Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sorcin

Gene

SRI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi83 – 941CuratedAdd BLAST12
Calcium bindingi113 – 1242CuratedAdd BLAST12

GO - Molecular functioni

  • calcium channel regulator activity Source: ProtInc
  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • calcium ion binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor binding Source: ProtInc

GO - Biological processi

  • action potential Source: ProtInc
  • calcium ion transport Source: Ensembl
  • cytoplasmic sequestering of transcription factor Source: Ensembl
  • heart development Source: ProtInc
  • intracellular sequestering of iron ion Source: ProtInc
  • muscle organ development Source: ProtInc
  • negative regulation of heart rate Source: BHF-UCL
  • negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
  • negative regulation of transcription regulatory region DNA binding Source: Ensembl
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  • positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  • proteolysis Source: GO_Central
  • regulation of calcium ion transport Source: BHF-UCL
  • regulation of cardiac muscle cell contraction Source: BHF-UCL
  • regulation of cell communication by electrical coupling Source: BHF-UCL
  • regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • regulation of heart contraction Source: ProtInc
  • regulation of high voltage-gated calcium channel activity Source: BHF-UCL
  • regulation of relaxation of muscle Source: BHF-UCL
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
  • regulation of striated muscle contraction Source: ProtInc
  • signal transduction Source: UniProtKB
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075142-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.
R-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-425561. Sodium/Calcium exchangers.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.
SIGNORiP30626.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorcin
Alternative name(s):
22 kDa protein
CP-22
Short name:
CP22
V19
Gene namesi
Name:SRI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11292. SRI.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • cytoplasm Source: UniProtKB
  • cytosol Source: BHF-UCL
  • dendritic spine neck Source: Ensembl
  • endoplasmic reticulum membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • membrane Source: BHF-UCL
  • mitochondrion Source: Ensembl
  • nucleoplasm Source: HPA
  • sarcoplasmic reticulum Source: BHF-UCL
  • sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
  • smooth endoplasmic reticulum Source: Ensembl
  • T-tubule Source: BHF-UCL
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi112F → L: Reduces affinity for calcium 5-fold. 1

Organism-specific databases

DisGeNETi6717.
OpenTargetsiENSG00000075142.
PharmGKBiPA36117.

Polymorphism and mutation databases

BioMutaiSRI.
DMDMi267021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737251 – 198SorcinAdd BLAST198

Proteomic databases

EPDiP30626.
MaxQBiP30626.
PaxDbiP30626.
PeptideAtlasiP30626.
PRIDEiP30626.
TopDownProteomicsiP30626-1. [P30626-1]

2D gel databases

OGPiP30626.

PTM databases

iPTMnetiP30626.
PhosphoSitePlusiP30626.
SwissPalmiP30626.

Expressioni

Tissue specificityi

Detected in cardiac myocytes.

Gene expression databases

BgeeiENSG00000075142.
CleanExiHS_SRI.
ExpressionAtlasiP30626. baseline and differential.
GenevisibleiP30626. HS.

Organism-specific databases

HPAiHPA019004.

Interactioni

Subunit structurei

Homodimer. Interacts with GCA, RYR2 and ANXA7.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANXA7P200732EBI-10816740,EBI-2338704
CALCOCO2Q131374EBI-750459,EBI-739580
PDE4CQ08493-33EBI-750459,EBI-10225541
PRR13Q9NZ813EBI-750459,EBI-740924
STAT3P407632EBI-750459,EBI-518675
TCF12Q990813EBI-750459,EBI-722877

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi112595. 37 interactors.
DIPiDIP-40970N.
IntActiP30626. 15 interactors.
MINTiMINT-4999795.
STRINGi9606.ENSP00000265729.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 32Combined sources5
Helixi36 – 43Combined sources8
Helixi44 – 46Combined sources3
Helixi51 – 60Combined sources10
Turni61 – 64Combined sources4
Beta strandi66 – 68Combined sources3
Helixi72 – 82Combined sources11
Beta strandi84 – 86Combined sources3
Beta strandi88 – 90Combined sources3
Helixi92 – 112Combined sources21
Beta strandi118 – 120Combined sources3
Helixi122 – 131Combined sources10
Helixi138 – 147Combined sources10
Beta strandi149 – 152Combined sources4
Beta strandi153 – 155Combined sources3
Helixi156 – 176Combined sources21
Helixi178 – 180Combined sources3
Beta strandi182 – 187Combined sources6
Helixi188 – 196Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JUOX-ray2.20A/B1-198[»]
2JC2X-ray2.50A/B/C/D1-198[»]
4U8DX-ray2.30A/B1-198[»]
4UPGX-ray2.10A30-198[»]
4USLX-ray1.65A1-198[»]
D1-32[»]
ProteinModelPortaliP30626.
SMRiP30626.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30626.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini70 – 103EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231982.
HOVERGENiHBG004492.
InParanoidiP30626.
OMAiGQQGVVN.
OrthoDBiEOG091G0ISY.
PhylomeDBiP30626.
TreeFamiTF314682.

Family and domain databases

CDDicd00051. EFh. 3 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDTDRSGTV DPQELQKALT TMGFRLSPQA VNSIAKRYST
160 170 180 190
NGKITFDDYI ACCVKLRALT DSFRRRDTAQ QGVVNFPYDD FIQCVMSV
Length:198
Mass (Da):21,676
Last modified:April 1, 1993 - v1
Checksum:iA4829C7650A5E3FA
GO
Isoform 2 (identifier: P30626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,345
Checksum:iA6B23B49FF8B9778
GO
Isoform 3 (identifier: P30626-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ
     191-198: FIQCVMSV → VSLRN

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,006
Checksum:i2F652A7283896808
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462771 – 17MAYPG…YYPGG → MQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_054463191 – 198FIQCVMSV → VSLRN in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12387 mRNA. Translation: AAA92155.1.
M32886 mRNA. Translation: AAA60588.1.
AK296601 mRNA. Translation: BAG59214.1.
BM739144 mRNA. No translation available.
AC003991 Genomic DNA. No translation available.
AC005075 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76909.1.
CH471091 Genomic DNA. Translation: EAW76910.1.
BC011025 mRNA. Translation: AAH11025.1.
CCDSiCCDS47638.1. [P30626-2]
CCDS5612.1. [P30626-1]
CCDS59063.1. [P30626-3]
PIRiS52094.
RefSeqiNP_001243820.1. NM_001256891.1.
NP_001243821.1. NM_001256892.1. [P30626-3]
NP_003121.1. NM_003130.3. [P30626-1]
NP_944490.1. NM_198901.1. [P30626-2]
UniGeneiHs.489040.

Genome annotation databases

EnsembliENST00000265729; ENSP00000265729; ENSG00000075142. [P30626-1]
ENST00000394641; ENSP00000378137; ENSG00000075142. [P30626-2]
ENST00000431660; ENSP00000391148; ENSG00000075142. [P30626-3]
GeneIDi6717.
KEGGihsa:6717.
UCSCiuc003ujq.3. human. [P30626-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12387 mRNA. Translation: AAA92155.1.
M32886 mRNA. Translation: AAA60588.1.
AK296601 mRNA. Translation: BAG59214.1.
BM739144 mRNA. No translation available.
AC003991 Genomic DNA. No translation available.
AC005075 Genomic DNA. No translation available.
CH471091 Genomic DNA. Translation: EAW76909.1.
CH471091 Genomic DNA. Translation: EAW76910.1.
BC011025 mRNA. Translation: AAH11025.1.
CCDSiCCDS47638.1. [P30626-2]
CCDS5612.1. [P30626-1]
CCDS59063.1. [P30626-3]
PIRiS52094.
RefSeqiNP_001243820.1. NM_001256891.1.
NP_001243821.1. NM_001256892.1. [P30626-3]
NP_003121.1. NM_003130.3. [P30626-1]
NP_944490.1. NM_198901.1. [P30626-2]
UniGeneiHs.489040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JUOX-ray2.20A/B1-198[»]
2JC2X-ray2.50A/B/C/D1-198[»]
4U8DX-ray2.30A/B1-198[»]
4UPGX-ray2.10A30-198[»]
4USLX-ray1.65A1-198[»]
D1-32[»]
ProteinModelPortaliP30626.
SMRiP30626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112595. 37 interactors.
DIPiDIP-40970N.
IntActiP30626. 15 interactors.
MINTiMINT-4999795.
STRINGi9606.ENSP00000265729.

PTM databases

iPTMnetiP30626.
PhosphoSitePlusiP30626.
SwissPalmiP30626.

Polymorphism and mutation databases

BioMutaiSRI.
DMDMi267021.

2D gel databases

OGPiP30626.

Proteomic databases

EPDiP30626.
MaxQBiP30626.
PaxDbiP30626.
PeptideAtlasiP30626.
PRIDEiP30626.
TopDownProteomicsiP30626-1. [P30626-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265729; ENSP00000265729; ENSG00000075142. [P30626-1]
ENST00000394641; ENSP00000378137; ENSG00000075142. [P30626-2]
ENST00000431660; ENSP00000391148; ENSG00000075142. [P30626-3]
GeneIDi6717.
KEGGihsa:6717.
UCSCiuc003ujq.3. human. [P30626-1]

Organism-specific databases

CTDi6717.
DisGeNETi6717.
GeneCardsiSRI.
HGNCiHGNC:11292. SRI.
HPAiHPA019004.
MIMi182520. gene.
neXtProtiNX_P30626.
OpenTargetsiENSG00000075142.
PharmGKBiPA36117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231982.
HOVERGENiHBG004492.
InParanoidiP30626.
OMAiGQQGVVN.
OrthoDBiEOG091G0ISY.
PhylomeDBiP30626.
TreeFamiTF314682.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075142-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.
R-HSA-418359. Reduction of cytosolic Ca++ levels.
R-HSA-425561. Sodium/Calcium exchangers.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.
SIGNORiP30626.

Miscellaneous databases

ChiTaRSiSRI. human.
EvolutionaryTraceiP30626.
GeneWikiiSRI_(gene).
GenomeRNAii6717.
PROiP30626.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075142.
CleanExiHS_SRI.
ExpressionAtlasiP30626. baseline and differential.
GenevisibleiP30626. HS.

Family and domain databases

CDDicd00051. EFh. 3 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORCN_HUMAN
AccessioniPrimary (citable) accession number: P30626
Secondary accession number(s): A8MTH6, B4DKK2, D6W5Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is encoded by an amplified gene in multidrug-resistant cells.
This protein has been shown to bind calcium with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.