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P30568

- GSTA_PLEPL

UniProt

P30568 - GSTA_PLEPL

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Protein
Glutathione S-transferase A
Gene
N/A
Organism
Pleuronectes platessa (European plaice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181Glutathione Reviewed prediction

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A (EC:2.5.1.18)
Short name:
GST-A
Alternative name(s):
GST class-theta
OrganismiPleuronectes platessa (European plaice)
Taxonomic identifieri8262 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaePleuronectiformesPleuronectoideiPleuronectidaePleuronectinaePleuronectes

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Glutathione S-transferase A
PRO_0000185946Add
BLAST

Expressioni

Tissue specificityi

Found in all the tissues examined. Highest values found in liver and in intestinal mucosa.

Inductioni

By epoxides and by antioxidants.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP30568.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8583GST N-terminal
Add
BLAST
Domaini92 – 217126GST C-terminal
Add
BLAST

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

HOVERGENiHBG051851.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30568-1 [UniParc]FASTAAdd to Basket

« Hide

MAKDMTLLWG SGSPPCWRVM IVLEEKNLQA YNSKLLSFEK GEHKSAEVMS    50
MNPRGQLPSF KHGSKVLNES YAACMYLESQ FKSQGNKLIP DCPAEQAMMY 100
QRMFEGLTLA QKMADVIYYS WKVPEAERHD SAVKRNKENL STELKLWEEY 150
LQKTSGSFVA GKSFSLADVS VFPGVAYLFR FGLTEERYPQ LTAYYNSLKE 200
RPSIKASWPP TWLESPQGQD MLKDV 225
Length:225
Mass (Da):25,724
Last modified:April 1, 1993 - v1
Checksum:i37899602D07C077F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401L → V figure 2 1 Publication
Sequence conflicti143 – 1442EL → DV figure 2 1 Publication
Sequence conflicti147 – 1482WE → SQ figure 2 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63761 mRNA. Translation: CAA45293.1.
PIRiS33308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63761 mRNA. Translation: CAA45293.1 .
PIRi S33308.

3D structure databases

ProteinModelPortali P30568.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051851.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the major hepatic glutathione S-transferase from a marine teleost flatfish, the plaice (Pleuronectes platessa), with structural similarities to plant, insect and mammalian Theta class isoenzymes."
    Leaver M.J., Scott K., George S.G.
    Biochem. J. 292:189-195(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiGSTA_PLEPL
AccessioniPrimary (citable) accession number: P30568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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