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P30597 (CHS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chitin synthase 1
EC=2.4.1.16
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Gene names
Name:chs1
ORF Names:SPAC13G6.12c, SPAC24B11.01c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length859 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a major role in cell wall biogenesis.

Catalytic activity

UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the chitin synthase family.

Ontologies

Keywords
   Biological processCell wall biogenesis/degradation
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processascospore wall assembly

Inferred from mutant phenotype. Source: GeneDB_Spombe

ascospore wall chitin biosynthetic process

Inferred from direct assay. Source: GeneDB_Spombe

   Cellular componentendoplasmic reticulum

Inferred from direct assay. Source: GeneDB_Spombe

integral to plasma membrane

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Molecular functionchitin synthase activity

Inferred from direct assay. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 859859Chitin synthase 1
PRO_0000193716

Regions

Transmembrane544 – 56421Helical; Potential
Transmembrane615 – 63521Helical; Potential
Transmembrane662 – 68221Helical; Potential
Transmembrane793 – 81321Helical; Potential
Transmembrane833 – 85321Helical; Potential

Experimental info

Sequence conflict2731K → R in AAA35297. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P30597 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 63443713A7ADE421

FASTA85997,990
        10         20         30         40         50         60 
MRRWFKKTLP RPPDEEESAG LTNKDIVETN HLYPTITNLS LNSDTSSILF DKNKKPLKPK 

        70         80         90        100        110        120 
IIIPDKEFDL DYYLKDETES IQSPFEGFTA QPNFSNFNKQ GNTMNREANF QRTNEKIQRN 

       130        140        150        160        170        180 
KSIKRVKLFH GNLILDCPIP KKLLVTLPQQ TEREFAYMRY SAATCDPQDF SKSLFTLRQP 

       190        200        210        220        230        240 
LFFQPRKTEI CIAITMYNED EVLFARTMHS VMKNISHLCT RKNSQVWGKD AWKKVVVCII 

       250        260        270        280        290        300 
SDGRTKIHPR TLAYLAAIGV YQDGIAKNQV NDKEVKAHIY EYTTQLSIDP NLKFKGSDRG 

       310        320        330        340        350        360 
IVPVQMIFCL KEKNQKKLNS HLWFFQAFCP ILKPEVCILL DAGTRPGDQS IYHLWKSFDL 

       370        380        390        400        410        420 
NPQVAGACGE IVVMKGKLGS GLINPLVATQ NFEYKMSNIL DKPVESVFGF ISVLPGAFSA 

       430        440        450        460        470        480 
YRFEALQNDS QGNGPLASYF KGELQNTGKS GIFEANMYLA EDRILCFELV SKKNEAWILH 

       490        500        510        520        530        540 
YVKSAYADTD VPDRIPEFVL QRRRWLNGSF FAAAYAICHY YRFFRTSHTI SRKFMLSIEF 

       550        560        570        580        590        600 
IYQLATIVFG WFNIGNFFII FYILTSSLAS TSANFLPGEI LFRIAIWIYA SLLVTCFVLA 

       610        620        630        640        650        660 
LGNRPHGSPN FYLSMVIMYS ILMGYLLFCS GWIAYRAISD AIHNASSTSS SYTSALLNSN 

       670        680        690        700        710        720 
VFINIVISLS STYGMYLVVS IISFDPWHMF TSFVQYIFLS IMYTNVLNVY AFCNTHDVSW 

       730        740        750        760        770        780 
GTKGDHFTNN DLGVARLLQK GADVEIAIPT NQSDIDAKYE DAVKLLASPS LEFNSPIINH 

       790        800        810        820        830        840 
GEQEDFYKNF RTYVVLTWIL SNLFLVGIVL SIPKINGISI SNNETSAYLS FLLWSVVAFS 

       850 
VFRFIGCIFY LFIRLCTGE

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Classification of fungal chitin synthases."
Bowen A.R., Chen-Wu J.L.-P., Momany M., Young R., Szaniszlo P.J., Robbins P.W.
Proc. Natl. Acad. Sci. U.S.A. 89:519-523(1992) [PubMed: 1731323] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-389.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA91105.1.
M82957 Genomic DNA. Translation: AAA35297.1.
PIRS62441.
RefSeqNP_592838.1. NM_001018239.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP30597.

Protein family/group databases

CAZyGT2. Glycosyltransferase Family 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC13G6.12c.1; SPAC13G6.12c.1:pep; SPAC13G6.12c.
GeneID2542858.
GenomeReviewsGene locus chs1 in contig CU329670_GR.
KEGGspo:SPAC13G6.12c.
NMPDRfig|4896.1.peg.2808.

Organism-specific databases

GeneDB_SpombeSPAC13G6.12c.

Phylogenomic databases

eggNOGfuNOG04531.
GeneTreeEFGT00050000001909.
HOGENOMHBG327157.
OMATMYNEDD.
OrthoDBEOG4GMZ52.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001975-MONOMER.

Gene expression databases

ArrayExpressP30597.

Family and domain databases

InterProIPR004834. Chitin_synth.
IPR013616. Chitin_synth_N.
[Graphical view]
KOK00698.
PfamPF01644. Chitin_synth_1. 1 hit.
PF08407. Chitin_synth_1N. 1 hit.
[Graphical view]
ProDomPD002998. Chitin_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameCHS1_SCHPO
AccessionPrimary (citable) accession number: P30597
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents