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Protein

Oxytocin receptor

Gene

OXTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • oxytocin receptor activity Source: ProtInc
  • peptide binding Source: GO_Central
  • peptide hormone binding Source: Ensembl
  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180914-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP30559.
SIGNORiP30559.

Protein family/group databases

TCDBi9.A.14.10.4. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:OXTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8529. OXTR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 74CytoplasmicSequence analysisAdd BLAST11
Transmembranei75 – 97Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini98 – 113ExtracellularSequence analysisAdd BLAST16
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 202ExtracellularSequence analysisAdd BLAST27
Transmembranei203 – 225Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini226 – 275CytoplasmicSequence analysisAdd BLAST50
Transmembranei276 – 294Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini295 – 309ExtracellularSequence analysisAdd BLAST15
Transmembranei310 – 332Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini333 – 389CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5021.
OpenTargetsiENSG00000180914.
PharmGKBiPA32858.

Chemistry databases

ChEMBLiCHEMBL2049.
DrugBankiDB01282. Carbetocin.
DB00107. Oxytocin.
GuidetoPHARMACOLOGYi369.

Polymorphism and mutation databases

BioMutaiOXTR.
DMDMi143811431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699981 – 389Oxytocin receptorAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation
Modified residuei366PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP30559.
PaxDbiP30559.
PeptideAtlasiP30559.
PRIDEiP30559.

PTM databases

iPTMnetiP30559.
PhosphoSitePlusiP30559.

Expressioni

Gene expression databases

BgeeiENSG00000180914.
CleanExiHS_OXTR.
ExpressionAtlasiP30559. baseline and differential.
GenevisibleiP30559. HS.

Organism-specific databases

HPAiCAB022700.

Interactioni

Protein-protein interaction databases

IntActiP30559. 1 interactor.
STRINGi9606.ENSP00000324270.

Chemistry databases

BindingDBiP30559.

Structurei

3D structure databases

ProteinModelPortaliP30559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30559.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
PhylomeDBiP30559.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
LLALSGNACV LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG
260 270 280 290 300
DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
310 320 330 340 350
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS
360 370 380
YLKGRRLGET SASKKSNSSS FVLSHRSSSQ RSCSQPSTA
Length:389
Mass (Da):42,772
Last modified:April 3, 2007 - v2
Checksum:i97E1845DA9676439
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308A → G in CAA56562 (PubMed:7798245).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03157016A → S.Corresponds to variant rs237906dbSNPEnsembl.1
Natural variantiVAR_031571218A → T.2 PublicationsCorresponds to variant rs4686302dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSiCCDS2570.1.
PIRiA55493.
RefSeqiNP_000907.2. NM_000916.3.
XP_011532064.1. XM_011533762.2.
UniGeneiHs.2820.

Genome annotation databases

EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
GeneIDi5021.
KEGGihsa:5021.
UCSCiuc003brc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Oxytocin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSiCCDS2570.1.
PIRiA55493.
RefSeqiNP_000907.2. NM_000916.3.
XP_011532064.1. XM_011533762.2.
UniGeneiHs.2820.

3D structure databases

ProteinModelPortaliP30559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30559. 1 interactor.
STRINGi9606.ENSP00000324270.

Chemistry databases

BindingDBiP30559.
ChEMBLiCHEMBL2049.
DrugBankiDB01282. Carbetocin.
DB00107. Oxytocin.
GuidetoPHARMACOLOGYi369.

Protein family/group databases

TCDBi9.A.14.10.4. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP30559.
PhosphoSitePlusiP30559.

Polymorphism and mutation databases

BioMutaiOXTR.
DMDMi143811431.

Proteomic databases

MaxQBiP30559.
PaxDbiP30559.
PeptideAtlasiP30559.
PRIDEiP30559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316793; ENSP00000324270; ENSG00000180914.
GeneIDi5021.
KEGGihsa:5021.
UCSCiuc003brc.4. human.

Organism-specific databases

CTDi5021.
DisGeNETi5021.
GeneCardsiOXTR.
H-InvDBHIX0030783.
HGNCiHGNC:8529. OXTR.
HPAiCAB022700.
MIMi167055. gene.
neXtProtiNX_P30559.
OpenTargetsiENSG00000180914.
PharmGKBiPA32858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP30559.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
PhylomeDBiP30559.
TreeFamiTF106499.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180914-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP30559.
SIGNORiP30559.

Miscellaneous databases

GeneWikiiOxytocin_receptor.
GenomeRNAii5021.
PROiP30559.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180914.
CleanExiHS_OXTR.
ExpressionAtlasiP30559. baseline and differential.
GenevisibleiP30559. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXYR_HUMAN
AccessioniPrimary (citable) accession number: P30559
Secondary accession number(s): Q15071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.