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P30574

- CBPY_CANAX

UniProt

P30574 - CBPY_CANAX

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Protein

Carboxypeptidase Y

Gene

CPY1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in degradation of small peptides.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei269 – 2691By similarity
Active sitei461 – 4611By similarity
Binding sitei464 – 4641SubstrateBy similarity
Active sitei518 – 5181By similarity
Binding sitei519 – 5191SubstrateBy similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase YSCY
Gene namesi
Name:CPY1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Vacuole
Note: Lysosome-like vacuoles.

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 127106Sequence AnalysisPRO_0000004289Add
BLAST
Chaini128 – 542415Carboxypeptidase YPRO_0000004290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi182 ↔ 421By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi316 ↔ 330By similarity
Disulfide bondi340 ↔ 363By similarity
Disulfide bondi347 ↔ 356By similarity
Disulfide bondi385 ↔ 391By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Inductioni

Transiently down-regulated during the early events of yeast to hyphae conversion.

Structurei

3D structure databases

ProteinModelPortaliP30574.
SMRiP30574. Positions 132-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30574 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSKSTLIA TLALTATSTN ALVVQNPFSN IQQALKLDLS YDKLTSKLTD
60 70 80 90 100
TFEQGKANII STIAKVMNEP LDGLTPEIKN IWSEMLMKFP NSITELNFKA
110 120 130 140 150
PPKKGKITTQ QFDFHVTDAQ VPNHKLRIKS TPKDLGIDTV KQYSGYLDVV
160 170 180 190 200
DEDKHFFYYF FESRNDPKND PVILWLNGGP GCSSLTGLFF ELGPSSIDKN
210 220 230 240 250
LKPVYNPHSW NANASVIFLD QPINVGYSYS SQSVSNTIAA GKDVYAFLQL
260 270 280 290 300
FFKNFPEYAN LDFHIAGESY AGHYIPAFAS EILTHPERNF NLTSVLIGNG
310 320 330 340 350
LTDPLVQYEY YEPMACGEGG EPSVLEPEEC DGMLNSLPRC LSLIESCYES
360 370 380 390 400
GSVWSCVPAT IYCNNGQMGP YQKTGRNVYD IRTMCEGSSL CYSQLEYIDQ
410 420 430 440 450
YLNLPEVKKA LGAEVDEYQS CNFDINRNFM FAGDWMKPYQ KNVIDLLEKE
460 470 480 490 500
LPVLIYAGDK DFICNWLGNQ AWTNRLEWSG SKGFTKAPVK SWKVGKNAAG
510 520 530 540
EVKNYKHFTF LRVFGGGHMV PYDQPENALD MVNRWISGDY KY
Length:542
Mass (Da):61,044
Last modified:November 1, 1995 - v2
Checksum:i7FA6B9F82F9D44AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95182 Genomic DNA. Translation: AAA34326.2.
PIRiJC1380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95182 Genomic DNA. Translation: AAA34326.2 .
PIRi JC1380.

3D structure databases

ProteinModelPortali P30574.
SMRi P30574. Positions 132-540.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2939.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The carboxypeptidase Y-encoding gene from Candida albicans and its transcription during yeast-to-hyphae conversion."
    Mukhtar M., Logan D.A., Kaufer N.F.
    Gene 121:173-177(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCBPY_CANAX
AccessioniPrimary (citable) accession number: P30574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3