Reviewed, UniProtKB/Swiss-Prot P30577 (CHS2_AJECA)

Names and origin

Protein names

Recommended name:
    Chitin synthase 2
    EC=2.4.1.16
Alternative name(s):
    Chitin-UDP acetyl-glucosaminyl transferase 2
    Class-III chitin synthase 2

Gene names

Name:

CHS2

Organism

Ajellomyces capsulata (Darling's disease fungus) (Histoplasma capsulatum)

Taxonomic identifier

5037 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces

Protein attributes

Sequence length	194 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class III subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›194	›194	Chitin synthase 2		PRO_0000193675
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	194	1

Sequences

	Sequence		Length	Mass (Da)
	P30577-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: D765CD2FB4F74856	FASTA	194	21,690
	10 20 30 40 50 60 KMLTSRTLHG VMQNIRDIVN LKKSEFWNKG GPAWQKIAVC LVFDGIDPCD KDTLDVLATI 70 80 90 100 110 120 GIYQDGVMKK DVDGKETIAH IFEYTTQLSV TANQQLIRPH DDGPSTLPPV QMMFCLKQKN 130 140 150 160 170 180 SKKINSHRWL FNAFGRILNP EICILLDAGT KPGHKSLLAL WEAFYNDKDL GGSCGEIHAM 190 LGKGWKNLIN PLVA

References

[1]	"Classification of fungal chitin synthases." Bowen A.R., Chen-Wu J.L.-P., Momany M., Young R., Szaniszlo P.J., Robbins P.W. Proc. Natl. Acad. Sci. U.S.A. 89:519-523(1992) [PubMed: 1731323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M82948 Genomic DNA. Translation: AAA33381.1.
PIR	H45189.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Enzyme and pathway databases
BRENDA	2.4.1.16. 266116.
Family and domain databases
InterPro	IPR004834. Chitin_synth. [Graphical view]
Pfam	PF01644. Chitin_synth_1. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHS2_AJECA

Accession

Primary (citable) accession number: P30577

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	October 13, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)