ID   OXYR_HUMAN              Reviewed;         389 AA.
AC   P30559; Q15071;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   24-JAN-2024, entry version 195.
DE   RecName: Full=Oxytocin receptor;
DE            Short=OT-R;
GN   Name=OXTR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-218.
RC   TISSUE=Uterus;
RX   PubMed=1313946; DOI=10.1038/356526a0;
RA   Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.;
RT   "Structure and expression of a human oxytocin receptor.";
RL   Nature 356:526-529(1992).
RN   [2]
RP   ERRATUM OF PUBMED:1313946, AND SEQUENCE REVISION.
RA   Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.;
RL   Nature 357:176-176(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-218.
RC   TISSUE=Ovary;
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
RX   PubMed=7798245; DOI=10.1016/s0021-9258(18)31656-9;
RA   Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T.,
RA   Kubota Y., Ogita K., Saji F.;
RT   "Structural organization of the human oxytocin receptor gene.";
RL   J. Biol. Chem. 269:32451-32456(1994).
CC   -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC       mediated by G proteins which activate a phosphatidylinositol-calcium
CC       second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Oxytocin entry;
CC       URL="https://en.wikipedia.org/wiki/Oxytocin";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X64878; CAA46097.1; -; mRNA.
DR   EMBL; AY389507; AAQ91333.1; -; mRNA.
DR   EMBL; X80282; CAA56562.1; -; Genomic_DNA.
DR   CCDS; CCDS2570.1; -.
DR   PIR; A55493; A55493.
DR   RefSeq; NP_000907.2; NM_000916.3.
DR   RefSeq; XP_011532064.1; XM_011533762.2.
DR   PDB; 6TPK; X-ray; 3.20 A; A=35-356.
DR   PDB; 7QVM; EM; 3.25 A; R=1-359.
DR   PDB; 7RYC; EM; 2.90 A; O=1-389.
DR   PDBsum; 6TPK; -.
DR   PDBsum; 7QVM; -.
DR   PDBsum; 7RYC; -.
DR   AlphaFoldDB; P30559; -.
DR   EMDB; EMD-14180; -.
DR   EMDB; EMD-24733; -.
DR   SMR; P30559; -.
DR   BioGRID; 111061; 14.
DR   ELM; P30559; -.
DR   IntAct; P30559; 18.
DR   MINT; P30559; -.
DR   STRING; 9606.ENSP00000324270; -.
DR   BindingDB; P30559; -.
DR   ChEMBL; CHEMBL2049; -.
DR   DrugBank; DB09059; Atosiban.
DR   DrugBank; DB01282; Carbetocin.
DR   DrugBank; DB00107; Oxytocin.
DR   DrugBank; DB13929; Relcovaptan.
DR   DrugBank; DB00067; Vasopressin.
DR   DrugCentral; P30559; -.
DR   GuidetoPHARMACOLOGY; 369; -.
DR   TCDB; 9.A.14.10.4; the g-protein-coupled receptor (gpcr) family.
DR   GlyCosmos; P30559; 3 sites, No reported glycans.
DR   GlyGen; P30559; 3 sites.
DR   iPTMnet; P30559; -.
DR   PhosphoSitePlus; P30559; -.
DR   SwissPalm; P30559; -.
DR   BioMuta; OXTR; -.
DR   DMDM; 143811431; -.
DR   MassIVE; P30559; -.
DR   MaxQB; P30559; -.
DR   PaxDb; 9606-ENSP00000324270; -.
DR   PeptideAtlas; P30559; -.
DR   ProteomicsDB; 54722; -.
DR   Antibodypedia; 10144; 410 antibodies from 35 providers.
DR   CPTC; P30559; 2 antibodies.
DR   DNASU; 5021; -.
DR   Ensembl; ENST00000316793.8; ENSP00000324270.2; ENSG00000180914.11.
DR   GeneID; 5021; -.
DR   KEGG; hsa:5021; -.
DR   MANE-Select; ENST00000316793.8; ENSP00000324270.2; NM_000916.4; NP_000907.2.
DR   UCSC; uc003brc.4; human.
DR   AGR; HGNC:8529; -.
DR   CTD; 5021; -.
DR   DisGeNET; 5021; -.
DR   GeneCards; OXTR; -.
DR   HGNC; HGNC:8529; OXTR.
DR   HPA; ENSG00000180914; Tissue enriched (breast).
DR   MalaCards; OXTR; -.
DR   MIM; 167055; gene.
DR   neXtProt; NX_P30559; -.
DR   OpenTargets; ENSG00000180914; -.
DR   PharmGKB; PA32858; -.
DR   VEuPathDB; HostDB:ENSG00000180914; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244882; -.
DR   HOGENOM; CLU_009579_15_3_1; -.
DR   InParanoid; P30559; -.
DR   OMA; AFIMCWT; -.
DR   OrthoDB; 2879183at2759; -.
DR   PhylomeDB; P30559; -.
DR   TreeFam; TF106499; -.
DR   PathwayCommons; P30559; -.
DR   Reactome; R-HSA-388479; Vasopressin-like receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   SignaLink; P30559; -.
DR   SIGNOR; P30559; -.
DR   BioGRID-ORCS; 5021; 15 hits in 1164 CRISPR screens.
DR   GeneWiki; Oxytocin_receptor; -.
DR   GenomeRNAi; 5021; -.
DR   Pharos; P30559; Tclin.
DR   PRO; PR:P30559; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P30559; Protein.
DR   Bgee; ENSG00000180914; Expressed in decidua and 142 other cell types or tissues.
DR   ExpressionAtlas; P30559; baseline and differential.
DR   GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004990; F:oxytocin receptor activity; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR   GO; GO:0042755; P:eating behavior; IEA:Ensembl.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0044849; P:estrous cycle; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0007595; P:lactation; TAS:ProtInc.
DR   GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR   GO; GO:0060137; P:maternal process involved in parturition; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0010701; P:positive regulation of norepinephrine secretion; IEA:Ensembl.
DR   GO; GO:0060406; P:positive regulation of penile erection; IEA:Ensembl.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR   GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR   GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR   GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR   GO; GO:0034059; P:response to anoxia; IEA:Ensembl.
DR   GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR   GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR   GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR   GO; GO:0001967; P:suckling behavior; IEA:Ensembl.
DR   GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR   CDD; cd15387; 7tmA_OT_R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002062; Oxytocn_rcpt.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF89; OXYTOCIN RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00665; OXYTOCINR.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P30559; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..389
FT                   /note="Oxytocin receptor"
FT                   /id="PRO_0000069998"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..63
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..97
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..294
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..332
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..389
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          7..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         366
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70536"
FT   MOD_RES         368
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70536"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        15
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        112..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         16
FT                   /note="A -> S (in dbSNP:rs237906)"
FT                   /id="VAR_031570"
FT   VARIANT         218
FT                   /note="A -> T (in dbSNP:rs4686302)"
FT                   /evidence="ECO:0000269|PubMed:1313946, ECO:0000269|Ref.3"
FT                   /id="VAR_031571"
FT   CONFLICT        308
FT                   /note="A -> G (in Ref. 4; CAA56562)"
FT                   /evidence="ECO:0000305"
FT   HELIX           36..66
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           75..91
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           94..101
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   STRAND          102..104
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           109..142
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   STRAND          144..146
FT                   /evidence="ECO:0007829|PDB:6TPK"
FT   HELIX           150..167
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   TURN            168..170
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           171..174
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   STRAND          175..181
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   STRAND          184..189
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   TURN            193..195
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           196..208
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           210..234
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   TURN            269..273
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           274..298
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           309..315
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           321..331
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   STRAND          332..334
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           335..344
FT                   /evidence="ECO:0007829|PDB:7RYC"
FT   HELIX           349..351
FT                   /evidence="ECO:0007829|PDB:6TPK"
SQ   SEQUENCE   389 AA;  42772 MW;  97E1845DA9676439 CRC64;
     MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV
     LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
     VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV
     ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA
     AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
     DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET
     SASKKSNSSS FVLSHRSSSQ RSCSQPSTA
//