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P30559 (OXYR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxytocin receptor

Short name=OT-R
Gene names
Name:OXTR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

cell surface receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

digestive tract development

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

estrous cycle phase

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Traceable author statement Ref.1. Source: ProtInc

heart development

Inferred from electronic annotation. Source: Ensembl

lactation

Traceable author statement Ref.1. Source: ProtInc

maternal behavior

Inferred from electronic annotation. Source: Ensembl

maternal process involved in parturition

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

muscle contraction

Traceable author statement Ref.1. Source: ProtInc

negative regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of synapse assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of uterine smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to anoxia

Inferred from electronic annotation. Source: Ensembl

response to cocaine

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

sleep

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

suckling behavior

Inferred from electronic annotation. Source: Ensembl

telencephalon development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cell-cell adherens junction

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 10858434. Source: ProtInc

microvillus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionoxytocin receptor activity

Traceable author statement PubMed 10858434. Source: ProtInc

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

vasopressin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Oxytocin receptor
PRO_0000069998

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6325Helical; Name=1; Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 9723Helical; Name=2; Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 22523Helical; Name=5; Potential
Topological domain226 – 27550Cytoplasmic Potential
Transmembrane276 – 29419Helical; Name=6; Potential
Topological domain295 – 30915Extracellular Potential
Transmembrane310 – 33223Helical; Name=7; Potential
Topological domain333 – 38957Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Natural variations

Natural variant161A → S.
Corresponds to variant rs237906 [ dbSNP | Ensembl ].
VAR_031570
Natural variant2181A → T. Ref.1 Ref.3
Corresponds to variant rs4686302 [ dbSNP | Ensembl ].
VAR_031571

Experimental info

Sequence conflict3081A → G in CAA56562. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P30559 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 97E1845DA9676439

FASTA38942,772
        10         20         30         40         50         60 
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 

       310        320        330        340        350        360 
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 

       370        380 
SASKKSNSSS FVLSHRSSSQ RSCSQPSTA 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of a human oxytocin receptor."
Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
Nature 356:526-529(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-218.
Tissue: Uterus.
[2]Erratum
Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.
Nature 357:176-176(1992)
Cited for: SEQUENCE REVISION.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-218.
Tissue: Ovary.
[4]"Structural organization of the human oxytocin receptor gene."
Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T., Kubota Y., Ogita K., Saji F.
J. Biol. Chem. 269:32451-32456(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
+Additional computationally mapped references.

Web resources

Wikipedia

Oxytocin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64878 mRNA. Translation: CAA46097.1.
AY389507 mRNA. Translation: AAQ91333.1.
X80282 Genomic DNA. Translation: CAA56562.1.
CCDSCCDS2570.1.
PIRA55493.
RefSeqNP_000907.2. NM_000916.3.
UniGeneHs.2820.

3D structure databases

ProteinModelPortalP30559.
SMRP30559. Positions 43-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111061. 2 interactions.
STRING9606.ENSP00000324270.

Chemistry

BindingDBP30559.
ChEMBLCHEMBL2049.
DrugBankDB01282. Carbetocin.
GuidetoPHARMACOLOGY369.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30559.

Polymorphism databases

DMDM143811431.

Proteomic databases

MaxQBP30559.
PaxDbP30559.
PRIDEP30559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316793; ENSP00000324270; ENSG00000180914.
GeneID5021.
KEGGhsa:5021.
UCSCuc003brc.3. human.

Organism-specific databases

CTD5021.
GeneCardsGC03M008767.
H-InvDBHIX0030783.
HGNCHGNC:8529. OXTR.
HPACAB022700.
MIM167055. gene.
neXtProtNX_P30559.
PharmGKBPA32858.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299951.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP30559.
KOK04229.
OMAGPPRRNE.
OrthoDBEOG7Z69CP.
PhylomeDBP30559.
TreeFamTF106499.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP30559.

Gene expression databases

ArrayExpressP30559.
BgeeP30559.
CleanExHS_OXTR.
GenevestigatorP30559.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOxytocin_receptor.
GenomeRNAi5021.
NextBio19332.
PROP30559.
SOURCESearch...

Entry information

Entry nameOXYR_HUMAN
AccessionPrimary (citable) accession number: P30559
Secondary accession number(s): Q15071
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries