Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • gastrin receptor activity Source: RGD

GO - Biological processi

  • apoptotic process Source: RGD
  • behavioral defense response Source: RGD
  • digestion Source: RGD
  • ERK1 and ERK2 cascade Source: RGD
  • estrous cycle Source: RGD
  • histamine secretion Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of somatostatin secretion Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to insulin Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:Cckbr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2290 Cckbr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 79Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini80 – 87CytoplasmicSequence analysis8
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 131ExtracellularSequence analysisAdd BLAST22
Transmembranei132 – 150Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini151 – 170CytoplasmicSequence analysisAdd BLAST20
Transmembranei171 – 189Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini190 – 219ExtracellularSequence analysisAdd BLAST30
Transmembranei220 – 242Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini243 – 338CytoplasmicSequence analysisAdd BLAST96
Transmembranei339 – 360Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini361 – 378ExtracellularSequence analysisAdd BLAST18
Transmembranei379 – 399Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini400 – 452CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3508
GuidetoPHARMACOLOGYi77

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694781 – 452Gastrin/cholecystokinin type B receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi413S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30553
PRIDEiP30553

PTM databases

iPTMnetiP30553
PhosphoSitePlusiP30553

Expressioni

Tissue specificityi

Parietal cells, pancreas, brain and various neoplastic tissues.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024077

Chemistry databases

BindingDBiP30553

Structurei

3D structure databases

ProteinModelPortaliP30553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 226Poly-Leu6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000294067
HOVERGENiHBG036927
InParanoidiP30553
KOiK04195
PhylomeDBiP30553

Family and domain databases

InterProiView protein in InterPro
IPR009126 Cholcskin_rcpt
IPR000314 Gastrin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01822 CCYSTOKININR
PR00527 GASTRINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKLNRSV QGPGPGSGSS LCRPGVSLLN SSSAGNLSCD PPRIRGTGTR
60 70 80 90 100
ELEMAIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAI SYLMGVSVSV STLNLVAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTMVQPVGP
210 220 230 240 250
RVLQCMHRWP SARVQQTWSV LLLLLLFFIP GVVIAVAYGL ISRELYLGLH
260 270 280 290 300
FDGENDSETQ SRARNQGGLP GGAAPGPVHQ NGGCRPVTSV AGEDSDGCCV
310 320 330 340 350
QLPRSRLEMT TLTTPTPGPV PGPRPNQAKL LAKKRVVRML LVIVLLFFLC
360 370 380 390 400
WLPVYSVNTW RAFDGPGAQR ALSGAPISFI HLLSYVSACV NPLVYCFMHR
410 420 430 440 450
RFRQACLDTC ARCCPRPPRA RPQPLPDEDP PTPSIASLSR LSYTTISTLG

PG
Length:452
Mass (Da):48,957
Last modified:April 1, 1993 - v1
Checksum:i006D811A6AA065C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99418 mRNA Translation: AAA40925.1
PIRiA46195
RefSeqiNP_037297.1, NM_013165.2
UniGeneiRn.90997

Genome annotation databases

GeneIDi25706
KEGGirno:25706
UCSCiRGD:2290 rat

Similar proteinsi

Entry informationi

Entry nameiGASR_RAT
AccessioniPrimary (citable) accession number: P30553
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health