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Protein

Gastrin-releasing peptide receptor

Gene

GRPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: ProtInc

GO - Biological processi

  • cell proliferation Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126010-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP30550.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:GRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4609. GRPR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 62Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini63 – 76CytoplasmicSequence analysisAdd BLAST14
Transmembranei77 – 96Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini97 – 114ExtracellularSequence analysisAdd BLAST18
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 152CytoplasmicSequence analysisAdd BLAST16
Transmembranei153 – 174Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini175 – 208ExtracellularSequence analysisAdd BLAST34
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 264CytoplasmicSequence analysisAdd BLAST30
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 298ExtracellularSequence analysisAdd BLAST13
Transmembranei299 – 325Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini326 – 384CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2925.
OpenTargetsiENSG00000126010.
PharmGKBiPA29002.

Chemistry databases

ChEMBLiCHEMBL4959.
GuidetoPHARMACOLOGYi39.

Polymorphism and mutation databases

BioMutaiGRPR.
DMDMi232185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696621 – 384Gastrin-releasing peptide receptorAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 196PROSITE-ProRule annotation
Lipidationi339S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiP30550.
PaxDbiP30550.
PeptideAtlasiP30550.
PRIDEiP30550.

PTM databases

iPTMnetiP30550.
PhosphoSitePlusiP30550.

Expressioni

Tissue specificityi

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.1 Publication

Gene expression databases

BgeeiENSG00000126010.
CleanExiHS_GRPR.
ExpressionAtlasiP30550. baseline and differential.
GenevisibleiP30550. HS.

Organism-specific databases

HPAiHPA069604.

Interactioni

Protein-protein interaction databases

BioGridi109181. 52 interactors.
STRINGi9606.ENSP00000369643.

Chemistry databases

BindingDBiP30550.

Structurei

3D structure databases

ProteinModelPortaliP30550.
SMRiP30550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP30550.
KOiK04169.
OMAiHFIASIC.
OrthoDBiEOG091G085Y.
PhylomeDBiP30550.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P30550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI
60 70 80 90 100
ILIGLIGNIT LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR
110 120 130 140 150
YLADRWLFGR IGCKLIPFIQ LTSVGVSVFT LTALSADRYK AIVRPMDIQA
160 170 180 190 200
SHALMKICLK AAFIWIISML LAIPEAVFSD LHPFHEESTN QTFISCAPYP
210 220 230 240 250
HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS AYNLPVEGNI
260 270 280 290 300
HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH
310 320 330 340 350
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS
360 370 380
TGRSTTCMTS LKSTNPSVAT FSLINGNICH ERYV
Length:384
Mass (Da):43,199
Last modified:April 1, 1993 - v1
Checksum:i70A75F11D9C82F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA. Translation: AAA88050.1.
AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
AK313588 mRNA. Translation: BAG36357.1.
CH471074 Genomic DNA. Translation: EAW98909.1.
BC074733 mRNA. Translation: AAH74733.1.
CCDSiCCDS14174.1.
PIRiA41007.
RefSeqiNP_005305.1. NM_005314.2.
UniGeneiHs.567282.

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010.
GeneIDi2925.
KEGGihsa:2925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA. Translation: AAA88050.1.
AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
AK313588 mRNA. Translation: BAG36357.1.
CH471074 Genomic DNA. Translation: EAW98909.1.
BC074733 mRNA. Translation: AAH74733.1.
CCDSiCCDS14174.1.
PIRiA41007.
RefSeqiNP_005305.1. NM_005314.2.
UniGeneiHs.567282.

3D structure databases

ProteinModelPortaliP30550.
SMRiP30550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109181. 52 interactors.
STRINGi9606.ENSP00000369643.

Chemistry databases

BindingDBiP30550.
ChEMBLiCHEMBL4959.
GuidetoPHARMACOLOGYi39.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30550.
PhosphoSitePlusiP30550.

Polymorphism and mutation databases

BioMutaiGRPR.
DMDMi232185.

Proteomic databases

EPDiP30550.
PaxDbiP30550.
PeptideAtlasiP30550.
PRIDEiP30550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010.
GeneIDi2925.
KEGGihsa:2925.

Organism-specific databases

CTDi2925.
DisGeNETi2925.
GeneCardsiGRPR.
HGNCiHGNC:4609. GRPR.
HPAiHPA069604.
MIMi305670. gene.
neXtProtiNX_P30550.
OpenTargetsiENSG00000126010.
PharmGKBiPA29002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP30550.
KOiK04169.
OMAiHFIASIC.
OrthoDBiEOG091G085Y.
PhylomeDBiP30550.
TreeFamiTF331292.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126010-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP30550.

Miscellaneous databases

GeneWikiiGastrin-releasing_peptide_receptor.
GenomeRNAii2925.
PROiP30550.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126010.
CleanExiHS_GRPR.
ExpressionAtlasiP30550. baseline and differential.
GenevisibleiP30550. HS.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPR_HUMAN
AccessioniPrimary (citable) accession number: P30550
Secondary accession number(s): B2R910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.