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Protein

Proto-oncogene Mas

Gene

Mas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7.By similarity1 Publication

GO - Molecular functioni

  1. angiotensin receptor activity Source: UniProtKB
  2. G-protein coupled receptor activity Source: MGI
  3. peptide binding Source: UniProtKB
  4. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: MGI
  2. cellular response to peptide hormone stimulus Source: Ensembl
  3. G-protein coupled receptor signaling pathway Source: MGI
  4. hippocampus development Source: Ensembl
  5. male gonad development Source: Ensembl
  6. negative regulation of protein phosphorylation Source: Ensembl
  7. positive regulation of cell proliferation Source: Ensembl
  8. positive regulation of DNA replication Source: Ensembl
  9. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  10. protein kinase C signaling Source: MGI
  11. regulation of inflammatory response Source: MGI
  12. response to activity Source: Ensembl
  13. response to drug Source: Ensembl
  14. response to gonadotropin Source: Ensembl
  15. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Mas
Gene namesi
Name:Mas1
Synonyms:Mas, Mas-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96918. Mas1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 6025Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 644CytoplasmicSequence Analysis
Transmembranei65 – 8622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10317ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12724Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 17123Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 18413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 22318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini245 – 26218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 32441CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Proto-oncogene MasPRO_0000069715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP30554.

PTM databases

PhosphoSiteiP30554.

Expressioni

Gene expression databases

BgeeiP30554.
CleanExiMM_MAS1.
ExpressionAtlasiP30554. baseline and differential.
GenevestigatoriP30554.

Interactioni

Subunit structurei

Interacts with AGTR1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP30554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG137333.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP30554.
KOiK04303.
OMAiYELSSGH.
OrthoDBiEOG79PJPH.
PhylomeDBiP30554.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNMTSLA EEKAMNTSSR NASLGSSHPP IPIVHWVIMS ISPLGFVENG
60 70 80 90 100
ILLWFLCFRM RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH
110 120 130 140 150
HYTIVTLSVT FLFGYNTGLY LLTAISVERC LSVLYPIWYR CHRPKHQSAF
160 170 180 190 200
VCALLWALSC LVTTMEYVMC IDSGEESHSR SDCRAVIIFI AILSFLVFTP
210 220 230 240 250
LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA MPMRVLYLLY
260 270 280 290 300
YEYWSAFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR
310 320
AFKDEMQPRR QEGNGNTVSI ETVV
Length:324
Mass (Da):37,055
Last modified:December 6, 2005 - v2
Checksum:i1708FCECAF4656A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191S → I in AAB69120 (PubMed:16141072).Curated
Sequence conflicti74 – 741I → M in CAA47964 (PubMed:8001672).Curated
Sequence conflicti140 – 1412RC → TS in CAA47964 (PubMed:8001672).Curated
Sequence conflicti156 – 1561W → C in CAA47964 (PubMed:8001672).Curated
Sequence conflicti207 – 2071T → S in CAA47964 (PubMed:8001672).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67735 Genomic DNA. Translation: CAA47964.1.
AK030261 mRNA. Translation: BAC26865.1.
AK030265 mRNA. Translation: BAC26868.1.
U96273 mRNA. Translation: AAB69120.1.
CCDSiCCDS28394.1.
PIRiS51001.
RefSeqiNP_032578.2. NM_008552.4.
XP_006523356.1. XM_006523293.2.
XP_006523357.1. XM_006523294.2.
XP_006523359.1. XM_006523296.2.
XP_006523360.1. XM_006523297.2.
XP_006523362.1. XM_006523299.2.
UniGeneiMm.425994.

Genome annotation databases

EnsembliENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037.
ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037.
ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037.
ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037.
ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037.
GeneIDi17171.
KEGGimmu:17171.
UCSCiuc008ald.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67735 Genomic DNA. Translation: CAA47964.1.
AK030261 mRNA. Translation: BAC26865.1.
AK030265 mRNA. Translation: BAC26868.1.
U96273 mRNA. Translation: AAB69120.1.
CCDSiCCDS28394.1.
PIRiS51001.
RefSeqiNP_032578.2. NM_008552.4.
XP_006523356.1. XM_006523293.2.
XP_006523357.1. XM_006523294.2.
XP_006523359.1. XM_006523296.2.
XP_006523360.1. XM_006523297.2.
XP_006523362.1. XM_006523299.2.
UniGeneiMm.425994.

3D structure databases

ProteinModelPortaliP30554.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi150.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30554.

Proteomic databases

PRIDEiP30554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037.
ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037.
ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037.
ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037.
ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037.
GeneIDi17171.
KEGGimmu:17171.
UCSCiuc008ald.2. mouse.

Organism-specific databases

CTDi4142.
MGIiMGI:96918. Mas1.

Phylogenomic databases

eggNOGiNOG137333.
HOGENOMiHOG000015412.
HOVERGENiHBG098384.
InParanoidiP30554.
KOiK04303.
OMAiYELSSGH.
OrthoDBiEOG79PJPH.
PhylomeDBiP30554.
TreeFamiTF336336.

Miscellaneous databases

NextBioi291464.
PROiP30554.
SOURCEiSearch...

Gene expression databases

BgeeiP30554.
CleanExiMM_MAS1.
ExpressionAtlasiP30554. baseline and differential.
GenevestigatoriP30554.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues."
    Metzger R., Bader M., Ludwig T., Berberich C., Bunnemann B., Ganten D.
    FEBS Lett. 357:27-32(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene."
    Schweifer N., Valk P.J., Delwel R., Cox R., Francis F., Meier-Ewert S., Lehrach H., Barlow D.P.
    Genomics 43:285-297(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-25.
    Strain: BCBA.
    Tissue: Testis.
  4. Cited for: FUNCTION AS RECEPTOR FOR ANGIOTENSIN 1-7.

Entry informationi

Entry nameiMAS_MOUSE
AccessioniPrimary (citable) accession number: P30554
Secondary accession number(s): O35944, Q8BHI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 6, 2005
Last modified: April 1, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.