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P30559

- OXYR_HUMAN

UniProt

P30559 - OXYR_HUMAN

Protein

Oxytocin receptor

Gene

OXTR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. oxytocin receptor activity Source: ProtInc
    2. peptide hormone binding Source: Ensembl
    3. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. digestive tract development Source: Ensembl
    3. eating behavior Source: Ensembl
    4. ERK1 and ERK2 cascade Source: Ensembl
    5. estrous cycle phase Source: Ensembl
    6. female pregnancy Source: ProtInc
    7. heart development Source: Ensembl
    8. lactation Source: ProtInc
    9. maternal behavior Source: Ensembl
    10. maternal process involved in parturition Source: Ensembl
    11. memory Source: Ensembl
    12. muscle contraction Source: ProtInc
    13. negative regulation of gastric acid secretion Source: Ensembl
    14. positive regulation of blood pressure Source: Ensembl
    15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    16. positive regulation of norepinephrine secretion Source: Ensembl
    17. positive regulation of penile erection Source: Ensembl
    18. positive regulation of synapse assembly Source: Ensembl
    19. positive regulation of synaptic transmission, GABAergic Source: Ensembl
    20. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
    21. positive regulation of uterine smooth muscle contraction Source: Ensembl
    22. response to amphetamine Source: Ensembl
    23. response to anoxia Source: Ensembl
    24. response to cocaine Source: Ensembl
    25. response to cytokine Source: Ensembl
    26. response to drug Source: Ensembl
    27. response to estradiol Source: Ensembl
    28. response to peptide hormone Source: Ensembl
    29. response to progesterone Source: Ensembl
    30. sleep Source: Ensembl
    31. social behavior Source: Ensembl
    32. sperm ejaculation Source: Ensembl
    33. suckling behavior Source: Ensembl
    34. telencephalon development Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinkiP30559.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxytocin receptor
    Short name:
    OT-R
    Gene namesi
    Name:OXTR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8529. OXTR.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell-cell adherens junction Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. microvillus Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Oxytocin receptorPRO_0000069998Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP30559.
    PaxDbiP30559.
    PRIDEiP30559.

    PTM databases

    PhosphoSiteiP30559.

    Expressioni

    Gene expression databases

    ArrayExpressiP30559.
    BgeeiP30559.
    CleanExiHS_OXTR.
    GenevestigatoriP30559.

    Organism-specific databases

    HPAiCAB022700.

    Interactioni

    Protein-protein interaction databases

    BioGridi111061. 2 interactions.
    STRINGi9606.ENSP00000324270.

    Structurei

    3D structure databases

    ProteinModelPortaliP30559.
    SMRiP30559. Positions 43-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 27550CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini295 – 30915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 38957CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29419Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33223Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP30559.
    KOiK04229.
    OMAiGPPRRNE.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiP30559.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30559-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL    50
    LLALSGNACV LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD 100
    ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR 150
    RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY 200
    ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG 250
    DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 300
    DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS 350
    YLKGRRLGET SASKKSNSSS FVLSHRSSSQ RSCSQPSTA 389
    Length:389
    Mass (Da):42,772
    Last modified:April 3, 2007 - v2
    Checksum:i97E1845DA9676439
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti308 – 3081A → G in CAA56562. (PubMed:7798245)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161A → S.
    Corresponds to variant rs237906 [ dbSNP | Ensembl ].
    VAR_031570
    Natural varianti218 – 2181A → T.2 Publications
    Corresponds to variant rs4686302 [ dbSNP | Ensembl ].
    VAR_031571

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64878 mRNA. Translation: CAA46097.1.
    AY389507 mRNA. Translation: AAQ91333.1.
    X80282 Genomic DNA. Translation: CAA56562.1.
    CCDSiCCDS2570.1.
    PIRiA55493.
    RefSeqiNP_000907.2. NM_000916.3.
    UniGeneiHs.2820.

    Genome annotation databases

    EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
    GeneIDi5021.
    KEGGihsa:5021.
    UCSCiuc003brc.3. human.

    Polymorphism databases

    DMDMi143811431.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Oxytocin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64878 mRNA. Translation: CAA46097.1 .
    AY389507 mRNA. Translation: AAQ91333.1 .
    X80282 Genomic DNA. Translation: CAA56562.1 .
    CCDSi CCDS2570.1.
    PIRi A55493.
    RefSeqi NP_000907.2. NM_000916.3.
    UniGenei Hs.2820.

    3D structure databases

    ProteinModelPortali P30559.
    SMRi P30559. Positions 43-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111061. 2 interactions.
    STRINGi 9606.ENSP00000324270.

    Chemistry

    BindingDBi P30559.
    ChEMBLi CHEMBL2049.
    DrugBanki DB01282. Carbetocin.
    GuidetoPHARMACOLOGYi 369.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30559.

    Polymorphism databases

    DMDMi 143811431.

    Proteomic databases

    MaxQBi P30559.
    PaxDbi P30559.
    PRIDEi P30559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316793 ; ENSP00000324270 ; ENSG00000180914 .
    GeneIDi 5021.
    KEGGi hsa:5021.
    UCSCi uc003brc.3. human.

    Organism-specific databases

    CTDi 5021.
    GeneCardsi GC03M008767.
    H-InvDB HIX0030783.
    HGNCi HGNC:8529. OXTR.
    HPAi CAB022700.
    MIMi 167055. gene.
    neXtProti NX_P30559.
    PharmGKBi PA32858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299951.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P30559.
    KOi K04229.
    OMAi GPPRRNE.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi P30559.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinki P30559.

    Miscellaneous databases

    GeneWikii Oxytocin_receptor.
    GenomeRNAii 5021.
    NextBioi 19332.
    PROi P30559.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P30559.
    Bgeei P30559.
    CleanExi HS_OXTR.
    Genevestigatori P30559.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of a human oxytocin receptor."
      Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
      Nature 356:526-529(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218.
      Tissue: Uterus.
    2. Erratum
      Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
      Nature 357:176-176(1992)
      Cited for: SEQUENCE REVISION.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218.
      Tissue: Ovary.
    4. "Structural organization of the human oxytocin receptor gene."
      Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F.
      J. Biol. Chem. 269:32451-32456(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.

    Entry informationi

    Entry nameiOXYR_HUMAN
    AccessioniPrimary (citable) accession number: P30559
    Secondary accession number(s): Q15071
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3