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Protein

Myo-inositol transporter 1

Gene

ITR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major transporter for myo-inositol.

GO - Molecular functioni

  • glucose transmembrane transporter activity Source: GO_Central
  • myo-inositol transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • myo-inositol transport Source: SGD
  • pseudohyphal growth Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30020-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-429593. Inositol transporters.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Protein family/group databases

TCDBi2.A.1.1.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 1
Gene namesi
Name:ITR1
Ordered Locus Names:YDR497C
ORF Names:D9719.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR497C.
SGDiS000002905. ITR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 129ExtracellularSequence analysisAdd BLAST27
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini151 – 163CytoplasmicSequence analysisAdd BLAST13
Transmembranei164 – 184Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini185 – 186ExtracellularSequence analysis2
Transmembranei187 – 207Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini208 – 215CytoplasmicSequence analysis8
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 246ExtracellularSequence analysis10
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 349CytoplasmicSequence analysisAdd BLAST82
Transmembranei350 – 370Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini371 – 376ExtracellularSequence analysis6
Transmembranei377 – 397Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini398 – 400CytoplasmicSequence analysis3
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 441ExtracellularSequence analysisAdd BLAST20
Transmembranei442 – 462Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini463 – 486CytoplasmicSequence analysisAdd BLAST24
Transmembranei487 – 507Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini508 – 510ExtracellularSequence analysis3
Transmembranei511 – 531Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini532 – 584CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504551 – 584Myo-inositol transporter 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources2 Publications

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30605.
PRIDEiP30605.
TopDownProteomicsiP30605.

PTM databases

iPTMnetiP30605.

Interactioni

Protein-protein interaction databases

BioGridi32548. 82 interactors.
DIPiDIP-7406N.
IntActiP30605. 23 interactors.
MINTiMINT-1356907.

Structurei

3D structure databases

ProteinModelPortaliP30605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
InParanoidiP30605.
KOiK08150.
OMAiLHANPAN.
OrthoDBiEOG092C305R.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ
60 70 80 90 100
RAPASDDEDR IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF
110 120 130 140 150
GYDTGYISSA LISIGTDLDH KVLTYGEKEI VTAATSLGAL ITSIFAGTAA
160 170 180 190 200
DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW QMAVGRLIMG FGVGIGSLIA
210 220 230 240 250
PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY VNNGWRILVG
260 270 280 290 300
LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER
310 320 330 340 350
KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF
360 370 380 390 400
TGWNSLMYFS GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR
410 420 430 440 450
TILLIGLPGM TMALVVCSIA FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF
460 470 480 490 500
IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI GTSYATATNW AGSLVIASTF
510 520 530 540 550
LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE EVQTILKDGF
560 570 580
NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI
Length:584
Mass (Da):63,570
Last modified:October 1, 1996 - v2
Checksum:i42543E30A102DC65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 44TL → HI in BAA14366 (PubMed:2040626).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90352 Genomic DNA. Translation: BAA14366.1.
U33057 Genomic DNA. Translation: AAB64939.1.
BK006938 Genomic DNA. Translation: DAA12329.1.
PIRiS69555.
RefSeqiNP_010785.1. NM_001180805.1.

Genome annotation databases

EnsemblFungiiYDR497C; YDR497C; YDR497C.
GeneIDi852108.
KEGGisce:YDR497C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90352 Genomic DNA. Translation: BAA14366.1.
U33057 Genomic DNA. Translation: AAB64939.1.
BK006938 Genomic DNA. Translation: DAA12329.1.
PIRiS69555.
RefSeqiNP_010785.1. NM_001180805.1.

3D structure databases

ProteinModelPortaliP30605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32548. 82 interactors.
DIPiDIP-7406N.
IntActiP30605. 23 interactors.
MINTiMINT-1356907.

Protein family/group databases

TCDBi2.A.1.1.8. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP30605.

Proteomic databases

MaxQBiP30605.
PRIDEiP30605.
TopDownProteomicsiP30605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR497C; YDR497C; YDR497C.
GeneIDi852108.
KEGGisce:YDR497C.

Organism-specific databases

EuPathDBiFungiDB:YDR497C.
SGDiS000002905. ITR1.

Phylogenomic databases

GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
InParanoidiP30605.
KOiK08150.
OMAiLHANPAN.
OrthoDBiEOG092C305R.

Enzyme and pathway databases

BioCyciYEAST:G3O-30020-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-429593. Inositol transporters.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiP30605.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITR1_YEAST
AccessioniPrimary (citable) accession number: P30605
Secondary accession number(s): D6VTB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.