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Protein

Mannose-specific lectin

Gene
N/A
Organism
Galanthus nivalis (Common snowdrop)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mannose-specific lectin.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin, Mannose-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-specific lectin
Alternative name(s):
Agglutinin
LecGNA 2
OrganismiGalanthus nivalis (Common snowdrop)
Taxonomic identifieri4670 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesAmaryllidaceaeAmaryllidoideaeGalanthus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Or 23; in 70% of the moleculesAdd BLAST19
ChainiPRO_000002158620 – 128Mannose-specific lectinAdd BLAST109
PropeptideiPRO_0000021587129 – 157Removed in mature formAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 75

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28Combined sources3
Beta strandi31 – 33Combined sources3
Beta strandi38 – 41Combined sources4
Beta strandi44 – 48Combined sources5
Beta strandi54 – 58Combined sources5
Beta strandi61 – 65Combined sources5
Beta strandi76 – 79Combined sources4
Beta strandi85 – 88Combined sources4
Beta strandi94 – 97Combined sources4
Beta strandi107 – 111Combined sources5
Beta strandi117 – 121Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JPCX-ray2.00A24-132[»]
1MSAX-ray2.29A/B/C/D24-132[»]
1NIVX-ray3.00A/C24-132[»]
ProteinModelPortaliP30617.
SMRiP30617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30617.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 132Bulb-type lectinPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Contains 1 bulb-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKASLLILA AIFLGVITPS CLSDNILYSG ETLSTGEFLN YGSFVFIMQE
60 70 80 90 100
DCNLVLYDVD KPIWATNTGG LSRSCFLSMQ TDGNLVVYNP SNKPIWASNT
110 120 130 140 150
GGQNGNYVCI LQKDRNVVIY GTDRWATGTH TGLVGIPASP PSEKYPTAGK

IKLVTAK
Length:157
Mass (Da):16,917
Last modified:April 1, 1993 - v1
Checksum:iB63AE3124DA2252B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti21C → Y.1
Natural varianti74S → H.1
Natural varianti76F → Y.1
Natural varianti109C → S.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55556 mRNA. Translation: AAA33346.1.
PIRiS19735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55556 mRNA. Translation: AAA33346.1.
PIRiS19735.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JPCX-ray2.00A24-132[»]
1MSAX-ray2.29A/B/C/D24-132[»]
1NIVX-ray3.00A/C24-132[»]
ProteinModelPortaliP30617.
SMRiP30617.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP30617.

Family and domain databases

Gene3Di2.90.10.10. 1 hit.
InterProiIPR001480. Bulb-type_lectin_dom.
[Graphical view]
PfamiPF01453. B_lectin. 1 hit.
[Graphical view]
SMARTiSM00108. B_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF51110. SSF51110. 1 hit.
PROSITEiPS50927. BULB_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEC_GALNI
AccessioniPrimary (citable) accession number: P30617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.