Reviewed, UniProtKB/Swiss-Prot P30550 (GRPR_HUMAN)

Names and origin

Protein names

Recommended name:
    Gastrin-releasing peptide receptor
      Short name=GRP-R
Alternative name(s):
    GRP-preferring bombesin receptor

Gene names

Name:

GRPR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Ref.1 Traceable author statement. Source: ProtInc cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	bombesin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Gastrin-releasing peptide receptor		PRO_0000069662
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 62	24	1 Potential
	Topological domain	63 – 76	14	Cytoplasmic Potential
	Transmembrane	77 – 96	20	2 Potential
	Topological domain	97 – 114	18	Extracellular Potential
	Transmembrane	115 – 136	22	3 Potential
	Topological domain	137 – 152	16	Cytoplasmic Potential
	Transmembrane	153 – 174	22	4 Potential
	Topological domain	175 – 208	34	Extracellular Potential
	Transmembrane	209 – 234	26	5 Potential
	Topological domain	235 – 264	30	Cytoplasmic Potential
	Transmembrane	265 – 285	21	6 Potential
	Topological domain	286 – 298	13	Extracellular Potential
	Transmembrane	299 – 325	27	7 Potential
	Topological domain	326 – 384	59	Cytoplasmic Potential
Amino acid modifications
	Lipidation	339	1	S-palmitoyl cysteine By similarity
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 196		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30550-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 70A75F11D9C82F19	FASTA	384	43,199
	10 20 30 40 50 60 MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT 70 80 90 100 110 120 LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ 130 140 150 160 170 180 LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD 190 200 210 220 230 240 LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS 250 260 270 280 290 300 AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 310 320 330 340 350 360 FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS 370 380 LKSTNPSVAT FSLINGNICH ERYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells." Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F. J. Biol. Chem. 266:18771-18779(1991) [PubMed: 1655761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter." Xiao D., Wang J., Hampton L.L., Weber H.C. Gene 264:95-103(2001) [PubMed: 11245983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M73481 mRNA. Translation: AAA88050.1. AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1. BC074733 mRNA. Translation: AAH74733.1.
IPI	IPI00026881.
PIR	A41007.
RefSeq	NP_005305.1.
UniGene	Hs.567282
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P30550.
Genome annotation databases
Ensembl	ENSG00000126010. Homo sapiens. [Contig view]
GeneID	2925.
KEGG	hsa:2925.
Organism-specific databases
GeneCards	GC0XP016051.
H-InvDB	HIX0056254.
HGNC	HGNC:4609. GRPR.
MIM	305670. gene.
PharmGKB	PA29002.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P30550.
HOVERGEN	P30550.
OMA	P30550. EGNIHVK.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P30550.
Bgee	P30550.
CleanEx	HS_GRPR.
GermOnline	ENSG00000126010. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001556. Bombsn_rcpt. IPR001966. Gastrin_pep_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF239. Bombsn_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00358. BOMBESINR. PR00640. GASTRINRELPR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	11597.
SOURCE	Search...

Entry information

Entry name

GRPR_HUMAN

Accession

Primary (citable) accession number: P30550

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)