Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P30554 (MAS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proto-oncogene Mas
Gene names
Name:Mas1
Synonyms:Mas, Mas-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 By similarity. Receptor for angiotensin 1-7. Ref.4

Subunit structure

Interacts with AGTR1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DiseaseProto-oncogene
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype Ref.4. Source: MGI

activation of NF-kappaB-inducing kinase activity

Inferred from mutant phenotype PubMed 19404405. Source: MGI

cellular response to peptide hormone stimulus

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of inositol phosphate biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein kinase C signaling

Inferred from electronic annotation. Source: Ensembl

regulation of inflammatory response

Inferred from mutant phenotype PubMed 19404405. Source: MGI

response to activity

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to gonadotropin

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionangiotensin receptor activity

Inferred from mutant phenotype Ref.4. Source: UniProtKB

peptide binding

Inferred from mutant phenotype Ref.4. Source: UniProtKB

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Proto-oncogene Mas
PRO_0000069715

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 6025Helical; Name=1; Potential
Topological domain61 – 644Cytoplasmic Potential
Transmembrane65 – 8622Helical; Name=2; Potential
Topological domain87 – 10317Extracellular Potential
Transmembrane104 – 12724Helical; Name=3; Potential
Topological domain128 – 14821Cytoplasmic Potential
Transmembrane149 – 17123Helical; Name=4; Potential
Topological domain172 – 18413Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 22318Cytoplasmic Potential
Transmembrane224 – 24421Helical; Name=6; Potential
Topological domain245 – 26218Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 32441Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict191S → I in AAB69120. Ref.2
Sequence conflict741I → M in CAA47964. Ref.1
Sequence conflict140 – 1412RC → TS in CAA47964. Ref.1
Sequence conflict1561W → C in CAA47964. Ref.1
Sequence conflict2071T → S in CAA47964. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P30554 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 1708FCECAF4656A4

FASTA32437,055
        10         20         30         40         50         60 
MDQSNMTSLA EEKAMNTSSR NASLGSSHPP IPIVHWVIMS ISPLGFVENG ILLWFLCFRM 

        70         80         90        100        110        120 
RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH HYTIVTLSVT FLFGYNTGLY 

       130        140        150        160        170        180 
LLTAISVERC LSVLYPIWYR CHRPKHQSAF VCALLWALSC LVTTMEYVMC IDSGEESHSR 

       190        200        210        220        230        240 
SDCRAVIIFI AILSFLVFTP LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA 

       250        260        270        280        290        300 
MPMRVLYLLY YEYWSAFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR 

       310        320 
AFKDEMQPRR QEGNGNTVSI ETVV 

« Hide

References

« Hide 'large scale' references
[1]"Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues."
Metzger R., Bader M., Ludwig T., Berberich C., Bunnemann B., Ganten D.
FEBS Lett. 357:27-32(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]"Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene."
Schweifer N., Valk P.J., Delwel R., Cox R., Francis F., Meier-Ewert S., Lehrach H., Barlow D.P.
Genomics 43:285-297(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-25.
Strain: BCBA.
Tissue: Testis.
[4]"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas."
Santos R.A.S., Simoes e Silva A.C., Maric C., Silva D.M.R., Machado R.P., de Buhr I., Heringer-Walther S., Pinheiro S.V.B., Lopes M.T., Bader M., Mendes E.P., Lemos V.S., Campagnole-Santos M.J., Schultheiss H.-P., Speth R., Walther T.
Proc. Natl. Acad. Sci. U.S.A. 100:8258-8263(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS RECEPTOR FOR ANGIOTENSIN 1-7.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67735 Genomic DNA. Translation: CAA47964.1.
AK030261 mRNA. Translation: BAC26865.1.
AK030265 mRNA. Translation: BAC26868.1.
U96273 mRNA. Translation: AAB69120.1.
CCDSCCDS28394.1.
PIRS51001.
RefSeqNP_032578.2. NM_008552.4.
XP_006523356.1. XM_006523293.1.
XP_006523357.1. XM_006523294.1.
XP_006523358.1. XM_006523295.1.
XP_006523359.1. XM_006523296.1.
XP_006523360.1. XM_006523297.1.
XP_006523361.1. XM_006523298.1.
XP_006523362.1. XM_006523299.1.
UniGeneMm.425994.

3D structure databases

ProteinModelPortalP30554.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY150.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30554.

Proteomic databases

PRIDEP30554.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037.
ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037.
ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037.
ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037.
ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037.
GeneID17171.
KEGGmmu:17171.
UCSCuc008ald.2. mouse.

Organism-specific databases

CTD4142.
MGIMGI:96918. Mas1.

Phylogenomic databases

eggNOGNOG137333.
HOGENOMHOG000015412.
HOVERGENHBG098384.
InParanoidP30554.
KOK04303.
OMAYELSSGH.
OrthoDBEOG79PJPH.
PhylomeDBP30554.
TreeFamTF336336.

Gene expression databases

BgeeP30554.
CleanExMM_MAS1.
GenevestigatorP30554.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR000820. Proto-oncogene_Mas.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF4. PTHR11334:SF4. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00533. MASONCOGENE.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291464.
PROP30554.
SOURCESearch...

Entry information

Entry nameMAS_MOUSE
AccessionPrimary (citable) accession number: P30554
Secondary accession number(s): O35944, Q8BHI8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries