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Protein

Chitin synthase 1

Gene

chs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a major role in cell wall biogenesis.

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).

GO - Molecular functioni

  • chitin synthase activity Source: PomBase

GO - Biological processi

  • ascospore formation Source: PomBase
  • ascospore wall assembly Source: PomBase
  • ascospore wall chitin biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin synthase 1 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Gene namesi
Name:chs1
ORF Names:SPAC13G6.12c, SPAC24B11.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13G6.12c.
PomBaseiSPAC13G6.12c. chs1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei544 – 56421HelicalSequence analysisAdd
BLAST
Transmembranei615 – 63521HelicalSequence analysisAdd
BLAST
Transmembranei662 – 68221HelicalSequence analysisAdd
BLAST
Transmembranei793 – 81321HelicalSequence analysisAdd
BLAST
Transmembranei833 – 85321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • integral component of plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Chitin synthase 1PRO_0000193716Add
BLAST

Proteomic databases

MaxQBiP30597.

Interactioni

Protein-protein interaction databases

BioGridi279304. 2 interactions.
MINTiMINT-4688217.

Family & Domainsi

Sequence similaritiesi

Belongs to the chitin synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000162144.
InParanoidiP30597.
KOiK00698.
OMAiMGAYQDG.
OrthoDBiEOG7W6WV3.
PhylomeDBiP30597.

Family and domain databases

InterProiIPR004835. Chitin_synth.
IPR004834. Chitin_synth_fun.
IPR013616. Chitin_synth_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22914. PTHR22914. 1 hit.
PfamiPF01644. Chitin_synth_1. 1 hit.
PF08407. Chitin_synth_1N. 1 hit.
[Graphical view]
ProDomiPD002998. Chitin_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

P30597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRWFKKTLP RPPDEEESAG LTNKDIVETN HLYPTITNLS LNSDTSSILF
60 70 80 90 100
DKNKKPLKPK IIIPDKEFDL DYYLKDETES IQSPFEGFTA QPNFSNFNKQ
110 120 130 140 150
GNTMNREANF QRTNEKIQRN KSIKRVKLFH GNLILDCPIP KKLLVTLPQQ
160 170 180 190 200
TEREFAYMRY SAATCDPQDF SKSLFTLRQP LFFQPRKTEI CIAITMYNED
210 220 230 240 250
EVLFARTMHS VMKNISHLCT RKNSQVWGKD AWKKVVVCII SDGRTKIHPR
260 270 280 290 300
TLAYLAAIGV YQDGIAKNQV NDKEVKAHIY EYTTQLSIDP NLKFKGSDRG
310 320 330 340 350
IVPVQMIFCL KEKNQKKLNS HLWFFQAFCP ILKPEVCILL DAGTRPGDQS
360 370 380 390 400
IYHLWKSFDL NPQVAGACGE IVVMKGKLGS GLINPLVATQ NFEYKMSNIL
410 420 430 440 450
DKPVESVFGF ISVLPGAFSA YRFEALQNDS QGNGPLASYF KGELQNTGKS
460 470 480 490 500
GIFEANMYLA EDRILCFELV SKKNEAWILH YVKSAYADTD VPDRIPEFVL
510 520 530 540 550
QRRRWLNGSF FAAAYAICHY YRFFRTSHTI SRKFMLSIEF IYQLATIVFG
560 570 580 590 600
WFNIGNFFII FYILTSSLAS TSANFLPGEI LFRIAIWIYA SLLVTCFVLA
610 620 630 640 650
LGNRPHGSPN FYLSMVIMYS ILMGYLLFCS GWIAYRAISD AIHNASSTSS
660 670 680 690 700
SYTSALLNSN VFINIVISLS STYGMYLVVS IISFDPWHMF TSFVQYIFLS
710 720 730 740 750
IMYTNVLNVY AFCNTHDVSW GTKGDHFTNN DLGVARLLQK GADVEIAIPT
760 770 780 790 800
NQSDIDAKYE DAVKLLASPS LEFNSPIINH GEQEDFYKNF RTYVVLTWIL
810 820 830 840 850
SNLFLVGIVL SIPKINGISI SNNETSAYLS FLLWSVVAFS VFRFIGCIFY

LFIRLCTGE
Length:859
Mass (Da):97,990
Last modified:November 1, 1995 - v2
Checksum:i63443713A7ADE421
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731K → R in AAA35297 (PubMed:1731323).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91105.1.
M82957 Genomic DNA. Translation: AAA35297.1.
PIRiS62441.
RefSeqiNP_592838.1. NM_001018239.2.

Genome annotation databases

EnsemblFungiiSPAC13G6.12c.1; SPAC13G6.12c.1:pep; SPAC13G6.12c.
GeneIDi2542858.
KEGGispo:SPAC13G6.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91105.1.
M82957 Genomic DNA. Translation: AAA35297.1.
PIRiS62441.
RefSeqiNP_592838.1. NM_001018239.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279304. 2 interactions.
MINTiMINT-4688217.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Proteomic databases

MaxQBiP30597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13G6.12c.1; SPAC13G6.12c.1:pep; SPAC13G6.12c.
GeneIDi2542858.
KEGGispo:SPAC13G6.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAC13G6.12c.
PomBaseiSPAC13G6.12c. chs1.

Phylogenomic databases

HOGENOMiHOG000162144.
InParanoidiP30597.
KOiK00698.
OMAiMGAYQDG.
OrthoDBiEOG7W6WV3.
PhylomeDBiP30597.

Miscellaneous databases

PROiP30597.

Family and domain databases

InterProiIPR004835. Chitin_synth.
IPR004834. Chitin_synth_fun.
IPR013616. Chitin_synth_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22914. PTHR22914. 1 hit.
PfamiPF01644. Chitin_synth_1. 1 hit.
PF08407. Chitin_synth_1N. 1 hit.
[Graphical view]
ProDomiPD002998. Chitin_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 201-389.

Entry informationi

Entry nameiCHS1_SCHPO
AccessioniPrimary (citable) accession number: P30597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.