P30559 (OXYR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxytocin receptor
Short name=OT-R

Gene names

Name:

OXTR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara digestive tract development Inferred from electronic annotation. Source: Compara eating behavior Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara estrous cycle phase Inferred from electronic annotation. Source: Compara female pregnancy Traceable author statement Ref.1. Source: ProtInc heart development Inferred from electronic annotation. Source: Compara lactation Traceable author statement Ref.1. Source: ProtInc maternal behavior Inferred from electronic annotation. Source: Compara maternal process involved in parturition Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara muscle contraction Traceable author statement Ref.1. Source: ProtInc negative regulation of gastric acid secretion Inferred from electronic annotation. Source: Compara positive regulation of blood pressure Inferred from electronic annotation. Source: Compara positive regulation of norepinephrine secretion Inferred from electronic annotation. Source: Compara positive regulation of penile erection Inferred from electronic annotation. Source: Compara positive regulation of synapse assembly Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara positive regulation of uterine smooth muscle contraction Inferred from electronic annotation. Source: Compara response to amphetamine Inferred from electronic annotation. Source: Compara response to anoxia Inferred from electronic annotation. Source: Compara response to cocaine Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara sleep Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara sperm ejaculation Inferred from electronic annotation. Source: Compara suckling behavior Inferred from electronic annotation. Source: Compara telencephalon development Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara cell-cell adherens junction Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 10858434. Source: ProtInc microvillus Inferred from electronic annotation. Source: Compara
Molecular_function	oxytocin receptor activity Traceable author statement PubMed 10858434. Source: ProtInc peptide hormone binding Inferred from electronic annotation. Source: Compara vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Oxytocin receptor		PRO_0000069998
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 63	25	Helical; Name=1; Potential
	Topological domain	64 – 74	11	Cytoplasmic Potential
	Transmembrane	75 – 97	23	Helical; Name=2; Potential
	Topological domain	98 – 113	16	Extracellular Potential
	Transmembrane	114 – 135	22	Helical; Name=3; Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 202	27	Extracellular Potential
	Transmembrane	203 – 225	23	Helical; Name=5; Potential
	Topological domain	226 – 275	50	Cytoplasmic Potential
	Transmembrane	276 – 294	19	Helical; Name=6; Potential
	Topological domain	295 – 309	15	Extracellular Potential
	Transmembrane	310 – 332	23	Helical; Name=7; Potential
	Topological domain	333 – 389	57	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 187		By similarity
Natural variations
	Natural variant	16	1	A → S. Corresponds to variant rs237906 [ dbSNP | Ensembl ].		VAR_031570
	Natural variant	218	1	A → T. Ref.1 Ref.3 Corresponds to variant rs4686302 [ dbSNP | Ensembl ].		VAR_031571
Experimental info
	Sequence conflict	308	1	A → G in CAA56562. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P30559 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 97E1845DA9676439	FASTA	389	42,772
	10 20 30 40 50 60 MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 70 80 90 100 110 120 LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 130 140 150 160 170 180 VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 190 200 210 220 230 240 ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 250 260 270 280 290 300 AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 310 320 330 340 350 360 DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 370 380 SASKKSNSSS FVLSHRSSSQ RSCSQPSTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of a human oxytocin receptor." Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H. Nature 356:526-529(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218. Tissue: Uterus.
[2]	Erratum Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H. Nature 357:176-176(1992) Cited for: SEQUENCE REVISION.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218. Tissue: Ovary.
[4]	"Structural organization of the human oxytocin receptor gene." Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F. J. Biol. Chem. 269:32451-32456(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
+	Additional computationally mapped references.

Web resources

Wikipedia

Oxytocin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64878 mRNA. Translation: CAA46097.1. AY389507 mRNA. Translation: AAQ91333.1. X80282 Genomic DNA. Translation: CAA56562.1.
IPI	IPI00026886.
PIR	A55493.
RefSeq	NP_000907.2. NM_000916.3.
UniGene	Hs.2820.
3D structure databases
ProteinModelPortal	P30559.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000324270.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30559.
Polymorphism databases
DMDM	143811431.
Proteomic databases
PaxDb	P30559.
PRIDE	P30559.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316793; ENSP00000324270; ENSG00000180914.
GeneID	5021.
KEGG	hsa:5021.
UCSC	uc003brc.3. human.
Organism-specific databases
CTD	5021.
GeneCards	GC03M008767.
H-InvDB	HIX0030783.
HGNC	HGNC:8529. OXTR.
HPA	CAB022700.
MIM	167055. gene.
neXtProt	NX_P30559.
PharmGKB	PA32858.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299951.
HOGENOM	HOG000237331.
HOVERGEN	HBG105710.
InParanoid	P30559.
KO	K04229.
OMA	GPPRRNE.
OrthoDB	EOG4VHK6S.
PhylomeDB	P30559.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P30559.
Bgee	P30559.
CleanEx	HS_OXTR.
Genevestigator	P30559.
GermOnline	ENSG00000180914. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002062. Oxytocn_rcpt. IPR001817. Vasoprsn_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00665. OXYTOCINR. PR00896. VASOPRESSINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30559.
ChEMBL	CHEMBL2049.
DrugBank	DB01282. Carbetocin.
GenomeRNAi	5021.
NextBio	19332.
SOURCE	Search...

Entry information

Entry name

OXYR_HUMAN

Accession

Primary (citable) accession number: P30559
Secondary accession number(s): Q15071

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.