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Reviewed, UniProtKB/Swiss-Prot P30559 (OXYR_HUMAN)

Last modified June 16, 2009. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Oxytocin receptor
      Short name=OT-R
Gene names
Name: OXTR
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Oxytocin receptor
PRO_0000069998

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 63251 Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 97232 Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 135223 Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 175214 Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 225235 Potential
Topological domain226 – 27550Cytoplasmic Potential
Transmembrane276 – 294196 Potential
Topological domain295 – 30915Extracellular Potential
Transmembrane310 – 332237 Potential
Topological domain333 – 38957Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Natural variations

Natural variant161A → S: dbSNP rs237906.
VAR_031570
Natural variant2181A → T: dbSNP rs4686302. Ref.1 Ref.3
VAR_031571

Experimental info

Sequence conflict3081A → G in CAA56562. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P30559-1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 97E1845DA9676439

FASTA38942,772
        10         20         30         40         50         60 
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 

       310        320        330        340        350        360 
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 

       370        380 
SASKKSNSSS FVLSHRSSSQ RSCSQPSTA 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of a human oxytocin receptor."
Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
Nature 356:526-529(1992) [PubMed: 1313946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218.
Tissue: Uterus.
[2]Erratum
Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
Nature 357:176-176(1992)
Cited for: SEQUENCE REVISION.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218.
Tissue: Ovary.
[4]"Structural organization of the human oxytocin receptor gene."
Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F.
J. Biol. Chem. 269:32451-32456(1994) [PubMed: 7798245] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
+Additional computationally mapped references.

Web resources

Wikipedia

Oxytocin entry

Cross-references

Sequence databases

X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
IPIIPI00026886.
PIRA55493.
RefSeqNP_000907.2.
UniGeneHs.2820

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP30559.

Genome annotation databases

EnsemblENSG00000180914. Homo sapiens. [Contig view]
GeneID5021.
KEGGhsa:5021.

Organism-specific databases

GeneCardsGC03M008767.
H-InvDBHIX0030783.
HGNCHGNC:8529. OXTR.
MIM167055. gene.
PharmGKBPA32858.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP30559.
HOVERGENP30559.
OMAP30559. LMSLDRC.

Gene expression databases

ArrayExpressP30559.
BgeeP30559.
CleanExHS_OXTR.
GermOnlineENSG00000180914. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERPTHR19264:SF46. Oxytocn_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01282. Carbetocin.
NextBio19332.
SOURCESearch...

Entry information

Entry nameOXYR_HUMAN
AccessionPrimary (citable) accession number: P30559
Secondary accession number(s): Q15071
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 3, 2007
Last modified: June 16, 2009
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents