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P30550 (GRPR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastrin-releasing peptide receptor

Short name=GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene names
Name:GRPR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain. Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Gastrin-releasing peptide receptor
PRO_0000069662

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6224Helical; Name=1; Potential
Topological domain63 – 7614Cytoplasmic Potential
Transmembrane77 – 9620Helical; Name=2; Potential
Topological domain97 – 11418Extracellular Potential
Transmembrane115 – 13622Helical; Name=3; Potential
Topological domain137 – 15216Cytoplasmic Potential
Transmembrane153 – 17422Helical; Name=4; Potential
Topological domain175 – 20834Extracellular Potential
Transmembrane209 – 23426Helical; Name=5; Potential
Topological domain235 – 26430Cytoplasmic Potential
Transmembrane265 – 28521Helical; Name=6; Potential
Topological domain286 – 29813Extracellular Potential
Transmembrane299 – 32527Helical; Name=7; Potential
Topological domain326 – 38459Cytoplasmic Potential

Amino acid modifications

Lipidation3391S-palmitoyl cysteine By similarity
Glycosylation201N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 196 By similarity

Sequences

Sequence LengthMass (Da)Tools
P30550 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 70A75F11D9C82F19

FASTA38443,199
        10         20         30         40         50         60 
MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT 

        70         80         90        100        110        120 
LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ 

       130        140        150        160        170        180 
LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD 

       190        200        210        220        230        240 
LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS 

       250        260        270        280        290        300 
AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH 

       310        320        330        340        350        360 
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS 

       370        380 
LKSTNPSVAT FSLINGNICH ERYV 

« Hide

References

« Hide 'large scale' references
[1]"Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells."
Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H., Worland P., Sausville E.A., Battey J.F.
J. Biol. Chem. 266:18771-18779(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter."
Xiao D., Wang J., Hampton L.L., Weber H.C.
Gene 264:95-103(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73481 mRNA. Translation: AAA88050.1.
AF293323, AF293321, AF293322 Genomic DNA. Translation: AAL96377.1.
AK313588 mRNA. Translation: BAG36357.1.
CH471074 Genomic DNA. Translation: EAW98909.1.
BC074733 mRNA. Translation: AAH74733.1.
PIRA41007.
RefSeqNP_005305.1. NM_005314.2.
UniGeneHs.567282.

3D structure databases

ProteinModelPortalP30550.
SMRP30550. Positions 11-349.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369643.

Chemistry

BindingDBP30550.
ChEMBLCHEMBL4959.
GuidetoPHARMACOLOGY39.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP30550.

Polymorphism databases

DMDM232185.

Proteomic databases

PaxDbP30550.
PRIDEP30550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380289; ENSP00000369643; ENSG00000126010.
GeneID2925.
KEGGhsa:2925.
UCSCuc004cxj.3. human.

Organism-specific databases

CTD2925.
GeneCardsGC0XP016141.
HGNCHGNC:4609. GRPR.
MIM305670. gene.
neXtProtNX_P30550.
PharmGKBPA29002.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328649.
HOGENOMHOG000230781.
HOVERGENHBG004898.
InParanoidP30550.
KOK04169.
OMACNISNHS.
OrthoDBEOG73V6KG.
PhylomeDBP30550.
TreeFamTF331292.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP30550.
CleanExHS_GRPR.
GenevestigatorP30550.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001556. Bombsn_rcpt.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGastrin-releasing_peptide_receptor.
GenomeRNAi2925.
NextBio11597.
PROP30550.
SOURCESearch...

Entry information

Entry nameGRPR_HUMAN
AccessionPrimary (citable) accession number: P30550
Secondary accession number(s): B2R910
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries