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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • angiotensin type II receptor activity Source: UniProtKB
  • angiotensin type I receptor activity Source: BHF-UCL
  • bradykinin receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  • angiotensin-activated signaling pathway Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • cell chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • kidney development Source: BHF-UCL
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • phospholipase C-activating angiotensin-activated signaling pathway Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of cellular protein metabolic process Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
  • positive regulation of phospholipase A2 activity Source: BHF-UCL
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
  • regulation of cell growth Source: BHF-UCL
  • regulation of cell proliferation Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • regulation of renal sodium excretion Source: BHF-UCL
  • regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCL
  • regulation of vasoconstriction Source: BHF-UCL
  • regulation of vasodilation Source: BHF-UCL
  • renin-angiotensin regulation of aldosterone production Source: BHF-UCL
  • Rho protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP30556.

Protein family/group databases

TCDBi9.A.14.13.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:336. AGTR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GOC
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Renal tubular dysgenesis (RTD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

See also OMIM:267430
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti282 – 2821T → M in RTD. 1 Publication
VAR_035086

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi267430. phenotype.
Orphaneti97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA43.

Chemistry

DrugBankiDB08822. Azilsartan medoxomil.
DB00796. Candesartan.
DB00876. Eprosartan.
DB01342. Forasartan.
DB01029. Irbesartan.
DB00678. Losartan.
DB00275. Olmesartan.
DB01347. Saprisartan.
DB01349. Tasosartan.
DB00966. Telmisartan.
DB00177. Valsartan.

Polymorphism and mutation databases

BioMutaiAGTR1.
DMDMi231519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1 angiotensin II receptorPRO_0000069153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Lipidationi355 – 3551S-palmitoyl cysteineSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30556.
PRIDEiP30556.

PTM databases

PhosphoSiteiP30556.

Expressioni

Tissue specificityi

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

BgeeiP30556.
CleanExiHS_AGTR1.
ExpressionAtlasiP30556. baseline and differential.
GenevisibleiP30556. HS.

Organism-specific databases

HPAiHPA003596.

Interactioni

Subunit structurei

Interacts with MAS1 (Probable). Interacts with ARRB1 (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP010192EBI-6623016,EBI-6622938

Protein-protein interaction databases

BioGridi106691. 24 interactions.
IntActiP30556. 5 interactions.
MINTiMINT-107041.
STRINGi9606.ENSP00000273430.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
ProteinModelPortaliP30556.
SMRiP30556. Positions 27-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256015.
HOVERGENiHBG104998.
InParanoidiP30556.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP30556.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:April 1, 1993 - v1
Checksum:i35FC856F53E911A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871Q → R in BAA02968 (PubMed:8135787).Curated
Sequence conflicti204 – 2052FL → SC in BAA02968 (PubMed:8135787).Curated
Sequence conflicti232 – 2321K → N in BAA02968 (PubMed:8135787).Curated
Sequence conflicti240 – 2401K → R in BAA02968 (PubMed:8135787).Curated
Sequence conflicti268 – 2681L → Q in BAA02968 (PubMed:8135787).Curated
Sequence conflicti311 – 3133RYF → KDI in BAA02968 (PubMed:8135787).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481L → V.
Corresponds to variant rs2011425 [ dbSNP | Ensembl ].
VAR_011846
Natural varianti163 – 1631A → T.
Corresponds to variant rs12721226 [ dbSNP | Ensembl ].
VAR_029206
Natural varianti222 – 2221L → V.1 Publication
Corresponds to variant rs17852013 [ dbSNP | Ensembl ].
VAR_070375
Natural varianti244 – 2441A → S.
Corresponds to variant rs12721225 [ dbSNP | Ensembl ].
VAR_029207
Natural varianti282 – 2821T → M in RTD. 1 Publication
VAR_035086
Natural varianti289 – 2891C → W.1 Publication
Corresponds to variant rs1064533 [ dbSNP | Ensembl ].
VAR_011847
Natural varianti336 – 3361T → P.
Corresponds to variant rs1801021 [ dbSNP | Ensembl ].
VAR_011848
Natural varianti341 – 3411P → H.1 Publication
Corresponds to variant rs17852012 [ dbSNP | Ensembl ].
VAR_070376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA. Translation: AAA35569.1.
Z11162 Genomic DNA. Translation: CAA77513.1.
M87290 mRNA. Translation: AAA35535.1.
S77410 mRNA. Translation: AAB34644.1.
M93394 mRNA. Translation: AAA58370.1.
D13814 mRNA. Translation: BAA02968.1.
X65699 mRNA. Translation: CAA46621.1.
AF245699 Genomic DNA. Translation: AAF70464.1.
AY221090 Genomic DNA. Translation: AAO65968.1.
BC022447 mRNA. Translation: AAH22447.1.
CCDSiCCDS3137.1.
PIRiI39418.
JC1104.
RefSeqiNP_000676.1. NM_000685.4.
NP_004826.5. NM_004835.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891.
ENST00000404754; ENSP00000385612; ENSG00000144891.
ENST00000461609; ENSP00000418851; ENSG00000144891.
ENST00000474935; ENSP00000418084; ENSG00000144891.
ENST00000475347; ENSP00000419783; ENSG00000144891.
ENST00000497524; ENSP00000419422; ENSG00000144891.
GeneIDi185.
KEGGihsa:185.
UCSCiuc003ewi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA. Translation: AAA35569.1.
Z11162 Genomic DNA. Translation: CAA77513.1.
M87290 mRNA. Translation: AAA35535.1.
S77410 mRNA. Translation: AAB34644.1.
M93394 mRNA. Translation: AAA58370.1.
D13814 mRNA. Translation: BAA02968.1.
X65699 mRNA. Translation: CAA46621.1.
AF245699 Genomic DNA. Translation: AAF70464.1.
AY221090 Genomic DNA. Translation: AAO65968.1.
BC022447 mRNA. Translation: AAH22447.1.
CCDSiCCDS3137.1.
PIRiI39418.
JC1104.
RefSeqiNP_000676.1. NM_000685.4.
NP_004826.5. NM_004835.4.
NP_033611.1. NM_009585.3.
UniGeneiHs.477887.
Hs.744837.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
ProteinModelPortaliP30556.
SMRiP30556. Positions 27-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106691. 24 interactions.
IntActiP30556. 5 interactions.
MINTiMINT-107041.
STRINGi9606.ENSP00000273430.

Chemistry

BindingDBiP30556.
ChEMBLiCHEMBL2094256.
DrugBankiDB08822. Azilsartan medoxomil.
DB00796. Candesartan.
DB00876. Eprosartan.
DB01342. Forasartan.
DB01029. Irbesartan.
DB00678. Losartan.
DB00275. Olmesartan.
DB01347. Saprisartan.
DB01349. Tasosartan.
DB00966. Telmisartan.
DB00177. Valsartan.
GuidetoPHARMACOLOGYi34.

Protein family/group databases

TCDBi9.A.14.13.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

PhosphoSiteiP30556.

Polymorphism and mutation databases

BioMutaiAGTR1.
DMDMi231519.

Proteomic databases

PaxDbiP30556.
PRIDEiP30556.

Protocols and materials databases

DNASUi185.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891.
ENST00000404754; ENSP00000385612; ENSG00000144891.
ENST00000461609; ENSP00000418851; ENSG00000144891.
ENST00000474935; ENSP00000418084; ENSG00000144891.
ENST00000475347; ENSP00000419783; ENSG00000144891.
ENST00000497524; ENSP00000419422; ENSG00000144891.
GeneIDi185.
KEGGihsa:185.
UCSCiuc003ewi.3. human.

Organism-specific databases

CTDi185.
GeneCardsiGC03P148415.
HGNCiHGNC:336. AGTR1.
HPAiHPA003596.
MIMi106165. gene.
267430. phenotype.
neXtProtiNX_P30556.
Orphaneti97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA43.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256015.
HOVERGENiHBG104998.
InParanoidiP30556.
KOiK04166.
OMAiCIVIWLL.
OrthoDBiEOG7J4473.
PhylomeDBiP30556.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP30556.

Miscellaneous databases

GeneWikiiAngiotensin_II_receptor_type_1.
GenomeRNAii185.
NextBioi752.
PROiP30556.
SOURCEiSearch...

Gene expression databases

BgeeiP30556.
CleanExiHS_AGTR1.
ExpressionAtlasiP30556. baseline and differential.
GenevisibleiP30556. HS.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor."
    Furuta H., Guo D.F., Inagami T.
    Biochem. Biophys. Res. Commun. 183:8-13(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphocyte.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor."
    Takayanagi R., Ohnaka K., Sakai Y., Nakao R., Yanase T., Haji M., Inagami T., Furuta H., Gou D.F., Nakamuta M., Nawata H.
    Biochem. Biophys. Res. Commun. 183:910-916(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  5. "Genetic analysis of the human type-1 angiotensin II receptor."
    Curnow K.M., Pascoe L., White P.C.
    Mol. Endocrinol. 6:1113-1118(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression."
    Konishi H., Kuroda S., Inada Y., Fujisawa Y.
    Biochem. Biophys. Res. Commun. 199:467-474(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TRP-289.
    Tissue: Placenta.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  8. "Cloning and sequencing of a human cDNA encoding the angiotensin II receptor type 1."
    Ostermann E., Castanon M.J.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  9. "Rapid identification of polymorphisms in genomic DNA: a high density SNP map of the type I angiotensin II receptor gene locus on chromosome 3q."
    Antonellis A., Rogus J.J., Pezzolesi M.G., Makita Y., Nam M., Doria A., Warram J.H., Krolewski A.S.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  10. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-222 AND HIS-341.
    Tissue: Brain.
  12. Cited for: INTERACTION WITH MAS1.
  13. Cited for: GLYCOSYLATION AT ASN-4.
  14. Cited for: VARIANT RTD MET-282.

Entry informationi

Entry nameiAGTR1_HUMAN
AccessioniPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 24, 2015
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.