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Protein

Oxytocin receptor

Gene

OXTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. oxytocin receptor activity Source: ProtInc
  2. peptide binding Source: GO_Central
  3. peptide hormone binding Source: Ensembl
  4. vasopressin receptor activity Source: GO_Central

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. cellular response to hormone stimulus Source: GO_Central
  3. digestive tract development Source: Ensembl
  4. eating behavior Source: Ensembl
  5. ERK1 and ERK2 cascade Source: Ensembl
  6. female pregnancy Source: ProtInc
  7. G-protein coupled receptor signaling pathway Source: GO_Central
  8. heart development Source: Ensembl
  9. lactation Source: ProtInc
  10. maternal behavior Source: GO_Central
  11. maternal process involved in parturition Source: Ensembl
  12. memory Source: Ensembl
  13. muscle contraction Source: ProtInc
  14. negative regulation of gastric acid secretion Source: Ensembl
  15. positive regulation of blood pressure Source: Ensembl
  16. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  17. positive regulation of norepinephrine secretion Source: Ensembl
  18. positive regulation of penile erection Source: Ensembl
  19. positive regulation of synapse assembly Source: Ensembl
  20. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  21. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  22. positive regulation of uterine smooth muscle contraction Source: Ensembl
  23. positive regulation of vasoconstriction Source: GO_Central
  24. regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  25. response to amphetamine Source: Ensembl
  26. response to anoxia Source: Ensembl
  27. response to cocaine Source: Ensembl
  28. response to cytokine Source: Ensembl
  29. response to drug Source: Ensembl
  30. response to estradiol Source: Ensembl
  31. response to peptide Source: GO_Central
  32. response to peptide hormone Source: Ensembl
  33. response to progesterone Source: Ensembl
  34. sleep Source: Ensembl
  35. social behavior Source: GO_Central
  36. sperm ejaculation Source: Ensembl
  37. suckling behavior Source: Ensembl
  38. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP30559.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:OXTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8529. OXTR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 27550CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei276 – 29419Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini295 – 30915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini333 – 38957CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell-cell adherens junction Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. microvillus Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32858.

Chemistry

DrugBankiDB01282. Carbetocin.
DB00107. Oxytocin.

Polymorphism and mutation databases

BioMutaiOXTR.
DMDMi143811431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Oxytocin receptorPRO_0000069998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP30559.
PaxDbiP30559.
PRIDEiP30559.

PTM databases

PhosphoSiteiP30559.

Expressioni

Gene expression databases

BgeeiP30559.
CleanExiHS_OXTR.
ExpressionAtlasiP30559. baseline and differential.
GenevestigatoriP30559.

Organism-specific databases

HPAiCAB022700.

Interactioni

Protein-protein interaction databases

BioGridi111061. 2 interactions.
STRINGi9606.ENSP00000324270.

Structurei

3D structure databases

ProteinModelPortaliP30559.
SMRiP30559. Positions 43-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30559.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
PhylomeDBiP30559.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
LLALSGNACV LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG
260 270 280 290 300
DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
310 320 330 340 350
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS
360 370 380
YLKGRRLGET SASKKSNSSS FVLSHRSSSQ RSCSQPSTA
Length:389
Mass (Da):42,772
Last modified:April 3, 2007 - v2
Checksum:i97E1845DA9676439
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti308 – 3081A → G in CAA56562 (PubMed:7798245).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → S.
Corresponds to variant rs237906 [ dbSNP | Ensembl ].
VAR_031570
Natural varianti218 – 2181A → T.2 Publications
Corresponds to variant rs4686302 [ dbSNP | Ensembl ].
VAR_031571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSiCCDS2570.1.
PIRiA55493.
RefSeqiNP_000907.2. NM_000916.3.
UniGeneiHs.2820.

Genome annotation databases

EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
GeneIDi5021.
KEGGihsa:5021.
UCSCiuc003brc.3. human.

Polymorphism and mutation databases

BioMutaiOXTR.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Oxytocin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSiCCDS2570.1.
PIRiA55493.
RefSeqiNP_000907.2. NM_000916.3.
UniGeneiHs.2820.

3D structure databases

ProteinModelPortaliP30559.
SMRiP30559. Positions 43-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111061. 2 interactions.
STRINGi9606.ENSP00000324270.

Chemistry

BindingDBiP30559.
ChEMBLiCHEMBL2049.
DrugBankiDB01282. Carbetocin.
DB00107. Oxytocin.
GuidetoPHARMACOLOGYi369.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30559.

Polymorphism and mutation databases

BioMutaiOXTR.
DMDMi143811431.

Proteomic databases

MaxQBiP30559.
PaxDbiP30559.
PRIDEiP30559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
GeneIDi5021.
KEGGihsa:5021.
UCSCiuc003brc.3. human.

Organism-specific databases

CTDi5021.
GeneCardsiGC03M008767.
H-InvDBHIX0030783.
HGNCiHGNC:8529. OXTR.
HPAiCAB022700.
MIMi167055. gene.
neXtProtiNX_P30559.
PharmGKBiPA32858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30559.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
PhylomeDBiP30559.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP30559.

Miscellaneous databases

GeneWikiiOxytocin_receptor.
GenomeRNAii5021.
NextBioi19332.
PROiP30559.
SOURCEiSearch...

Gene expression databases

BgeeiP30559.
CleanExiHS_OXTR.
ExpressionAtlasiP30559. baseline and differential.
GenevestigatoriP30559.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a human oxytocin receptor."
    Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
    Nature 356:526-529(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218.
    Tissue: Uterus.
  2. Erratum
    Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
    Nature 357:176-176(1992)
    Cited for: SEQUENCE REVISION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218.
    Tissue: Ovary.
  4. "Structural organization of the human oxytocin receptor gene."
    Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F.
    J. Biol. Chem. 269:32451-32456(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.

Entry informationi

Entry nameiOXYR_HUMAN
AccessioniPrimary (citable) accession number: P30559
Secondary accession number(s): Q15071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 3, 2007
Last modified: April 29, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.