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Protein

Myo-inositol transporter 2

Gene

ITR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Minor transporter for myo-inositol.

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • myo-inositol transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-33501-MONOMER
ReactomeiR-SCE-189200 Cellular hexose transport
R-SCE-429593 Inositol transporters

Protein family/group databases

TCDBi2.A.1.1.104 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 2
Gene namesi
Name:ITR2
Ordered Locus Names:YOL103W
ORF Names:HRB612
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL103W
SGDiS000005463 ITR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 152ExtracellularSequence analysisAdd BLAST27
Transmembranei153 – 173Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini174 – 179CytoplasmicSequence analysis6
Transmembranei180 – 200Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini201 – 209ExtracellularSequence analysis9
Transmembranei210 – 230Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini231 – 240CytoplasmicSequence analysis10
Transmembranei241 – 261Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini262 – 269ExtracellularSequence analysis8
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 359CytoplasmicSequence analysisAdd BLAST69
Transmembranei360 – 380Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini381 – 396ExtracellularSequence analysisAdd BLAST16
Transmembranei397 – 417Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini418 – 423CytoplasmicSequence analysis6
Transmembranei424 – 444Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini445 – 465ExtracellularSequence analysisAdd BLAST21
Transmembranei466 – 486Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini487 – 506CytoplasmicSequence analysisAdd BLAST20
Transmembranei507 – 527Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini528 – 533ExtracellularSequence analysis6
Transmembranei534 – 554Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini555 – 609CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504581 – 609Myo-inositol transporter 2Add BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30606
PaxDbiP30606
PRIDEiP30606

PTM databases

iPTMnetiP30606

Interactioni

Protein-protein interaction databases

BioGridi34300, 67 interactors
DIPiDIP-6553N
IntActiP30606, 1 interactor
STRINGi4932.YOL103W

Structurei

3D structure databases

ProteinModelPortaliP30606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144116
HOGENOMiHOG000202868
InParanoidiP30606
KOiK08150
OMAiVFQLMIT
OrthoDBiEOG092C305R

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC
60 70 80 90 100
EEDNDGQKPK KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT
110 120 130 140 150
FNQSISPFII TLTFVASISG FMFGYDTGYI SSALISINRD LDNKVLTYGE
160 170 180 190 200
KELITAATSL GALITSVGAG TAADVFGRRP CLMFSNLMFL IGAILQITAH
210 220 230 240 250
KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT VINSLWLTGG
260 270 280 290 300
QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG
310 320 330 340 350
DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE
360 370 380 390 400
LHTVPSNFRA LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI
410 420 430 440 450
IVSGTNFVFT LIAFFCIDKI GRRYILLIGL PGMTVALVIC AIAFHFLGIK
460 470 480 490 500
FNGADAVVAS DGFSSWGIVI IVFIIVYAAF YALGIGTVPW QQSELFPQNV
510 520 530 540 550
RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA GVACLSTIFC
560 570 580 590 600
YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF

EPTQEIVES
Length:609
Mass (Da):66,710
Last modified:October 3, 2006 - v2
Checksum:i5922363C7DF02EE1
GO

Sequence cautioni

The sequence BAA14367 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA88159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA99119 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90353 Genomic DNA Translation: BAA14367.1 Different initiation.
Z48149 Genomic DNA Translation: CAA88159.1 Different initiation.
Z74845 Genomic DNA Translation: CAA99119.1 Different initiation.
BK006948 Genomic DNA Translation: DAA10681.1
PIRiB40538
RefSeqiNP_014538.2, NM_001183357.1

Genome annotation databases

EnsemblFungiiYOL103W; YOL103W; YOL103W
GeneIDi854050
KEGGisce:YOL103W

Similar proteinsi

Entry informationi

Entry nameiITR2_YEAST
AccessioniPrimary (citable) accession number: P30606
Secondary accession number(s): D6W1W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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