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Protein

Myo-inositol transporter 1

Gene

ITR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major transporter for myo-inositol.

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • myo-inositol transport Source: SGD
  • pseudohyphal growth Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30020-MONOMER
ReactomeiR-SCE-189200 Cellular hexose transport
R-SCE-429593 Inositol transporters

Protein family/group databases

TCDBi2.A.1.1.8 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 1
Gene namesi
Name:ITR1
Ordered Locus Names:YDR497C
ORF Names:D9719.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR497C
SGDiS000002905 ITR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 129ExtracellularSequence analysisAdd BLAST27
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini151 – 163CytoplasmicSequence analysisAdd BLAST13
Transmembranei164 – 184Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini185 – 186ExtracellularSequence analysis2
Transmembranei187 – 207Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini208 – 215CytoplasmicSequence analysis8
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 246ExtracellularSequence analysis10
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 349CytoplasmicSequence analysisAdd BLAST82
Transmembranei350 – 370Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini371 – 376ExtracellularSequence analysis6
Transmembranei377 – 397Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini398 – 400CytoplasmicSequence analysis3
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 441ExtracellularSequence analysisAdd BLAST20
Transmembranei442 – 462Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini463 – 486CytoplasmicSequence analysisAdd BLAST24
Transmembranei487 – 507Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini508 – 510ExtracellularSequence analysis3
Transmembranei511 – 531Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini532 – 584CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504551 – 584Myo-inositol transporter 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP30605
PaxDbiP30605
PRIDEiP30605
TopDownProteomicsiP30605

PTM databases

iPTMnetiP30605

Interactioni

Protein-protein interaction databases

BioGridi32548, 113 interactors
DIPiDIP-7406N
IntActiP30605, 24 interactors
MINTiP30605
STRINGi4932.YDR497C

Structurei

3D structure databases

ProteinModelPortaliP30605
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
InParanoidiP30605
KOiK08150
OMAiLCEIRSQ
OrthoDBiEOG092C305R

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ
60 70 80 90 100
RAPASDDEDR IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF
110 120 130 140 150
GYDTGYISSA LISIGTDLDH KVLTYGEKEI VTAATSLGAL ITSIFAGTAA
160 170 180 190 200
DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW QMAVGRLIMG FGVGIGSLIA
210 220 230 240 250
PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY VNNGWRILVG
260 270 280 290 300
LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER
310 320 330 340 350
KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF
360 370 380 390 400
TGWNSLMYFS GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR
410 420 430 440 450
TILLIGLPGM TMALVVCSIA FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF
460 470 480 490 500
IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI GTSYATATNW AGSLVIASTF
510 520 530 540 550
LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE EVQTILKDGF
560 570 580
NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI
Length:584
Mass (Da):63,570
Last modified:October 1, 1996 - v2
Checksum:i42543E30A102DC65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 44TL → HI in BAA14366 (PubMed:2040626).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90352 Genomic DNA Translation: BAA14366.1
U33057 Genomic DNA Translation: AAB64939.1
BK006938 Genomic DNA Translation: DAA12329.1
PIRiS69555
RefSeqiNP_010785.1, NM_001180805.1

Genome annotation databases

EnsemblFungiiYDR497C; YDR497C; YDR497C
GeneIDi852108
KEGGisce:YDR497C

Similar proteinsi

Entry informationi

Entry nameiITR1_YEAST
AccessioniPrimary (citable) accession number: P30605
Secondary accession number(s): D6VTB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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