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Protein

Cholecystokinin receptor type A

Gene

Cckar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • cholecystokinin receptor activity Source: RGD
  • peptide binding Source: GO_Central

GO - Biological processi

  • actin cytoskeleton reorganization Source: RGD
  • animal organ regeneration Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • eating behavior Source: RGD
  • feeding behavior Source: RGD
  • gastric acid secretion Source: RGD
  • insulin secretion Source: RGD
  • pancreas development Source: RGD
  • pancreatic juice secretion Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of somatostatin secretion Source: RGD
  • reduction of food intake in response to dietary excess Source: RGD
  • regulation of calcium ion transport Source: RGD
  • regulation of hormone secretion Source: RGD
  • regulation of potassium ion transport Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD
  • response to peptide Source: GO_Central
  • response to radiation Source: RGD
  • response to starvation Source: RGD
  • response to steroid hormone Source: RGD
  • temperature homeostasis Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:Cckar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2289 Cckar

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 82Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini83 – 92CytoplasmicSequence analysis10
Transmembranei93 – 119Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini120 – 130ExtracellularSequence analysisAdd BLAST11
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 172CytoplasmicSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini194 – 225ExtracellularSequence analysisAdd BLAST32
Transmembranei226 – 249Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini250 – 329CytoplasmicSequence analysisAdd BLAST80
Transmembranei330 – 350Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini351 – 365ExtracellularSequence analysisAdd BLAST15
Transmembranei366 – 389Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini390 – 444CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2871
GuidetoPHARMACOLOGYi76

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692261 – 444Cholecystokinin receptor type AAdd BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi33 ↔ 44PROSITE-ProRule annotation1 Publication
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 211PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi403S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30551
PRIDEiP30551

PTM databases

iPTMnetiP30551
PhosphoSitePlusiP30551

Miscellaneous databases

PMAP-CutDBiP30551

Expressioni

Tissue specificityi

Pancreas and brain. Also expressed in the gastrointestinal system and vagus nerve.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063137

Chemistry databases

BindingDBiP30551

Structurei

3D structure databases

ProteinModelPortaliP30551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000198281
HOVERGENiHBG036927
InParanoidiP30551
KOiK04194
PhylomeDBiP30551

Family and domain databases

Gene3Di4.10.670.10, 1 hit
InterProiView protein in InterPro
IPR009126 Cholcskin_rcpt
IPR000596 Cholcy_rcpt_A
IPR015276 CholecystokininA_recpt_N
IPR036472 CholecystokininA_recpt_N_sf
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF09193 CholecysA-Rec_N, 1 hit
PRINTSiPR01822 CCYSTOKININR
PR00524 CCYSTOKNINAR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSPARQHL VESSRMDVVD SLLMNGSNIT PPCELGLENE TLFCLDQPQP
60 70 80 90 100
SKEWQSALQI LLYSIIFLLS VLGNTLVITV LIRNKRMRTV TNIFLLSLAV
110 120 130 140 150
SDLMLCLFCM PFNLIPNLLK DFIFGSAVCK TTTYFMGTSV SVSTFNLVAI
160 170 180 190 200
SLERYGAICR PLQSRVWQTK SHALKVIAAT WCLSFTIMTP YPIYSNLVPF
210 220 230 240 250
TKNNNQTANM CRFLLPSDAM QQSWQTFLLL ILFLLPGIVM VVAYGLISLE
260 270 280 290 300
LYQGIKFDAS QKKSAKEKKP STGSSTRYED SDGCYLQKSR PPRKLELQQL
310 320 330 340 350
SSGSGGSRLN RIRSSSSAAN LIAKKRVIRM LIVIVVLFFL CWMPIFSANA
360 370 380 390 400
WRAYDTVSAE KHLSGTPISF ILLLSYTSSC VNPIIYCFMN KRFRLGFMAT
410 420 430 440
FPCCPNPGPP GVRGEVGEEE DGRTIRALLS RYSYSHMSTS APPP
Length:444
Mass (Da):49,657
Last modified:April 1, 1993 - v1
Checksum:iB435BE7505C2FB11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88096 mRNA Translation: AAA40899.1
D50608 Genomic DNA Translation: BAA09170.1
PIRiA42685
RefSeqiNP_036820.1, NM_012688.3
UniGeneiRn.10184

Genome annotation databases

GeneIDi24889
KEGGirno:24889

Similar proteinsi

Entry informationi

Entry nameiCCKAR_RAT
AccessioniPrimary (citable) accession number: P30551
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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