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Protein

Protein transport protein SEC1

Gene

SEC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the final stage of protein secretion.

GO - Molecular functioni

  • SNARE binding Source: SGD

GO - Biological processi

  • exocytosis Source: SGD
  • positive regulation of vesicle fusion Source: SGD
  • protein transport Source: UniProtKB-KW
  • vesicle docking involved in exocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29754-MONOMER.
ReactomeiR-SCE-114516. Disinhibition of SNARE formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC1
Gene namesi
Name:SEC1
Ordered Locus Names:YDR164C
ORF Names:YD8358.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR164C.
SGDiS000002571. SEC1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Protein transport protein SEC1PRO_0000206297Add
BLAST

Proteomic databases

MaxQBiP30619.
TopDownProteomicsiP30619.

PTM databases

iPTMnetiP30619.

Interactioni

Subunit structurei

Interacts with MSO1.

GO - Molecular functioni

  • SNARE binding Source: SGD

Protein-protein interaction databases

BioGridi32215. 88 interactions.
DIPiDIP-2498N.
IntActiP30619. 15 interactions.
MINTiMINT-566939.

Structurei

3D structure databases

ProteinModelPortaliP30619.
SMRiP30619. Positions 26-644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005206.
HOGENOMiHOG000065951.
InParanoidiP30619.
KOiK15292.
OMAiPRERMEP.
OrthoDBiEOG7034S0.

Family and domain databases

Gene3Di3.40.50.1910. 3 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 3 hits.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

P30619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLIELQRN YLIGVLNQIE TKNNLKFLII DKTVETILSY LFLTPQELLN
60 70 80 90 100
NVTSVDLIDS PTRKGQSSIE AIYILEPTKY NINCIDADFM VRPPKYRRCH
110 120 130 140 150
IRFLPGLTNP IFQFFQSKRY IAQNLESFKP IELGFFVKES QFFETLQMEH
160 170 180 190 200
SLQVFFNNNC KALIPTNVRK IVGSLVSLCV ITGEYPIVRY SVSNPVEEED
210 220 230 240 250
ARNGNAVVNA NSLTRSIANA FQIAIDTYAR NNPDFPPQNT ERPRSILIIT
260 270 280 290 300
DRTLDPFAPI LHDFSYQAMA YDLVANVDTQ KDIYHYSAEN EAGEQEEKVS
310 320 330 340 350
KLVDLYDPDW IDLKHQHIMD ANEYIQGRIK ELIAKNPLLV DRSNVKNTTD
360 370 380 390 400
LLSVVAHLKD FDEERRRLIL HKTLVDECLG ENAERKLADI SAIEQNLSGF
410 420 430 440 450
GMDFSGEKIK HIIDDLLPAL AMKEPTILDK LRYIIAYALF RGGIIELDFI
460 470 480 490 500
KLLNFIGVTH EHENFQQYLK IFRNYDLIDF KLIKDKPKDK PFQKEWFHDT
510 520 530 540 550
LVNDPNIYHT SRFVPAVGNI LSKVIANPLL LSEQYFPYLK DKPIELLNEE
560 570 580 590 600
EFQAGLANTS ANSSSSLRNP RHKAAWTTKS SNIKKNIPRQ RFFYYVIGGI
610 620 630 640 650
SIPEIKAAYD QSNLKNRDIF IGSDEILTPT KFLDEVERLQ NPREFFKFKE
660 670 680 690 700
DQRQQVNPPD FLLREMKPVA QPVSHVHLKS QDNSPKSGTS SPKAAGSLKS
710 720
EPPEKEKKRS KFSRFLKRKS HHDK
Length:724
Mass (Da):83,480
Last modified:April 1, 1993 - v1
Checksum:iB3C12AD4E01273B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62451 Genomic DNA. Translation: CAA44308.1.
Z50046 Genomic DNA. Translation: CAA90384.1.
BK006938 Genomic DNA. Translation: DAA12004.1.
PIRiS17479.
RefSeqiNP_010448.1. NM_001180471.1.

Genome annotation databases

EnsemblFungiiYDR164C; YDR164C; YDR164C.
GeneIDi851742.
KEGGisce:YDR164C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62451 Genomic DNA. Translation: CAA44308.1.
Z50046 Genomic DNA. Translation: CAA90384.1.
BK006938 Genomic DNA. Translation: DAA12004.1.
PIRiS17479.
RefSeqiNP_010448.1. NM_001180471.1.

3D structure databases

ProteinModelPortaliP30619.
SMRiP30619. Positions 26-644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32215. 88 interactions.
DIPiDIP-2498N.
IntActiP30619. 15 interactions.
MINTiMINT-566939.

PTM databases

iPTMnetiP30619.

Proteomic databases

MaxQBiP30619.
TopDownProteomicsiP30619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR164C; YDR164C; YDR164C.
GeneIDi851742.
KEGGisce:YDR164C.

Organism-specific databases

EuPathDBiFungiDB:YDR164C.
SGDiS000002571. SEC1.

Phylogenomic databases

GeneTreeiENSGT00390000005206.
HOGENOMiHOG000065951.
InParanoidiP30619.
KOiK15292.
OMAiPRERMEP.
OrthoDBiEOG7034S0.

Enzyme and pathway databases

BioCyciYEAST:G3O-29754-MONOMER.
ReactomeiR-SCE-114516. Disinhibition of SNARE formation.

Miscellaneous databases

NextBioi969481.
PROiP30619.

Family and domain databases

Gene3Di3.40.50.1910. 3 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 3 hits.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene localized on chromosome IV."
    Aalto M.K., Ruohonen L., Hosono K., Keraenen S.
    Yeast 7:643-650(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 208353 / W303-1A.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSEC1_YEAST
AccessioniPrimary (citable) accession number: P30619
Secondary accession number(s): D6VSE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 11, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.