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P30556 (AGTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 147. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-1 angiotensin II receptor
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name=AT1
Gene names
Name:AGTR1
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with MAS1 Probable. Interacts with ARRB1 By similarity. Ref.12

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Liver, lung, adrenal and adrenocortical adenomas.

Post-translational modification

C-terminal Ser or Thr residues may be phosphorylated.

Involvement in disease

Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay Ref.1. Source: BHF-UCL

Rho protein signal transduction

Inferred from direct assay PubMed 15611106. Source: UniProtKB

angiotensin-activated signaling pathway

Inferred from direct assay PubMed 15611106Ref.3. Source: GOC

calcium-mediated signaling

Inferred from direct assay Ref.3. Source: BHF-UCL

cell chemotaxis

Inferred from direct assay PubMed 15635042. Source: UniProtKB

kidney development

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

low-density lipoprotein particle remodeling

Non-traceable author statement PubMed 17069818. Source: BHF-UCL

phospholipase C-activating G-protein coupled receptor signaling pathway

Non-traceable author statement PubMed 17159080. Source: BHF-UCL

phospholipase C-activating angiotensin-activated signaling pathway

Inferred from direct assay PubMed 10993080. Source: GOC

positive regulation of NAD(P)H oxidase activity

Traceable author statement PubMed 17159080. Source: BHF-UCL

positive regulation of cellular protein metabolic process

Inferred from mutant phenotype PubMed 18971559. Source: BHF-UCL

positive regulation of cholesterol esterification

Inferred from mutant phenotype PubMed 18971559. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.3. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from direct assay Ref.3. Source: BHF-UCL

positive regulation of inflammatory response

Traceable author statement PubMed 17159080. Source: BHF-UCL

positive regulation of macrophage derived foam cell differentiation

Inferred by curator PubMed 18971559. Source: BHF-UCL

positive regulation of phospholipase A2 activity

Inferred from mutant phenotype PubMed 17069818. Source: BHF-UCL

positive regulation of reactive oxygen species metabolic process

Traceable author statement PubMed 17159080. Source: BHF-UCL

regulation of blood vessel size by renin-angiotensin

Inferred by curator PubMed 10993080. Source: BHF-UCL

regulation of cell growth

Non-traceable author statement PubMed 17159080. Source: BHF-UCL

regulation of cell proliferation

Non-traceable author statement PubMed 17159080. Source: BHF-UCL

regulation of inflammatory response

Inferred by curator Ref.1. Source: BHF-UCL

regulation of renal sodium excretion

Non-traceable author statement PubMed 17159080. Source: BHF-UCL

regulation of systemic arterial blood pressure by renin-angiotensin

Inferred by curator Ref.1. Source: BHF-UCL

regulation of vasoconstriction

Inferred from direct assay PubMed 15117835. Source: BHF-UCL

regulation of vasodilation

Inferred by curator Ref.1. Source: BHF-UCL

renin-angiotensin regulation of aldosterone production

Non-traceable author statement PubMed 17159080. Source: BHF-UCL

   Cellular_componentintegral component of membrane

Non-traceable author statement Ref.6. Source: UniProtKB

integral component of plasma membrane

Inferred by curator Ref.1. Source: BHF-UCL

plasma membrane

Inferred from direct assay PubMed 19023134. Source: UniProtKB

   Molecular_functionangiotensin type I receptor activity

Inferred from direct assay PubMed 10993080. Source: BHF-UCL

angiotensin type II receptor activity

Inferred from direct assay PubMed 15611106. Source: UniProtKB

bradykinin receptor binding

Inferred from physical interaction PubMed 10993080. Source: BHF-UCL

protein heterodimerization activity

Inferred from physical interaction PubMed 10993080. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AGTP010192EBI-6623016,EBI-6622938

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Type-1 angiotensin II receptor
PRO_0000069153

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5225Helical; Name=1; Potential
Topological domain53 – 6412Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10215Extracellular Potential
Transmembrane103 – 12422Helical; Name=3; Potential
Topological domain125 – 14218Cytoplasmic Potential
Transmembrane143 – 16220Helical; Name=4; Potential
Topological domain163 – 19230Extracellular Potential
Transmembrane193 – 21422Helical; Name=5; Potential
Topological domain215 – 24026Cytoplasmic Potential
Transmembrane241 – 26222Helical; Name=6; Potential
Topological domain263 – 27513Extracellular Potential
Transmembrane276 – 29621Helical; Name=7; Potential
Topological domain297 – 35963Cytoplasmic Potential

Amino acid modifications

Lipidation3551S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) (complex) Ref.13
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 180 By similarity

Natural variations

Natural variant481L → V.
Corresponds to variant rs2011425 [ dbSNP | Ensembl ].
VAR_011846
Natural variant1631A → T.
Corresponds to variant rs12721226 [ dbSNP | Ensembl ].
VAR_029206
Natural variant2221L → V. Ref.11
Corresponds to variant rs17852013 [ dbSNP | Ensembl ].
VAR_070375
Natural variant2441A → S.
Corresponds to variant rs12721225 [ dbSNP | Ensembl ].
VAR_029207
Natural variant2821T → M in RTD. Ref.14
VAR_035086
Natural variant2891C → W. Ref.6
Corresponds to variant rs1064533 [ dbSNP | Ensembl ].
VAR_011847
Natural variant3361T → P.
Corresponds to variant rs1801021 [ dbSNP | Ensembl ].
VAR_011848
Natural variant3411P → H. Ref.11
Corresponds to variant rs17852012 [ dbSNP | Ensembl ].
VAR_070376

Experimental info

Sequence conflict1871Q → R in BAA02968. Ref.6
Sequence conflict204 – 2052FL → SC in BAA02968. Ref.6
Sequence conflict2321K → N in BAA02968. Ref.6
Sequence conflict2401K → R in BAA02968. Ref.6
Sequence conflict2681L → Q in BAA02968. Ref.6
Sequence conflict311 – 3133RYF → KDI in BAA02968. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P30556 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 35FC856F53E911A6

FASTA35941,061
        10         20         30         40         50         60 
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 

        70         80         90        100        110        120 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT 

       130        140        150        160        170        180 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC 

       190        200        210        220        230        240 
AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK 

       250        260        270        280        290        300 
IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 

       310        320        330        340        350 
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor."
Furuta H., Guo D.F., Inagami T.
Biochem. Biophys. Res. Commun. 183:8-13(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lymphocyte.
[3]"Cloning and characterization of a human angiotensin II type 1 receptor."
Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.
Biochem. Biophys. Res. Commun. 183:989-995(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor."
Takayanagi R., Ohnaka K., Sakai Y., Nakao R., Yanase T., Haji M., Inagami T., Furuta H., Gou D.F., Nakamuta M., Nawata H.
Biochem. Biophys. Res. Commun. 183:910-916(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[5]"Genetic analysis of the human type-1 angiotensin II receptor."
Curnow K.M., Pascoe L., White P.C.
Mol. Endocrinol. 6:1113-1118(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression."
Konishi H., Kuroda S., Inada Y., Fujisawa Y.
Biochem. Biophys. Res. Commun. 199:467-474(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TRP-289.
Tissue: Placenta.
[7]"Type 1 angiotensin II receptors of adrenal tumors."
Nawata H., Takayanagi R., Ohnaka K., Sakai Y., Imasaki K., Yanase T., Ikuyama S., Tanaka S., Ohe K.
Steroids 60:28-34(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[8]"Cloning and sequencing of a human cDNA encoding the angiotensin II receptor type 1."
Ostermann E., Castanon M.J.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[9]"Rapid identification of polymorphisms in genomic DNA: a high density SNP map of the type I angiotensin II receptor gene locus on chromosome 3q."
Antonellis A., Rogus J.J., Pezzolesi M.G., Makita Y., Nam M., Doria A., Warram J.H., Krolewski A.S.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[10]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-222 AND HIS-341.
Tissue: Brain.
[12]"G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor."
Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., Gembardt F., Kellett E., Martini L., Vanderheyden P., Schultheiss H.P., Walther T.
Circulation 111:1806-1813(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MAS1.
[13]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-4.
[14]"Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., Joubert M., Antignac C., Gubler M.-C.
Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RTD MET-282.
+Additional computationally mapped references.

Web resources

GeneReviews
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91464 Genomic DNA. Translation: AAA35569.1.
Z11162 Genomic DNA. Translation: CAA77513.1.
M87290 mRNA. Translation: AAA35535.1.
S77410 mRNA. Translation: AAB34644.1.
M93394 mRNA. Translation: AAA58370.1.
D13814 mRNA. Translation: BAA02968.1.
X65699 mRNA. Translation: CAA46621.1.
AF245699 Genomic DNA. Translation: AAF70464.1.
AY221090 Genomic DNA. Translation: AAO65968.1.
BC022447 mRNA. Translation: AAH22447.1.
PIRI39418.
JC1104.
RefSeqNP_000676.1. NM_000685.4.
NP_004826.5. NM_004835.4.
NP_033611.1. NM_009585.3.
UniGeneHs.477887.
Hs.744837.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
ProteinModelPortalP30556.
SMRP30556. Positions 16-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106691. 13 interactions.
IntActP30556. 5 interactions.
MINTMINT-107041.
STRING9606.ENSP00000273430.

Chemistry

BindingDBP30556.
ChEMBLCHEMBL2094256.
DrugBankDB00796. Candesartan.
DB00876. Eprosartan.
DB01342. Forasartan.
DB01029. Irbesartan.
DB00678. Losartan.
DB00275. Olmesartan.
DB01347. Saprisartan.
DB00421. Spironolactone.
DB01349. Tasosartan.
DB00966. Telmisartan.
DB00177. Valsartan.
GuidetoPHARMACOLOGY34.

Protein family/group databases

TCDB9.A.14.13.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteP30556.

Polymorphism databases

DMDM231519.

Proteomic databases

PaxDbP30556.
PRIDEP30556.

Protocols and materials databases

DNASU185.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349243; ENSP00000273430; ENSG00000144891.
ENST00000402260; ENSP00000385641; ENSG00000144891.
ENST00000404754; ENSP00000385612; ENSG00000144891.
ENST00000418473; ENSP00000398832; ENSG00000144891.
ENST00000461609; ENSP00000418851; ENSG00000144891.
ENST00000474935; ENSP00000418084; ENSG00000144891.
ENST00000475347; ENSP00000419783; ENSG00000144891.
ENST00000497524; ENSP00000419422; ENSG00000144891.
ENST00000542281; ENSP00000443186; ENSG00000144891.
GeneID185.
KEGGhsa:185.
UCSCuc003ewi.3. human.

Organism-specific databases

CTD185.
GeneCardsGC03P148415.
HGNCHGNC:336. AGTR1.
HPAHPA003596.
MIM106165. gene.
267430. phenotype.
neXtProtNX_P30556.
Orphanet97369. Renal tubular dysgenesis of genetic origin.
PharmGKBPA43.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256015.
HOVERGENHBG104998.
InParanoidP30556.
KOK04166.
OMACIVIWLL.
OrthoDBEOG7J4473.
PhylomeDBP30556.
TreeFamTF330024.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP30556.

Gene expression databases

ArrayExpressP30556.
BgeeP30556.
CleanExHS_AGTR1.
GenevestigatorP30556.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAngiotensin_II_receptor_type_1.
GenomeRNAi185.
NextBio752.
PROP30556.
SOURCESearch...

Entry information

Entry nameAGTR1_HUMAN
AccessionPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries