Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

  • peptide hormone binding Source: RGD
  • V1A vasopressin receptor binding Source: UniProtKB
  • vasopressin receptor activity Source: RGD

GO - Biological processi

  • calcium-mediated signaling Source: RGD
  • cellular response to hormone stimulus Source: GO_Central
  • cellular response to water deprivation Source: RGD
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • grooming behavior Source: RGD
  • maternal aggressive behavior Source: RGD
  • maternal behavior Source: RGD
  • myotube differentiation Source: RGD
  • negative regulation of female receptivity Source: RGD
  • negative regulation of transmission of nerve impulse Source: RGD
  • penile erection Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cellular pH reduction Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of glutamate secretion Source: RGD
  • positive regulation of glycogen catabolic process Source: UniProtKB
  • positive regulation of heart rate Source: RGD
  • positive regulation of prostaglandin biosynthetic process Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of urine volume Source: UniProtKB
  • positive regulation of vasoconstriction Source: RGD
  • regulation of corticotropin secretion Source: UniProtKB
  • regulation of systemic arterial blood pressure by vasopressin Source: RGD
  • response to corticosterone Source: RGD
  • response to inorganic substance Source: RGD
  • response to organic substance Source: RGD
  • response to peptide Source: GO_Central
  • social behavior Source: UniProtKB
  • sperm ejaculation Source: RGD
  • telencephalon development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2185. Avpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 76Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 110Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 147Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 190Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini191 – 220ExtracellularSequence analysisAdd BLAST30
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 299CytoplasmicSequence analysisAdd BLAST58
Transmembranei300 – 319Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini320 – 337ExtracellularSequence analysisAdd BLAST18
Transmembranei338 – 357Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini358 – 424CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

  • cytoplasmic vesicle Source: RGD
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14N → Q: Reduced ligand binding affinity. 1 Publication1
Mutagenesisi27N → Q: Reduced ligand binding affinity. 1 Publication1
Mutagenesisi115Y → D: No significant change in affinity for arginine vasopressin or oxytocin. Increased affinity for 1-deamino, D-Arg8-vasopressin. 1 Publication1
Mutagenesisi115Y → F: 17-fold increase in affinity for oxytocin. No change in affinity for arginine vasopressin or 1-deamino, D-Arg8-vasopressin. 1 Publication1
Mutagenesisi115Y → L: 50-fold decrease in affinity for arginine vasopressin. Little affect on affinity for oxytocin or 1-deamino, D-Arg8-vasopressin. 1 Publication1
Mutagenesisi371C → G: Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-372. 1 Publication1
Mutagenesisi372C → G: Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-371. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2868.
GuidetoPHARMACOLOGYi366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702011 – 424Vasopressin V1a receptorAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Lipidationi371S-palmitoyl cysteine1 Publication1
Lipidationi372S-palmitoyl cysteine1 Publication1
Modified residuei410PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated on three cysteine residues, of which only two are identified.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30560.
PRIDEiP30560.

PTM databases

PhosphoSitePlusiP30560.
SwissPalmiP30560.

Expressioni

Tissue specificityi

Localized within gonadotropes of the anterior pituitary of the brain. Broadly distributed throughout the cerebral cortex.2 Publications

Gene expression databases

BgeeiENSRNOG00000004400.
ExpressionAtlasiP30560. baseline and differential.
GenevisibleiP30560. RN.

Interactioni

GO - Molecular functioni

  • V1A vasopressin receptor binding Source: UniProtKB

Protein-protein interaction databases

MINTiMINT-4996637.
STRINGi10116.ENSRNOP00000005829.

Chemistry databases

BindingDBiP30560.

Structurei

3D structure databases

ProteinModelPortaliP30560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30560.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiP30560.
TreeFamiTF106499.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSQDR SVGNSSPWWP LTTEGSNGSQ EAARLGEGDS PLGDVRNEEL
60 70 80 90 100
AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IATSWVLSFI LSTPQYFIFS VIEIEVNNGT
210 220 230 240 250
KTQDCWATFI QPWGTRAYVT WMTSGVFVAP VVVLGTCYGF ICYHIWRNIR
260 270 280 290 300
GKTASSRHSK GDKGSGEAVG PFHKGLLVTP CVSSVKSISR AKIRTVKMTF
310 320 330 340 350
VIVSAYILCW APFFIVQMWS VWDENFIWTD SENPSITITA LLASLNSCCN
360 370 380 390 400
PWIYMFFSGH LLQDCVQSFP CCHSMAQKFA KDDSDSMSRR QTSYSNNRSP
410 420
TNSTGMWKDS PKSSKSIRFI PVST
Length:424
Mass (Da):47,655
Last modified:June 13, 2006 - v4
Checksum:i4F452C8DF7B4C900
GO

Sequence cautioni

The sequence CAA77748 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115 – 116YR → SS (PubMed:8670090).Curated2
Sequence conflicti115 – 116YR → SS (PubMed:8511367).Curated2
Sequence conflicti390 – 424RQTSY…IPVST → KTDFLF in CAA77748 (PubMed:1560825).CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11690 mRNA. Translation: CAA77748.1. Different initiation.
U39450 Genomic DNA. Translation: AAC52507.1.
BC088095 Genomic DNA. Translation: AAH88095.1.
PIRiS71837.
RefSeqiNP_444178.2. NM_053019.2.
UniGeneiRn.32282.

Genome annotation databases

EnsembliENSRNOT00000005829; ENSRNOP00000005829; ENSRNOG00000004400.
GeneIDi25107.
KEGGirno:25107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11690 mRNA. Translation: CAA77748.1. Different initiation.
U39450 Genomic DNA. Translation: AAC52507.1.
BC088095 Genomic DNA. Translation: AAH88095.1.
PIRiS71837.
RefSeqiNP_444178.2. NM_053019.2.
UniGeneiRn.32282.

3D structure databases

ProteinModelPortaliP30560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996637.
STRINGi10116.ENSRNOP00000005829.

Chemistry databases

BindingDBiP30560.
ChEMBLiCHEMBL2868.
GuidetoPHARMACOLOGYi366.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP30560.
SwissPalmiP30560.

Proteomic databases

PaxDbiP30560.
PRIDEiP30560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005829; ENSRNOP00000005829; ENSRNOG00000004400.
GeneIDi25107.
KEGGirno:25107.

Organism-specific databases

CTDi552.
RGDi2185. Avpr1a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30560.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiP30560.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP30560.

Gene expression databases

BgeeiENSRNOG00000004400.
ExpressionAtlasiP30560. baseline and differential.
GenevisibleiP30560. RN.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1AR_RAT
AccessioniPrimary (citable) accession number: P30560
Secondary accession number(s): Q5M8D1, Q62874, Q9QW18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of AVPR1A in the brain increases the duration of social memory.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.