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P30554

- MAS_MOUSE

UniProt

P30554 - MAS_MOUSE

Protein

Proto-oncogene Mas

Gene

Mas1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 By similarity. Receptor for angiotensin 1-7.By similarity1 Publication

    GO - Molecular functioni

    1. angiotensin receptor activity Source: UniProtKB
    2. peptide binding Source: UniProtKB
    3. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: MGI
    2. cellular response to peptide hormone stimulus Source: Ensembl
    3. G-protein coupled receptor signaling pathway Source: MGI
    4. hippocampus development Source: Ensembl
    5. male gonad development Source: Ensembl
    6. negative regulation of protein phosphorylation Source: Ensembl
    7. positive regulation of cell proliferation Source: Ensembl
    8. positive regulation of DNA replication Source: Ensembl
    9. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    10. protein kinase C signaling Source: Ensembl
    11. regulation of inflammatory response Source: MGI
    12. response to activity Source: Ensembl
    13. response to drug Source: Ensembl
    14. response to gonadotropin Source: Ensembl
    15. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene Mas
    Gene namesi
    Name:Mas1
    Synonyms:Mas, Mas-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:96918. Mas1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Proto-oncogene MasPRO_0000069715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP30554.

    PTM databases

    PhosphoSiteiP30554.

    Expressioni

    Gene expression databases

    BgeeiP30554.
    CleanExiMM_MAS1.
    GenevestigatoriP30554.

    Interactioni

    Subunit structurei

    Interacts with AGTR1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP30554.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 644CytoplasmicSequence Analysis
    Topological domaini87 – 10317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 18413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 22318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini245 – 26218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 32441CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 6025Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12724Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 17123Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG137333.
    HOGENOMiHOG000015412.
    HOVERGENiHBG098384.
    InParanoidiP30554.
    KOiK04303.
    OMAiYELSSGH.
    OrthoDBiEOG79PJPH.
    PhylomeDBiP30554.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR000820. Proto-oncogene_Mas.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF4. PTHR11334:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00533. MASONCOGENE.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30554-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQSNMTSLA EEKAMNTSSR NASLGSSHPP IPIVHWVIMS ISPLGFVENG    50
    ILLWFLCFRM RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH 100
    HYTIVTLSVT FLFGYNTGLY LLTAISVERC LSVLYPIWYR CHRPKHQSAF 150
    VCALLWALSC LVTTMEYVMC IDSGEESHSR SDCRAVIIFI AILSFLVFTP 200
    LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA MPMRVLYLLY 250
    YEYWSAFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR 300
    AFKDEMQPRR QEGNGNTVSI ETVV 324
    Length:324
    Mass (Da):37,055
    Last modified:December 6, 2005 - v2
    Checksum:i1708FCECAF4656A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191S → I in AAB69120. (PubMed:16141072)Curated
    Sequence conflicti74 – 741I → M in CAA47964. (PubMed:8001672)Curated
    Sequence conflicti140 – 1412RC → TS in CAA47964. (PubMed:8001672)Curated
    Sequence conflicti156 – 1561W → C in CAA47964. (PubMed:8001672)Curated
    Sequence conflicti207 – 2071T → S in CAA47964. (PubMed:8001672)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67735 Genomic DNA. Translation: CAA47964.1.
    AK030261 mRNA. Translation: BAC26865.1.
    AK030265 mRNA. Translation: BAC26868.1.
    U96273 mRNA. Translation: AAB69120.1.
    CCDSiCCDS28394.1.
    PIRiS51001.
    RefSeqiNP_032578.2. NM_008552.4.
    XP_006523356.1. XM_006523293.1.
    XP_006523357.1. XM_006523294.1.
    XP_006523358.1. XM_006523295.1.
    XP_006523359.1. XM_006523296.1.
    XP_006523360.1. XM_006523297.1.
    XP_006523361.1. XM_006523298.1.
    XP_006523362.1. XM_006523299.1.
    UniGeneiMm.425994.

    Genome annotation databases

    EnsembliENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037.
    ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037.
    ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037.
    ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037.
    ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037.
    GeneIDi17171.
    KEGGimmu:17171.
    UCSCiuc008ald.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67735 Genomic DNA. Translation: CAA47964.1 .
    AK030261 mRNA. Translation: BAC26865.1 .
    AK030265 mRNA. Translation: BAC26868.1 .
    U96273 mRNA. Translation: AAB69120.1 .
    CCDSi CCDS28394.1.
    PIRi S51001.
    RefSeqi NP_032578.2. NM_008552.4.
    XP_006523356.1. XM_006523293.1.
    XP_006523357.1. XM_006523294.1.
    XP_006523358.1. XM_006523295.1.
    XP_006523359.1. XM_006523296.1.
    XP_006523360.1. XM_006523297.1.
    XP_006523361.1. XM_006523298.1.
    XP_006523362.1. XM_006523299.1.
    UniGenei Mm.425994.

    3D structure databases

    ProteinModelPortali P30554.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 150.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30554.

    Proteomic databases

    PRIDEi P30554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089015 ; ENSMUSP00000086409 ; ENSMUSG00000068037 .
    ENSMUST00000161747 ; ENSMUSP00000123902 ; ENSMUSG00000068037 .
    ENSMUST00000162333 ; ENSMUSP00000125108 ; ENSMUSG00000068037 .
    ENSMUST00000165020 ; ENSMUSP00000132300 ; ENSMUSG00000068037 .
    ENSMUST00000167152 ; ENSMUSP00000131341 ; ENSMUSG00000068037 .
    GeneIDi 17171.
    KEGGi mmu:17171.
    UCSCi uc008ald.2. mouse.

    Organism-specific databases

    CTDi 4142.
    MGIi MGI:96918. Mas1.

    Phylogenomic databases

    eggNOGi NOG137333.
    HOGENOMi HOG000015412.
    HOVERGENi HBG098384.
    InParanoidi P30554.
    KOi K04303.
    OMAi YELSSGH.
    OrthoDBi EOG79PJPH.
    PhylomeDBi P30554.
    TreeFami TF336336.

    Miscellaneous databases

    NextBioi 291464.
    PROi P30554.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30554.
    CleanExi MM_MAS1.
    Genevestigatori P30554.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR000820. Proto-oncogene_Mas.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF4. PTHR11334:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00533. MASONCOGENE.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues."
      Metzger R., Bader M., Ludwig T., Berberich C., Bunnemann B., Ganten D.
      FEBS Lett. 357:27-32(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene."
      Schweifer N., Valk P.J., Delwel R., Cox R., Francis F., Meier-Ewert S., Lehrach H., Barlow D.P.
      Genomics 43:285-297(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-25.
      Strain: BCBA.
      Tissue: Testis.
    4. Cited for: FUNCTION AS RECEPTOR FOR ANGIOTENSIN 1-7.

    Entry informationi

    Entry nameiMAS_MOUSE
    AccessioniPrimary (citable) accession number: P30554
    Secondary accession number(s): O35944, Q8BHI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3