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Protein

Cholecystokinin receptor type A

Gene

Cckar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

  • cholecystokinin receptor activity Source: RGD

GO - Biological processi

  • actin cytoskeleton reorganization Source: RGD
  • animal organ regeneration Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • eating behavior Source: RGD
  • feeding behavior Source: RGD
  • gastric acid secretion Source: RGD
  • insulin secretion Source: RGD
  • pancreas development Source: RGD
  • pancreatic juice secretion Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of somatostatin secretion Source: RGD
  • reduction of food intake in response to dietary excess Source: RGD
  • regulation of calcium ion transport Source: RGD
  • regulation of hormone secretion Source: RGD
  • regulation of potassium ion transport Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD
  • response to radiation Source: RGD
  • response to starvation Source: RGD
  • response to steroid hormone Source: RGD
  • temperature homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:Cckar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2289. Cckar.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 82Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini83 – 92CytoplasmicSequence analysis10
Transmembranei93 – 119Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini120 – 130ExtracellularSequence analysisAdd BLAST11
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 172CytoplasmicSequence analysisAdd BLAST20
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini194 – 225ExtracellularSequence analysisAdd BLAST32
Transmembranei226 – 249Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini250 – 329CytoplasmicSequence analysisAdd BLAST80
Transmembranei330 – 350Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini351 – 365ExtracellularSequence analysisAdd BLAST15
Transmembranei366 – 389Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini390 – 444CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: RGD
  • endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: RGD
  • plasma membrane Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2871.
GuidetoPHARMACOLOGYi76.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692261 – 444Cholecystokinin receptor type AAdd BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi33 ↔ 44PROSITE-ProRule annotation1 Publication
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 211PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Lipidationi403S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30551.
PRIDEiP30551.

PTM databases

iPTMnetiP30551.
PhosphoSitePlusiP30551.

Miscellaneous databases

PMAP-CutDBP30551.

Expressioni

Tissue specificityi

Pancreas and brain. Also expressed in the gastrointestinal system and vagus nerve.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063137.

Chemistry databases

BindingDBiP30551.

Structurei

3D structure databases

ProteinModelPortaliP30551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000198281.
HOVERGENiHBG036927.
InParanoidiP30551.
KOiK04194.
PhylomeDBiP30551.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSPARQHL VESSRMDVVD SLLMNGSNIT PPCELGLENE TLFCLDQPQP
60 70 80 90 100
SKEWQSALQI LLYSIIFLLS VLGNTLVITV LIRNKRMRTV TNIFLLSLAV
110 120 130 140 150
SDLMLCLFCM PFNLIPNLLK DFIFGSAVCK TTTYFMGTSV SVSTFNLVAI
160 170 180 190 200
SLERYGAICR PLQSRVWQTK SHALKVIAAT WCLSFTIMTP YPIYSNLVPF
210 220 230 240 250
TKNNNQTANM CRFLLPSDAM QQSWQTFLLL ILFLLPGIVM VVAYGLISLE
260 270 280 290 300
LYQGIKFDAS QKKSAKEKKP STGSSTRYED SDGCYLQKSR PPRKLELQQL
310 320 330 340 350
SSGSGGSRLN RIRSSSSAAN LIAKKRVIRM LIVIVVLFFL CWMPIFSANA
360 370 380 390 400
WRAYDTVSAE KHLSGTPISF ILLLSYTSSC VNPIIYCFMN KRFRLGFMAT
410 420 430 440
FPCCPNPGPP GVRGEVGEEE DGRTIRALLS RYSYSHMSTS APPP
Length:444
Mass (Da):49,657
Last modified:April 1, 1993 - v1
Checksum:iB435BE7505C2FB11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88096 mRNA. Translation: AAA40899.1.
D50608 Genomic DNA. Translation: BAA09170.1.
PIRiA42685.
RefSeqiNP_036820.1. NM_012688.3.
UniGeneiRn.10184.

Genome annotation databases

GeneIDi24889.
KEGGirno:24889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88096 mRNA. Translation: AAA40899.1.
D50608 Genomic DNA. Translation: BAA09170.1.
PIRiA42685.
RefSeqiNP_036820.1. NM_012688.3.
UniGeneiRn.10184.

3D structure databases

ProteinModelPortaliP30551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063137.

Chemistry databases

BindingDBiP30551.
ChEMBLiCHEMBL2871.
GuidetoPHARMACOLOGYi76.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30551.
PhosphoSitePlusiP30551.

Proteomic databases

PaxDbiP30551.
PRIDEiP30551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24889.
KEGGirno:24889.

Organism-specific databases

CTDi886.
RGDi2289. Cckar.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000198281.
HOVERGENiHBG036927.
InParanoidiP30551.
KOiK04194.
PhylomeDBiP30551.

Miscellaneous databases

PMAP-CutDBP30551.
PROiP30551.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKAR_RAT
AccessioniPrimary (citable) accession number: P30551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.