1993 - v1
Checksum:i6C6EA2921623DB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11115 Genomic DNA Translation: CAA77456.1
PIRiS15799
RefSeqiNP_498972.1, NM_066571.4
UniGeneiCel.10680

Genome annotation databases

EnsemblMetazoaiZK637.11; ZK637.11; WBGene00000388
GeneIDi176260
KEGGicel:CELE_ZK637.11
UCSCiZK637.11 c. elegans

Entry informationi

Entry nameiMPIP3_CAEEL
AccessioniPrimary (citable) accession number: P30634
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health