P30550 (GRPR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin-releasing peptide receptor
Short name=GRP-R

Alternative name(s):
GRP-preferring bombesin receptor

Gene names

Name:

GRPR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.1. Source: ProtInc regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement PubMed 8391296. Source: ProtInc
Molecular_function	G-protein coupled peptide receptor activity Traceable author statement PubMed 7838118. Source: ProtInc bombesin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Gastrin-releasing peptide receptor		PRO_0000069662
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 62	24	Helical; Name=1; Potential
	Topological domain	63 – 76	14	Cytoplasmic Potential
	Transmembrane	77 – 96	20	Helical; Name=2; Potential
	Topological domain	97 – 114	18	Extracellular Potential
	Transmembrane	115 – 136	22	Helical; Name=3; Potential
	Topological domain	137 – 152	16	Cytoplasmic Potential
	Transmembrane	153 – 174	22	Helical; Name=4; Potential
	Topological domain	175 – 208	34	Extracellular Potential
	Transmembrane	209 – 234	26	Helical; Name=5; Potential
	Topological domain	235 – 264	30	Cytoplasmic Potential
	Transmembrane	265 – 285	21	Helical; Name=6; Potential
	Topological domain	286 – 298	13	Extracellular Potential
	Transmembrane	299 – 325	27	Helical; Name=7; Potential
	Topological domain	326 – 384	59	Cytoplasmic Potential
Amino acid modifications
	Lipidation	339	1	S-palmitoyl cysteine By similarity
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 196		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P30550 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 70A75F11D9C82F19	FASTA	384	43,199
	10 20 30 40 50 60 MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT 70 80 90 100 110 120 LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ 130 140 150 160 170 180 LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD 190 200 210 220 230 240 LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS 250 260 270 280 290 300 AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 310 320 330 340 350 360 FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS 370 380 LKSTNPSVAT FSLINGNICH ERYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells." Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F. J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter." Xiao D., Wang J., Hampton L.L., Weber H.C. Gene 264:95-103(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73481 mRNA. Translation: AAA88050.1. AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1. AK313588 mRNA. Translation: BAG36357.1. CH471074 Genomic DNA. Translation: EAW98909.1. BC074733 mRNA. Translation: AAH74733.1.
IPI	IPI00026881.
PIR	A41007.
RefSeq	NP_005305.1. NM_005314.2.
UniGene	Hs.567282.
3D structure databases
ProteinModelPortal	P30550.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369643.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P30550.
Polymorphism databases
DMDM	232185.
Proteomic databases
PaxDb	P30550.
PRIDE	P30550.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380289; ENSP00000369643; ENSG00000126010.
GeneID	2925.
KEGG	hsa:2925.
UCSC	uc004cxj.3. human.
Organism-specific databases
CTD	2925.
GeneCards	GC0XP016141.
HGNC	HGNC:4609. GRPR.
MIM	305670. gene.
neXtProt	NX_P30550.
PharmGKB	PA29002.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG328649.
HOGENOM	HOG000230781.
HOVERGEN	HBG004898.
InParanoid	P30550.
KO	K04169.
OMA	CNISNHS.
OrthoDB	EOG476K0C.
PhylomeDB	P30550.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P30550.
CleanEx	HS_GRPR.
Genevestigator	P30550.
GermOnline	ENSG00000126010. Homo sapiens.
Family and domain databases
InterPro	IPR001556. Bombsn_rcpt. IPR001966. Gastrin_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00358. BOMBESINR. PR00640. GASTRINRELPR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P30550.
ChEMBL	CHEMBL4959.
GenomeRNAi	2925.
NextBio	11597.
SOURCE	Search...

Entry information

Entry name

GRPR_HUMAN

Accession

Primary (citable) accession number: P30550
Secondary accession number(s): B2R910

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.