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Protein

Myo-inositol transporter 2

Gene

ITR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Minor transporter for myo-inositol.

GO - Molecular functioni

  • glucose transmembrane transporter activity Source: GO_Central
  • myo-inositol transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • myo-inositol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33501-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-429593. Inositol transporters.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Protein family/group databases

TCDBi2.A.1.1.104. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 2
Gene namesi
Name:ITR2
Ordered Locus Names:YOL103W
ORF Names:HRB612
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL103W.
SGDiS000005463. ITR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 152ExtracellularSequence analysisAdd BLAST27
Transmembranei153 – 173Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini174 – 179CytoplasmicSequence analysis6
Transmembranei180 – 200Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini201 – 209ExtracellularSequence analysis9
Transmembranei210 – 230Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini231 – 240CytoplasmicSequence analysis10
Transmembranei241 – 261Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini262 – 269ExtracellularSequence analysis8
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 359CytoplasmicSequence analysisAdd BLAST69
Transmembranei360 – 380Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini381 – 396ExtracellularSequence analysisAdd BLAST16
Transmembranei397 – 417Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini418 – 423CytoplasmicSequence analysis6
Transmembranei424 – 444Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini445 – 465ExtracellularSequence analysisAdd BLAST21
Transmembranei466 – 486Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini487 – 506CytoplasmicSequence analysisAdd BLAST20
Transmembranei507 – 527Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini528 – 533ExtracellularSequence analysis6
Transmembranei534 – 554Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini555 – 609CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504581 – 609Myo-inositol transporter 2Add BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP30606.
PRIDEiP30606.

PTM databases

iPTMnetiP30606.

Interactioni

Protein-protein interaction databases

BioGridi34300. 29 interactors.
DIPiDIP-6553N.
MINTiMINT-689981.

Structurei

3D structure databases

ProteinModelPortaliP30606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
InParanoidiP30606.
KOiK08150.
OMAiYVNTEDE.
OrthoDBiEOG092C305R.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC
60 70 80 90 100
EEDNDGQKPK KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT
110 120 130 140 150
FNQSISPFII TLTFVASISG FMFGYDTGYI SSALISINRD LDNKVLTYGE
160 170 180 190 200
KELITAATSL GALITSVGAG TAADVFGRRP CLMFSNLMFL IGAILQITAH
210 220 230 240 250
KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT VINSLWLTGG
260 270 280 290 300
QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG
310 320 330 340 350
DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE
360 370 380 390 400
LHTVPSNFRA LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI
410 420 430 440 450
IVSGTNFVFT LIAFFCIDKI GRRYILLIGL PGMTVALVIC AIAFHFLGIK
460 470 480 490 500
FNGADAVVAS DGFSSWGIVI IVFIIVYAAF YALGIGTVPW QQSELFPQNV
510 520 530 540 550
RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA GVACLSTIFC
560 570 580 590 600
YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF

EPTQEIVES
Length:609
Mass (Da):66,710
Last modified:October 3, 2006 - v2
Checksum:i5922363C7DF02EE1
GO

Sequence cautioni

The sequence BAA14367 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA88159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA99119 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90353 Genomic DNA. Translation: BAA14367.1. Different initiation.
Z48149 Genomic DNA. Translation: CAA88159.1. Different initiation.
Z74845 Genomic DNA. Translation: CAA99119.1. Different initiation.
BK006948 Genomic DNA. Translation: DAA10681.1.
PIRiB40538.
RefSeqiNP_014538.2. NM_001183357.1.

Genome annotation databases

EnsemblFungiiYOL103W; YOL103W; YOL103W.
GeneIDi854050.
KEGGisce:YOL103W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90353 Genomic DNA. Translation: BAA14367.1. Different initiation.
Z48149 Genomic DNA. Translation: CAA88159.1. Different initiation.
Z74845 Genomic DNA. Translation: CAA99119.1. Different initiation.
BK006948 Genomic DNA. Translation: DAA10681.1.
PIRiB40538.
RefSeqiNP_014538.2. NM_001183357.1.

3D structure databases

ProteinModelPortaliP30606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34300. 29 interactors.
DIPiDIP-6553N.
MINTiMINT-689981.

Protein family/group databases

TCDBi2.A.1.1.104. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP30606.

Proteomic databases

MaxQBiP30606.
PRIDEiP30606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL103W; YOL103W; YOL103W.
GeneIDi854050.
KEGGisce:YOL103W.

Organism-specific databases

EuPathDBiFungiDB:YOL103W.
SGDiS000005463. ITR2.

Phylogenomic databases

GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
InParanoidiP30606.
KOiK08150.
OMAiYVNTEDE.
OrthoDBiEOG092C305R.

Enzyme and pathway databases

BioCyciYEAST:G3O-33501-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-429593. Inositol transporters.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiP30606.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITR2_YEAST
AccessioniPrimary (citable) accession number: P30606
Secondary accession number(s): D6W1W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.