Reviewed, UniProtKB/Swiss-Prot P30583 (CHSC_EMENI)

Names and origin

Protein names

Recommended name:
    Chitin synthase C
    EC=2.4.1.16
Alternative name(s):
    Chitin-UDP acetyl-glucosaminyl transferase C
    Class-I chitin synthase C

Gene names

Name:	chsC
Synonyms:	chs1
ORF Names:	AN4566

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	983 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class I subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 983	983	Chitin synthase C		PRO_0000193690
Regions
	Transmembrane	605 – 625	21	Potential
	Transmembrane	637 – 657	21	Potential
	Transmembrane	672 – 692	21	Potential
	Transmembrane	715 – 735	21	Potential
	Transmembrane	745 – 765	21	Potential
	Transmembrane	845 – 865	21	Potential
	Transmembrane	890 – 910	21	Potential
Experimental info
	Sequence conflict	281 – 282	2	SK → RS in BAA75501. Ref.1
	Sequence conflict	675	1	L → F in BAA75501. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P30583-1 [UniParc]. Last modified May 26, 2009. Version 2. Checksum: 82F26E7FB2E37D5A	FASTA	983	112,088
	10 20 30 40 50 60 MSYNRLGDPY GDDRDARSPI MNPSSLSNRS PSPGRPLDGY QLSDAPYGHH HHIEMPSSDR 70 80 90 100 110 120 LAEQPTYSVE RIPQSYGHNE AYEAQHQHYP GYEYSVDPEA HHDAYYTQPY QPTVTPGHDD 130 140 150 160 170 180 YDLGQYPGHQ HSYQDDEPIL QPEDPFQAQN PYSDDYQEDM TIAPTPSPAP LRRWKTVKEV 190 200 210 220 230 240 QLFQGNLVLD CPIAPKLLNQ IPHAENGQRD EFTHMRYSAA TCDPKDFFEE RFTLRQKLFA 250 260 270 280 290 300 KPRHTELFIV VTMYNEDDFL FARTMVGVFK NIEHMCSRTR SKTWGKDAWK KIVVCVISDG 310 320 330 340 350 360 RAKINPRTRA VLAGLGCYQD GIAKQQVNGK DVTAHIYEYT TQVGMELKGN QVHLKPRSGV 370 380 390 400 410 420 PVQMIFCLKE KNQKKINSHR WFFQAFGRVL DPNICVLLDA GTQPGKDSIY RLWKAFDVEP 430 440 450 460 470 480 MCGGACGEIK VMLDHGKKLF NPLVAGQNFE YKLSNILDKP LESAFGFISV LPGAFSAYRY 490 500 510 520 530 540 IALQNDKNGQ GPLERYFLGE KMHGANAGIF TANMYLAEDR ILCFEIVTKR NCRWLLQYVK 550 560 570 580 590 600 SSTGETDVPD QMAEFILQRR RWLNGSFFAA VYAITHFYQL WRSDHSFIRK FMLLIETIYQ 610 620 630 640 650 660 TINMLFAWFG IGNFFLVFHI LTTYLGDADL LGTAGKVLGV VFEWLYLATL VTCFVLSLGN 670 680 690 700 710 720 RPGGSNKLYM TMVYLWVFIM IYLAFAAVFV TVRSIQEEVK DGSFTFSTLF TNSTFFSIIV 730 740 750 760 770 780 SLGSTYVMWF IASIIFMDPW HMFTCFIQYI LLTPTYINVL NIYAFCNTHD ITWGTKGDDK 790 800 810 820 830 840 AEKLPSANLK PGGKVDVNIP QDDGDLNAQY EAELMKFAQK PPKEIKTISE EERQADYYKG 850 860 870 880 890 900 FRSSVVLVWV FCNFALGAVV LSSAGLDRFS DDAEAAETDR NNRAMIYMAV VLWSVAGLSI 910 920 930 940 950 960 FKFLGAMWFL VVRMVSIFSR FISSVSTASN MICSSEVSNL FHRSRITLQA FNGRRFLSIP 970 980 AGSAYRNDDK DNGLWNVIVF MSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a chitin synthase gene (chsC) of Aspergillus nidulans." Motoyama T., Kojima N., Horiuchi H., Ohta A., Takagi M. Biosci. Biotechnol. Biochem. 58:2254-2257(1994) [PubMed: 7765719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FGSC 89.
[2]	Horiuchi H. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.
[4]	"Classification of fungal chitin synthases." Bowen A.R., Chen-Wu J.L.-P., Momany M., Young R., Szaniszlo P.J., Robbins P.W. Proc. Natl. Acad. Sci. U.S.A. 89:519-523(1992) [PubMed: 1731323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-446.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023911 Genomic DNA. Translation: BAA75501.1. AACD01000078 Genomic DNA. Translation: EAA60909.1. M82938 Genomic DNA. Translation: AAA33302.1.
PIR	A59054.
RefSeq	XP_662170.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Genome annotation databases
GeneID	2872365.
KEGG	ani:AN4566.2.
Enzyme and pathway databases
BRENDA	2.4.1.16. 3859.
Family and domain databases
InterPro	IPR004834. Chitin_synth. IPR013616. Chitin_synth_N. [Graphical view]
Pfam	PF01644. Chitin_synth_1. 1 hit. PF08407. Chitin_synth_1N. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHSC_EMENI

Accession

Primary (citable) accession number: P30583
Secondary accession number(s): O94165, Q5B4G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	May 26, 2009
Last modified:	October 13, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)