P30621 (MOXR_METEA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MoxR

Alternative name(s):
Protein MxaR

Gene names

Name:	moxR
Synonyms:	mxaR
Ordered Locus Names:	MexAM1_META1p4534

Organism

Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP]

Taxonomic identifier

272630 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › Methylobacterium extorquens group › Methylobacterium extorquens

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in the regulation of formation of active methanol dehydrogenase.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the MoxR family.

Ontologies

Keywords
Biological process	Methanol utilization
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC methanol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Protein MoxR		PRO_0000096543
Regions
	Nucleotide binding	53 – 60	8	ATP Potential
Experimental info
	Sequence conflict	192	1	Missing in CAA69191. Ref.1
	Sequence conflict	255 – 265	11	GPAGIRLPGIA → APPHPLARHR in CAA69191. Ref.1
	Sequence conflict	327	1	Q → E in CAA69191. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P30621 [UniParc]. Last modified September 22, 2009. Version 3. Checksum: 7019BABA2856D94F	FASTA	343	38,614
	10 20 30 40 50 60 MNTLRPGDAM LTDWRDAAAR FEREIAKAVV GQDRAIRLLT IAIFARGHVM LEGDVGVGKT 70 80 90 100 110 120 TLLRAVARGL GGAYERVEGT VDMMPTDLIY HTYLGEDGRP RVEPGPVLRR AEDLSVFFFN 130 140 150 160 170 180 EINRARPQVH ALLLRIMAER SVSAFNREYR FPNLQVFADR NRVEREETFE LPAAARDRFL 190 200 210 220 230 240 MEIGMEAPRD ARARRDLVFD PRFHDTDRLT EEVEAGVLDF ERIGTIASAI QHAISAEPAI 250 260 270 280 290 300 EAYVVGLWEA LVRPGPAGIR LPGIAMDRLV QGGASPRGVA FLVRAARVRA WLEGRDWLVP 310 320 330 340 EDIRAVFPEV MAHRVFLEPV YEMRRAQIVP DLIRAVFETV PAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The methanol oxidation genes mxaFJGIR (S) ACKLD in Methylobacterium extorquens." Amaratunga K., Goodwin P.M., O'Connor C.D., Anthony C. FEMS Microbiol. Lett. 146:31-38(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Erratum Amaratunga K., Goodwin P.M., O'Connor C.D., Anthony C. FEMS Microbiol. Lett. 150:175-177(1997) [PubMed] [Europe PMC] [Abstract]
[3]	"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources." Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E. PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14718 / DSM 1338 / AM1.
[4]	"The second subunit of methanol dehydrogenase of Methylobacterium extorquens AM1." Nunn D.N., Day D., Anthony C. Biochem. J. 260:857-862(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07864 Genomic DNA. Translation: CAA69191.1. CP001510 Genomic DNA. Translation: ACS42165.1. X15792 Genomic DNA. No translation available.
RefSeq	YP_002965442.1. NC_012808.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P30621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACS42165; ACS42165; MexAM1_META1p4534.
GeneID	7994320.
KEGG	mea:Mex_1p4534.
PATRIC	22514711. VBIMetExt101010_4410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0714.
HOGENOM	HOG000236943.
OMA	RPRVEPG.
ProtClustDB	CLSK931578.
Enzyme and pathway databases
BioCyc	MEXT272630:GBY6-4279-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011703. ATPase_AAA-3. IPR016366. ATPase_chaperone_AAA_MoxR_prd. IPR001270. Chaprnin_ClpA/B. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF07726. AAA_3. 1 hit. [Graphical view]
PIRSF	PIRSF002849. AAA_ATPase_chaperone_MoxR_prd. 1 hit.
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MOXR_METEA

Accession

Primary (citable) accession number: P30621
Secondary accession number(s): C5AQA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	September 22, 2009
Last modified:	May 29, 2013
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program