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P30568 (GSTA_PLEPL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase A

Short name=GST-A
EC=2.5.1.18
Alternative name(s):
GST class-theta
OrganismPleuronectes platessa (European plaice)
Taxonomic identifier8262 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPleuronectiformesPleuronectoideiPleuronectidaePleuronectinaePleuronectes

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Found in all the tissues examined. Highest values found in liver and in intestinal mucosa.

Induction

By epoxides and by antioxidants.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Glutathione S-transferase A
PRO_0000185946

Regions

Domain3 – 8583GST N-terminal
Domain92 – 217126GST C-terminal

Sites

Binding site181Glutathione Potential

Experimental info

Sequence conflict1401L → V figure 2 Ref.1
Sequence conflict143 – 1442EL → DV figure 2 Ref.1
Sequence conflict147 – 1482WE → SQ figure 2 Ref.1

Sequences

Sequence LengthMass (Da)Tools
P30568 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 37899602D07C077F

FASTA22525,724
        10         20         30         40         50         60 
MAKDMTLLWG SGSPPCWRVM IVLEEKNLQA YNSKLLSFEK GEHKSAEVMS MNPRGQLPSF 

        70         80         90        100        110        120 
KHGSKVLNES YAACMYLESQ FKSQGNKLIP DCPAEQAMMY QRMFEGLTLA QKMADVIYYS 

       130        140        150        160        170        180 
WKVPEAERHD SAVKRNKENL STELKLWEEY LQKTSGSFVA GKSFSLADVS VFPGVAYLFR 

       190        200        210        220 
FGLTEERYPQ LTAYYNSLKE RPSIKASWPP TWLESPQGQD MLKDV 

« Hide

References

[1]"Cloning and characterization of the major hepatic glutathione S-transferase from a marine teleost flatfish, the plaice (Pleuronectes platessa), with structural similarities to plant, insect and mammalian Theta class isoenzymes."
Leaver M.J., Scott K., George S.G.
Biochem. J. 292:189-195(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63761 mRNA. Translation: CAA45293.1.
PIRS33308.

3D structure databases

ProteinModelPortalP30568.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051851.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTA_PLEPL
AccessionPrimary (citable) accession number: P30568
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families