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Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: RGD
  • behavioral defense response Source: RGD
  • digestion Source: RGD
  • ERK1 and ERK2 cascade Source: RGD
  • estrous cycle Source: RGD
  • histamine secretion Source: RGD
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of somatostatin secretion Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to insulin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:Cckbr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2290. Cckbr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence analysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini80 – 878CytoplasmicSequence analysis
Transmembranei88 – 10922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini110 – 13122ExtracellularSequence analysisAdd
BLAST
Transmembranei132 – 15019Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini151 – 17020CytoplasmicSequence analysisAdd
BLAST
Transmembranei171 – 18919Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini190 – 21930ExtracellularSequence analysisAdd
BLAST
Transmembranei220 – 24223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini243 – 33896CytoplasmicSequence analysisAdd
BLAST
Transmembranei339 – 36022Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini361 – 37818ExtracellularSequence analysisAdd
BLAST
Transmembranei379 – 39921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini400 – 45253CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2096986.
GuidetoPHARMACOLOGYi77.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Gastrin/cholecystokinin type B receptorPRO_0000069478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi413 – 4131S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30553.
PRIDEiP30553.

PTM databases

iPTMnetiP30553.
PhosphoSiteiP30553.

Expressioni

Tissue specificityi

Parietal cells, pancreas, brain and various neoplastic tissues.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024077.

Chemistry

BindingDBiP30553.

Structurei

3D structure databases

ProteinModelPortaliP30553.
SMRiP30553. Positions 358-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2266Poly-Leu

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP30553.
KOiK04195.
PhylomeDBiP30553.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKLNRSV QGPGPGSGSS LCRPGVSLLN SSSAGNLSCD PPRIRGTGTR
60 70 80 90 100
ELEMAIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAI SYLMGVSVSV STLNLVAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTMVQPVGP
210 220 230 240 250
RVLQCMHRWP SARVQQTWSV LLLLLLFFIP GVVIAVAYGL ISRELYLGLH
260 270 280 290 300
FDGENDSETQ SRARNQGGLP GGAAPGPVHQ NGGCRPVTSV AGEDSDGCCV
310 320 330 340 350
QLPRSRLEMT TLTTPTPGPV PGPRPNQAKL LAKKRVVRML LVIVLLFFLC
360 370 380 390 400
WLPVYSVNTW RAFDGPGAQR ALSGAPISFI HLLSYVSACV NPLVYCFMHR
410 420 430 440 450
RFRQACLDTC ARCCPRPPRA RPQPLPDEDP PTPSIASLSR LSYTTISTLG

PG
Length:452
Mass (Da):48,957
Last modified:April 1, 1993 - v1
Checksum:i006D811A6AA065C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99418 mRNA. Translation: AAA40925.1.
PIRiA46195.
RefSeqiNP_037297.1. NM_013165.2.
UniGeneiRn.90997.

Genome annotation databases

GeneIDi25706.
KEGGirno:25706.
UCSCiRGD:2290. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99418 mRNA. Translation: AAA40925.1.
PIRiA46195.
RefSeqiNP_037297.1. NM_013165.2.
UniGeneiRn.90997.

3D structure databases

ProteinModelPortaliP30553.
SMRiP30553. Positions 358-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024077.

Chemistry

BindingDBiP30553.
ChEMBLiCHEMBL2096986.
GuidetoPHARMACOLOGYi77.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30553.
PhosphoSiteiP30553.

Proteomic databases

PaxDbiP30553.
PRIDEiP30553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25706.
KEGGirno:25706.
UCSCiRGD:2290. rat.

Organism-specific databases

CTDi887.
RGDi2290. Cckbr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP30553.
KOiK04195.
PhylomeDBiP30553.

Miscellaneous databases

PROiP30553.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression."
    Wank S.A., Pisegna J.R., de Weerth A.
    Proc. Natl. Acad. Sci. U.S.A. 89:8691-8695(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGASR_RAT
AccessioniPrimary (citable) accession number: P30553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.