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Protein

Gastrin-releasing peptide receptor

Gene

GRPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. bombesin receptor activity Source: InterPro
  2. G-protein coupled peptide receptor activity Source: ProtInc

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:GRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4609. GRPR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6224Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 7614CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei77 – 9620Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17422Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 20834ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini235 – 26430CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini286 – 29813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei299 – 32527Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini326 – 38459CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29002.

Polymorphism and mutation databases

BioMutaiGRPR.
DMDMi232185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Gastrin-releasing peptide receptorPRO_0000069662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 196PROSITE-ProRule annotation
Lipidationi339 – 3391S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30550.
PaxDbiP30550.
PRIDEiP30550.

PTM databases

PhosphoSiteiP30550.

Expressioni

Tissue specificityi

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.1 Publication

Gene expression databases

BgeeiP30550.
CleanExiHS_GRPR.
ExpressionAtlasiP30550. baseline and differential.
GenevestigatoriP30550.

Interactioni

Protein-protein interaction databases

BioGridi109181. 1 interaction.
STRINGi9606.ENSP00000369643.

Structurei

3D structure databases

ProteinModelPortaliP30550.
SMRiP30550. Positions 11-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG328649.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP30550.
KOiK04169.
OMAiQLLCCQP.
OrthoDBiEOG73V6KG.
PhylomeDBiP30550.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI
60 70 80 90 100
ILIGLIGNIT LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR
110 120 130 140 150
YLADRWLFGR IGCKLIPFIQ LTSVGVSVFT LTALSADRYK AIVRPMDIQA
160 170 180 190 200
SHALMKICLK AAFIWIISML LAIPEAVFSD LHPFHEESTN QTFISCAPYP
210 220 230 240 250
HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS AYNLPVEGNI
260 270 280 290 300
HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH
310 320 330 340 350
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS
360 370 380
TGRSTTCMTS LKSTNPSVAT FSLINGNICH ERYV
Length:384
Mass (Da):43,199
Last modified:April 1, 1993 - v1
Checksum:i70A75F11D9C82F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA. Translation: AAA88050.1.
AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
AK313588 mRNA. Translation: BAG36357.1.
CH471074 Genomic DNA. Translation: EAW98909.1.
BC074733 mRNA. Translation: AAH74733.1.
CCDSiCCDS14174.1.
PIRiA41007.
RefSeqiNP_005305.1. NM_005314.2.
UniGeneiHs.567282.

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010.
GeneIDi2925.
KEGGihsa:2925.
UCSCiuc004cxj.3. human.

Polymorphism and mutation databases

BioMutaiGRPR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA. Translation: AAA88050.1.
AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
AK313588 mRNA. Translation: BAG36357.1.
CH471074 Genomic DNA. Translation: EAW98909.1.
BC074733 mRNA. Translation: AAH74733.1.
CCDSiCCDS14174.1.
PIRiA41007.
RefSeqiNP_005305.1. NM_005314.2.
UniGeneiHs.567282.

3D structure databases

ProteinModelPortaliP30550.
SMRiP30550. Positions 11-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109181. 1 interaction.
STRINGi9606.ENSP00000369643.

Chemistry

BindingDBiP30550.
ChEMBLiCHEMBL4959.
GuidetoPHARMACOLOGYi39.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP30550.

Polymorphism and mutation databases

BioMutaiGRPR.
DMDMi232185.

Proteomic databases

MaxQBiP30550.
PaxDbiP30550.
PRIDEiP30550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010.
GeneIDi2925.
KEGGihsa:2925.
UCSCiuc004cxj.3. human.

Organism-specific databases

CTDi2925.
GeneCardsiGC0XP016141.
HGNCiHGNC:4609. GRPR.
MIMi305670. gene.
neXtProtiNX_P30550.
PharmGKBiPA29002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328649.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP30550.
KOiK04169.
OMAiQLLCCQP.
OrthoDBiEOG73V6KG.
PhylomeDBiP30550.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiGastrin-releasing_peptide_receptor.
GenomeRNAii2925.
NextBioi11597.
PROiP30550.
SOURCEiSearch...

Gene expression databases

BgeeiP30550.
CleanExiHS_GRPR.
ExpressionAtlasiP30550. baseline and differential.
GenevestigatoriP30550.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
    Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
    J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter."
    Xiao D., Wang J., Hampton L.L., Weber H.C.
    Gene 264:95-103(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGRPR_HUMAN
AccessioniPrimary (citable) accession number: P30550
Secondary accession number(s): B2R910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 29, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.