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P30559

- OXYR_HUMAN

UniProt

P30559 - OXYR_HUMAN

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Protein

Oxytocin receptor

Gene
OXTR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. oxytocin receptor activity Source: ProtInc
  2. peptide hormone binding Source: Ensembl
  3. vasopressin receptor activity Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. digestive tract development Source: Ensembl
  3. eating behavior Source: Ensembl
  4. ERK1 and ERK2 cascade Source: Ensembl
  5. estrous cycle phase Source: Ensembl
  6. female pregnancy Source: ProtInc
  7. heart development Source: Ensembl
  8. lactation Source: ProtInc
  9. maternal behavior Source: Ensembl
  10. maternal process involved in parturition Source: Ensembl
  11. memory Source: Ensembl
  12. muscle contraction Source: ProtInc
  13. negative regulation of gastric acid secretion Source: Ensembl
  14. positive regulation of blood pressure Source: Ensembl
  15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  16. positive regulation of norepinephrine secretion Source: Ensembl
  17. positive regulation of penile erection Source: Ensembl
  18. positive regulation of synapse assembly Source: Ensembl
  19. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  20. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  21. positive regulation of uterine smooth muscle contraction Source: Ensembl
  22. response to amphetamine Source: Ensembl
  23. response to anoxia Source: Ensembl
  24. response to cocaine Source: Ensembl
  25. response to cytokine Source: Ensembl
  26. response to drug Source: Ensembl
  27. response to estradiol Source: Ensembl
  28. response to peptide hormone Source: Ensembl
  29. response to progesterone Source: Ensembl
  30. sleep Source: Ensembl
  31. social behavior Source: Ensembl
  32. sperm ejaculation Source: Ensembl
  33. suckling behavior Source: Ensembl
  34. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP30559.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:OXTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8529. OXTR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Extracellular Reviewed predictionAdd
BLAST
Transmembranei39 – 6325Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini64 – 7411Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei75 – 9723Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini98 – 11316Extracellular Reviewed predictionAdd
BLAST
Transmembranei114 – 13522Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini136 – 15419Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei155 – 17521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini176 – 20227Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22523Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini226 – 27550Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei276 – 29419Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini295 – 30915Extracellular Reviewed predictionAdd
BLAST
Transmembranei310 – 33223Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini333 – 38957Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell-cell adherens junction Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. microvillus Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Oxytocin receptorPRO_0000069998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP30559.
PaxDbiP30559.
PRIDEiP30559.

PTM databases

PhosphoSiteiP30559.

Expressioni

Gene expression databases

ArrayExpressiP30559.
BgeeiP30559.
CleanExiHS_OXTR.
GenevestigatoriP30559.

Organism-specific databases

HPAiCAB022700.

Interactioni

Protein-protein interaction databases

BioGridi111061. 2 interactions.
STRINGi9606.ENSP00000324270.

Structurei

3D structure databases

ProteinModelPortaliP30559.
SMRiP30559. Positions 43-331.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30559.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
PhylomeDBiP30559.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30559-1 [UniParc]FASTAAdd to Basket

« Hide

MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL    50
LLALSGNACV LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD 100
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR 150
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY 200
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG 250
DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 300
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS 350
YLKGRRLGET SASKKSNSSS FVLSHRSSSQ RSCSQPSTA 389
Length:389
Mass (Da):42,772
Last modified:April 3, 2007 - v2
Checksum:i97E1845DA9676439
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → S.
Corresponds to variant rs237906 [ dbSNP | Ensembl ].
VAR_031570
Natural varianti218 – 2181A → T.2 Publications
Corresponds to variant rs4686302 [ dbSNP | Ensembl ].
VAR_031571

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti308 – 3081A → G in CAA56562. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSiCCDS2570.1.
PIRiA55493.
RefSeqiNP_000907.2. NM_000916.3.
UniGeneiHs.2820.

Genome annotation databases

EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
GeneIDi5021.
KEGGihsa:5021.
UCSCiuc003brc.3. human.

Polymorphism databases

DMDMi143811431.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Oxytocin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64878 mRNA. Translation: CAA46097.1 .
AY389507 mRNA. Translation: AAQ91333.1 .
X80282 Genomic DNA. Translation: CAA56562.1 .
CCDSi CCDS2570.1.
PIRi A55493.
RefSeqi NP_000907.2. NM_000916.3.
UniGenei Hs.2820.

3D structure databases

ProteinModelPortali P30559.
SMRi P30559. Positions 43-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111061. 2 interactions.
STRINGi 9606.ENSP00000324270.

Chemistry

BindingDBi P30559.
ChEMBLi CHEMBL2049.
DrugBanki DB01282. Carbetocin.
GuidetoPHARMACOLOGYi 369.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P30559.

Polymorphism databases

DMDMi 143811431.

Proteomic databases

MaxQBi P30559.
PaxDbi P30559.
PRIDEi P30559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316793 ; ENSP00000324270 ; ENSG00000180914 .
GeneIDi 5021.
KEGGi hsa:5021.
UCSCi uc003brc.3. human.

Organism-specific databases

CTDi 5021.
GeneCardsi GC03M008767.
H-InvDB HIX0030783.
HGNCi HGNC:8529. OXTR.
HPAi CAB022700.
MIMi 167055. gene.
neXtProti NX_P30559.
PharmGKBi PA32858.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299951.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi P30559.
KOi K04229.
OMAi GPPRRNE.
OrthoDBi EOG7Z69CP.
PhylomeDBi P30559.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinki P30559.

Miscellaneous databases

GeneWikii Oxytocin_receptor.
GenomeRNAii 5021.
NextBioi 19332.
PROi P30559.
SOURCEi Search...

Gene expression databases

ArrayExpressi P30559.
Bgeei P30559.
CleanExi HS_OXTR.
Genevestigatori P30559.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a human oxytocin receptor."
    Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
    Nature 356:526-529(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218.
    Tissue: Uterus.
  2. Erratum
    Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
    Nature 357:176-176(1992)
    Cited for: SEQUENCE REVISION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218.
    Tissue: Ovary.
  4. "Structural organization of the human oxytocin receptor gene."
    Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F.
    J. Biol. Chem. 269:32451-32456(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.

Entry informationi

Entry nameiOXYR_HUMAN
AccessioniPrimary (citable) accession number: P30559
Secondary accession number(s): Q15071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3