Reviewed, UniProtKB/Swiss-Prot P30559 (OXYR_HUMAN)

Names and origin

Protein names

Recommended name:
    Oxytocin receptor
      Short name=OT-R

Gene names

Name:

OXTR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW female pregnancy Ref.1 Traceable author statement. Source: ProtInc lactation Ref.1 Traceable author statement. Source: ProtInc muscle contraction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	oxytocin receptor activity Traceable author statement. Source: ProtInc vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Oxytocin receptor		PRO_0000069998
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 63	25	1 Potential
	Topological domain	64 – 74	11	Cytoplasmic Potential
	Transmembrane	75 – 97	23	2 Potential
	Topological domain	98 – 113	16	Extracellular Potential
	Transmembrane	114 – 135	22	3 Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 175	21	4 Potential
	Topological domain	176 – 202	27	Extracellular Potential
	Transmembrane	203 – 225	23	5 Potential
	Topological domain	226 – 275	50	Cytoplasmic Potential
	Transmembrane	276 – 294	19	6 Potential
	Topological domain	295 – 309	15	Extracellular Potential
	Transmembrane	310 – 332	23	7 Potential
	Topological domain	333 – 389	57	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 187		By similarity
Natural variations
	Natural variant	16	1	A → S: dbSNP rs237906.		VAR_031570
	Natural variant	218	1	A → T: dbSNP rs4686302. Ref.1 Ref.3		VAR_031571
Experimental info
	Sequence conflict	308	1	A → G in CAA56562. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P30559-1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 97E1845DA9676439	FASTA	389	42,772
	10 20 30 40 50 60 MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 70 80 90 100 110 120 LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 130 140 150 160 170 180 VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 190 200 210 220 230 240 ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 250 260 270 280 290 300 AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 310 320 330 340 350 360 DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 370 380 SASKKSNSSS FVLSHRSSSQ RSCSQPSTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of a human oxytocin receptor." Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H. Nature 356:526-529(1992) [PubMed: 1313946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218. Tissue: Uterus.
[2]	Erratum Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H. Nature 357:176-176(1992) Cited for: SEQUENCE REVISION.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218. Tissue: Ovary.
[4]	"Structural organization of the human oxytocin receptor gene." Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F. J. Biol. Chem. 269:32451-32456(1994) [PubMed: 7798245] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
+	Additional computationally mapped references.

Web resources

Wikipedia

Oxytocin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	X64878 mRNA. Translation: CAA46097.1. AY389507 mRNA. Translation: AAQ91333.1. X80282 Genomic DNA. Translation: CAA56562.1.
IPI	IPI00026886.
PIR	A55493.
RefSeq	NP_000907.2.
UniGene	Hs.2820
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P30559.
Genome annotation databases
Ensembl	ENSG00000180914. Homo sapiens. [Contig view]
GeneID	5021.
KEGG	hsa:5021.
Organism-specific databases
GeneCards	GC03M008767.
H-InvDB	HIX0030783.
HGNC	HGNC:8529. OXTR.
MIM	167055. gene.
PharmGKB	PA32858.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P30559.
HOVERGEN	P30559.
OMA	P30559. LMSLDRC.
Gene expression databases
ArrayExpress	P30559.
Bgee	P30559.
CleanEx	HS_OXTR.
GermOnline	ENSG00000180914. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002062. Oxytocn_rcpt. IPR001817. Vasoprsn_rcpt. [Graphical view]
PANTHER	PTHR19264:SF46. Oxytocn_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00665. OXYTOCINR. PR00896. VASOPRESSINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB01282. Carbetocin.
NextBio	19332.
SOURCE	Search...

Entry information

Entry name

OXYR_HUMAN

Accession

Primary (citable) accession number: P30559
Secondary accession number(s): Q15071

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 3, 2007
Last modified:	June 16, 2009
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)