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Protein

Proteinase-activated receptor 1

Gene

F2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB
  • G-protein beta-subunit binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • heterotrimeric G-protein binding Source: UniProtKB
  • signaling receptor binding Source: MGI
  • thrombin-activated receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 1
Short name:
PAR-1
Alternative name(s):
Thrombin receptor
Gene namesi
Name:F2r
Synonyms:Cf2r, Par1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:101802 F2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 107ExtracellularSequence analysisAdd BLAST66
Transmembranei108 – 133Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini134 – 142CytoplasmicSequence analysis9
Transmembranei143 – 162Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini163 – 181ExtracellularSequence analysisAdd BLAST19
Transmembranei182 – 203Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini204 – 223CytoplasmicSequence analysisAdd BLAST20
Transmembranei224 – 244Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini245 – 273ExtracellularSequence analysisAdd BLAST29
Transmembranei274 – 293Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23
Transmembranei317 – 339Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini340 – 354ExtracellularSequence analysisAdd BLAST15
Transmembranei355 – 379Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini380 – 430CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000001274222 – 41Removed for receptor activationBy similarityAdd BLAST20
ChainiPRO_000001274342 – 430Proteinase-activated receptor 1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 259PROSITE-ProRule annotation
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei423PhosphoserineBy similarity1

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Cleavage; by thrombinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP30558
PaxDbiP30558
PeptideAtlasiP30558
PRIDEiP30558

PTM databases

iPTMnetiP30558
PhosphoSitePlusiP30558

Expressioni

Gene expression databases

BgeeiENSMUSG00000048376
CleanExiMM_F2R
GenevisibleiP30558 MM

Interactioni

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB
  • G-protein beta-subunit binding Source: UniProtKB
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

IntActiP30558, 1 interactor
STRINGi10090.ENSMUSP00000061754

Structurei

3D structure databases

ProteinModelPortaliP30558
SMRiP30558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 65Asp/Glu-rich (acidic)6
Compositional biasi88 – 91Poly-Pro4

Domaini

The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCV Eukaryota
ENOG4110Q89 LUCA
GeneTreeiENSGT00910000143980
HOGENOMiHOG000232200
HOVERGENiHBG108233
InParanoidiP30558
KOiK03914
OMAiVVYMLHL
OrthoDBiEOG091G0I94
PhylomeDBiP30558
TreeFamiTF330775

Family and domain databases

CDDicd15369 7tmA_PAR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003912 Protea_act_rcpt
IPR000935 Thrmbn_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01428 PROTEASEAR
PR00908 THROMBINR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRRLLIVA LGLSLCGPLL SSRVPMSQPE SERTDATVNP RSFFLRNPSE
60 70 80 90 100
NTFELVPLGD EEEEEKNESV LLEGRAVYLN ISLPPHTPPP PFISEDASGY
110 120 130 140 150
LTSPWLTLFM PSVYTIVFIV SLPLNVLAIA VFVLRMKVKK PAVVYMLHLA
160 170 180 190 200
MADVLFVSVL PFKISYYFSG TDWQFGSGMC RFATAAFYGN MYASIMLMTV
210 220 230 240 250
ISIDRFLAVV YPIQSLSWRT LGRANFTCVV IWVMAIMGVV PLLLKEQTTR
260 270 280 290 300
VPGLNITTCH DVLSENLMQG FYSYYFSAFS AIFFLVPLIV STVCYTSIIR
310 320 330 340 350
CLSSSAVANR SKKSRALFLS AAVFCIFIVC FGPTNVLLIV HYLFLSDSPG
360 370 380 390 400
TEAAYFAYLL CVCVSSVSCC IDPLIYYYAS SECQRHLYSI LCCKESSDPN
410 420 430
SCNSTGQLMP SKMDTCSSHL NNSIYKKLLA
Length:430
Mass (Da):47,790
Last modified:November 1, 1997 - v2
Checksum:i395FD64FAE52C9BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162F → S in AAA40438 (Ref. 1) Curated1
Sequence conflicti189G → Y in AAA40438 (Ref. 1) Curated1
Sequence conflicti223R → G in AAA40438 (Ref. 1) Curated1
Sequence conflicti262V → L in AAA40438 (Ref. 1) Curated1
Sequence conflicti365S → T in AAA40438 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03529 mRNA Translation: AAA40438.1
U36757, U36756 Genomic DNA Translation: AAB38308.1
AK085990 mRNA Translation: BAC39587.1
AK159282 mRNA Translation: BAE34960.1
AK160032 mRNA Translation: BAE35575.1
BC031516 mRNA Translation: AAH31516.1
AH003565 Genomic DNA Translation: AAB00198.1
CCDSiCCDS26701.1
RefSeqiNP_034299.2, NM_010169.3
UniGeneiMm.24816

Genome annotation databases

EnsembliENSMUST00000059193; ENSMUSP00000061754; ENSMUSG00000048376
GeneIDi14062
KEGGimmu:14062
UCSCiuc007rmn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPAR1_MOUSE
AccessioniPrimary (citable) accession number: P30558
Secondary accession number(s): P97507, Q3TVP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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