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Protein

Globin-like protein

Gene

glb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a globin and may play a role in oxygen transport.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-like protein
Gene namesi
Name:glb-1
Synonyms:cbg-1, glo
ORF Names:ZK637.13
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK637.13; CE36418; WBGene00014030; glb-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Globin-like proteinPRO_0000052463Add
BLAST

Proteomic databases

EPDiP30627.
PaxDbiP30627.

2D gel databases

World-2DPAGE0011:P30627.

Expressioni

Tissue specificityi

Expressed mainly in a subset of neuronal cells and in head muscular tissue.1 Publication

Inductioni

By hypoxia.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi6239.ZK637.13.2.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Helixi16 – 194Combined sources
Helixi25 – 4117Combined sources
Helixi43 – 486Combined sources
Turni50 – 545Combined sources
Helixi57 – 615Combined sources
Helixi64 – 8320Combined sources
Helixi87 – 10115Combined sources
Helixi102 – 1043Combined sources
Helixi110 – 12213Combined sources
Turni123 – 1253Combined sources
Helixi130 – 15324Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WTGX-ray1.50A1-159[»]
2WTHX-ray2.80A/B1-159[»]
ProteinModelPortaliP30627.
SMRiP30627. Positions 2-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30627.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.Curated

Phylogenomic databases

eggNOGiENOG410JBPP. Eukaryota.
ENOG411150K. LUCA.
HOGENOMiHOG000112731.
InParanoidiP30627.
OMAiDPALWMA.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR012085. Globin_nematode.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF002026. Nematode_globin. 1 hit.
SUPFAMiSSF46458. SSF46458. 1 hit.

Sequencei

Sequence statusi: Complete.

P30627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMNRQEISD LCVKSLEGRM VGTEAQNIEN GNAFYRYFFT NFPDLRVYFK
60 70 80 90 100
GAEKYTADDV KKSERFDKQG QRILLACHLL ANVYTNEEVF KGYVRETINR
110 120 130 140 150
HRIYKMDPAL WMAFFTVFTG YLESVGCLND QQKAAWMALG KEFNAESQTH

LKNSNLPHV
Length:159
Mass (Da):18,501
Last modified:August 16, 2004 - v2
Checksum:i0C2E473C56F59CFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18264 mRNA. Translation: CAA79148.1.
S66164 mRNA. Translation: AAB28512.3.
Z11115 Genomic DNA. Translation: CAA77458.2.
PIRiJC1516.
T41748.
RefSeqiNP_498974.2. NM_066573.6.
UniGeneiCel.19513.

Genome annotation databases

EnsemblMetazoaiZK637.13.1; ZK637.13.1; WBGene00014030.
ZK637.13.2; ZK637.13.2; WBGene00014030.
GeneIDi176261.
KEGGicel:CELE_ZK637.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18264 mRNA. Translation: CAA79148.1.
S66164 mRNA. Translation: AAB28512.3.
Z11115 Genomic DNA. Translation: CAA77458.2.
PIRiJC1516.
T41748.
RefSeqiNP_498974.2. NM_066573.6.
UniGeneiCel.19513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WTGX-ray1.50A1-159[»]
2WTHX-ray2.80A/B1-159[»]
ProteinModelPortaliP30627.
SMRiP30627. Positions 2-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK637.13.2.

2D gel databases

World-2DPAGE0011:P30627.

Proteomic databases

EPDiP30627.
PaxDbiP30627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK637.13.1; ZK637.13.1; WBGene00014030.
ZK637.13.2; ZK637.13.2; WBGene00014030.
GeneIDi176261.
KEGGicel:CELE_ZK637.13.

Organism-specific databases

CTDi176261.
WormBaseiZK637.13; CE36418; WBGene00014030; glb-1.

Phylogenomic databases

eggNOGiENOG410JBPP. Eukaryota.
ENOG411150K. LUCA.
HOGENOMiHOG000112731.
InParanoidiP30627.
OMAiDPALWMA.

Miscellaneous databases

EvolutionaryTraceiP30627.
PROiP30627.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR012085. Globin_nematode.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF002026. Nematode_globin. 1 hit.
SUPFAMiSSF46458. SSF46458. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene structure and evolutionary context of Caenorhabditis elegans globin."
    Kloek A.P., Sherman D.R., Goldberg D.E.
    Gene 129:215-221(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of a globin gene in Caenorhabditis elegans."
    Mansell J.B., Timms K., Tate W.P., Moens L., Trotman C.N.
    Biochem. Mol. Biol. Int. 30:643-647(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  4. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  5. "Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties."
    Geuens E., Hoogewijs D., Nardini M., Vinck E., Pesce A., Kiger L., Fago A., Tilleman L., De Henau S., Marden M.C., Weber R.E., Van Doorslaer S., Vanfleteren J., Moens L., Bolognesi M., Dewilde S.
    BMC Biochem. 11:17-17(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS), SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, IRON-BINDING SITE.

Entry informationi

Entry nameiGLBH_CAEEL
AccessioniPrimary (citable) accession number: P30627
Secondary accession number(s): Q26332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.