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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • angiotensin type II receptor activity Source: UniProtKB
  • angiotensin type I receptor activity Source: BHF-UCL
  • bradykinin receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  • angiotensin-activated signaling pathway Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • cell chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • kidney development Source: BHF-UCL
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • phospholipase C-activating angiotensin-activated signaling pathway Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of cellular protein metabolic process Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
  • positive regulation of phospholipase A2 activity Source: BHF-UCL
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
  • regulation of cell growth Source: BHF-UCL
  • regulation of cell proliferation Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • regulation of renal sodium excretion Source: BHF-UCL
  • regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCL
  • regulation of vasoconstriction Source: BHF-UCL
  • regulation of vasodilation Source: BHF-UCL
  • renin-angiotensin regulation of aldosterone production Source: BHF-UCL
  • Rho protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144891-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP30556.
SIGNORiP30556.

Protein family/group databases

TCDBi9.A.14.13.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:336. AGTR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
See also OMIM:267430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant rs104893677dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi185.
MalaCardsiAGTR1.
MIMi267430. phenotype.
OpenTargetsiENSG00000144891.
Orphaneti97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA43.

Chemistry databases

ChEMBLiCHEMBL227.
DrugBankiDB08822. Azilsartan medoxomil.
DB00796. Candesartan.
DB00876. Eprosartan.
DB01342. Forasartan.
DB01029. Irbesartan.
DB00678. Losartan.
DB00275. Olmesartan.
DB01347. Saprisartan.
DB01349. Tasosartan.
DB00966. Telmisartan.
DB00177. Valsartan.
GuidetoPHARMACOLOGYi34.

Polymorphism and mutation databases

BioMutaiAGTR1.
DMDMi231519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691531 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) (complex)1 Publication1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Lipidationi355S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30556.
PeptideAtlasiP30556.
PRIDEiP30556.

PTM databases

iPTMnetiP30556.
PhosphoSitePlusiP30556.

Expressioni

Tissue specificityi

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

BgeeiENSG00000144891.
CleanExiHS_AGTR1.
ExpressionAtlasiP30556. baseline and differential.
GenevisibleiP30556. HS.

Organism-specific databases

HPAiHPA003596.

Interactioni

Subunit structurei

Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarityCurated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP010192EBI-6623016,EBI-6622938

GO - Molecular functioni

  • bradykinin receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi106691. 29 interactors.
IntActiP30556. 5 interactors.
MINTiMINT-107041.
STRINGi9606.ENSP00000273430.

Chemistry databases

BindingDBiP30556.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 20Combined sources4
Helixi27 – 55Combined sources29
Turni56 – 59Combined sources4
Helixi62 – 80Combined sources19
Helixi82 – 89Combined sources8
Helixi98 – 131Combined sources34
Helixi142 – 159Combined sources18
Helixi161 – 166Combined sources6
Beta strandi167 – 174Combined sources8
Beta strandi178 – 182Combined sources5
Helixi191 – 194Combined sources4
Helixi198 – 203Combined sources6
Helixi205 – 221Combined sources17
Helixi236 – 267Combined sources32
Beta strandi269 – 271Combined sources3
Helixi274 – 292Combined sources19
Helixi294 – 303Combined sources10
Helixi306 – 316Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
4ZUDX-ray2.80A2-315[»]
ProteinModelPortaliP30556.
SMRiP30556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP30556.
KOiK04166.
PhylomeDBiP30556.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:April 1, 1993 - v1
Checksum:i35FC856F53E911A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187Q → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti204 – 205FL → SC in BAA02968 (PubMed:8135787).Curated2
Sequence conflicti232K → N in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti240K → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti268L → Q in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti311 – 313RYF → KDI in BAA02968 (PubMed:8135787).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029206163A → T.Corresponds to variant rs12721226dbSNPEnsembl.1
Natural variantiVAR_070375222L → V.1 PublicationCorresponds to variant rs17852013dbSNPEnsembl.1
Natural variantiVAR_029207244A → S.Corresponds to variant rs12721225dbSNPEnsembl.1
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant rs104893677dbSNPEnsembl.1
Natural variantiVAR_011847289C → W.1 PublicationCorresponds to variant rs1064533dbSNPEnsembl.1
Natural variantiVAR_011848336T → P.Corresponds to variant rs1801021dbSNPEnsembl.1
Natural variantiVAR_070376341P → H.1 PublicationCorresponds to variant rs17852012dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA. Translation: AAA35569.1.
Z11162 Genomic DNA. Translation: CAA77513.1.
M87290 mRNA. Translation: AAA35535.1.
S77410 mRNA. Translation: AAB34644.1.
M93394 mRNA. Translation: AAA58370.1.
D13814 mRNA. Translation: BAA02968.1.
X65699 mRNA. Translation: CAA46621.1.
AF245699 Genomic DNA. Translation: AAF70464.1.
AY221090 Genomic DNA. Translation: AAO65968.1.
BC022447 mRNA. Translation: AAH22447.1.
CCDSiCCDS3137.1.
PIRiI39418.
JC1104.
RefSeqiNP_000676.1. NM_000685.4.
NP_004826.5. NM_004835.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891.
ENST00000404754; ENSP00000385612; ENSG00000144891.
ENST00000461609; ENSP00000418851; ENSG00000144891.
ENST00000474935; ENSP00000418084; ENSG00000144891.
ENST00000475347; ENSP00000419783; ENSG00000144891.
ENST00000497524; ENSP00000419422; ENSG00000144891.
GeneIDi185.
KEGGihsa:185.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA. Translation: AAA35569.1.
Z11162 Genomic DNA. Translation: CAA77513.1.
M87290 mRNA. Translation: AAA35535.1.
S77410 mRNA. Translation: AAB34644.1.
M93394 mRNA. Translation: AAA58370.1.
D13814 mRNA. Translation: BAA02968.1.
X65699 mRNA. Translation: CAA46621.1.
AF245699 Genomic DNA. Translation: AAF70464.1.
AY221090 Genomic DNA. Translation: AAO65968.1.
BC022447 mRNA. Translation: AAH22447.1.
CCDSiCCDS3137.1.
PIRiI39418.
JC1104.
RefSeqiNP_000676.1. NM_000685.4.
NP_004826.5. NM_004835.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
4ZUDX-ray2.80A2-315[»]
ProteinModelPortaliP30556.
SMRiP30556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106691. 29 interactors.
IntActiP30556. 5 interactors.
MINTiMINT-107041.
STRINGi9606.ENSP00000273430.

Chemistry databases

BindingDBiP30556.
ChEMBLiCHEMBL227.
DrugBankiDB08822. Azilsartan medoxomil.
DB00796. Candesartan.
DB00876. Eprosartan.
DB01342. Forasartan.
DB01029. Irbesartan.
DB00678. Losartan.
DB00275. Olmesartan.
DB01347. Saprisartan.
DB01349. Tasosartan.
DB00966. Telmisartan.
DB00177. Valsartan.
GuidetoPHARMACOLOGYi34.

Protein family/group databases

TCDBi9.A.14.13.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP30556.
PhosphoSitePlusiP30556.

Polymorphism and mutation databases

BioMutaiAGTR1.
DMDMi231519.

Proteomic databases

PaxDbiP30556.
PeptideAtlasiP30556.
PRIDEiP30556.

Protocols and materials databases

DNASUi185.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891.
ENST00000404754; ENSP00000385612; ENSG00000144891.
ENST00000461609; ENSP00000418851; ENSG00000144891.
ENST00000474935; ENSP00000418084; ENSG00000144891.
ENST00000475347; ENSP00000419783; ENSG00000144891.
ENST00000497524; ENSP00000419422; ENSG00000144891.
GeneIDi185.
KEGGihsa:185.

Organism-specific databases

CTDi185.
DisGeNETi185.
GeneCardsiAGTR1.
HGNCiHGNC:336. AGTR1.
HPAiHPA003596.
MalaCardsiAGTR1.
MIMi106165. gene.
267430. phenotype.
neXtProtiNX_P30556.
OpenTargetsiENSG00000144891.
Orphaneti97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA43.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP30556.
KOiK04166.
PhylomeDBiP30556.
TreeFamiTF330024.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144891-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.
SignaLinkiP30556.
SIGNORiP30556.

Miscellaneous databases

GeneWikiiAngiotensin_II_receptor_type_1.
GenomeRNAii185.
PROiP30556.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144891.
CleanExiHS_AGTR1.
ExpressionAtlasiP30556. baseline and differential.
GenevisibleiP30556. HS.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGTR1_HUMAN
AccessioniPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.