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P30550

- GRPR_HUMAN

UniProt

P30550 - GRPR_HUMAN

Protein

Gastrin-releasing peptide receptor

Gene

GRPR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. bombesin receptor activity Source: InterPro
    2. G-protein coupled peptide receptor activity Source: ProtInc

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. regulation of cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin-releasing peptide receptor
    Short name:
    GRP-R
    Alternative name(s):
    GRP-preferring bombesin receptor
    Gene namesi
    Name:GRPR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4609. GRPR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Gastrin-releasing peptide receptorPRO_0000069662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 196PROSITE-ProRule annotation
    Lipidationi339 – 3391S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP30550.
    PaxDbiP30550.
    PRIDEiP30550.

    PTM databases

    PhosphoSiteiP30550.

    Expressioni

    Tissue specificityi

    Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.1 Publication

    Gene expression databases

    BgeeiP30550.
    CleanExiHS_GRPR.
    GenevestigatoriP30550.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369643.

    Structurei

    3D structure databases

    ProteinModelPortaliP30550.
    SMRiP30550. Positions 43-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 20834ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 26430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini286 – 29813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 38459CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17422Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 32527Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG328649.
    HOGENOMiHOG000230781.
    HOVERGENiHBG004898.
    InParanoidiP30550.
    KOiK04169.
    OMAiCNISNHS.
    OrthoDBiEOG73V6KG.
    PhylomeDBiP30550.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001556. Bombsn_rcpt.
    IPR001966. Gastrin_pep_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00358. BOMBESINR.
    PR00640. GASTRINRELPR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P30550-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI    50
    ILIGLIGNIT LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR 100
    YLADRWLFGR IGCKLIPFIQ LTSVGVSVFT LTALSADRYK AIVRPMDIQA 150
    SHALMKICLK AAFIWIISML LAIPEAVFSD LHPFHEESTN QTFISCAPYP 200
    HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS AYNLPVEGNI 250
    HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 300
    FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS 350
    TGRSTTCMTS LKSTNPSVAT FSLINGNICH ERYV 384
    Length:384
    Mass (Da):43,199
    Last modified:April 1, 1993 - v1
    Checksum:i70A75F11D9C82F19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73481 mRNA. Translation: AAA88050.1.
    AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
    AK313588 mRNA. Translation: BAG36357.1.
    CH471074 Genomic DNA. Translation: EAW98909.1.
    BC074733 mRNA. Translation: AAH74733.1.
    CCDSiCCDS14174.1.
    PIRiA41007.
    RefSeqiNP_005305.1. NM_005314.2.
    UniGeneiHs.567282.

    Genome annotation databases

    EnsembliENST00000380289; ENSP00000369643; ENSG00000126010.
    GeneIDi2925.
    KEGGihsa:2925.
    UCSCiuc004cxj.3. human.

    Polymorphism databases

    DMDMi232185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73481 mRNA. Translation: AAA88050.1 .
    AF293323 , AF293321 , AF293322 Genomic DNA. Translation: AAL96377.1 .
    AK313588 mRNA. Translation: BAG36357.1 .
    CH471074 Genomic DNA. Translation: EAW98909.1 .
    BC074733 mRNA. Translation: AAH74733.1 .
    CCDSi CCDS14174.1.
    PIRi A41007.
    RefSeqi NP_005305.1. NM_005314.2.
    UniGenei Hs.567282.

    3D structure databases

    ProteinModelPortali P30550.
    SMRi P30550. Positions 43-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369643.

    Chemistry

    BindingDBi P30550.
    ChEMBLi CHEMBL4959.
    GuidetoPHARMACOLOGYi 39.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P30550.

    Polymorphism databases

    DMDMi 232185.

    Proteomic databases

    MaxQBi P30550.
    PaxDbi P30550.
    PRIDEi P30550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380289 ; ENSP00000369643 ; ENSG00000126010 .
    GeneIDi 2925.
    KEGGi hsa:2925.
    UCSCi uc004cxj.3. human.

    Organism-specific databases

    CTDi 2925.
    GeneCardsi GC0XP016141.
    HGNCi HGNC:4609. GRPR.
    MIMi 305670. gene.
    neXtProti NX_P30550.
    PharmGKBi PA29002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328649.
    HOGENOMi HOG000230781.
    HOVERGENi HBG004898.
    InParanoidi P30550.
    KOi K04169.
    OMAi CNISNHS.
    OrthoDBi EOG73V6KG.
    PhylomeDBi P30550.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Gastrin-releasing_peptide_receptor.
    GenomeRNAii 2925.
    NextBioi 11597.
    PROi P30550.
    SOURCEi Search...

    Gene expression databases

    Bgeei P30550.
    CleanExi HS_GRPR.
    Genevestigatori P30550.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001556. Bombsn_rcpt.
    IPR001966. Gastrin_pep_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00358. BOMBESINR.
    PR00640. GASTRINRELPR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
      Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
      J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter."
      Xiao D., Wang J., Hampton L.L., Weber H.C.
      Gene 264:95-103(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGRPR_HUMAN
    AccessioniPrimary (citable) accession number: P30550
    Secondary accession number(s): B2R910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3